Article
Cardiac & Cardiovascular Systems
Parag Goyal, Michael Kim, Udhay Krishnan, Stephen A. Mccullough, Jim W. Cheung, Luke K. Kim, Ambarish Pandey, Barry A. Borlaug, Evelyn M. Horn, Monika M. Safford, Hooman Kamel
Summary: The study found that post-operative atrial fibrillation is associated with incident heart failure hospitalization among patients undergoing both cardiac and non-cardiac surgeries. These findings highlight the adverse prognostic impact of post-operative atrial fibrillation and suggest that it may be a marker for identifying patients with subclinical heart failure and those at elevated risk for heart failure.
EUROPEAN HEART JOURNAL
(2022)
Review
Medicine, General & Internal
Leonard Bergau, Philipp Bengel, Vanessa Sciacca, Thomas Fink, Christian Sohns, Philipp Sommer
Summary: Atrial fibrillation is the most common sustained arrhythmia worldwide and is strongly associated with heart failure. Two therapeutic strategies, rhythm control and rate control, are accepted as the standard of care in AF patients with heart failure. Recent important studies have investigated the optimal therapeutic strategy in HF patients.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Cardiac & Cardiovascular Systems
Yogesh N. Reddy, Barry A. Borlaug, Bernard J. Gersh
Summary: Atrial fibrillation is the most common arrhythmia in heart failure patients and can be both the cause and consequence of clinical heart failure. Some patients may benefit from maintaining sinus rhythm with catheter ablation. There is a close relationship between atrial fibrillation, left atrial myopathy, mitral regurgitation, and heart failure with preserved ejection fraction, with potential clinical benefits to catheter ablation therapy. Treatment of atrial fibrillation also requires consideration of the degree of atrial myopathy and chronicity of atrial fibrillation.
Review
Medicine, General & Internal
Michael Derndorfer, Shaojie Chen, Helmut Puererfellner
Summary: Atrial fibrillation (AF) and heart failure (HF) are closely linked, with successful treatment of one potentially benefiting the other; adherence to guidelines is crucial, with AF patients potentially benefiting from ablation and HF patients having alternative treatment options depending on their LVEF levels.
JOURNAL OF CLINICAL MEDICINE
(2021)
Article
Biochemistry & Molecular Biology
Konstantinos D. Rizas, Luisa Freyer, Nikolay Sappler, Lukas von Stuelpnagel, Peter Spielbichler, Aresa Krasniqi, Michael Schreinlechner, Felix N. Wenner, Fabian Theurl, Amira Behroz, Elodie Eiffener, Mathias P. Klemm, Annika Schneidewind, Martin Zens, Theresa Dolejsi, Ulrich Mansmann, Steffen Massberg, Axel Bauer
Summary: The study compared the efficacy of digital smart devices in detecting atrial fibrillation (AF) and found that digital screening technology more than doubled the detection rate of treatment-relevant AF compared to usual care. This technology has the potential for broad applicability and further studies are needed to assess if digital screening for AF leads to better treatment outcomes.
Article
Medicine, General & Internal
Aditya Bhat, Henry H. L. Chen, Shaun Khanna, Gary C. H. Gan, Walter P. Abhayaratna, Maria Carmo P. Nunes, Chandini Raina MacIntyre, Timothy C. Tan
Summary: According to a study, heart failure, increased right atrial size, and impaired left atrial function are independent predictors of persistent/permanent atrial fibrillation.
EUROPEAN JOURNAL OF CLINICAL INVESTIGATION
(2021)
Article
Cardiac & Cardiovascular Systems
Mary Rezk, Amar Taha, Susanne J. Nielsen, Tomas Gudbjartsson, Lennart Bergfeldt, Anders Ahlsson, Anders Jeppsson
Summary: This study aimed to explore the association between the clinical course of new-onset postoperative atrial fibrillation (POAF) and long-term outcomes. The findings showed that a more complicated course of POAF was associated with increased long-term risk for heart failure hospitalization but not for all-cause mortality or thromboembolic complications.
