Article
Biochemistry & Molecular Biology
Judith Morawietz, Hanna Koerber, Eva-Maria Packeiser, Andreas Beineke, Sandra Goericke-Pesch
Summary: Chronic asymptomatic orchitis (CAO) is a common cause of acquired non-obstructive azoospermia in dogs. The study found that the disturbance of spermatogenesis in CAO is correlated with an increase in TUNEL+ cells. Gene expression analysis revealed increased levels of Bax, Bcl-2, caspase 9, Fas, caspase 8, and caspase 3 in CAO, while FasL expression was downregulated. Sertoli cells and B lymphocytes play a significant role in the pathophysiology of canine CAO.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Agriculture, Dairy & Animal Science
Taojie Zhang, Wang-Dui Basang, Weihua Chang, Shengdong Huo, Xingbin Ma, Xianghong Ju, Sijiu Yu, Sheng Cui
Summary: In yak, P53 and Fas play a crucial role in inducing GC apoptosis, while Bax, Bcl-2, Casp9, and P53 are involved in oviduct epithelial regeneration.
JOURNAL OF ANIMAL PHYSIOLOGY AND ANIMAL NUTRITION
(2021)
Article
Cell Biology
Amreen Salwa, Alessandra Ferraresi, Eleonora Secomandi, Letizia Vallino, Riccardo Moia, Andrea Patriarca, Beatrice Garavaglia, Gianluca Gaidano, Ciro Isidoro
Summary: Diffuse large B-cell lymphoma (DLBCL) is a heterogeneous cancer characterized by dysregulated autophagy and apoptosis. The expression of BCL2 and BECN1 is inversely correlated in DLBCL patients, and cells with high BCL-2 expression are resistant to chemotherapy while cells with high BECLIN-1 expression are sensitive. Modulating BECLIN-1-dependent autophagy can affect the prognosis of DLBCL patients and potentially enhance the efficacy of chemotherapy.
Review
Oncology
Maria Huguet, Jose-Tomas Navarro, Jose Molto, Josep-Maria Ribera, Gustavo Tapia
Summary: Non-Hodgkin lymphoma (NHL) is a common HIV-related neoplasm, with diffuse large B-cell lymphoma (DLBCL) being the most common subtype. DLBCL in people with HIV presents with aggressive characteristics. The introduction of combined antiretroviral therapy (cART) and the use of cART with chemotherapy have significantly improved the prognosis for people with HIV and DLBCL, approaching that of the general population.
Review
Hematology
Eliza A. Hawkes, Allison Barraclough, Laurie H. Sehn
Summary: Diffuse large B-cell lymphoma (DLBCL), the most common lymphoma subtype, has a good prognosis in limited-stage DLBCL (LS-DLBCL) patients. Recent studies have provided new insights and strategies for the treatment of LS-DLBCL, including the use of PET scans and clinical trials. However, there is currently no standard definition for LS-DLBCL, and treatment strategies vary across studies, posing challenges in interpretation.
Article
Cell Biology
Xue Wu, Yuan Li, Wandong Zhang, Jing Zhang, Baoan Chen, Zheng Ge
Summary: This study analyzed the gene changes for diagnosis and prognosis of DLBCL using publicly available data. The results showed that high expression of RAC1 is associated with clinical stage and overall survival in DLBCL.
Article
Veterinary Sciences
Luca Aresu, Chiara Agnoli, Arturo Nicoletti, Antonella Fanelli, Valeria Martini, Francesco Bertoni, Laura Marconato
Summary: Canine Burkitt-like lymphoma (B-LL) is a rare tumor in dogs classified as a high-grade B-cell malignancy. Compared to the human counterpart, phenotypical differences are observed, and despite treatment, prognosis remains poor. However, around 30% of dogs can survive more than 1 year.
