Article
Cardiac & Cardiovascular Systems
Dimitrios Farmakis, Jasper Tromp, Smaragdi Marinaki, Wouter Ouwerkerk, Christiane E. E. Angermann, Vasiliki Bistola, Ulf Dahlstrom, Kenneth Dickstein, Georg Ertl, Mathieu Ghadanfar, Mahmoud Hassanein, Achim Obergfell, Sergio V. V. Perrone, Eftihia Polyzogopoulou, Anja Schweizer, Ioannis Boletis, John G. F. Cleland, Sean P. P. Collins, Carolyn S. P. Lam, Gerasimos Filippatos
Summary: This study analyzed healthcare resource utilization in patients with heart failure of different ejection fraction types and found high utilization across all three groups. Despite clinical differences, patients with HFmrEF and HFpEF had better long-term cardiovascular outcomes compared to HFrEF. However, the risk for non-cardiovascular events was similar among the groups.
EUROPEAN JOURNAL OF HEART FAILURE
(2023)
Article
Cardiac & Cardiovascular Systems
Gerasimos Filippatos, Javed Butler, Dimitrios Farmakis, Faiez Zannad, Anne Pernille Ofstad, Joao Pedro Ferreira, Jennifer B. Green, Julio Rosenstock, Sven Schnaidt, Martina Brueckmann, Stuart J. Pocock, Milton Packer, Stefan D. Anker
Summary: In patients with heart failure and preserved ejection fraction, empagliflozin significantly reduces the risk of heart failure outcomes, regardless of diabetes status at baseline.
Article
Cardiac & Cardiovascular Systems
Chih-Weim Hsiang, Chin Lin, Wen-Cheng Liu, Chin-Sheng Lin, Wei-Chou Chang, Hsian-He Hsu, Guo-Shu Huang, Yu-Sheng Lou, Chia-Cheng Lee, Chih-Hung Wang, Wen-Hui Fang
Summary: The study developed a deep-learning model to identify left ventricular ejection fraction (LVEF) <= 35% via chest X-ray images, which demonstrated excellent performance in internal and external validation and could potentially be used for early prediction of cardiovascular disease development.
CANADIAN JOURNAL OF CARDIOLOGY
(2022)
Article
Transplantation
Giovanni Tripepi, Graziella D'Arrigo, Francesca Mallamaci, Gerard London, Navdeep Tangri, Jesse Yenchih Hsu, Harvey Feldman, Carmine Zoccali
Summary: In a study involving 1352 CKD patients, LVMI, SHARP score, and the CRIC model were all significantly associated with the risk of death and de novo HF. LVMI did not provide additional prognostic value for stratifying the risk of death or HF compared to the SHARP score and the CRIC model.
NEPHROLOGY DIALYSIS TRANSPLANTATION
(2021)
Article
Cardiac & Cardiovascular Systems
Shaoping Wang, Yi Lyu, Shujuan Cheng, Yuchao Zhang, Xiaoyan Gu, Ming Gong, Jinghua Liu
Summary: This study aimed to investigate the predictive roles of pre-operative left ventricular size and ejection fraction in ejection fraction improvement and outcome following revascularization in patients with coronary artery disease and left ventricular dysfunction. The results showed that pre-operative left ventricular end-systolic diameter and ejection fraction were predictive of ejection fraction improvement after revascularization, and smaller left ventricular end-systolic diameter and lower ejection fraction were associated with better outcomes.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2022)
Article
Cardiac & Cardiovascular Systems
Shuo-Ming Ou, Chieh-Ju Chao, Ming-Tsun Tsai, Kuo-Hua Lee, Wei-Cheng Tseng, Pin-Jie Bin, Yao-Ping Lin, Chien-Yi Hsu, Der-Cherng Tarng
Summary: Heart failure is prevalent in patients with chronic kidney disease (CKD), and its impact on renal function and long-term outcomes in different subtypes of heart failure remains uncertain. This study found that heart failure is associated with worse clinical outcomes, and patients with HFrEF have the highest risk.
Article
Medicine, General & Internal
Takahiro Doi, Tomoaki Nakata, Takahiro Noto, Tomohiro Mita, Daigo Nagahara, Satoshi Yuda, Akiyoshi Hashimoto
Summary: This study analyzed the relationship between left ventricular mechanical dyssynchrony, left ventricular hypertrophy, cardiac sympathetic innervation, and lethal cardiac events in heart failure patients. The results showed that patients with greater phase SD, greater LVMI, and lower MIBG HMR were more likely to experience lethal cardiac events.