ANNALS OF THORACIC SURGERY
(2022)
Article
Cardiac & Cardiovascular Systems
Yuya Takahashi, Takanori Yamaguchi, Toyokazu Otsubo, Kana Nakashima, Kodai Shinzato, Ryosuke Osako, Shigeki Shichida, Yuki Kawano, Akira Fukui, Atsushi Kawaguchi, Shinichi Aishima, Tsunenori Saito, Naohiko Takahashi, Koichi Node
Summary: This study aimed to histologically validate atrial structural remodelling associated with atrial fibrillation. The histological correlates of atrial structural remodelling were fibrosis, increased intercellular space, myofibrillar loss, and decreased nuclear density. Each histological component was defined using electron microscopy and immunohistochemistry studies.
EUROPEAN HEART JOURNAL
(2023)
Article
Cardiac & Cardiovascular Systems
Dorothee Jakob, Alexander Klesen, Benoit Allegrini, Elisa Darkow, Diana Aria, Ramona Emig, Ana Simon Chica, Eva A. Rog-Zielinska, Tim Guth, Friedhelm Beyersdorf, Fabian A. Kari, Susanne Proksch, Stephane N. Hatem, Matthias Karck, Stephan R. Kunzel, Helene Guizouarn, Constanze Schmidt, Peter Kohl, Ursula Ravens, Remi Peyronnet
Summary: The study found that human atrial fibroblasts contain at least two types of ion channels activated during stretch: Piezol and BKca. Sustained atrial fibrillation is associated with increased Piezol and decreased BKca activity, indicating differential regulation of these channels.
JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY
(2021)
Article
Medicine, General & Internal
Monika Gawalko, Monika Budnik, Iwona Gorczyca, Olga Jelonek, Beata Uzieblo-Zyczkowska, Malgorzata Maciorowska, Maciej Wojcik, Robert Blaszczyk, Tomasz Tokarek, Renata Rajtar-Salwa, Jacek Bil, Michal Wojewodzki, Anna Szpotowicz, Malgorzata Krzciuk, Janusz Bednarski, Elwira Bakula-Ostalska, Anna Tomaszuk-Kazberuk, Anna Szyszkowska, Marcin Welnicki, Artur Mamcarz, Agnieszka Kaplon-Cieslicka
Summary: The study found that over 70% of hospitalized AF patients have coexisting HF, but there is still a significant number of patients not receiving the recommended OAC. Differences were observed in treatment between HF and non-HF patients, warranting further attention.
JOURNAL OF CLINICAL MEDICINE
(2021)
Article
Cardiac & Cardiovascular Systems
Jean-Baptiste Guichard, Feng Xiong, Xiao-Yan Qi, Nathalie L'Heureux, Roddy Hiram, Jiening Xiao, Patrice Naud, Jean-Claude Tardif, Antoine Da Costa, Stanley Nattel
Summary: This study assessed the specific contributions of atrial fibrillation-related atrial arrhythmia vs. associated ventricular arrhythmia to remodeling. The results showed that both atrial tachyarrhythmia and rapid ventricular response during AF produce distinct atrial remodelling, providing new insights into AF-related remodeling and ventricular rate-control considerations.
CARDIOVASCULAR RESEARCH
(2021)
Article
Cardiac & Cardiovascular Systems
James M. Brophy, Lyne Nadeau
Summary: This retrospective cohort claims database study explores the optimal drug choice for rate control in atrial fibrillation patients. The study finds that discharge prescriptions for digoxin alone or a combination of digoxin and beta-blockers are not associated with increased risk of recurrent cardiovascular hospitalizations and death compared to prescriptions for beta-blockers alone. More research is needed to improve the precision of these estimates.
