Article
Biochemistry & Molecular Biology
Lijun Wang, Songqing Lai, Xueliang Zhou, Qing Wan, Yong Luo, Huaxi Zou, Qicai Wu, Li Wan, Jichun Liu, Huang Huang
Summary: Ischemic preconditioning and ischemic postconditioning have protective effects on myocardial ischemia/reperfusion injury by alleviating oxidative stress and stabilizing mitochondrial function through the Notch1/Hes1/VDAC1 signaling pathway.
JOURNAL OF BIOCHEMICAL AND MOLECULAR TOXICOLOGY
(2022)
Article
Physiology
William N. Morley, Coral L. Murrant, Jamie F. Burr
Summary: The effects of the humoral component of ischemic preconditioning on skeletal muscle tissue were examined, but no significant improvements in contractile function or exercise performance were observed.
EUROPEAN JOURNAL OF APPLIED PHYSIOLOGY
(2023)
Article
Clinical Neurology
Yi-Na Zhang, Qiong Wu, Nan-Nan Zhang, Hui-Sheng Chen
Summary: Ischemic preconditioning (IPC) can protect the blood-brain barrier (BBB) by interfering with glycocalyx, improving neurological pathology in rat models of cerebral ischemia-reperfusion injury (IRI).
TRANSLATIONAL STROKE RESEARCH
(2022)
Article
Biochemistry & Molecular Biology
Changjiang Gu, Fanqi Kong, Junkai Zeng, Xiangwu Geng, Yanqing Sun, Xiongsheng Chen
Summary: Delayed remote ischemic preconditioning (RIPC) has protective effects against spinal cord ischemia-reperfusion injury (SCIRI) in mice, and SIRT3 is involved in this protection through the NMDAR-AMPK-PGC-1 alpha signaling pathway.
CELL AND BIOSCIENCE
(2023)
Article
Critical Care Medicine
Elizabeth Magdelin Hines, Samantha Dowling, Fergus Hegerty, Anita Pelecanos, Kevin Tetsworth
Summary: In this study, one in six patients who underwent emergency fasciotomy for acute compartment syndrome developed an infection within 30 days post-procedure. Burn and trauma patients had significantly higher infection rates compared to vascular patients. Pseudomonas aeruginosa was the most prevalent organism in wound infections, comprising over a third of all infections. Amputation was required in ten patients for infection control, with six of these cases related to Pseudomonas infection and resulting in one patient mortality. Antibiotic therapy combining aminoglycosides, beta-lactams, and quinolones should be considered for empiric treatment of fasciotomy wound infections, especially in burns or trauma cases. Routine peri-operative prophylactic antibiotic coverage following emergency decompression for acute compartment syndrome should be strongly considered.
INJURY-INTERNATIONAL JOURNAL OF THE CARE OF THE INJURED
(2021)
Article
Physiology
Badr Khbouz, Francois Lallemand, Arianna Cirillo, Pascal Rowart, David Legouis, Nor Eddine Sounni, Agnes Noel, Pascal De Tullio, Sophie de Seigneux, Francois Jouret
Summary: This study investigates the protective effects and mechanisms of kidney-centered irradiation against renal ischemia-reperfusion injury (I/R). Kidney irradiation increased vascular surface in the renal parenchyma and conferred resistance against renal I/R damage. These findings suggest potential strategies for the treatment of ischemic acute kidney injury.
AMERICAN JOURNAL OF PHYSIOLOGY-RENAL PHYSIOLOGY
(2022)
Article
Pharmacology & Pharmacy
Ludmila Filaretova, Olga Komkova, Maria Sudalina, Natalia Yarushkina
Summary: Remote ischemic preconditioning (RIPC) has been shown to protect various organs from ischemia-reperfusion injury, with glucocorticoids potentially playing a role in this protective effect. Studies demonstrated that RIPC reduced gastric erosion area in rats, and the involvement of glucocorticoids was confirmed through experiments with glucocorticoid inhibitors and receptor antagonists.
FRONTIERS IN PHARMACOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Paramjit S. Tappia, Anureet K. Shah, Bram Ramjiawan, Naranjan S. Dhalla
Summary: Ischemia/reperfusion injury can compromise cardiac function recovery, but ischemic preconditioning (IP) can reduce oxidative stress and intracellular Ca2+ overload, improving cardiac function and providing cardioprotective effects.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Orthopedics
Prangmalee Leurcharusmee, Passakorn Sawaddiruk, Yodying Punjasawadwong, Nantawit Sugandhavesa, Kasisin Klunklin, Siam Tongprasert, Patraporn Sitilertpisan, Nattayaporn Apaijai, Nipon Chattipakorn, Siriporn C. Chattipakorn
Summary: The study found that ischemic preconditioning (IPC) can protect muscle strength after total knee arthroplasty (TKA) by enhancing mitochondrial fusion proteins and preventing I/R injury. Additionally, IPC significantly increased the expression of Mfn2 and Opa1 proteins, positively impacting postoperative muscle recovery.
