Journal
EUROPEAN JOURNAL OF HUMAN GENETICS
Volume 19, Issue 5, Pages 593-596Publisher
NATURE PUBLISHING GROUP
DOI: 10.1038/ejhg.2010.240
Keywords
nicotine addiction; CHRNA5-A3-B4 cluster; genetic association
Funding
- Compagnia di San Paolo
- Torino
- Cariplo Fundation
- Milano
- Italian Ministry of Health
- Telethon Fundation
- Italian Ministry of Universities [FIRB -RBIN064YAT]
- Regione Campania, Italy
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Large-scale population studies have established that genetic factors contribute to individual differences in smoking behavior. Linkage and genome-wide association studies have shown many chromosomal regions and genes associated with different smoking behaviors. One study was the association of single-nucleotide polymorphisms (SNPs) in the CHRNA5-A3-B4 gene cluster to nicotine addiction. Here, we report a replication of this association in the Italian population represented by three genetically isolated populations. One, the Val Borbera, is a genetic isolate from North-Western Italy; the Cilento population, is located in South-Western Italy; and the Carlantino village is located in South-Eastern Italy. Owing to their position and their isolation, the three populations have a different environment, different history and genetic structure. The variant A of the rs1051730 SNP was significantly associated with smoking quantity in two populations, Val Borbera and Cilento, no association was found in Carlantino population probably because difference in LD pattern in the variant region. European Journal of Human Genetics (2011) 19, 593-596; doi:10.1038/ejhg.2010.240; published online 19 January 2011
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