Article
Pharmacology & Pharmacy
Cheng Wang, Xianghuang Mei, Yanrong Wu, Yuting Yang, Zhenguo Zeng
Summary: This study revealed for the first time that cinobufagin inhibited the inflammatory response in LPS-induced ALI, which lays the foundation for further understanding and development of cinobufagin as a potential new drug for ALI.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Immunology
Cheng Wang, Yuting Yang, Chaoqi Zhou, Xianghuang Mei, Jing Liu, Kaihang Luo, Jia Zhou, Cheng Qin, Zhenguo Zeng
Summary: This study investigated the expression of WWOX in mouse lung and epithelial cells and explored its role in the LPS-induced ALI model. The researchers found that overexpressing WWOX could activate autophagy and suppress inflammatory responses, thus protecting against LPS-induced ALI.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2023)
Article
Pharmacology & Pharmacy
Xin Lv, Tingting Yao, Rongling He, Yijun He, Mengyu Li, Yuanyuan Han, Yan Zhang, Lingzhi Long, Guoliang Jiang, Xiaoyun Cheng, Yanyun Xie, Ling Huang, Zhangzhe Peng, Gaoyun Hu, Qianbin Li, Lijian Tao, Jie Meng
Summary: Fluorofenidone demonstrates protective effects against LPS-induced ALI by alleviating lung tissue injury, reducing inflammation, and inhibiting the activation of the MAPK/NF-κB signaling pathway.
FRONTIERS IN PHARMACOLOGY
(2021)
Review
Biochemistry & Molecular Biology
Yan Zhang, Jin Zhang, Zhiling Fu
Summary: This review discusses the potential therapeutic effects of molecular hydrogen on acute lung injury (ALI) and its underlying mechanisms, aiming to provide a theoretical basis for the clinical treatment of ALI and COVID-19.
MOLECULAR MEDICINE
(2022)
Article
Biochemistry & Molecular Biology
Wenfang Xia, Zhou Pan, Huanming Zhang, Qingshan Zhou, Yu Liu
Summary: This study investigates the role of estrogen-related receptor alpha (ERRα) in sepsis-induced acute lung injury (ALI). The results show that overexpression of ERRα can ameliorate LPS-induced endothelial hyperpermeability, apoptosis, and inhibit autophagy, while knockdown of ERRα exacerbates these effects. Administration of an ERRα agonist can alleviate pathological damage, increase the levels of junctional proteins, and decrease apoptosis-related protein expression. Promoting ERRα expression enhances autophagy and reduces sepsis-induced ALI. ERRα is essential for maintaining the integrity of adherens junctions by regulating the balance between autophagy and apoptosis.
MOLECULAR MEDICINE
(2023)
Article
Cell Biology
Xiaolei Gong, Limin Zhu, Jinlong Liu, Chunxiang Li, Zhuoming Xu, Jinfen Liu, Haibo Zhang
Summary: The novel lncRNA MIR3142HG plays a crucial role in LPS-induced ALI by regulating the miR-450b-5p/HMGB1 signaling pathway, indicating its potential as a therapeutic target for ALI treatment.
MOLECULAR AND CELLULAR BIOCHEMISTRY
(2021)
Article
Urology & Nephrology
Ruolin Wang, Siheng Shen, Luyong Jian, Shuhua Liu, Qi Yuan, Huahui Guo, Jiasheng Huang, Penghui Chen, Renfa Huang
Summary: This study investigated the role of autophagy in AKI-induced ALI and found that autophagy can effectively ameliorate the injury by suppressing inflammation and oxidative stress.
Article
Immunology
Bo Yang, Ling Ma, Yuli Wei, Yunyao Cui, Xiaohe Li, Yiying Wei, Shanshan Zhang, Liang Zhang, Honggang Zhou, Guangshun Wang, Xiaoping Li
Summary: Isorhamnetin can attenuate the injury of type II alveolar epithelial cells by inhibiting the TLR4/NF-κB pathway, promote autophagy to reduce lung injury caused by LPS, and inhibit LPS-induced epithelial cell apoptosis.
IMMUNOPHARMACOLOGY AND IMMUNOTOXICOLOGY
(2022)
Article
Cell Biology
Jiayao Zhao, Qun Liang, Chenfei Fu, Didi Cong, Long Wang, Xiaoxin Xu
Summary: Sepsis-induced acute lung injury (ALI) is a severe syndrome with a heavy burden on family and society. Autophagy, as a key factor in cellular homeostasis, plays an important role in the pathophysiological process of sepsis-induced ALI. Regulating autophagy may be beneficial for this disease, although its role in the etiology and treatment is not well characterized.
CELLULAR SIGNALLING
(2023)
Article
Biochemistry & Molecular Biology
Qijian Ji, Zhaorui Sun, Zhizhou Yang, Wei Zhang, Yi Ren, Weijun Chen, Mengya Yao, Shinan Nie
Summary: The study found that autophagy can counteract cell apoptosis in LPS-treated MLE-12 cells, while promoting autophagy effectively reduces cell apoptosis.