JOURNAL OF ORTHOPAEDIC TRANSLATION
(2022)
Article
Medicine, Research & Experimental
Asmaa A. Khalifa, Mennatallah A. Ali, Nahed H. Elsokkary, Samar S. Elblehi, Mahmoud M. El-Mas
Summary: This study investigated the protective effects of simultaneous exposure to a minimal dose of erythropoietin (EPO) and remote ischemic preconditioning (RIPC) against skeletal muscle ischemia and reperfusion (S-I/R) injury. The results showed that the combined application of RIPC and EPO significantly ameliorated the structural and functional abnormalities as well as mitochondrial oxidative and apoptotic damage caused by S-I/R injury.
Article
Multidisciplinary Sciences
Geetanjali Singh, Vibhav Varshney, Ahsas Goyal, Nemat Ali, Muzaffar Iqbal, Ishnoor Kaur, Celia Vargas-De-La-Cruz, Tapan Behl
Summary: The study found that chrysin enhances the therapeutic effect of ischemic preconditioning (IPC) in diabetic rat hearts via the PI3K-Akt-eNOS signaling pathway, reducing ischemia-reperfusion injury.
Article
Cardiac & Cardiovascular Systems
Marco Moscarelli, Gianni D. Angelini, Costanza Emanueli, Saadeh Suleiman, Martino Pepe, Gaetano Contegiacomo, Prakash P. Punjabi
Summary: The study, based on multiple studies, confirmed the cardioprotective effect of RIPC on patients undergoing valve intervention, but did not observe improvement in post-operative clinical outcomes.
INTERNATIONAL JOURNAL OF CARDIOLOGY
(2021)
Article
Medicine, General & Internal
Xinyao Tian, Yan Hu, Yuanxing Liu, Zhe Yang, Haiyang Xie, Lin Zhou, Shusen Zheng
Summary: The study utilized microarray to detect changes in circRNA and mRNA expression in response to hepatic ischemia-reperfusion injury and ischemic preconditioning intervention, identifying a potential target circRNA closely related to protective signaling. By constructing circRNA-miRNA-mRNA axes, the study revealed factors that may play a vital role in the protective mechanism of ischemic preconditioning.
FRONTIERS IN MEDICINE
(2021)
Article
Orthopedics
He Zhang, Mengyao Liu, Hubert T. Kim, Brian T. Feeley, Xuhui Liu
Summary: This study found that preconditioning (PC) has little effect on improving tissue viability at the acute phase of ischemia-reperfusion injury (IRI), but it shows a long-term beneficial role in improving hindlimb function and muscle regeneration, evidenced by increased central nuclei regenerating myofibers. The effects of PC are related to inducing muscle fibro-adipogenic progenitor (FAP) brown/beige-like adipocyte (BAT) differentiation through the beta 3 adrenergic receptor (beta 3AR) signaling pathway.
JOURNAL OF ORTHOPAEDIC RESEARCH
(2021)
Article
Chemistry, Medicinal
Bennet Y. Weber, Gabor B. Brenner, Bernadett Kiss, Tamas G. Gergely, Nabil Sayour, Huimin Tian, Andras Makkos, Aniko Gorbe, Peter Ferdinandy, Zoltan Giricz
Summary: The chronic administration of rosiglitazone does not have significant hidden cardiotoxic effects in myocardial ischemia/reperfusion injury models. However, it may inhibit the antiarrhythmic effects of ischemic preconditioning, which requires further exploration.
Article
Dermatology
Ersoy Acer, Hilal Kaya Erdogan, Evin Kocaturk, Zeynep Nurhan Saracoglu, Ozkan Alatas, Muzaffer Bilgin
JOURNAL OF COSMETIC DERMATOLOGY
(2020)
Article
Hematology
Evin Kocaturk, Zeynep Kusku Kiraz, Hava Uskudar Teke, Sukru Saygin Demir, Ibrahim Ozkan Alatas
INTERNATIONAL JOURNAL OF LABORATORY HEMATOLOGY
(2020)
Article
Cardiac & Cardiovascular Systems
Aykut Sahin, Emrah Sisli
Summary: The study identified neutrophil-lymphocyte ratio (NLR) as a predictor of mortality in patients undergoing coronary artery bypass grafting (CABG). Postoperative 1st hour and 1st day NLR levels were significantly higher in patients who died.
