Review
Biochemical Research Methods
Meysam Gachpazan, Arash Mohammadinejad, Amin Saeidinia, Hamid Reza Rahimi, Majid Ghayour-Mobarhan, Farveh Vakilian, Majid Rezayi
Summary: Heart disease poses a serious threat to human health globally, leading to rising mortality rates. B-type natriuretic peptide is a crucial biomarker for diagnosis of heart failure, but faces challenges such as low concentration and short half-life in blood.
ANALYTICAL AND BIOANALYTICAL CHEMISTRY
(2021)
Article
Medicine, General & Internal
Nadia Aspromonte, Luigi Cappannoli, Pietro Scicchitano, Francesco Massari, Ivan Pantano, Massimo Massetti, Filippo Crea, Roberto Valle
Summary: The study found that low pre-discharge BNP levels were associated with low rates of cardiovascular events in HF patients, independently of the frequency of follow-up. Additionally, age, creatinine, and BNP were identified as independent predictors of events in HF patients.
JOURNAL OF CLINICAL MEDICINE
(2021)
Article
Cardiac & Cardiovascular Systems
Tara Perunovic, Jens P. Goetze
Summary: Multiple mechanisms contribute to essential hypertension, and antihypertensive drugs primarily target increased sympathetic nervous system activity, altered production of vasoactive mediators, vascular inflammation, fibrosis, and increased peripheral resistance. C-type natriuretic peptide (CNP) is an endothelium-derived peptide that influences vascular signaling through two receptors, NPR-B and NPR-C. This article summarizes the effects of CNP on the vasculature in relation to essential hypertension and proposes targeting the CNP system as a potential tool for managing long-term essential hypertension.
JACC-BASIC TO TRANSLATIONAL SCIENCE
(2023)
Article
Cardiac & Cardiovascular Systems
Andrea K. Roalfe, Sarah L. Lay-Flurrie, Jose M. Ordonez-Mena, Clare R. Goyder, Nicholas R. Jones, F. D. Richard Hobbs, Clare J. Taylor
Summary: This study reported contemporary trends in NP testing and HF diagnosis rates in adult patients in England from 2004-18. It found that NP testing in primary care has increased over time, with most patients with HF still not having an NP test recorded prior to diagnosis.
EUROPEAN HEART JOURNAL
(2022)
Article
Cardiac & Cardiovascular Systems
Akihisa Kimura, Hiroyuki Takahama, Toshio Nishikimi, Seiji Takashio, Tomohiro Hayashi, Chiaki Nagai-Okatani, Yasuaki Nakagawa, Satoshi Yasuda, Toshihisa Anzai, Naoto Minamino, Chisato Izumi
Summary: The study found that the ratio of mature BNP to total BNP in plasma at hospital admission may predict left ventricular contractile recovery in patients with heart failure. Patients in the HFrecEF group had significantly higher %emBNP levels on admission compared to the HFcrEF group, suggesting a potential association between mature BNP levels and ventricular contractile recovery.
Article
Cardiac & Cardiovascular Systems
Akihisa Kimura, Hiroyuki Takahama, Toshio Nishikimi, Seiji Takashio, Tomohiro Hayashi, Chiaki Nagai-Okatani, Yasuaki Nakagawa, Satoshi Yasuda, Toshihisa Anzai, Naoto Minamino, Chisato Izumi
Summary: This study aimed to investigate the relationship between the ratio of bioactive mature BNP to total BNP and the reverse remodelling capacity in patients with heart failure with reduced EF. The findings suggest that the ratio of mature BNP to total BNP in plasma at the time of hospital admission may predict left ventricular contractile recovery. Preservation of the capacity to convert proBNP to mature BNP is associated with future ventricular contractile recovery.
Article
Cardiac & Cardiovascular Systems
Mi-Jeong Kim, Jung Sun Cho, Kyusup Lee, Woojin Kwon, Chaeryeon Ohn, Myunhee Lee, Dae-Won Kim, Tae-Seok Kim, Mahn-Won Park
Summary: This study aims to predict long-term outcomes of heart failure patients by combining various non-invasive cardiac examinations. The results showed that the combination of plasma NT-proBNP level and echocardiographic findings (Echo-LVFP) could stratify patients into three groups and predict adverse outcomes. Left atrial mechanics and exercise capacity further improved the accuracy of prognosis.
Article
Cardiac & Cardiovascular Systems
Moritake Iguchi, Takao Kato, Hidenori Yaku, Takeshi Morimoto, Yasutaka Inuzuka, Yodo Tamaki, Neiko Ozasa, Erika Yamamoto, Yusuke Yoshikawa, Takeshi Kitai, Yasuhiro Hamatani, Yugo Yamashita, Nobutoyo Masunaga, Hisashi Ogawa, Mitsuru Ishii, Yoshimori An, Ryoji Taniguchi, Masashi Kato, Mamoru Takahashi, Toshikazu Jinnai, Tomoyuki Ikeda, Kazuya Nagao, Takafumi Kawai, Akihiro Komasa, Ryusuke Nishikawa, Yuichi Kawase, Takashi Morinaga, Mitsunori Kawato, Yuta Seko, Mamoru Toyofuku, Yutaka Furukawa, Kenji Ando, Kazushige Kadota, Mitsuru Abe, Masaharu Akao, Yukihito Sato, Koichiro Kuwahara, Takeshi Kimura
Summary: During hospitalization for acute decompensated heart failure, 1.6% of patients developed ischemic stroke. Men, ACS, absence of prior heart failure hospitalization, and high BNP/NT-proBNP levels at admission were independently associated with ischemic stroke.