FRONTIERS IN VETERINARY SCIENCE
(2021)
Article
Medicine, Research & Experimental
Angelica Maria Gamboa-Cedeno, Mariangeles Diaz, Nancy Cristaldo, Victoria Otero, Natalia Schutz, Dorotea Fantl, Silvana Cugliari, Marta Zerga, Erica Rojas-Bilbao, Federico Jauk, Hernan Garcia Rivello, Myriam Nunez, Stella Maris Ranuncolo
Summary: The study highlights the potential of BCL-2 as a prognostic biomarker and a new therapeutic target in classical Hodgkin Lymphoma (cHL). Additionally, it reveals the cytotoxic effect of venetoclax in human cHL cell lines for the first time.
Article
Medicine, General & Internal
Cheng-Han Wu, Jyh-Pyng Gau, Chieh-Lin Jerry Teng, Yu-Hsuan Shih, Yu-Chen Su, Ren-Ching Wang, Tsung-Chih Chen
Summary: Double-hit genetics leads to reduced CR and OS in DLBCL patients. Bulky disease and positive DE immunophenotype are associated with DH genetics. Combination of bulky disease and positive DE immunophenotype predicts DH genetics.
Article
Cell Biology
Uly Sumarni, Ulrich Reidel, Juergen Eberle
Summary: The study found that PEP005 can induce apoptosis in some CTCL cell lines, but is ineffective in others. This suggests a potential therapeutic strategy for CTCL involving PEP005, particularly in cells where apoptosis is induced.
Article
Surgery
Zhuoya Zhou, Jing Chen
Summary: This study is the largest population-based study to date on independent prognostic factors of CCSV-DLBCL. Age, race, surgical resection, radiation, and chemotherapy are closely associated with patients' survival outcomes.
ASIAN JOURNAL OF SURGERY
(2023)
Review
Biochemistry & Molecular Biology
Xiao-jie Liang, Xin-yu Song, Jia-lin Wu, Dan Liu, Bing-yu Lin, Hong-sheng Zhou, Liang Wang
Summary: This article provides an overview of the research advances in DLBCL prognostic biomarkers using a multi-omics approach. It emphasizes the urgent need for highly specific and sensitive biomarkers to predict the therapeutic response of DLBCL and assess patient benefit from systemic chemotherapy. The use of systems biology in DLBCL research is highlighted for its comprehensive quantification and identification of biomarkers and its potential to address major biological problems with high accuracy and sensitivity.
INTERNATIONAL JOURNAL OF BIOLOGICAL SCIENCES
(2022)
Article
Hematology
Shu-Yun Ma, Xiao-Peng Tian, Jun Cai, Ning Su, Yu Fang, Yu-Chen Zhang, Jin-Ni Wang, Robert Peter Gale, Qing-Qing Cai
Summary: A prognostic score for DLBCL patients based on infiltrating immune cells was constructed, showing that the immune risk score is an accurate and independent survival predictor in DLBCL patients.
BRITISH JOURNAL OF HAEMATOLOGY
(2021)
Article
Oncology
Yan Qin, Tian Qiu, Zucheng Xie, Xinrui Chen, Peng Liu, Jianliang Yang, Xiaohui He, Lin Gui, Shengyu Zhou, Hongxin Jiang, Changgong Zhang, Sheng Yang, Le Tang, Yuankai Shi
Summary: This study investigates the clinical and molecular differences between DLBCL patients with MYD88(L265P) and MYD88(other). The results show that MYD88(L265P) is more common in the non-GCB subtype and associated with testicle/ CNS involvement, PIM1 mutation, and high mutation frequency. On the other hand, MYD88(other) is more likely to have advanced stage, multiple extranodal sites, elevated LDH, and other genetic alterations. In the non-GCB subtype, MYD88(other) is associated with worse progression-free survival when treated with R-CHOP-like regimen.
JOURNAL OF CANCER RESEARCH AND CLINICAL ONCOLOGY
(2023)
Article
Oncology
Ki Rim Lee, Jeong-Ok Lee, Jong Seok Lee, Jin Ho Paik
Summary: This study demonstrates that the expression of nuclear Peli1 and Bcl-6 forms distinctive risk groups in DLBCL, which may help predict prognosis in patients.