CANADIAN JOURNAL OF CARDIOLOGY
(2023)
Review
Biochemistry & Molecular Biology
Gerhild Euler, Jens Kockskaemper, Rainer Schulz, Mariana S. Parahuleva
Summary: HF and AF are major life-threatening diseases worldwide, and recent studies suggest JDP2 as a potential prognostic marker and therapeutic target for these diseases. Studies in genetically modified mice show impressive involvement of JDP2 in HF and AF.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Multidisciplinary Sciences
Maarten Hulsmans, Maximilian J. Schloss, I-Hsiu Lee, Aneesh Bapat, Yoshiko Iwamoto, Claudio Vinegoni, Alexandre Paccalet, Masahiro Yamazoe, Jana Grune, Steffen Pabel, Noor Momin, Hana Seung, Nina Kumowski, Fadi E. Pulous, Daniel Keller, Constanze Bening, Ursula Green, Jochen K. Lennerz, Richard N. Mitchell, Andrew Lewis, Barbara Casadei, Oriol Iborra-Egea, Antoni Bayes-Genis, Samuel Sossalla, Chin Siang Ong, Richard N. Pierson, Jon C. Aster, David Rohde, Gregory R. Wojtkiewicz, Ralph Weissleder, Filip K. Swirski, George Tellides, George Tolis, Serguei Melnitchouk, David J. Milan, Patrick T. Ellinor, Kamila Naxerova, Matthias Nahrendorf
Summary: This study deciphered the role of immune and stromal cells in atrial fibrillation and identified SPP1(+) macrophages as potential targets for immunotherapy in atrial fibrillation.
Article
Cardiac & Cardiovascular Systems
Bernadet T. Santema, Vicente Artola Arita, Iziah E. Sama, Marielle Kloosterman, Maarten P. van den Berg, Hans L. A. Nienhuis, Isabelle C. Van Gelder, Peter van der Meer, Faiez Zannad, Marco Metra, Jozine M. Ter Maaten, John G. Cleland, Leong L. Ng, Stefan D. Anker, Chim C. Lang, Nilesh J. Samani, Kenneth Dickstein, Gerasimos Filippatos, Dirk J. van Veldhuisen, Carolyn S. P. Lam, Michiel Rienstra, Adriaan A. Voors
Summary: By comparing 92 biomarkers from different pathophysiological domains, the study found 24 biomarkers that were dysregulated in patients with HF and AF. Pathway overrepresentation analyses revealed that AF patients were associated with three pathways related to amyloid-beta, indicating the need for further confirmation in future studies.
CARDIOVASCULAR RESEARCH
(2022)
Article
Cardiac & Cardiovascular Systems
Jan D. Schmitto, Yuriy Pya, Daniel Zimpfer, Thomas Krabatsch, Jens Garbade, Vivek Rao, Michiel Morshuis, Friedhelm Beyersdorf, Silvana Marasco, Poornima Sood, Laura Damme, Ivan Netuka
EUROPEAN JOURNAL OF HEART FAILURE
(2019)
Article
Cardiac & Cardiovascular Systems
Nir Uriel, Diego Medvedofsky, Teruhiko Imamura, Jiri Maly, Eric Kruse, Peter Ivak, Poornima Sood, Roberto M. Lang, Francesco Maffessanti, Dominik Berliner, Johann Bauersachs, Axel Haverich, Michael Zelizko, Ivan Netuka, Jan D. Schmitto
JOURNAL OF CARDIAC FAILURE
(2019)
Article
Cardiac & Cardiovascular Systems
Christos Zormpas, Johanna Mueller-Leisse, Thorben Koenig, Jan D. Schmitto, Christian Veltmann, David Duncker
