Review
Medicine, General & Internal
Cristian Statescu, Carina Ureche, Stefana Enachi, Rodica Radu, Radu A. Sascau
Summary: Non-ischemic cardiomyopathy presents a heterogeneous group of diseases with an unfavorable long-term prognosis. Cardiac resynchronization therapy (CRT) is beneficial for symptomatic heart failure patients, especially in non-ischemic dilated cardiomyopathy. Multimodality cardiac imaging shows promise in refining CRT selection criteria and improving response rates.
Article
Cardiac & Cardiovascular Systems
Philippe C. Wouters, Geert E. Leenders, Maarten J. Cramer, Mathias Meine, Frits W. Prinzen, Pieter A. Doevendans, Bart W. L. De Boeck
Summary: Cardiac resynchronization therapy (CRT) induces acute and ongoing mechanical recoordination and improves left ventricular (LV) function. Acute recoordination is related to long-term reverse remodelling, but acute improvements in LV systolic function do not necessarily correlate with reverse remodelling.
INTERNATIONAL JOURNAL OF CARDIOVASCULAR IMAGING
(2021)
Article
Oncology
Rosaria Sofia, Veronica Melita, Antonio De Vita, Antonio Ruggiero, Alberto Romano, Giorgio Attina, Lisa Birritella, Priscilla Lamendola, Antonella Lombardo, Gaetano Antonio Lanza, Angelica Bibiana Delogu
Summary: In long-term pediatric cancer survivors who received anthracycline therapy, this study found a significantly reduced three-dimensional left ventricle ejection fraction, despite no significant differences in two-dimensional left ventricle ejection fraction and longitudinal strain values. These findings suggest that long-term cancer survivors who had received anthracycline therapy may exhibit subclinical features of myocardial dysfunction. Further studies are needed to validate new imaging techniques, including speckle tracking echocardiography and three-dimensional echocardiography, for identifying patients at risk for cardiomyopathy in the long-term follow-up of childhood cancer survivors.
FRONTIERS IN ONCOLOGY
(2021)
Article
Agriculture, Dairy & Animal Science
Jorge Isidoro Matos, Sara Nieves Garcia-Rodriguez, Noelia Costa-Rodriguez, Alicia Caro-Vadillo, Elena Carreton, Jose Alberto Montoya-Alonso
Summary: This study assessed the diagnostic value of echocardiography tissue Doppler imaging (TDI) in determining the presence of pulmonary hypertension (PH) in dogs with heartworm disease. The TDI measurements showed significant differences between dogs with and without PH, and cut-off values with excellent sensitivity and specificity were found. The TDI mode may be a useful adjunct diagnostic method for PH in dogs with Dirofilaria immitis.
Article
Multidisciplinary Sciences
Eleonora Sulas, Emanuele Ortu, Monica Urru, Roberto Tumbarello, Luigi Raffo, Giuliana Solinas, Danilo Pani
Summary: Fetal echocardiography requires expertise and Pulsed-wave Doppler is used for heart activity reference. This study evaluates the impact of signal processing steps on detecting accuracy, finding that binarisation and envelope extraction are crucial. The best approaches achieved over 98% accuracy in detecting measurable PWD heartbeats.
Article
Geriatrics & Gerontology
Nawaz Z. Safdar, Stephe Kamalathasan, Ankit Gupta, Joshua Wren, Rory Bird, Dorothy Papp, Rebecca Latto, Ali Ahmed, Victoria Palin, John Gierula, Klaus K. Witte, Sam Straw
Summary: Older patients receiving CRT for the management of heart failure have similar clinical response, complications, and outcomes compared to younger patients.
Review
Cardiac & Cardiovascular Systems
Felicity de Vere, Nadeev Wijesuriya, Mark K. K. Elliott, Vishal Mehta, Sandra Howell, Martin Bishop, Marina Strocchi, Steven A. A. Niederer, Christopher A. A. Rinaldi
Summary: Arrhythmia is common in patients receiving CRT, but trials often exclude patients with recent arrhythmia history. Achieving close to 100% BVP is important for CRT patients, making arrhythmia control even more crucial. This review examines the impact of atrial and ventricular arrhythmias on CRT and discusses optimal management approaches.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2023)
Article
Cardiac & Cardiovascular Systems
Mohamed Abdelbaset Ahmed, Muhammed Gercek, Philipp Sommer, Volker Rudolph, Daniel Dumitrescu, Lothar Faber, Henrik Fox
Summary: Cardiac resynchronisation therapy is an important treatment for patients with symptomatic heart failure. Mechanical dyssynchrony on echocardiography can predict the effectiveness of the therapy and the long-term survival of the patients.
