Review
Peripheral Vascular Disease
Kenichi Katsurada, Keisuke Shinohara, Jiro Aoki, Shinsuke Nanto, Kazuomi Kario
Summary: Renal nerves play a critical role in regulating blood pressure and fluid volume, with dysfunction implicated in cardiovascular diseases. Afferent renal sensory nerves project to the hypothalamus to modulate sympathetic outflow, while efferent renal sympathetic nerves affect renin secretion and vascular resistance. Studies on renal denervation show promise for treating hypertension and heart failure in both basic and clinical research settings.
HYPERTENSION RESEARCH
(2022)
Article
Peripheral Vascular Disease
Lindsea C. Booth, R. Anethra U. de Silva, Roberto B. Pontes, Song T. Yao, Sally G. Hood, Yugeesh R. Lankadeva, Junko Kosaka, Nina Eikelis, Gavin W. Lambert, Markus P. Schlaich, Clive N. May
Summary: Clinical studies suggest that renal denervation (RDN) has beneficial effects on the autonomic control of the heart in heart failure, with experimental evidence showing improvements in sodium handling and clearance. In sheep with established heart failure, catheter-based RDN led to decreased heart rate, increased parasympathetic control, and improved kidney function, indicating potential benefits for both the heart and kidneys in heart failure.
Review
Medicine, General & Internal
Kameel Kassab, Ronak Soni, Adnan Kassier, Tim A. Fischell
Summary: Activation of the sympathetic nervous system in heart failure patients is a major pathophysiologic mechanism associated with worse outcomes. Renal denervation, originally developed for poorly controlled hypertension, has been investigated for its effect in heart failure patients. This paper provides an overview of the potential impact of renal denervation on altering the various pathophysiologic pathways that contribute to heart failure.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Cardiac & Cardiovascular Systems
Pingan Chen, Zhiqin Guo, Yufeng Chen, Lushan Chen, Shaonan Li, Yanlin Xian, Guorong Liu
Summary: This study investigated the reinnervation of renal arteries after renal denervation in chronic heart failure, finding that reinervation did not affect the therapeutic role of RDN in CHF. Additionally, inhibiting neural regeneration had no clinical significance and did not affect the efficacy of RDN in CHF.
Review
Physiology
Thomas E. Sharp, David J. Lefer
Summary: Heart failure is a global pandemic with challenges in treatment, particularly in patient tolerance to neurohormonal pharmacotherapies. Renal denervation as a novel therapeutic strategy provides a potential possibility to attenuate the progression of HF.
ANNUAL REVIEW OF PHYSIOLOGY, VOL 83
(2021)
Article
Pediatrics
Bo Pan, Di Hu, Huichao Sun, Tiewei Lv, Wangguo Xu, Jie Tian
Summary: This study summarized the differences between pediatric diastolic heart failure and systolic heart failure in terms of primary causes, clinical features, and short-term prognosis. B-type natriuretic peptide has limited diagnostic value in pediatric DHF. Diastolic function indicators significantly improved after treatment in DHF patients.
FRONTIERS IN PEDIATRICS
(2022)
Article
Integrative & Complementary Medicine
Hai Xu, Zhixin Jiang, Wanying Jiang, Junyu Huo, Qijun Shan
Summary: The study demonstrated that RDN can improve diastolic function in patients with refractory hypertension and PAF, mainly through reducing heart rate and mean arterial pressure.
EVIDENCE-BASED COMPLEMENTARY AND ALTERNATIVE MEDICINE
(2022)
Article
Cardiac & Cardiovascular Systems
Yuri Umeta, Takako Iino, Ken Miura, Kodai Kudo, Yoshikazu Tamura, Wakana Sato, Katsuhito Seki, Kenji Iino, Hiroyuki Watanabe
Summary: In adults, ADPAF indicates RV restriction, and it suggests a less favorable prognosis in patients with reduced RV function.
JOURNAL OF CARDIOLOGY
(2021)
Article
Cardiac & Cardiovascular Systems
Pingan Chen, Zhiqin Guo, Yufeng Chen, Lushan Chen, Shaonan Li, Yanlin Xian, Guorong Liu
Summary: The study confirmed the occurrence of renal artery reinnervation in CHF rats after RDN, which did not impact the therapeutic effect of RDN in CHF, and inhibiting neural regeneration had no clinical significance in relation to the efficacy of RDN for CHF.