JOURNAL OF CLINICAL MEDICINE
(2021)
Article
Cardiac & Cardiovascular Systems
Hyun-Jung Lee, Hyung-Kwan Kim, Tae-Min Rhee, You-J Ung Choi, In-Chang Hwang, Yeonyee E. Yoon, Jun-Bean Park, Seung-Pyo Lee, Yong-Jin Kim, Goo-Yeong Cho
Summary: LARS can be used to categorize LV diastolic function and predict HF events in patients with hypertrophic cardiomyopathy.
CIRCULATION-CARDIOVASCULAR IMAGING
(2022)
Article
Cardiac & Cardiovascular Systems
Zijie Ding, Jinping Si, Xuexia Zhang, Yuze Hu, Xinxin Zhang, Yanli Zhang, Ying Liu
Summary: This study investigated the frequency and prognostic implications of changes in left ventricular ejection fraction (LVEF) in patients with heart failure (HF). The results showed that changes in LVEF are strongly correlated with patient outcomes, especially in those with significant changes. Therefore, the trajectories of LVEF and types of HF changes are recommended as useful tools for prognostication.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2023)
Article
Medicine, General & Internal
Banafsheh Arshi, Sven Geurts, Martijn J. Tilly, Marten van den Berg, Jan A. Kors, Dimitris Rizopoulos, M. Arfan Ikram, Maryam Kavousi
Summary: HRV indices are associated with worse systolic function in men and improvement in left atrial size in women. Higher HRV is associated with a higher risk of new-onset HF in men.
Article
Medicine, General & Internal
Silvia Oghina, Wulfran Bougouin, Mounira Kharoubi, Louis Bonnefous, Arnault Galat, Soulef Guendouz, Melanie Bezard, Fabien Le Bras, Jean-Francois Deux, Emmanuel Itti, Anissa Moktefi, Pascale Fanen, Emmanuel Teiger, Dania Mohty, Thibaud Damy, Diane Bodez
Summary: All LVDF patterns can be observed in CA, and one quarter of CA patients have a better prognosis with grade I LVDF.
JOURNAL OF CLINICAL MEDICINE
(2021)
Article
Cardiac & Cardiovascular Systems
Daniel Burkhoff, Veli K. Topkara, Gabriel Sayer, Nir Uriel
Summary: This review provides a comprehensive overview of research into LVAD therapy for heart failure, including the hemodynamic effects of LVAD support and the structural, cellular, and molecular aspects of LVAD-associated reverse remodeling. The review also discusses the synergistic effects of LVAD support with heart failure therapies on clinical outcomes and myocardial biology.
CIRCULATION RESEARCH
(2021)
Article
Medicine, General & Internal
Vincenzo De Marzo, Gianluigi Savarese, Lucia Tricarico, Sofia Hassan, Massimo Iacoviello, Italo Porto, Pietro Ameri
Summary: Combination medical therapy including neurohormonal inhibitors and newer drugs, especially ARNI and SGLT2i, confers the maximum benefit with regard to HFrEF prognosis.
JOURNAL OF INTERNAL MEDICINE
(2022)
Article
Cardiac & Cardiovascular Systems
Aditi Nayak, Shelley A. Hall, Nir Uriel, Daniel J. Goldstein, Joseph C. Cleveland Jr, Jennifer A. Cowger, Christopher T. Salerno, Yoshifumi Naka, Douglas Horstmanshof, Daniel Crandall, Aijia Wang, Mandeep R. Mehra
Summary: This study aimed to identify risk predictors of mortality through 5 years among HM3 LVAD recipients conditional on discharge from index hospitalization. The findings revealed that long-term survival in successfully discharged HM3 LVAD recipients is largely influenced by clinical events experienced during the index surgical hospitalization in tandem with baseline factors.
JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY
(2023)
Article
Cardiac & Cardiovascular Systems
Xinxin Zhang, Yuxi Sun, Yanli Zhang, Feifei Chen, Mengyuan Dai, Jinping Si, Jing Yang, Xiao Li, Jiaxin Li, Yunlong Xia, Gary Tse, Ying Liu
Summary: This study found that heart failure with recovered ejection fraction is a distinct phenotype with better clinical outcomes compared to persistent HFrEF. HFrecEF patients have relatively better short-term survival at 24 months, but no significant difference thereafter.
Article
Peripheral Vascular Disease
Floran Sahiti, Caroline Morbach, Vladimir Cejka, Theresa Tiffe, Martin Wagner, Felizitas A. Eichner, Gotz Gelbrich, Peter U. Heuschmann, Stefan Stoerk
Summary: Myocardial work, a new echocardiography-based diagnostic tool, quantifies left ventricular performance and is impacted by cardiovascular risk factors, with hypertension and obesity having a stronger association in women. This innovative concept enhances understanding of pathophysiological processes in health and cardiac disease.