HEART SURGERY FORUM
(2021)
Article
Urology & Nephrology
Nadide Melike Sav, Pelin Kosger, Betul Can, Nuran Cetin, Birsen Ucar, Ozkan Alatas, Fahrettin Akyuz, Bilal Yildiz
Summary: This study found that patients with a solitary kidney are at a higher risk of developing cardiovascular disease, as their kidney function and blood pressure are abnormal. Therefore, close monitoring of these patients should be conducted to prevent severe kidney impairment.
CLINICAL AND EXPERIMENTAL NEPHROLOGY
(2022)
Article
Oncology
Gozde Nur Yurttas, Zeynep Canan Ozdemir, Cihan Tanrikut, Ezgi Kar, Zeynep Kusku Kiraz, Ozkan Alatas, Dilek Burukoglu Donmez, Ozcan Bor
Summary: This study investigates the effects of N-acetylcysteine (NAC) on liver and pancreatic damage induced by L-asparaginase (L-ASP) in rats. The results indicate that NAC can reduce the damage caused by L-ASP.
LEUKEMIA & LYMPHOMA
(2022)
Article
Chemistry, Medicinal
Mehlika D. Altintop, Belgin Sever, Gulsen Akalin Ciftci, Ipek Ertorun, Ozkan Alastas, Ahmet Ozdemir
Summary: New thiosemicarbazones were synthesized and tested as potential anti-inflammatory agents. Compound 4-[4-(piperidin-1-ylsulfonyl)phenyl]-1-[4-(4-cyanophenoxy)benzylidene]thiosemicarbazide showed the highest potency as a selective COX-1 inhibitor. These compounds exhibited low cytotoxic activity and favorable pharmacokinetic properties, suggesting they could serve as oral anti-inflammatory and antioxidant agents.
ARCHIV DER PHARMAZIE
(2022)
Article
Surgery
Zeynep Kusku Kiraz, Ezgi Kar, Fatih Kar, Evin Kocaturk, Medine Nur Kebapci, I. Ozkan Alatas, Sema Uslu
Summary: Oral glucose loading during OGTT may affect oxidative status, leading to decreased TAS and increased TOS levels with increasing glucose and insulin levels. Within five hours of OGTT, oxidative stress parameters and thiol/disulfide balance were found to deteriorate in all groups.
JOURNAL OF INVESTIGATIVE SURGERY
(2022)
Article
Pediatrics
Nuran Cetin, Evin Kocaturk, Asli Kavaz Tufan, Zeynep Kusku Kiraz, Ozkan Alatas
Summary: Immature granulocytes may serve as a biomarker for inflammation in children with predialysis CKD.
PEDIATRIC NEPHROLOGY
(2023)
Article
Radiology, Nuclear Medicine & Medical Imaging
Nevin Aydin, Pinar Yildiz, Dondu Uskudar Cansu, Elif Gundogdu, Ruya Mutluay, Goknur Yorulmaz, Melisa Sahin Tekin, Evin Kocaturk, I. Ozkan Alatas, Elif Doyuk Kartal, Nurettin Erben, Gul Durmaz, Nilgun Kasifoglu, Tercan Us, Garip Sahin, Cengiz Bal, Senay Yilmaz, Cengiz Korkmaz
Summary: This study investigated the correlation between CO-RADS classification, CT patterns of the lung, and laboratory data in patients with a positive RT-PCR test. The results showed that creatinine can be considered an important marker for lung involvement, while LDH can be considered an important marker for parenchymal involvement. The structured total CT scoring system was proposed as an alternative method for evaluation.
BMC MEDICAL IMAGING
(2022)
Article
Ophthalmology
Omer Sozer, Onur Ozalp, Eray Atalay, Sukru Saygin Demir, Ibrahim Ozkan Alatas, Nilgun Yildirim
Summary: This study evaluated the blood levels of vitamin B12, folic acid, riboflavin, and homocysteine in KC patients and healthy subjects. The results showed no differences in homocysteine, vitamin B12, and folic acid levels between the KC group and control group. However, the riboflavin levels were significantly lower in the KC group, suggesting a possible risk factor in the pathogenesis of KC.
JOURNAL OF CATARACT AND REFRACTIVE SURGERY
(2023)
Article
Pharmacology & Pharmacy
Cigdem Cengelli Unel, Ezgi Eroglu, Orhan Ozatik, Kevser Erol
Summary: This study identifies chlorogenic acid as a potential agent in mitigating chemotherapy-induced peripheral neuropathy (CIPN) and suggests that nitric oxide plays a modulatory role in this effect.