INTERNATIONAL JOURNAL OF CARDIOVASCULAR IMAGING
(2023)
Article
Cardiac & Cardiovascular Systems
Odette A. E. Salden, Alwin Zweerink, Philippe Wouters, Cornelis P. Allaart, Bastiaan Geelhoed, Frederik J. de Lange, Alexander H. Maass, Michiel Rienstra, Kevin Vernooy, Marc A. Vos, Mathias Meine, Frits W. Prinzen, Maarten J. Cramer
Summary: Evaluation of systolic septal rebound stretch (SRSsept) may enhance patient selection for cardiac resynchronization therapy (CRT) and provides additional predictive information over ApRock assessment in patients without left bundle branch block (LBBB).
EUROPEAN HEART JOURNAL-CARDIOVASCULAR IMAGING
(2021)
Article
Multidisciplinary Sciences
Xiang Ji, Xia Zhang, Guojie Li
Summary: The function of the left atrium is impaired in patients with rheumatoid arthritis, with the impairment worsening as the disease progresses. 2D-STI technology can assist in evaluating this dysfunction by assessing various strain parameters.
SCIENTIFIC REPORTS
(2021)
Article
Medicine, General & Internal
Wenjing Bi, Yangjie Xiao, Xin Wang, Li Cui, Guang Song, Zeyu Yang, Ying Zhang, Weidong Ren
Summary: This study aimed to evaluate the impact of assisted reproductive technology (ART) on fetal and infant cardiac remodeling. The results showed that ART fetuses demonstrated cardiac alterations compared to spontaneously conceived controls, including globular enlarged left ventricle (LV), larger right ventricle (RV), and reduced LV systolic deformation. However, these alterations did not persist in early infancy. Furthermore, different ART procedures showed similar unfavorable changes in the fetal heart.
Article
Cardiac & Cardiovascular Systems
Ahmed M. Dohain, Wael Lotfy, Gaser Abdelmohsen, Rodina Sobhy, Osama Abdelaziz, Marwa Elsaadany, Mohamed H. Abdelsalam, Hossam Ibrahim
Summary: The study evaluated cardiac function in children with cardiomyopathy induced by ectopic atrial tachycardia, finding abnormalities in left ventricular and right ventricular function, as well as reduced right atrial reservoir function.
PACE-PACING AND CLINICAL ELECTROPHYSIOLOGY
(2021)
Review
Medicine, General & Internal
Maria Bonou, Sophie Mavrogeni, Chris J. Kapelios, George Markousis-Mavrogenis, Constantina Aggeli, Evangelos Cholongitas, Athanase D. Protogerou, John Barbetseas
Summary: Increased cardiac fat depots play a significant role in arrhythmias, with mechanisms involving inflammation, pathological changes, autonomic nervous system regulation, etc. Current imaging modalities provide valuable insights into the relationship between cardiac fat and arrhythmias, but further research is needed to support their use in risk prediction.
Article
Acoustics
Sara Zand, Hakimeh Sadeghian, Ali Kazemisaied, Haleh Ashraf, Masoumeh Lotfi-Tokaldany, Arash Jalali
Summary: This study investigates the clinical and echocardiographic predictors of echocardiographic super-response to cardiac resynchronization therapy (CRT) in heart failure patients. The results show that lower left ventricular end-systolic volume and higher anteroseptal-to-posterior wall delay are associated with super-response.
JOURNAL OF CLINICAL ULTRASOUND
(2023)
Review
Cardiac & Cardiovascular Systems
Marco Guglielmo, Andrew Lin, Damini Dey, Andrea Baggiano, Laura Fusini, Giuseppe Muscogiuri, Gianluca Pontone
Summary: EAT and PCAT are not inert fat tissues, they secrete adipokines that have significant effects on cardiovascular health; PCAT inflammation is associated with CAD and cardiovascular events, and CCT has become a key technology for assessing EAT and PCAT.
Article
Cardiac & Cardiovascular Systems
Eva M. Boorsma, Jozine M. Ter Maaten, Kevin Damman, Bart J. van Essen, Faiez Zannad, Dirk J. van Veldhuisen, Nilesh J. Samani, Kenneth Dickstein, Marco Metra, Gerasimos Filippatos, Chim C. Lang, Leong Ng, Stefan D. Anker, John G. Cleland, Pierpaolo Pellicori, Ron T. Gansevoort, Hiddo J. L. Heerspink, Adriaan A. Voors, Johanna E. Emmens
Summary: Albuminuria is common in patients with heart failure and is associated with clinical symptoms and biomarkers of congestion. It is also related to the severity and prognosis of heart failure.
