Defining Th-cell subsets in a classical and tissue-specific manner: Examples from the skin

The Aryl Hydrocarbon Receptor: Multitasking in the Immune System

(2014) Brigitta Stockinger et al.   Annual Review of Immunology

The aryl hydrocarbon receptor is functionally upregulated early in the course of human T-cell activation

(2014) Laurie Prigent et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

The Transcription Factors T-bet and Runx Are Required for the Ontogeny of Pathogenic Interferon-γ-Producing T Helper 17 Cells

(2014) Yan Wang et al.   IMMUNITY

Tissue-resident T cells,in situimmunity and transplantation

(2014) Damian L. Turner et al.   IMMUNOLOGICAL REVIEWS

CCR10 regulates balanced maintenance and function of resident regulatory and effector T cells to promote immune homeostasis in the skin

(2014) Mingcan Xia et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Secukinumab in Plaque Psoriasis — Results of Two Phase 3 Trials

(2014) Richard G. Langley et al.   NEW ENGLAND JOURNAL OF MEDICINE

Intraindividual genome expression analysis reveals a specific molecular signature of psoriasis and eczema

(2014) M. Quaranta et al.   Science Translational Medicine

IL-17 and GM-CSF Expression Are Antagonistically Regulated by Human T Helper Cells

(2014) R. Noster et al.   Science Translational Medicine

Immunology of atopic eczema: overcoming the Th1/Th2 paradigm

(2013) K. Eyerich et al.   ALLERGY

The who's who of T-cell differentiation: Human memory T-cell subsets

(2013) Yolanda D. Mahnke et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

Helper T-cell identity and evolution of differential transcriptomes and epigenomes

(2013) Golnaz Vahedi et al.   IMMUNOLOGICAL REVIEWS

Tissue-resident memory T cells

(2013) Haina Shin et al.   IMMUNOLOGICAL REVIEWS

Transcription factors and CD4 T cells seeking identity: masters, minions, setters and spikers

(2013) Golnaz Vahedi et al.   IMMUNOLOGY

Th17 Cells Carrying TCR Recognizing Epidermal Autoantigen Induce Psoriasis-like Skin Inflammation

(2013) S. Nishimoto et al.   JOURNAL OF IMMUNOLOGY

The developmental pathway for CD103+CD8+ tissue-resident memory T cells of skin

(2013) Laura K Mackay et al.   NATURE IMMUNOLOGY

IL-29 Is Produced by TH17 Cells and Mediates the Cutaneous Antiviral Competence in Psoriasis

(2013) K. Wolk et al.   Science Translational Medicine

Regulation von pro- und antiinflammatorischen Th17-Zellen

(2013) C.E. Zielinski   ZEITSCHRIFT FUR RHEUMATOLOGIE

Foxp3 Exploits a Pre-Existent Enhancer Landscape for Regulatory T Cell Lineage Specification

(2012) Robert M. Samstein et al.   CELL

A Validated Regulatory Network for Th17 Cell Specification

(2012) Maria Ciofani et al.   CELL

STATs Shape the Active Enhancer Landscape of T Cell Populations

(2012) Golnaz Vahedi et al.   CELL

Human Th17 subsets

(2012) Federica Sallusto et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

Does “autoreactivity” play a role in atopic dermatitis?

(2012) Ting Seng Tang et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Microbial-Induced Th17: Superhero or Supervillain?

(2012) M. J. McGeachy et al.   JOURNAL OF IMMUNOLOGY

Skin infection generates non-migratory memory CD8+ TRM cells providing global skin immunity

(2012) Xiaodong Jiang et al.   NATURE

Pathogen-induced human TH17 cells produce IFN-γ or IL-10 and are regulated by IL-1β

(2012) Christina E. Zielinski et al.   NATURE

Skin Effector Memory T Cells Do Not Recirculate and Provide Immune Protection in Alemtuzumab-Treated CTCL Patients

(2012) R. A. Clark et al.   Science Translational Medicine

Role of the Commensal Microbiota in Normal and Pathogenic Host Immune Responses

(2011) Dan R. Littman et al.   Cell Host & Microbe

IL-22 and TNF-α represent a key cytokine combination for epidermal integrity during infection withCandida albicans

(2011) Stefanie Eyerich et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

Gain-of-function humanSTAT1mutations impair IL-17 immunity and underlie chronic mucocutaneous candidiasis

(2011) Luyan Liu et al.   JOURNAL OF EXPERIMENTAL MEDICINE

IL-21 Promotes Skin Recruitment of CD4+ Cells and Drives IFN- -Dependent Epidermal Hyperplasia

