Journal
EUROPEAN JOURNAL OF IMMUNOLOGY
Volume 39, Issue 5, Pages 1425-1434Publisher
WILEY
DOI: 10.1002/eji.200839059
Keywords
Apoptosis; CD127; CD8 T cells; HIV-1
Categories
Funding
- National Key Basic Research Program of China [2006CB504205]
- National Natural Science Foundation of China [30801040]
- National Grand Program on Key Infectious Disease [2008ZX10001-002]
- National Science Fund for Distinguished Young Scholars [30525042]
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Chronic HIV-1 infection can induce a significant decrease in CD127 expression on CD8 T cells, but the underlying mechanisms and immunological consequences are unclear. in this study, we investigated CD127 expression on CD8 T cells from a total of 51 HIV-1-infected subjects and 16 healthy individuals and analyzed the association between CD127 expression and CD8 T-cell apoptosis in these HIV-1-infected subjects. We found that CD127 expression on total CD8 T cells was significantly down-regulated, which was correlated with the increased CD8 T-cell apoptosis and disease progression of chronic HIV-1 infection. The in vitro addition of IL-7 efficiently rescued the spontaneous apoptosis of CD8 T cells from HIV-1-infected individuals. IL-7 stimulation also transiently down-regulated CD127 expression, whereas some of the CD127(-) CD8 T cells regained CD127 expression soon after IL-7 was retracted from the incubation medium. Thus, IL-7 stimulation reduced apoptosis of both CD127(+) and CD127(-)CD8 T cells to some degree. These data indicate that CD127 loss might impair IL-7 signaling and increase CD8 T-cell apoptosis during HIV-1 infection. This study, therefore, will extend the notion that IL-7 could be a good candidate for immunotherapy in HIV-1-infected patients.
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