FUNDAMENTAL & CLINICAL PHARMACOLOGY
(2023)
Article
Medicine, General & Internal
Fikriye Yasemin Ozatik, Orhan Ozatik, Yasemin Teksen, Semra Yigitaslan, Neziha Senem Ari
Summary: Hydrogen sulfide has a protective and therapeutic effect on cyclophosphamide-induced hemorrhagic cystitis and testicular dysfunction, indicating its potential in facilitating cancer treatment.
TURKISH JOURNAL OF MEDICAL SCIENCES
(2021)
Article
Obstetrics & Gynecology
Mekin Sezik, Afsin Koker, Ozlem Ozmen, Mehmet Haligur, Duygu Kasikci, Ahmet Aydogan, Orhan Ozatik
TURKISH JOURNAL OF OBSTETRICS AND GYNECOLOGY
(2020)
Article
Ophthalmology
Onur Ozalp, Eray Atalay, Ibrahim Ozkan Alata, Zeynep Kusku Kiraz, Nilgun Yildirim
TURK OFTALMOLOJI DERGISI-TURKISH JOURNAL OF OPHTHALMOLOGY
(2019)
Article
Biochemistry & Molecular Biology
Ferzane Mercan, Muhittin A. Serdar, Mehmet Senes, Dildar Konukoglu, Tamer Cevat Inal, Ozkan Alatas, Asli Pinar, Ozlem Savci, Muhammet Guven, Mehmet Gunduz, Ertugrul Egin, Yasal Onder Tipioglu, Ahmet Tekin, Dogan Yucel
TURKISH JOURNAL OF BIOCHEMISTRY-TURK BIYOKIMYA DERGISI
(2019)
Editorial Material
Surgery
Meghal Shah, Tejas S. Sathe, Sukriti Bansal, Anai N. Kothari, Sophie Dream
JOURNAL OF SURGICAL RESEARCH
(2024)
Letter
Surgery
Zafer Turkyilmaz, Ramazan Karabulut, Kaan Sonmez
JOURNAL OF SURGICAL RESEARCH
(2024)
Letter
Surgery
Priyanka Jadhav, Gerald Gollin
JOURNAL OF SURGICAL RESEARCH
(2024)
Review
Surgery
Kheira Hireche, Ludovic Canaud, Pierre Antoine Peyron, Linda Sakhri, Isabelle Serres, Sanaa Kamel, Youcef Lounes, Thomas Gandet, Pierre Alric
Summary: This study evaluated the elastic properties of commonly used vascular substitutes for pulmonary artery replacement and compared their compliance and stiffness indexes to human pulmonary artery. The results showed that allogenic arterial grafts appeared to be the most suitable vascular substitutes in terms of compliance and stiffness for PA replacement.
JOURNAL OF SURGICAL RESEARCH
(2024)
Article
Surgery
Margaret Siu, Aixa Perez Coulter, Heather M. Grant, Reginald Alouidor, Michael Tirabassi
Summary: There is no significant difference in adverse respiratory events between intubated, critically ill patients requiring operative intervention who are kept NPO for 6 hours or longer compared to those kept NPO for less than 6 hours. Patients commonly experience periods of fasting much longer than the recommended 6-hour period by the American Society of Anesthesiologists.
JOURNAL OF SURGICAL RESEARCH
(2024)
Article
Surgery
Whitney Elks, Allison G. McNickle, Matthew Kelecy, Kavita Batra, Shirley Wong, Shawn Wang, Lisa Angotti, Deborah A. Kuhls, Charles St Hill, Syed F. Saquib, Paul J. Chestovich, Douglas R. Fraser
Summary: This study aimed to compare the effects of early and late enteral feeding after PEG placement on achieving nutritional therapy goals and adverse outcomes. The results showed that patients with early initiation of feeds achieved a higher percentage of goals on day 0 without an increased rate of adverse events.
JOURNAL OF SURGICAL RESEARCH
(2024)
Article
Surgery
Manisha B. Bhatia, Cassandra M. Anderson, Abdiwahab N. Hussein, Brian Opondo, Nereah Aruwa, Otieno Okumu, Sarah G. Fisher, Tasha Sparks Joplin, JoAnna L. Hunter-Squires, Brian W. Gray, Peter W. Saula
Summary: This study aimed to understand postoperative pediatric nutrition practices in Kenya and the United States. The results showed that in the United States, patients initiated enteral nutrition earlier and had shorter hospital stays. However, in Kenya, patients initiated enteral nutrition earlier but had no significant difference in hospital stays.
