Article
Cell Biology
Leila Fonderflick, Timothee Baudu, Olivier Adotevi, Michael Guittaut, Pascale Adami, Regis Delage-Mourroux
Summary: Vaccine therapy is a promising method of research to promote T cell immune response and to develop novel antitumor immunotherapy protocols. Increasing evidence shows that autophagy plays a role in antigen processing and presentation to T cells.
Review
Immunology
Mami Matsuda-Lennikov, Izumi Ohigashi, Yousuke Takahama
Summary: Thymoproteasomes and immunoproteasomes are two types of tissue-specific proteasomes that play important roles in the development of CD8(+) T cells.
CURRENT OPINION IN IMMUNOLOGY
(2022)
Article
Virology
Leon C. W. Lin, Sarah N. Croft, Nathan P. Croft, Yik Chun Wong, Stewart A. Smith, Swee-Seong Tang, Anthony W. Purcell, David C. Tscharke
Summary: The study investigated the CD8(+) T cell priming pathways for Vaccinia virus (VACV) by engineering the virus to express inhibitors of antigen presentation. While the inhibitors had diverse impacts on CD8(+) T cell responses, unexpectedly, the direct priming of CD8(+) T cells by poxviruses was robust enough to withstand potent viral inhibitors of antigen presentation. This demonstrates the flexibility and robustness of immune processes in activating immune responses required to fight infection.
JOURNAL OF VIROLOGY
(2021)
Editorial Material
Hematology
Alan H. Lazarus, John W. Semple
Summary: A study found that patients with chronic ITP have clonal expansions of a specific subset of CD8 T cells called terminally differentiated effector memory (TEMRA) T cells. These cells persist over the course of the disease, are more prominent in refractory ITP, and are more prevalent when the platelet count is low.
Review
Biochemistry & Molecular Biology
Eliza Mari Kwesi-Maliepaard, Heinz Jacobs, Fred van Leeuwen
Summary: T-AIM cells are a subset of memory T cells that develop memory features independently of antigen exposure. They exhibit characteristics similar to conventional memory cells, including antigen-specific responses and responsiveness to innate stimuli. T-AIM cells are suggested to provide additional levels of protection against infections and cancer.
CELLULAR AND MOLECULAR LIFE SCIENCES
(2021)
Article
Biology
Scott M. Anthony, Natalija Van Braeckel-Budimir, Steven J. Moioffer, Stephanie van de Wall, Qiang Shan, Rahul Vijay, Ramakrishna Sompallae, Stacey M. Hartwig, Isaac J. Jensen, Steven M. Varga, Noah S. Butler, Hai-Hui Xue, Vladimir P. Badovinac, John T. Harty
Summary: IAV infection generates Trm CD8(+)T cells in mice, while repeated antigen exposure produces 4M CD8(+)T cells with enhanced protective capacity. Enhanced protection by 4M cells is associated with increased expression of granzyme A/B and stable maintenance of CD69(+)CD103(+) 4M CD8(+)T cells, improving control of viral infections in mLN.
Article
Biochemistry & Molecular Biology
Huafeng Zhang, Jincheng Liu, Zhuoshun Yang, Liping Zeng, Keke Wei, Liyan Zhu, Liang Tang, Dianheng Wang, Yabo Zhou, Jiadi Lv, Nannan Zhou, Ke Tang, Jingwei Ma, Bo Huang
Summary: Glycolysis plays a crucial role in the recall response of CD8(+) memory T cells. This study reveals that intracellular glycogen serves as the major carbon source for the early recall response, and TCR signaling regulates this process through the phosphorylation of PYGB. This discovery highlights the specific dependence of memory T cell activation on glycogen and its potential therapeutic implications.
Article
Medicine, Research & Experimental
Wanqiong Yuan, Xiaoqing Ren, Junxiong Zhu, Jie Huang, Wang Zhang, Chenggui Zhang, Zhiyuan Guan, Hong Wang, Huijie Leng, Chunli Song
Summary: This study found that simvastatin intraosseous (i.o.) injection effectively suppresses cancer progression by increasing the proportion and cytotoxicity of CD8(+) T cells, downregulating the expression of PD-1, TIM3, and CTLA4 in CD8(+) T cells, and activating the T-cell antigen receptor signaling pathway. Simvastatin i.o. may be a potential strategy for cancer treatment.