Article
Cardiac & Cardiovascular Systems
Hidekatsu Fukuta, Toshihiko Goto, Kazuaki Wakami, Takeshi Kamiya, Nobuyuki Ohte
Summary: Despite the major progress in heart failure treatment, the burden of heart failure is increasing in the Western world. Recent studies have shown that catheter-based renal denervation (RDN) may have potential benefits in improving left ventricular function and exercise capacity in heart failure patients with reduced EF.
HEART FAILURE REVIEWS
(2022)
Article
Cardiac & Cardiovascular Systems
Karl-Patrik Kresoja, Karl-Philipp Rommel, Karl Fengler, Maximilian von Roeder, Christian Besler, Christian Luecke, Matthias Gutberlet, Steffen Desch, Holger Thiele, Michael Boehm, Philipp Lurz
Summary: Arterial hypertension is a common comorbidity in patients with HFpEF, leading to adverse hemodynamics. RDN may improve hemodynamics in HFpEF patients, reducing LV stiffness and diastolic pressures.
CIRCULATION-HEART FAILURE
(2021)
Review
Medicine, General & Internal
Irving H. H. Zucker, Zhiqiu Xia, Han-Jun Wang
Summary: Cardio-renal syndrome (CRS) type 2 is characterized by progressive loss of renal function following a primary insult to the myocardium, accompanied by declining pump performance. Treatments for CRS are challenging, and the disease often leads to end-stage renal disease that cannot be effectively treated by conventional therapy. This review focuses on the role of renal nerves in mediating renal dysfunction in CRS and discusses potential interventions such as renal denervation and abrogation of systemic reflexes to alleviate renal dysfunction in chronic heart failure.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Cardiac & Cardiovascular Systems
C. H. Lee, M. Z. Wu, D. T. W. Lui, C. H. Y. Fong, Q. W. Ren, S. Y. Yu, M. M. A. Yuen, W. S. Chow, J. Y. Huang, A. Xu, K. H. Yiu, K. S. L. Lam
Summary: This study found that serum TSP2 levels were independently associated with incident heart failure and deterioration in diastolic function in patients with type 2 diabetes.
CARDIOVASCULAR DIABETOLOGY
(2022)
Article
Medicine, General & Internal
Nathalie Noirclerc, Olivier Huttin, Christian de Chillou, Christine Selton-Suty, Laura Fillipetti, Jean Marc Sellal, Erwan Bozec, Erwan Donal, Zohra Lamiral, Masatake Kobayashi, Joao Pedro Ferreira, Patrick Rossignol, Nicolas Girerd
Summary: The study found that patients with paroxysmal atrial fibrillation exhibit early cardiac remodeling, characterized by increased left ventricular mass and left atrial enlargement. Although less than 10% of patients show diastolic dysfunction, there is a significant association with atrial fibrillation.
JOURNAL OF CLINICAL MEDICINE
(2021)
Article
Rheumatology
Laura Ross, Shreeya Patel, Wendy Stevens, Andrew Burns, David Prior, Andre La Gerche, Mandana Nikpour
Summary: This study aimed to quantify the prevalence and progression of left ventricular diastolic dysfunction (LVDD) and heart failure with preserved ejection fraction (HFpEF) in patients with systemic sclerosis (SSc). The study found that LVDD was a common finding in SSc and showed a tendency to worsen over time. LVDD was associated with more severe dyspnoea but not with clinical signs of heart failure.
CLINICAL AND EXPERIMENTAL RHEUMATOLOGY
(2022)
Article
Respiratory System
Renaud Tamisier, Jean-Louis Pepin, Holger Woehrle, Muriel Salvat, Gilles Barone-Rochette, Cecile Rocca, Eik Vettorazzi, Helmut Teschler, Martin Cowie, Patrick Levy
Summary: This study investigated the effect of ASV on sympathetic tone in patients with HFrEF and CSA. The results showed that ASV did not effectively suppress sympathetic activation in heart failure patients and was associated with increased cardiovascular mortality.
EUROPEAN RESPIRATORY JOURNAL
(2023)
Review
Cardiac & Cardiovascular Systems
Athanasios Rempakos, Spyridon Kostantinis, Bahadir Simsek, Judit Karacsonyi, Salman Allana, Mohaned Egred, Hani Jneid, Kambis Mashayekhi, Carlo Di Mario, Oleg Krestyaninov, Dmitrii Khelimski, Anastasios Milkas, Yader Sandoval, M. Nicholas Burke, Emmanouil S. S. Brilakis
Summary: Balloon undilatable lesions are lesions that cannot be expanded despite successful cross by a guidewire and a balloon. These lesions can be either de novo or in-stent. A systematic approach using various techniques such as high-pressure balloon inflation, plaque modification balloons, intravascular lithotripsy, very high-pressure balloon inflation, coronary atherectomy, laser coronary angioplasty, and extraplaque lesion crossing can effectively treat these lesions, increasing procedure efficiency, success, and safety.