MOLECULAR IMMUNOLOGY
(2021)
Article
Immunology
Shuai Mao, Jian Lv, Meng Chen, Ningning Guo, Yu Fang, Jingjing Tong, Xianghu He, Gang Wu, Zhihua Wang
Summary: The expression of Serinc2 is upregulated in acute lung injury caused by cecal ligation and puncture. Knockout of Serinc2 worsens lung injury in mice induced by cecal ligation and puncture. Serinc2 deficiency leads to increased expression of inflammatory factors and over-activation of multiple signaling pathways. On the other hand, overexpression of Serinc2 in RAW264.7 cells can suppress the inflammatory response induced by lipopolysaccharide and alleviate cell apoptosis.
JOURNAL OF INFLAMMATION-LONDON
(2022)
Article
Immunology
Zhiling Fu, Xiuying Wu, Fushuang Zheng, Yan Zhang
Summary: Sevoflurane suppresses apoptosis and inflammation by activating protective autophagy, thereby ameliorating LPS-induced ALI. The AMPK/ULK1/PIKFYVE pathway plays a key role in this process.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Jianhua Li, Mengyu Li, Ling Li, Jiamin Ma, Chengye Yao, Shanglong Yao
Summary: GYY4137 alleviates septicemia-induced ferroptosis and inhibits autophagy activation in ALI by increasing the expression of GPx4 and SLC7A11 and blocking mTOR signaling pathway.
MOLECULAR IMMUNOLOGY
(2022)
Article
Cell Biology
Nursel Dikmen, Mustafa Cellat, Muhammed Etyemez, Cafer Tayer Isler, Ahmet Uyar, Tuba Aydin, Mehmet Guvenc
Summary: The study demonstrated that oleuropein, a component of olive leaf, has protective effects against LPS-induced ALI in rats, reducing inflammatory cytokines and oxidative stress, and improving the histopathological conditions of lung tissue.
Article
Pharmacology & Pharmacy
Guoli Zhang, Fei Xie, Yunbo Sun, Xiang Yu, Zhimei Xiao, Rongzhen Fang, Jingfei Li, Qian Li, Lina Du, Yiguang Jin
Summary: The study aimed to prepare and investigate the effects of Jojoba oil nanoemulsion dry powder on acute lung injury. The results showed that JNDs could effectively alleviate lung injury and have good anti-inflammatory and antioxidant effects.
Editorial Material
Surgery
Meghal Shah, Tejas S. Sathe, Sukriti Bansal, Anai N. Kothari, Sophie Dream
JOURNAL OF SURGICAL RESEARCH
(2024)
Letter
Surgery
Zafer Turkyilmaz, Ramazan Karabulut, Kaan Sonmez
JOURNAL OF SURGICAL RESEARCH
(2024)
Letter
Surgery
Priyanka Jadhav, Gerald Gollin
JOURNAL OF SURGICAL RESEARCH
(2024)
Review
Surgery
Kheira Hireche, Ludovic Canaud, Pierre Antoine Peyron, Linda Sakhri, Isabelle Serres, Sanaa Kamel, Youcef Lounes, Thomas Gandet, Pierre Alric
Summary: This study evaluated the elastic properties of commonly used vascular substitutes for pulmonary artery replacement and compared their compliance and stiffness indexes to human pulmonary artery. The results showed that allogenic arterial grafts appeared to be the most suitable vascular substitutes in terms of compliance and stiffness for PA replacement.
JOURNAL OF SURGICAL RESEARCH
(2024)
Article
Surgery
Margaret Siu, Aixa Perez Coulter, Heather M. Grant, Reginald Alouidor, Michael Tirabassi
Summary: There is no significant difference in adverse respiratory events between intubated, critically ill patients requiring operative intervention who are kept NPO for 6 hours or longer compared to those kept NPO for less than 6 hours. Patients commonly experience periods of fasting much longer than the recommended 6-hour period by the American Society of Anesthesiologists.
JOURNAL OF SURGICAL RESEARCH
(2024)
Article
Surgery
Whitney Elks, Allison G. McNickle, Matthew Kelecy, Kavita Batra, Shirley Wong, Shawn Wang, Lisa Angotti, Deborah A. Kuhls, Charles St Hill, Syed F. Saquib, Paul J. Chestovich, Douglas R. Fraser
Summary: This study aimed to compare the effects of early and late enteral feeding after PEG placement on achieving nutritional therapy goals and adverse outcomes. The results showed that patients with early initiation of feeds achieved a higher percentage of goals on day 0 without an increased rate of adverse events.
JOURNAL OF SURGICAL RESEARCH
(2024)
Article
Surgery
Manisha B. Bhatia, Cassandra M. Anderson, Abdiwahab N. Hussein, Brian Opondo, Nereah Aruwa, Otieno Okumu, Sarah G. Fisher, Tasha Sparks Joplin, JoAnna L. Hunter-Squires, Brian W. Gray, Peter W. Saula
Summary: This study aimed to understand postoperative pediatric nutrition practices in Kenya and the United States. The results showed that in the United States, patients initiated enteral nutrition earlier and had shorter hospital stays. However, in Kenya, patients initiated enteral nutrition earlier but had no significant difference in hospital stays.