JOURNAL OF THE AMERICAN HEART ASSOCIATION
(2021)
Article
Cardiac & Cardiovascular Systems
Xiao Liu, Ayiguli Abudukeremu, Peng Yu, Zhengyu Cao, Runlu Sun, Maoxiong Wu, Zhiteng Chen, Jianyong Ma, Wengen Zhu, Yangxin Chen, Yuling Zhang, Jingfeng Wang
Summary: The study found that B-type natriuretic peptide (BNP) is associated with an increased risk of stroke in patients with HFpEF and may be a valuable biomarker for stroke prediction in HFpEF.
JOURNAL OF THE AMERICAN HEART ASSOCIATION
(2022)
Review
Pharmacology & Pharmacy
Koichiro Kuwahara
Summary: Natriuretic peptides, such as ANP and BNP, are important in cardioprotection in heart failure by antagonizing the effects of angiotensin II, while CNP plays a role in regulating vascular tone and blood pressure. These peptides are also being studied for their potential as biomarkers and therapeutics in cardiovascular disease.
PHARMACOLOGY & THERAPEUTICS
(2021)
Article
Cardiac & Cardiovascular Systems
James L. Januzzi, Xi Tan, Lingfeng Yang, Joanne E. Brady, Mei Yang, Puja Banka, Dominik Lautsch
Summary: The study found that NT-proBNP testing was not frequently performed in patients with heart failure with reduced ejection fraction (HFrEF) in US clinical practice, and the concentrations varied across different data sources and subgroups within HFrEF.
Article
Cardiac & Cardiovascular Systems
Luis E. Rohde, Conrado R. Hoffmann Filho, Marciane M. Rover, Eneida Rejane Rabelo-Silva, Leticia Lopez, Luiz C. S. Passos, Odilson M. Silvestre, Silvia M. Martins, Jose A. de Figueiredo Neto, Fabio S. Silveira, Manoel F. Canesin, Marcus V. Simoes, Fabio Akio Nishijuka, Eduardo G. Bertoldi, Luiz C. Danzmann, Ricardo Mourilhe-Rocha, Ellen Hettwer Magedanz, Mauro Esteves, Fabio M. de Castilho, Miguel M. Fernandes-Silva, Luiz E. F. Ritt, Mariana Blacher, Rafael M. Soares, Alexandre B. Cavalcanti, Felix Ramirez
Summary: The MESSAGE-HF study aims to evaluate a telemonitoring strategy based on automated text messaging and telephone support for heart failure patients. The study involves educating and supporting patients through daily text messages, with follow-ups at 30, 90, and 180 days to assess outcomes such as changes in NT-proBNP levels and health-related quality of life. If proven effective, this strategy could be applied to a broader population worldwide.
Article
Cardiac & Cardiovascular Systems
Luis E. Rohde, Conrado R. Hoffmann Filho, Marciane M. Rover, Eneida Rejane Rabelo-Silva, Leticia Lopez, Luiz C. S. Passos, Odilson M. Silvestre, Silvia M. Martins, Jose A. de Figueiredo Neto, Fabio S. Silveira, Manoel F. Canesin, Marcus V. Simoes, Fabio Akio Nishijuka, Eduardo G. Bertoldi, Luiz C. Danzmann, Ricardo Mourilhe-Rocha, Ellen Hettwer Magedanz, Mauro Esteves, Fabio M. de Castilho, Miguel M. Fernandes-Silva, Luiz E. F. Ritt, Mariana Blacher, Rafael M. Soares, Alexandre B. Cavalcanti, Felix Ramirez
Summary: The MESSAGE-HF trial aims to evaluate a telemonitoring strategy using automated text messaging and telephone support for heart failure patients, with a focus on improving self-care and reducing hospital readmission rates. If successful, this simple and tailored telemonitoring system could have global applications in promoting education and self-care for a broader population.
Article
Cardiac & Cardiovascular Systems
Massimo Volpe, Johann Bauersachs, Antoni Bayes-Genis, Javed Butler, Alain Cohen-Solal, Giovanna Gallo, Andrea Simone Deichl, Muhammad Shahzeb Khan, Allegra Battistoni, Burkert Pieske, Yoshihiko Saito, Shelley Zieroth
Summary: Current international guidelines recommend switching ACE-i or ARBs to sacubitril/valsartan (S/V) in stable outpatients affected by heart failure with reduced ejection fraction (HFrEF) who remain symptomatic despite being on optimal medical therapy. New data may support further clinical applications and benefits of S/V beyond ambulatory HFrEF patients, possibly also in HFmrEF patients. Additional clinical trial data are required to confirm the potential benefits of S/V in patients with mid-range or preserved EF, or in combination with sodium-glucose co-transporter 2 inhibitors or in post-myocardial infarction HF.
INTERNATIONAL JOURNAL OF CARDIOLOGY
(2021)
Article
Engineering, Environmental
Yi Wang, Aiping Tu, Xinwen Zhang, Mengyao Li, Laicheng Liu, Yongfei Li, Jiangling Wu, Pu Zhang
Summary: The study involved the fabrication of defect-rich CoOOH nanorings as probes to improve clinical diagnosis for children heart failure. The ultrasensitive and specific detection of the HF biomarker BNP was achieved through fluorescence resonance energy transfer, showing a high correlation with CLIA.
CHEMICAL ENGINEERING JOURNAL
(2021)