CATHETERIZATION AND CARDIOVASCULAR INTERVENTIONS
(2023)
Editorial Material
Cardiac & Cardiovascular Systems
Niccolo Ciardetti, Giulia Nardi, Carlo Di Mario
EUROPEAN HEART JOURNAL
(2023)
Article
Cardiac & Cardiovascular Systems
Alex Bottle, Roger Newson, Puji Faitna, Benedict Hayhoe, Martin R. Cowie
Summary: This study aimed to explore risk prediction models for heart failure based on general practitioners' electronic health records and compare the data from two different cohorts. The results showed that the survival rates were similar in different years, but the later population was older, frailer, and had more comorbidities. The study also found consistent predictors including age, sex, blood pressure, body mass index, GP visits before diagnosis, and some comorbidities.
Article
Cardiac & Cardiovascular Systems
Brian C. Case, Rebecca Torguson, Corey Shea, Cheng Zhang, Kayode O. Kuku, Ishani Patel, Tim J. F. ten Cate, Hector M. Garcia-Garcia, Carlo Di Mario, Gary S. Mintz, Ron Waksman
Summary: Intravascular ultrasound and near-infrared spectroscopy can identify vulnerable coronary atherosclerotic plaques. The association between statins and nonculprit lesion arterial wall lipidic content and subsequent nonculprit major adverse cardiac events was evaluated in this study. Patients were divided into two groups based on statin therapy and statin-naive status and underwent intravascular ultrasound and near-infrared spectroscopy analysis. Statin initiation at discharge provided the most benefit for events related to nonculprit lesions.
AMERICAN JOURNAL OF CARDIOLOGY
(2023)
Editorial Material
Cardiac & Cardiovascular Systems
Carlo Di Mario, Giulia Nardi
CATHETERIZATION AND CARDIOVASCULAR INTERVENTIONS
(2023)
Article
Cardiac & Cardiovascular Systems
Alexandre Avran, Andrea Zuffi, Cecilia Gobbi, Alessio Gasperetti, Marco Schiavone, Gerald S. Werner, Mashayekhi Kambis, Nicolas Boudou, Alfredo R. Galassi, George Sianos, Moussa Idali, Roberto Garbo, Andrea Gagnor, Gabriele Gasparini, Alexander Bufe, Leszek Bryniarski, Artis Kalnins, Daniel Weilenmann, Jaroslaw Wojcik, Pierfrancesco Agostoni, Nenad Z. Bozinovic, Mauro Carlino, Sergey Furkalo, David Hildick-Smith, Laurent Drogoul, Julien Lemoine, Antonio Serra, Stefano Carugo, Imre Ungi, Joseph Dens, Nicolaus Reifart, Joseph Cosma, Vincenzo Mallia, Giuseppe Vadala, Giuseppe Biondi-Zoccai, Carlo Di Mario
Summary: This study analyzed the in-hospital clinical outcomes of female patients undergoing percutaneous coronary intervention (PCI) for chronic total occlusion (CTO). The results showed that female patients had a higher procedural success rate but a higher risk of procedural complications.
CATHETERIZATION AND CARDIOVASCULAR INTERVENTIONS
(2023)
Article
Cardiac & Cardiovascular Systems
Emanuele Barbato, Emanuele Gallinoro, Mohamed Abdel-Wahab, Daniele Andreini, Didier Carrie, Carlo Di Mario, Dariusz Dudek, Javier Escaned, Jean Fajadet, Giulio Guagliumi, Jonathan Hill, Margaret McEntegart, Kambis Mashayekhi, Nikolasos Mezilis, Yoshinobu Onuma, Krzyszstof Reczuch, Richard Shlofmitz, Giulio Stefanini, Giuseppe Tarantini, Gabor G. Toth, Beatriz Vaquerizo, William Wijns, Flavio L. Ribichini
Summary: Since the publication of the 2015 EAPCI consensus, there has been a significant increase in PCI performed in cases of severely calcified coronary artery disease. This has been driven by the growing need for interventions in elderly patients and the availability of new technologies. The current EAPCI clinical consensus statement provides comprehensive guidance on the management of heavily calcified coronary stenoses, including imaging assessment, tool and technique selection, and considerations for complications and training.
