Centenarian controls increase variant effect sizes by an average twofold in an extreme case–extreme control analysis of Alzheimer’s disease

Amsterdam Dementia Cohort: Performing Research to Optimize Care

(2018) Wiesje M. van der Flier et al.   JOURNAL OF ALZHEIMERS DISEASE

Optimizing Patient Care and Research: The Amsterdam Dementia Cohort

(2018) Wiesje M. van der Flier et al.   JOURNAL OF ALZHEIMERS DISEASE

Four Genome-Wide Association Studies Identify New Extreme Longevity Variants

(2017) Paola Sebastiani et al.   JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES

Rare coding variants in PLCG2, ABI3, and TREM2 implicate microglial-mediated innate immunity in Alzheimer's disease

(2017) Rebecca Sims et al.   NATURE GENETICS

Genome-wide meta-analysis associates HLA-DQA1/DRB1 and LPA and lifestyle factors with human longevity

(2017) Peter K. Joshi et al.   Nature Communications

The Longitudinal Aging Study Amsterdam: cohort update 2016 and major findings

(2016) Emiel O. Hoogendijk et al.   EUROPEAN JOURNAL OF EPIDEMIOLOGY

Genetic landscape of APOE in human longevity revealed by high-throughput sequencing

(2016) Seungjin Ryu et al.   MECHANISMS OF AGEING AND DEVELOPMENT

A reference panel of 64,976 haplotypes for genotype imputation

(2016)   NATURE GENETICS

Next-generation genotype imputation service and methods

(2016) Sayantan Das et al.   NATURE GENETICS

Centenarians as super-controls to assess the biological relevance of genetic risk factors for common age-related diseases: A proof of principle on type 2 diabetes

(2016) Paolo Garagnani et al.   Aging-US

Polygenic Overlap Between C-Reactive Protein, Plasma Lipids, and Alzheimer Disease

(2015) R. S. Desikan et al.   CIRCULATION

Phenotypic extremes in rare variant study designs

(2015) Gina M Peloso et al.   EUROPEAN JOURNAL OF HUMAN GENETICS

The genetic landscape of Alzheimer disease: clinical implications and perspectives

(2015) Caroline Van Cauwenberghe et al.   GENETICS IN MEDICINE

A novel Alzheimer disease locus located near the gene encoding tau protein

(2015) G Jun et al.   MOLECULAR PSYCHIATRY

A global reference for human genetic variation

(2015) Richard A. Gibbs et al.   NATURE

Loss-of-function variants in ABCA7 confer risk of Alzheimer's disease

(2015) Stacy Steinberg et al.   NATURE GENETICS

Rare-Variant Association Analysis: Study Designs and Statistical Tests

(2014) Seunggeung Lee et al.   AMERICAN JOURNAL OF HUMAN GENETICS

GWAS of Longevity in CHARGE Consortium Confirms APOE and FOXO3 Candidacy

(2014) Linda Broer et al.   JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES

A General Approach for Haplotype Phasing across the Full Spectrum of Relatedness

(2014) Jared O'Connell et al.   PLoS Genetics

Identification of rare variants in Alzheimer’s disease

(2014) Jenny Lord et al.   Frontiers in Genetics

Genetics of healthy aging and longevity

(2013) Angela R. Brooks-Wilson   HUMAN GENETICS

Meta-analysis of 74,046 individuals identifies 11 new susceptibility loci for Alzheimer's disease

(2013) Jean-Charles Lambert et al.   NATURE GENETICS

Detecting Rare Variant Effects Using Extreme Phenotype Sampling in Sequencing Association Studies

(2012) Ian J. Barnett et al.   GENETIC EPIDEMIOLOGY

Genetic Analysis of 16 NMR-Lipoprotein Fractions in Humans, the GOLDN Study

(2012) Aldi T. Kraja et al.   LIPIDS

Variant of TREM2 Associated with the Risk of Alzheimer's Disease

(2012) Thorlakur Jonsson et al.   NEW ENGLAND JOURNAL OF MEDICINE

TREM2 Variants in Alzheimer's Disease

(2012) Rita Guerreiro et al.   NEW ENGLAND JOURNAL OF MEDICINE

Using extreme phenotype sampling to identify the rare causal variants of quantitative traits in association studies

(2011) Dalin Li et al.   GENETIC EPIDEMIOLOGY

Cohort Profile: The Longitudinal Aging Study Amsterdam

(2011) M. Huisman et al.   INTERNATIONAL JOURNAL OF EPIDEMIOLOGY

Common variants at MS4A4/MS4A6E, CD2AP, CD33 and EPHA1 are associated with late-onset Alzheimer's disease

(2011) Adam C Naj et al.   NATURE GENETICS

Common variants at ABCA7, MS4A6A/MS4A4E, EPHA1, CD33 and CD2AP are associated with Alzheimer's disease

(2011) Paul Hollingworth et al.   NATURE GENETICS

Genome-wide Analysis of Genetic Loci Associated With Alzheimer Disease

(2010) Sudha Seshadri   JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION

Data quality control in genetic case-control association studies

(2010) Carl A Anderson et al.   Nature Protocols

New approaches to population stratification in genome-wide association studies

(2010) Alkes L. Price et al.   NATURE REVIEWS GENETICS

Dementia incidence continues to increase with age in the oldest old: The 90+ study

(2009) María M. Corrada et al.   ANNALS OF NEUROLOGY

Why Match? Investigating Matched Case-Control Study Designs with Causal Effect Estimation

(2009) Sherri Rose et al.  

Genome-wide association study identifies variants at CLU and CR1 associated with Alzheimer's disease

(2009) Jean-Charles Lambert et al.   NATURE GENETICS

Genome-wide association study identifies variants at CLU and PICALM associated with Alzheimer's disease

(2009) Denise Harold et al.   NATURE GENETICS