JOURNAL OF HUMAN HYPERTENSION
(2022)
Article
Cardiac & Cardiovascular Systems
Guelmisal Gueder, Joana Wilkesmann, Nina Scholz, Robert Leppich, Peter Dueking, Billy Sperlich, Christian Rost, Stefan Frantz, Caroline Morbach, Floran Sahiti, Ulrich Stefenelli, Margret Breunig, Stefan Stoerk
Summary: The study demonstrated that implementing a supervised HF exercise program is feasible, safe, and has the potential to improve quality of life and surrogate markers of HF severity, especially in terms of psychological and social aspects for heart failure patients.
CLINICAL RESEARCH IN CARDIOLOGY
(2022)
Letter
Biochemistry & Molecular Biology
Sandra Ihne, Malte Kircher, Aikaterini Papagianni, Oliver Goetze, Caroline Morbach, Rudolf A. Werner, Daniel Zeller, Claudia Sommer, Andreas Rosenwald, Kerstin Amann, Reinhold P. Linke, Constantin Lapa, Hermann Einsele, Andreas Geier, Laura Obici, Giovanni Palladini, Stefan Knop, Stefan Stoerk
AMYLOID-JOURNAL OF PROTEIN FOLDING DISORDERS
(2022)
Article
Cardiac & Cardiovascular Systems
Suleman Aktaa, Marija Polovina, Giuseppe Rosano, Amr Abdin, Manuel Anguita, Mitja Lainscak, Lars H. Lund, Theresa McDonagh, Marco Metra, Richard Mindham, Massimo Piepoli, Stefan Stoerk, Mariya P. Tokmakova, Petar Seferovic, Chris P. Gale, Andrew J. S. Coats
Summary: The study aims to develop a set of quality indicators for evaluating the quality of care for adults with heart failure. Through a systematic process including constructing a conceptual framework, conducting a literature review, using the Delphi method, and evaluating feasibility, a set of indicators across five domains of care were selected. These indicators can be used to quantify and improve adherence to recommended clinical practices and enhance patient outcomes.
EUROPEAN JOURNAL OF HEART FAILURE
(2022)
Article
Health Care Sciences & Services
Mathias Kaspar, Georg Fette, Monika Hanke, Maximilian Ertl, Frank Puppe, Stefan Stoerk
Summary: This study demonstrates the feasibility of an automated transformation and transfer process for transferring highly structured and granular data from a hospital information system to a study's electronic data capture system. The process takes into account the specific data and visit structures of the study, and is able to automate the transfer of a large amount of data with good accuracy.
HEALTH INFORMATICS JOURNAL
(2022)
Article
Endocrinology & Metabolism
Ann-Cathrin Koschker, Bodo Warrings, Caroline Morbach, Florian Seyfried, Nicole Rickert, Pius Jung, Andreas Geier, Ulrich Dischinger, Maike Krauthausen, Martin J. Herrmann, Christine Stier, Stefan Frantz, Uwe Malzahn, Stefan Stoerk, Martin Fassnacht
Summary: Obesity is a rapidly emerging health problem and a well-established risk factor for cardiovascular diseases. The Würzburg Obesity Study (WAS) is a randomized controlled trial comparing the effects of Roux-en-Y gastric bypass (RYGB) with psychotherapy-supported lifestyle modification in morbidly obese patients. This study aims to provide valuable data on the impact of RYGB on cardiovascular and other functions.
ENDOCRINE CONNECTIONS
(2022)
Article
Endocrinology & Metabolism
Martin Christa, Stefanie Hahner, Herbert Koestler, Wolfgang Rudolf Bauer, Stefan Stoerk, Andreas Max Weng
Summary: Sodium MRI can non-invasively assess sodium storage in cardiovascular diseases and provide information about sodium distribution in different tissues. This study found that sodium was uniformly distributed and behaved similarly in different skeletal muscles in patients with Conn's syndrome.
EUROPEAN JOURNAL OF ENDOCRINOLOGY
(2022)
Article
Urology & Nephrology
Fabian Hammer, Bernd Genser, Benjamin Dieplinger, Margot Egger, Thomas Mueller, Christiane Drechsler, Winfried Maerz, Stefan Stoerk, Christoph Wanner, Vera Krane
Summary: This study aimed to investigate the predictive value of sST2 in diabetic patients receiving hemodialysis. The results showed that high sST2 concentrations were strongly associated with an increased risk of all-cause mortality, cardiovascular mortality, and death due to infection.