EUROPEAN HEART JOURNAL
(2023)
Article
Cardiac & Cardiovascular Systems
Joao Pedro Ferreira, John G. Cleland, Nicolas Girerd, Erwan Bozec, Patrick Rossignol, Pierpaolo Pellicori, Franco Cosmi, Beatrice Mariottoni, Scott D. Solomon, Bertram Pitt, Marc A. Pfeffer, Amil M. Shah, Johannes Petutschnigg, Burkert Pieske, Frank Edelmann, Faiez Zannad
Summary: This study used meta-analysis of individual-patient data to find that spironolactone improves cardiac structure and function in patients with heart failure and preserved ejection fraction (HFpEF).
EUROPEAN JOURNAL OF HEART FAILURE
(2023)
Article
Cardiac & Cardiovascular Systems
Wouter Ouwerkerk, Jasper Tromp, John G. F. Cleland, Christiane E. Angermann, Ulf Dahlstrom, Georg Ertl, Mahmoud Hassanein, Sergio Perrone, Mathieu Ghadanfar, Anja Schweizer, Achim Obergfell, Kenneth Dickstein, Gerasimos Filippatos, Sean P. Collins, Carolyn S. P. Lam
Summary: In patients with acute heart failure, delayed administration of intravenous diuretics was not significantly associated with in-hospital mortality, but was associated with increased 30-day mortality, especially in high-risk patients. This association was independent of left ventricular ejection fraction or geographic region.
EUROPEAN JOURNAL OF HEART FAILURE
(2023)
Article
Cardiac & Cardiovascular Systems
Carrie Purcell, Anthony Purvis, John G. F. Cleland, Aynsley Cowie, Hasnain M. Dalal, Tracy Ibbotson, Clare Murphy, Rod S. Taylor
Summary: REACH-HF is a comprehensive home-based rehabilitation and self-management programme for people with heart failure. It has been proven to be effective and cost-effective in a multi-centre randomized trial. The SCOT:REACH-HF study assessed the implementation of REACH-HF in NHS Scotland.
EUROPEAN JOURNAL OF CARDIOVASCULAR NURSING
(2023)
Article
Cardiac & Cardiovascular Systems
Kieran F. Docherty, John J. V. McMurray, Brian L. Claggett, Zi Michael Miao, Kirkwood F. Adams, Alexandra Arias-Mendoza, John G. F. Cleland, Rafael Diaz, Luis E. Echeverria Correa, G. Michael Felker, Candida Fonseca, Jing Li, Marco Metra, Karen Sliwa-Hahnle, Scott D. Solomon, Hans J. Vandekerckhove, Dragos Vinereanu, Adriaan A. Voors, Stephen B. Heitner, Stuart Kupfer, Fady I. Malik, Lisa Meng, John R. Teerlink
Summary: This study aimed to examine the effect of omecamtiv mecarbil in heart failure patients according to the NT-proBNP levels. The results showed that omecamtiv mecarbil had a greater benefit in patients with higher baseline NT-proBNP levels, especially those without atrial fibrillation/flutter.
EUROPEAN JOURNAL OF HEART FAILURE
(2023)
Article
Cardiac & Cardiovascular Systems
Zachary I. Whinnett, Matthew J. Shun-Shin, Mark Tanner, Paul Foley, Badri Chandrasekaran, Philip Moore, Shaumik Adhya, Norman Qureshi, Amal Muthumala, Rebecca Lane, Aldo Rinaldi, Sharad Agarwal, Francisco Leyva, Jonathan Behar, Sukh Bassi, Andre Ng, Paul Scott, Rachana Prasad, Jon Swinburn, Joseph Tomson, Amarjit Sethi, Jaymin Shah, Phang Boon Lim, Andreas Kyriacou, Dewi Thomas, Jenny Chuen, Ravi Kamdar, Prapa Kanagaratnam, Myril Mariveles, Leah Burden, Katherine March, James P. Howard, Ahran Arnold, Pugazhendhi Vijayaraman, Berthold Stegemann, Nicholas Johnson, Emanuela Falaschetti, Darrel P. Francis, John G. F. Cleland, Daniel Keene
Summary: The study evaluated the effects of optimized His bundle pacing compared to no-pacing in patients with heart failure. It was found that His bundle pacing significantly improved quality of life and was preferred by the majority of patients. However, it did not show any significant changes in peak oxygen uptake or left ventricular ejection fraction.