(2011) M. Sarra et al.   JOURNAL OF IMMUNOLOGY

Epigenetic Changes at Il12rb2 and Tbx21 in Relation to Plasticity Behavior of Th17 Cells

(2011) D. Bending et al.   JOURNAL OF IMMUNOLOGY

Mutual Antagonism of T Cells Causing Psoriasis and Atopic Eczema

(2011) Stefanie Eyerich et al.   NEW ENGLAND JOURNAL OF MEDICINE

Chronic Mucocutaneous Candidiasis in Humans with Inborn Errors of Interleukin-17 Immunity

(2011) A. Puel et al.   SCIENCE

Neutrophils Activate Plasmacytoid Dendritic Cells by Releasing Self-DNA-Peptide Complexes in Systemic Lupus Erythematosus

(2011) R. Lande et al.   Science Translational Medicine

Staphylococcal exotoxins are strong inducers of IL-22: A potential role in atopic dermatitis

(2010) Margarete Niebuhr et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Identification of a novel subset of human circulating memory CD4+ T cells that produce both IL-17A and IL-4

(2010) Lorenzo Cosmi et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Autoantibodies against IL-17A, IL-17F, and IL-22 in patients with chronic mucocutaneous candidiasis and autoimmune polyendocrine syndrome type I

(2010) Anne Puel et al.   JOURNAL OF EXPERIMENTAL MEDICINE

IL-17 Amplifies Human Contact Hypersensitivity by Licensing Hapten Nonspecific Th1 Cells to Kill Autologous Keratinocytes

(2010) D. Pennino et al.   JOURNAL OF IMMUNOLOGY

Comparison of Ustekinumab and Etanercept for Moderate-to-Severe Psoriasis

(2010) Christopher E.M. Griffiths et al.   NEW ENGLAND JOURNAL OF MEDICINE

IL-17 and IL-22: siblings, not twins

(2010) Stefanie Eyerich et al.   TRENDS IN IMMUNOLOGY

Visualizing CD4 T-cell migration into inflamed skin and its inhibition by CCR4/CCR10 blockades usingin vivoimaging model

(2009) X. Wang et al.   BRITISH JOURNAL OF DERMATOLOGY

Cytokine modulation of atopic dermatitis filaggrin skin expression

(2009) Michael D. Howell et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Identification of a human helper T cell population that has abundant production of interleukin 22 and is distinct from TH-17, TH1 and TH2 cells

(2009) Sara Trifari et al.   NATURE IMMUNOLOGY

Production of interleukin 22 but not interleukin 17 by a subset of human skin-homing memory T cells

(2009) Thomas Duhen et al.   NATURE IMMUNOLOGY

Psoriasis

(2009) Frank O. Nestle et al.   NEW ENGLAND JOURNAL OF MEDICINE

A HomozygousCARD9Mutation in a Family with Susceptibility to Fungal Infections

(2009) Erik-Oliver Glocker et al.   NEW ENGLAND JOURNAL OF MEDICINE

Staphylococcus aureus in the Community: Colonization Versus Infection

(2009) Maureen Miller et al.   PLoS One

Loricrin and involucrin expression is down-regulated by Th2 cytokines through STAT-6

(2008) Byung Eui Kim et al.   CLINICAL IMMUNOLOGY

Is FOXP3 a bona fide marker for human regulatory T cells?

(2008) Maria-Grazia Roncarolo et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

IL-17 in atopic eczema: Linking allergen-specific adaptive and microbial-triggered innate immune response

(2008) Kilian Eyerich et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Th2 Cytokines Act on S100/A11 to Downregulate Keratinocyte Differentiation

(2008) Michael D. Howell et al.   JOURNAL OF INVESTIGATIVE DERMATOLOGY

Patients with Chronic Mucocutaneous Candidiasis Exhibit Reduced Production of Th17-Associated Cytokines IL-17 and IL-22

(2008) Kilian Eyerich et al.   JOURNAL OF INVESTIGATIVE DERMATOLOGY

Differentiation of human TH-17 cells does require TGF-β!

(2008) Anne O'Garra et al.   NATURE IMMUNOLOGY

Transforming growth factor-β 'reprograms' the differentiation of T helper 2 cells and promotes an interleukin 9–producing subset

(2008) Marc Veldhoen et al.   NATURE IMMUNOLOGY

Atopic Dermatitis

(2008) Thomas Bieber   NEW ENGLAND JOURNAL OF MEDICINE