CLINICAL KIDNEY JOURNAL
(2022)
Article
Biology
Kim K. Sommer, Ali Amr, Udo Bavendiek, Felix Beierle, Peter Brunecker, Henning Dathe, Juergen Eils, Maximilian Ertl, Georg Fette, Matthias Gietzelt, Bettina Heidecker, Kristian Hellenkamp, Peter Heuschmann, Jennifer D. E. Hoos, Tibor Kesztyues, Fabian Kerwagen, Aljoscha Kindermann, Dagmar Krefting, Ulf Landmesser, Michael Marschollek, Benjamin Meder, Angela Merzweiler, Fabian Prasser, Ruediger Pryss, Jendrik Richter, Philipp Schneider, Stefan Stoerk, Christoph Dieterich
Summary: Predicting the risk of heart failure in patients is crucial for tailoring preventive, diagnostic, and therapeutic strategies to suit individual patients and effectively utilize healthcare resources. However, existing risk scores are rarely implemented in routine care due to the difficulty of their calculation and the unavailability of necessary data in an interoperable format. In this study, we demonstrate the feasibility of using clinical routine data from multiple medical centers to calculate heart failure risk scores, offering a potential solution that can be applied in various clinical care settings.
Article
Multidisciplinary Sciences
Moritz T. Huttelmaier, Alexander Gabel, Maria Seewald, Carsten Jungbauer, Stefan Frantz, Stefan Stoerk, Thomas H. Fischer
Summary: This study investigated the impact of the COVID-19 pandemic on physical activity and frequency of implantable cardioverter-defibrillator (ICD) therapies in patients with cardiac implantable electronic devices. The results showed that physical activity decreased during the pandemic, especially during the lockdown periods. Younger patients resumed their previous levels of physical activity when restrictions were eased.
Article
Biochemistry & Molecular Biology
Jan Traub, Katja Grondey, Tobias Gassenmaier, Dominik Schmitt, Georg Fette, Stefan Frantz, Valerie Boivin-Jahns, Roland Jahns, Stefan Stoerk, Guido Stoll, Theresa Reiter, Ulrich Hofmann, Martin S. Weber, Anna Frey
Summary: The study found that serum levels of glial fibrillary acidic protein (GFAP) increased in the first 3 months after ST-elevation myocardial infarction (STEMI), and remained elevated without further increases after 6 and 12 months. In contrast, neurofilament light chain (NfL) levels remained unchanged throughout the one-year period. These findings support the idea of central nervous system involvement after myocardial infarction, with GFAP potentially serving as a peripheral biomarker for chronic glial damage.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Review
Biology
Jan Traub, Anna Frey, Stefan Stoerk
Summary: Acute and chronic cardiac disorders can lead to cognitive impairment and dementia. The underlying mechanisms and pathways involved in this association are not well understood, but dysregulated and persistent inflammatory processes in the brain have been proposed as potential causes. Recent advances in brain imaging techniques have shown increased neuroinflammation in certain brain regions of patients with cardiac disease, which is linked to altered cognition. Microglia, a type of immune cell in the brain, play a crucial role in this process by interacting with other brain cells. This review explores the current evidence linking cognitive impairment and chronic neuroinflammation in patients with cardiac disorders and discusses the potential for targeted drug interventions.
Article
Cardiac & Cardiovascular Systems
Nicolas Verheyen, Angelika Batzner, David Zach, Andreas Zirlik, Brenda Gerull, Stefan Frantz, Christoph Maack, Stefan Stoerk, Hubert Seggewiss, Caroline Morbach
Summary: This study aimed to investigate whether echocardiography-derived parameters obtained at rest can aid in determining the presence of left ventricular outflow tract obstruction (LVOTO) in hypertrophic cardiomyopathy (HCM) patients. Among 142 HCM patients, the distance between the mitral leaflet tip and ventricular septum (TIS) in the apical three-chamber view was found to be independently associated with LVOTO. A TIS value of <= 14 mm had a sensitivity of 97% and specificity of 57% in identifying LVOTO.
EUROPEAN HEART JOURNAL-CARDIOVASCULAR IMAGING
(2023)
Article
Cardiac & Cardiovascular Systems
Angelika Batzner, Patrick Hahn, Caroline Morbach, Stefan Stoerk, Christoph Maack, Nicolas Verheyen, Brenda Gerull, Stefan Frantz, Hubert Seggewiss
Summary: Non-invasive estimation of LVSP in HOCM is feasible by combining conventional BP and averaged CWmean and CWmax gradients. This approach may lead to a more reliable estimation of MyW in HOCM.
EUROPEAN HEART JOURNAL-CARDIOVASCULAR IMAGING
(2023)
Article
Primary Health Care
Marion Eisele, Anja Rakebrandt, Sigrid Boczor, Eva Blozik, Jens-Martin Traeder, Stefan Stoerk, Christoph Herrmann-Lingen, Martin Scherer
Summary: This study investigated whether general practitioners' awareness of patients' symptoms of depression and anxiety would affect the change in quality of life. The results showed that there was no association between the general practitioners' awareness of psychosocial distress and the change in quality of life. Psychosocial distress strongly impairs the quality of life in heart failure patients.