Journal
EUROPEAN JOURNAL OF IMMUNOLOGY
Volume 38, Issue 9, Pages 2386-2388Publisher
WILEY
DOI: 10.1002/eji.200838763
Keywords
DC; developmental immunology; transcription factors
Categories
Funding
- NIAID NIH HHS [R01 AI097348] Funding Source: Medline
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DC play central roles in priming both innate and adaptive immune responses. Multiple DC subsets have been identified on the basis of their phenotype and function. Plasmacytoid DC (pDC) are professional IFN-producing cells that play an essential role in anti-viral immunity. A series of recent studies demonstrates that the regulation of pDC development is different from other types of DC. In this issue of the European Journal of immunology, new insight is provided into how human pDC development is regulated by various transcription factors, in particular by the Ets family protein Spi-B and E-box protein E2-2.
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