JOURNAL OF SURGICAL RESEARCH
(2024)
Article
Surgery
David P. Stonko, Joseph Edwards, Hossam Abdou, Rebecca Treffalls, Patrick Walker, Jonathan J. Morrison
Summary: Raising mean arterial pressure (MAP) >90 mmHg with norepinephrine can increase gastroduodenal artery (GDA) flow and delay bowel ischemia.
JOURNAL OF SURGICAL RESEARCH
(2024)
Article
Surgery
David R. Mann, Kathryn E. Engelhardt, Barry C. Gibney, Macelyn E. Batten, Eric C. Klipsch, Rupak Mukherjee, Ian C. Bostock
Summary: Pathologic upstaging is associated with decreased overall survival in cT1b esophageal cancer. Esophagectomy has better survival outcomes compared to endoscopic local tumor excision. Neoadjuvant chemoradiation therapy does not improve overall survival in cT1b lesions.
JOURNAL OF SURGICAL RESEARCH
(2024)
Article
Surgery
Ross Mudgway, Zachary Tran, Juan C. Quispe Espiritu, Woo Bin Bong, Hayden Schultz, Vamsi Vemireddy, Aarthy Kannappan, Marcos Michelotti, Kaushik Mukherjee, Jeffrey Quigley, Keith Scharf, Daniel Srikureja, Sharon S. Lum, Esther Wu
Summary: Comparison of medium-term outcomes between robotic-assisted cholecystectomy (RC) and laparoscopic cholecystectomy (LC) using validated quality of life (QoL) and pain assessments did not show significant differences.
JOURNAL OF SURGICAL RESEARCH
(2024)
Article
Surgery
Ningjie Chen, Haitao Wang, Yang Shao, Jincun Yang, Guodong Song
Summary: This study aimed to compare the therapeutic effects of activated platelet-rich plasma (PRP) prepared from elderly individuals and young adults in treating pressure ulcers (PUs). The results showed that PRP from young adults had higher platelet concentrations and greater production of growth factors, leading to better wound healing.
JOURNAL OF SURGICAL RESEARCH
(2024)
Article
Surgery
Brendin R. Beaulieu-Jones, Margaret T. Berrigan, Kortney A. Robinson, Jayson S. Marwaha, Tara S. Kent, Gabriel A. Brat
Summary: Introduction: Prescription opioids, including those prescribed after surgery, have greatly contributed to the US opioid epidemic. Educating opioid prescribers is a crucial component of ensuring the safe use of opioids among surgical patients. This study implemented an annual education curriculum for new surgical prescribers, resulting in significant improvements in knowledge and comfort levels. However, there remains a persistent knowledge and comfort gap among these prescribers.
JOURNAL OF SURGICAL RESEARCH
(2024)
Article
Surgery
Sneha G. Bhat, Madhuri Nagaraj, Courtney Balentine, Timothy Hogan, Jennie Meier, Hillary Prince, Kareem Abdelfattah, Herbert Zeh, Benjamin Levi
Summary: This pilot study examined the effects of a structured mental fitness program on academic surgeons and found significant improvement in Positive Intelligence (PQ) scores, as well as increased connectedness and shared language among participants. However, there were no significant changes in sleep, well-being, or teaching evaluations.
JOURNAL OF SURGICAL RESEARCH
(2024)
Article
Surgery
Kristin E. Cox, Michael A. Turner, Siamak Amirfakhri, Thinzar M. Lavin, Mojgan Hosseini, Pradipta Ghosh, Marygorret Obonyo, Takashi Murakami, Robert M. Hoffman, Paul J. Yazaki, Michael Bouvet
Summary: This study demonstrates the potential of using humanized anti-carcinoembryonic antigen (CEA) antibodies conjugated with near-infrared dyes to specifically label gastric cancers in mouse models. Orthotopic models showed bright and specific labeling with more than ten times higher tumor-to-background ratios compared to the control. This tumor-specific fluorescent antibody has promising potential as a clinical tool for improving visualization of gastric cancer margins during surgical resection.
JOURNAL OF SURGICAL RESEARCH
(2024)
Review
Surgery
Sarah Maki, Melissa Leon, Emily Glenn, Tiffany Tanner, Crystal Krause
Summary: This scoping review analyzed the literature on the use of broadband personality tests in the bariatric surgical population to optimize weight loss outcomes. The study found significant associations between personality scales and weight loss, but inconsistent reporting of outcome measures made it challenging to draw concrete conclusions. The American Society for Metabolic and Bariatric Surgery recommends standardization of outcome reporting to improve the reliability of predicting weight loss outcomes.
JOURNAL OF SURGICAL RESEARCH
(2024)