EUROPEAN HEART JOURNAL
(2023)
Article
Cardiac & Cardiovascular Systems
Domenico D'Amario, David Meerkin, Attilio Restivo, Hueseyin Ince, Horst Sievert, Andrea Wiese, Ulrich Schaefer, Carlo Trani, Antoni Bayes-Genis, Francisco I. Leyva, Zachary Whinnett, Carlo Di Mario, Michael Jonas, Habib J. Manhal, Ignacio Amat-Santos, Maria Del Trigo, Tuvia Ben Gal, Binyamin Ben Avraham, Tal Hasin, Sebastian Feickert, Giuseppe D'Ancona, Omar Abdul-Jawad Altisent, Oran Koren, Oren T. Caspi, William Abraham, Filippo D. Crea, Stefan Anker, Ran Kornowski, Leor Perl
Summary: The study evaluated a novel left atrial pressure (LAP) monitoring system in heart failure patients and found that it was safe and provided a good correlation with invasive pulmonary capillary wedge pressure (PCWP). Initial evidence also suggests possible improvement in heart failure clinical symptoms.
EUROPEAN JOURNAL OF HEART FAILURE
(2023)
Article
Health Care Sciences & Services
Arvind Singhal, Jillian P. Riley, Martin R. Cowie
Summary: Prior to the Covid-19 pandemic, heart failure (HF) disease management programmes were predominantly in-person, but the pandemic necessitated a shift to teleconsultations. Telemedicine consultations were found to be more convenient for patients, saved them time, and were generally acceptable to clinicians. However, it also brought changes to workflows, consultation dynamics, and clinical assessment methods.
BMC HEALTH SERVICES RESEARCH
(2023)
Article
Cardiac & Cardiovascular Systems
Margarita Brida, Salvatore De Rosa, Antoine Legendre, Magalie Ladouceur, Laura Dos Subira, Giancarlo Scognamiglio, Carlo Di Mario, Jolien Roos-Hesselink, Eva Goossens, Gerhard Diller, Michael A. Gatzoulis
Summary: The rates of successful surgical repair and life expectancy for patients with congenital heart disease have significantly increased in recent decades. However, exposure to cardiovascular risk factors has led to a shift in the clinical trajectory of adult congenital heart disease, with an increasing burden of acquired cardiovascular disease, primarily atherosclerotic cardiovascular disease (ASCVD). Currently, comprehensive guidance for the prevention and management of acquired heart disease in adult congenital heart disease patients is lacking. This document provides an overview of acquired heart disease and offers guidance on ASCVD prevention for both specialists and non-specialists in adult congenital heart disease, aiming to reduce the cardiovascular burden in this growing population.
EUROPEAN HEART JOURNAL
(2023)
Article
Health Care Sciences & Services
Thomas Woodcock, Dionne Matthew, Raffaele Palladino, Mable Nakubulwa, Trish Winn, Hugh Bethell, Stephen Hiles, Susan Moggan, Jackie Dowell, Paul Sullivan, Derek Bell, Martin R. Cowie
Summary: This study evaluates the impact of a care bundle intervention on improving care for patients with acute heart failure. The intervention includes testing NT-proBNP, transthoracic Doppler echocardiography, and specialist evaluation. The study finds that this intervention is associated with reduced emergency readmissions and improved in-hospital mortality for acute heart failure patients.
BMJ QUALITY & SAFETY
(2023)
Article
Cardiac & Cardiovascular Systems
Martin R. Cowie, Praveen Thokala, Zenichi Ihara, Philip B. Adamson, Christiane Angermann
Summary: Based on the most recent data, this paper updates the cost-effectiveness analysis of CardioMEMS compared to usual care for patients with persistent New York Heart Association class III symptoms and at least one heart failure hospitalization within 12 months. The results suggest that CardioMEMS is likely to be cost-effective in the United Kingdom.
Article
Cardiac & Cardiovascular Systems
Ryan Walkley, A. Joy Allen, Martin R. Cowie, Ross Maconachie, Lisa Anderson
Summary: When relying on clinical assessment alone, an estimated 22% of acute heart failure (AHF) patients are missed. Therefore, clinical guidelines recommend the use of NT-proBNP for AHF diagnosis. However, there has been poor uptake of NT-proBNP testing due to concerns over low specificity. This study proposes the use of age-specific thresholds to improve the specificity of NT-proBNP testing.
Meeting Abstract
Respiratory System
C. Fisser, A. Ebert, L. Gall, J. Bureck, J. Priefert, S. Fredersdorf, F. Zeman, D. Linz, H. Woehrle, R. Tamisier, H. Teschler, M. Cowie, M. Arzt