EUROPEAN JOURNAL OF HEART FAILURE
(2023)
Article
Cardiac & Cardiovascular Systems
Joao Pedro Ferreirra, John G. Cleland, Nicolas Girerd, Patrick Rossignol, Pierpaolo Pellicori, Franco Cosmi, Beatrice Mariottoni, Arantxa Gonzalez, Javier Diez, Scott D. Solomon, Brian Claggett, Marc A. Pfeffer, Bertram Pitt, Johannes Petutschnigg, Burkert Pieske, Frank Edelmann, Faiez Zannad
Summary: Spironolactone reduces serum concentrations of PICP in patients with HFpEF, indicating its anti-fibrotic effect.
INTERNATIONAL JOURNAL OF CARDIOLOGY
(2023)
Editorial Material
Cardiac & Cardiovascular Systems
Milton Packer, John G. F. Cleland
JOURNAL OF CARDIAC FAILURE
(2023)
Article
Cardiac & Cardiovascular Systems
Joao Pedro Ferreira, John G. F. Cleland, Nicolas Girerd, Pierpaolo Pellicori, Mark R. Hazebroek, Job Verdonschot, Timothy J. Collier, Johannes Petutschnigg, Andrew L. Clark, Jan A. Staessen, Stephane Heymans, Patrick Rossignol, Faiez Zannad
Summary: The study investigated the effect of spironolactone on QRS duration in patients with stage B HFpEF. Spironolactone was found to significantly reduce the QRS duration after 9 months of treatment, indicating improved myocardial electrical activation. This effect was not associated with changes in LV mass or volume.
AMERICAN JOURNAL OF CARDIOLOGY
(2023)
Article
Cardiac & Cardiovascular Systems
George Markousis-Mavrogenis, Waldemar B. Minich, Ali A. Al-Mubarak, Stefan D. Anker, John G. F. Cleland, Kenneth Dickstein, Chim C. Lang, Leong L. Ng, Nilesh J. Samani, Faiez Zannad, Marco Metra, Petra Seemann, Antonia Hoeg, Patricio Lopez, Dirk J. van Veldhuisen, Rudolf A. de Boer, Adriaan A. Voors, Peter van der Meer, Lutz Schomburg, Nils Bomer
Summary: The study examined the importance of autoantibodies against adrenergic/muscarinic receptors in heart failure. The findings suggest that anti-beta 1 AABs are independently associated with HF rehospitalization, while other AABs are mainly related to comorbidities and medication use.
CARDIOVASCULAR RESEARCH
(2023)
Article
Cardiac & Cardiovascular Systems
Nicolas Girerd, Daniel Levy, Kevin Duarte, Joao Pedro Ferreira, Christie Ballantyne, Timothy Collier, Anne Pizard, Jens Bjoerkman, Javed Butler, Andrew Clark, John G. Cleland, Christian Delles, Javier Diez, Arantxa Gonzalez, Mark Hazebroek, Jennifer Ho, Anne-Cecile Huby, Shih-Jen Hwang, Roberto Latini, Beatrice Mariottoni, Alexandre Mebazaa, Pierpaolo Pellicori, Naveed Sattar, Peter Sever, Jan A. Staessen, Job Verdonschot, Stephane Heymans, Patrick Rossignol, Faiez Zannad
Summary: This study identified protein biomarkers associated with new-onset heart failure in three independent cohorts. The inclusion of these biomarkers in addition to clinical risk factors improved the prediction of heart failure risk. The B-type natriuretic peptide and N-terminal pro-B-type natriuretic peptide were found to be particularly relevant in predicting heart failure.
CIRCULATION-HEART FAILURE
(2023)
Article
Cardiac & Cardiovascular Systems
Antonio Iaconelli, Joe Cuthbert, Syed Kazmi, Pasquale Maffia, Andrew L. Clark, John G. F. Cleland, Pierpaolo Pellicori
Summary: This study found that venous congestion is more closely associated with prognosis in patients with chronic heart failure than pulmonary hypertension.
CLINICAL RESEARCH IN CARDIOLOGY
(2023)
Letter
Cardiac & Cardiovascular Systems
Vincenzo C. C. Leo, Syed Kazmi, Jack Brownrigg, Marzieh Araghi, Harpreet S. S. Sarna, Pierpaolo Pellicori, Joe Cuthbert, John G. F. Cleland, Andrew L. L. Clark
Editorial Material
Cardiac & Cardiovascular Systems
Joe J. Cuthbert, John G. F. Cleland
CARDIOVASCULAR RESEARCH
(2023)
Letter
Cardiac & Cardiovascular Systems
Alberto Guarnaccia, Gianfranco Sinagra, John G. F. Cleland