JOURNAL OF ELECTROCARDIOLOGY
(2019)
Editorial Material
Cardiac & Cardiovascular Systems
Jasmin S. Hanke, Guenes Dogan, Jan D. Schmitto
JOURNAL OF THORACIC AND CARDIOVASCULAR SURGERY
(2019)
Correction
Cell Biology
B. A. Mohamed, N. Hartmann, P. Tirilomis, K. Sekeres, W. Li, S. Neef, C. Richter, E. M. Zeisberg, L. Kattner, M. Didie, K. Guan, J. D. Schmitto, S. E. Lehnart, S. Luther, N. Voigt, T. Seidler, S. Sossalla, G. Hasenfuss, K. Toischer
SCIENCE TRANSLATIONAL MEDICINE
(2019)
Meeting Abstract
Cardiac & Cardiovascular Systems
J. D. Schmitto, M. Ozbaran, C. Engin, A. Simon, V. Horvath, J. Roussel, M. Pac, U. Kervan, S. Klotz, F. Wagner, T. Schloeglhofer, D. Zimpfer
JOURNAL OF HEART AND LUNG TRANSPLANTATION
(2019)
Meeting Abstract
Cardiac & Cardiovascular Systems
D. Saeed, J. Garbade, F. Gustafsson, J. Lavee, M. Morshuis, D. Zimpfer, E. Potapov, Y. Pya, J. Schmitto, S. M. Shaw
JOURNAL OF HEART AND LUNG TRANSPLANTATION
(2019)
Meeting Abstract
Cardiac & Cardiovascular Systems
L. Napp, C. Baum, G. Dogan, J. S. Hanke, T. Meyer, P. Goettel, K. Brandes, S. Sarikouch, C. Bara, J. Bauersachs, A. Haverich, J. Mueller, J. D. Schmitto
JOURNAL OF HEART AND LUNG TRANSPLANTATION
(2019)
Meeting Abstract
Cardiac & Cardiovascular Systems
K. K. Mirza, F. Gustafsson, Y. Pya, S. Shaw, A. Diegeler, I. Netuka, J. Lavee, J. Garbade, M. Morshuis, J. Heatley, D. Saeed, V. Potapov, J. Schmitto, D. Zimpfer
JOURNAL OF HEART AND LUNG TRANSPLANTATION
(2019)
Article
Respiratory System
Stephan Hohmann, Christian Veltmann, David Duncker, Thorben Koenig, Dominik Berliner, Jasmin Hanke, Guenes Dogan, Anamika Chatterjee, Christina Feldmann, Bryan Lynch, Daniel Burkhoff, Axel Haverich, Johann Bauersachs, Jan D. Schmitto
JOURNAL OF THORACIC DISEASE
(2019)
Article
Engineering, Biomedical
Thomas Schmidt, Philipp Mewes, Jan-Dirk Hoffmann, Frerk Mueller-von Aschwege, Jenny I. Glitza, Jan D. Schmitto, Sebastian Schulte-Eistrup, Juergen R. Sindermann, Nils Reiss
Meeting Abstract
Cardiac & Cardiovascular Systems
L. Christian Napp, Guenes Dogan, Jasmin Hanke, Silvia Mariani, Peter Gottel, Kersten Brandes, Samir Sarikouch, Christoph Bara, Johannes Muller, Jan Schmitto
JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY
(2019)
Article
Multidisciplinary Sciences
Constanca Figueiredo, Dorothee Eicke, Yuliia Yuzefovych, Murat Avsar, Jasmin Sarah Hanke, Michael Pflaum, Jan-Dieter Schmitto, Rainer Blasczyk, Axel Haverich, Bettina Wiegmann
SCIENTIFIC REPORTS
(2019)
Article
Engineering, Biomedical
Christin Walter, Florian Fischer, Jasmin S. Hanke, Guenes Dogan, Jan Dieter Schmitto, Axel Haverich, Nils Reiss, Thomas Schmidt, Jan-Dirk Hoffmann, Christina Feldmann
INTERNATIONAL JOURNAL OF ARTIFICIAL ORGANS
(2020)
Editorial Material
Respiratory System
Silvia Mariani, Anamika Chatterjee, Jasmin S. Hanke, Katharina Homann, Gunes Dogan, Axel Haverich, Jan D. Schmitto
JOURNAL OF THORACIC DISEASE
(2019)