BIOMEDICINE & PHARMACOTHERAPY
(2022)
Article
Immunology
Vishnu Raman, Lars M. Howell, Shoshana M. K. Bloom, Christopher L. Hall, Victoria E. Wetherby, Lisa M. Minter, Ashish A. Kulkarni, Neil S. Forbes
Summary: This study genetically engineered Salmonella to deliver exogenous antigens into tumor cells, aiming to activate antigen-specific CD8 T cells for immunotherapy. The results showed that intracellular delivery of the antigen reduced tumor growth and triggered a cytotoxic T cell response. In mice, intracellular delivery of the antigen cleared established tumors and increased survival.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Immunology
Hiroyuki Kondo, Takahiro Kageyama, Shigeru Tanaka, Kunihiro Otsuka, Shin-ichi Tsukumo, Yoichi Mashimo, Yoshihiro Onouchi, Hiroshi Nakajima, Koji Yasutomo
Summary: Three weeks after receiving the BNT162b2 vaccine, females in the Japanese population showed a higher number and stronger function of memory CD8+ T cells compared to males. Memory precursor effector cells were more abundant in females, and their memory CD8+ T cells had stronger responses to S protein stimulation. These findings provide important insights into the sex differences in cellular immune responses to mRNA vaccination.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Oncology
Liang Lin, Shih-Feng Cho, Lijie Xing, Kenneth Wen, Yuyin Li, Tengteng Yu, Phillip A. Hsieh, Hailin Chen, Metin Kurtoglu, Yi Zhang, C. Andrew Stewart, Nikhil Munshi, Kenneth C. Anderson, Yu-Tzu Tai
Summary: The study introduces a novel CD8+ CAR T-cell product, Descartes-08, for the treatment of multiple myeloma, with predictable pharmacokinetics and limited risks of uncontrolled proliferation and drug resistance. Preclinical data and ongoing clinical trials have demonstrated the effectiveness and safety of Descartes-08 in inhibiting myeloma growth and providing durable responses in patients.
Article
Biochemistry & Molecular Biology
Eunjung Cho, Seongeun Han, Hyeon Seok Eom, Sang-Jin Lee, Chungyong Han, Rohit Singh, Seon-Hee Kim, Bo-Mi Park, Byoung-Gie Kim, Young H. Kim, Byoung S. Kwon, Ki Taek Nam, Beom K. Choi
Summary: The interaction between regulatory T (Treg) cells and self-reactive T cells is crucial for maintaining immune tolerance. This study reveals that self-antigens can activate CD8(+) T cells and induce delayed proliferation of Treg cells. The P53 signaling pathway plays a critical role in this process. Understanding the mechanisms of Treg cell stimulation and its implications in autoimmune diseases and cancer immunotherapy is important.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Immunology
Tresa Rani Sarraf, Malini Sen
Summary: This study demonstrates the crucial role of Wnt5A signaling in antigen processing and CD8 T cell activation. The results show that Wnt5A signaling regulates actin and proteasome dynamics to support antigen processing and presentation, and depletion of Wnt5A leads to impaired antigen processing and reduced CD8 T cell activation. These findings highlight the importance of Wnt5A in cell-mediated immunity.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Immunology
Anastasia A. Minervina, Mikhail Pogorelyy, Allison M. Kirk, Jeremy Chase Crawford, E. Kaitlynn Allen, Ching-Heng Chou, Robert C. Mettelman, Kim J. Allison, Chun-Yang Lin, David C. Brice, Xun Zhu, Kasi Vegesana, Gang Wu, Sanchit Trivedi, Pratibha Kottapalli, Daniel Darnell, Suzanne McNeely, Scott R. Olsen, Stacey Schultz-Cherry, Jeremie H. Estepp, Maureen A. McGargill, Joshua Wolf, Paul G. Thomas
Summary: Thomas and colleagues explore the impact of multiple SARS-CoV-2 antigen exposures on T cell immunity. They find that vaccination after infection leads to expansion of spike-specific T cells, while individuals after breakthrough infection mount vigorous non-spike-specific responses. They also observe that all exposures elicit diverse T cell immune repertoires, with no evidence of repertoire narrowing from repeated exposure.
Article
Immunology
Adele Friot, Sophia Djebali, Severine Valsesia, Peggy Parroche, Maxence Dubois, Jessica Baude, Francois Vandenesch, Jacqueline Marvel, Yann Leverrier
Summary: Staphylococcus aureus is a pathogen associated with various diseases and the emergence of antibiotic-resistant strains has raised concerns. Developing vaccines may help overcome these resistant strains, but the ability of S. aureus to internalize into cells poses a challenge. This study explores the potential of CD8(+) T cells to recognize and kill S. aureus-infected dendritic cells, paving the way for CD8(+) T cell-based therapies against S. aureus.
FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Hiroyuki Uechi, Erina Kuranaga, Tomohiro Iriki, Kohei Takano, Shoshiro Hirayama, Masayuki Miura, Jun Hamazaki, Shigeo Murata
MOLECULAR AND CELLULAR BIOLOGY
(2018)
Article
Multidisciplinary Sciences
Tatsuyuki Matsudaira, Kojiro Mukai, Taishin Noguchi, Junya Hasegawa, Tomohisa Hatta, Shun-ichiro Iemura, Tohru Natsume, Norio Miyamura, Hiroshi Nishina, Jun Nakayama, Kentaro Semba, Takuya Tomita, Shigeo Murata, Hiroyuki Arai, Tomohiko Taguchi
NATURE COMMUNICATIONS
(2017)
Article
Reproductive Biology
Rosie T. Jiang, Anna Yemelyanova, Deyin Xing, Ravi K. Anchoori, Jun Hamazaki, Shigeo Murata, Jeffrey D. Seidman, Tian-Li Wang, Richard B. S. Roden
JOURNAL OF OVARIAN RESEARCH
(2017)
Article
Multidisciplinary Sciences
Shoshiro Hirayama, Munechika Sugihara, Daisuke Morito, Shun-ichiro Iemura, Tohru Natsume, Shigeo Murata, Kazuhiro Nagata
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2018)
Article
Cell Biology
Wei Wu, Kazutaka Sahara, Shoshiro Hirayama, Xian Zhao, Ayaka Watanabe, Jun Hamazaki, Hideki Yashiroda, Shigeo Murata
Review
Immunology
Shigeo Murata, Yousuke Takahama, Masanori Kasahara, Keiji Tanaka
Article
Cell Biology
Ryota Otsubo, Hitomi Mimuro, Hiroshi Ashida, Jun Hamazaki, Shigeo Murata, Chihiro Sasakawa
CELLULAR MICROBIOLOGY
(2019)
Review
Genetics & Heredity
Yousuke Takahama, Izumi Ohigashi, Shigeo Murata, Keiji Tanaka
Article
Immunology
Anca Apavaloaei, Sylvie Brochu, Mengqi Dong, Alexandre Rouette, Marie-Pierre Hardy, Geno Villafano, Shigeo Murata, Heather J. Melichar, Claude Perreault
JOURNAL OF IMMUNOLOGY
(2019)
Article
Biochemistry & Molecular Biology
Takuya Tomita, Shoshiro Hirayama, Yasuyuki Sakurai, Yuki Ohte, Hidehito Yoshihara, Yasushi Saeki, Jun Hamazaki, Shigeo Murata
MOLECULAR AND CELLULAR BIOLOGY
(2019)
Review
Multidisciplinary Sciences
Shun Koizumi, Jun Hamazaki, Shigeo Murata
PROCEEDINGS OF THE JAPAN ACADEMY SERIES B-PHYSICAL AND BIOLOGICAL SCIENCES
(2018)
Article
Cell Biology
Utano Tomaru, Saori Konno, Syota Miyajima, Rikuto Kimoto, Mari Onodera, Shizuka Kiuchi, Shigeo Murata, Akihiro Ishizu, Masanori Kasahara
Meeting Abstract
Clinical Neurology
H. Nakano, S. Murata, T. Kodama, H. Nakae, M. Soma
MOVEMENT DISORDERS
(2018)
Article
Medicine, Research & Experimental
Izumi Ohigashi, Yuki Ohte, Kazuya Setoh, Hiroshi Nakase, Akiko Maekawa, Hiroshi Kiyonari, Yoko Hamazaki, Miho Sekai, Tetsuo Sudo, Yasuharu Tabara, Hiromi Sawai, Yosuke Omae, Rika Yuliwulandari, Yasuhito Tanaka, Masashi Mizokami, Hiroshi Inoue, Masanori Kasahara, Nagahiro Minato, Katsushi Tokunaga, Keiji Tanaka, Fumihiko Matsuda, Shigeo Murata, Yousuke Takahama
Article
Immunology
Takeshi Nitta, Yuta Kochi, Ryunosuke Muro, Yoshihiko Tomofuji, Tadashi Okamura, Shigeo Murata, Harumi Suzuki, Takayuki Sumida, Kazuhiko Yamamoto, Hiroshi Takayanagi
SCIENCE IMMUNOLOGY
(2017)