JOURNAL OF SURGICAL RESEARCH
(2024)
Article
Surgery
David P. Stonko, Joseph Edwards, Hossam Abdou, Rebecca Treffalls, Patrick Walker, Jonathan J. Morrison
Summary: Raising mean arterial pressure (MAP) >90 mmHg with norepinephrine can increase gastroduodenal artery (GDA) flow and delay bowel ischemia.
JOURNAL OF SURGICAL RESEARCH
(2024)
Article
Surgery
David R. Mann, Kathryn E. Engelhardt, Barry C. Gibney, Macelyn E. Batten, Eric C. Klipsch, Rupak Mukherjee, Ian C. Bostock
Summary: Pathologic upstaging is associated with decreased overall survival in cT1b esophageal cancer. Esophagectomy has better survival outcomes compared to endoscopic local tumor excision. Neoadjuvant chemoradiation therapy does not improve overall survival in cT1b lesions.
JOURNAL OF SURGICAL RESEARCH
(2024)
Article
Surgery
Ross Mudgway, Zachary Tran, Juan C. Quispe Espiritu, Woo Bin Bong, Hayden Schultz, Vamsi Vemireddy, Aarthy Kannappan, Marcos Michelotti, Kaushik Mukherjee, Jeffrey Quigley, Keith Scharf, Daniel Srikureja, Sharon S. Lum, Esther Wu
Summary: Comparison of medium-term outcomes between robotic-assisted cholecystectomy (RC) and laparoscopic cholecystectomy (LC) using validated quality of life (QoL) and pain assessments did not show significant differences.
JOURNAL OF SURGICAL RESEARCH
(2024)
Article
Surgery
Ningjie Chen, Haitao Wang, Yang Shao, Jincun Yang, Guodong Song
Summary: This study aimed to compare the therapeutic effects of activated platelet-rich plasma (PRP) prepared from elderly individuals and young adults in treating pressure ulcers (PUs). The results showed that PRP from young adults had higher platelet concentrations and greater production of growth factors, leading to better wound healing.
JOURNAL OF SURGICAL RESEARCH
(2024)
Article
Surgery
Brendin R. Beaulieu-Jones, Margaret T. Berrigan, Kortney A. Robinson, Jayson S. Marwaha, Tara S. Kent, Gabriel A. Brat
Summary: Introduction: Prescription opioids, including those prescribed after surgery, have greatly contributed to the US opioid epidemic. Educating opioid prescribers is a crucial component of ensuring the safe use of opioids among surgical patients. This study implemented an annual education curriculum for new surgical prescribers, resulting in significant improvements in knowledge and comfort levels. However, there remains a persistent knowledge and comfort gap among these prescribers.
JOURNAL OF SURGICAL RESEARCH
(2024)
Article
Surgery
Sneha G. Bhat, Madhuri Nagaraj, Courtney Balentine, Timothy Hogan, Jennie Meier, Hillary Prince, Kareem Abdelfattah, Herbert Zeh, Benjamin Levi
Summary: This pilot study examined the effects of a structured mental fitness program on academic surgeons and found significant improvement in Positive Intelligence (PQ) scores, as well as increased connectedness and shared language among participants. However, there were no significant changes in sleep, well-being, or teaching evaluations.
JOURNAL OF SURGICAL RESEARCH
(2024)
Article
Surgery
Kristin E. Cox, Michael A. Turner, Siamak Amirfakhri, Thinzar M. Lavin, Mojgan Hosseini, Pradipta Ghosh, Marygorret Obonyo, Takashi Murakami, Robert M. Hoffman, Paul J. Yazaki, Michael Bouvet
Summary: This study demonstrates the potential of using humanized anti-carcinoembryonic antigen (CEA) antibodies conjugated with near-infrared dyes to specifically label gastric cancers in mouse models. Orthotopic models showed bright and specific labeling with more than ten times higher tumor-to-background ratios compared to the control. This tumor-specific fluorescent antibody has promising potential as a clinical tool for improving visualization of gastric cancer margins during surgical resection.
JOURNAL OF SURGICAL RESEARCH
(2024)
Review
Surgery
Sarah Maki, Melissa Leon, Emily Glenn, Tiffany Tanner, Crystal Krause
Summary: This scoping review analyzed the literature on the use of broadband personality tests in the bariatric surgical population to optimize weight loss outcomes. The study found significant associations between personality scales and weight loss, but inconsistent reporting of outcome measures made it challenging to draw concrete conclusions. The American Society for Metabolic and Bariatric Surgery recommends standardization of outcome reporting to improve the reliability of predicting weight loss outcomes.
JOURNAL OF SURGICAL RESEARCH
(2024)