Article
Cell Biology
Ruiyao Xu, Xianxian Wang, Sadia Safi, Nico Braunegger, Agnes Hipgrave Ederveen, Michelle Rottmann, Joachim Wittbrodt, Manfred Wuhrer, Janine Wesslowski, Gary Davidson
Summary: Reception of Wnt signals is mediated by Frizzled receptors and a co-receptor LRP6 or LRP5. Precise control of receptor activation is crucial to regulate Wnt/beta-catenin signaling for proper cellular function. A glycosyltransferase B3GnT2-like has been identified to modify LRP6 and enhance Wnt/beta-catenin signaling. This study highlights the importance of LRP6 as a regulatory hub in Wnt signaling and provides insight into the selective targeting of a signaling pathway component by a specific glycosyltransferase.
Article
Biochemistry & Molecular Biology
Erin A. Nekritz, Ruth Rodriguez-Barrueco, Koon-Kiu Yan, Meredith L. Davis, Rachel L. Werner, Laura Devis-Jauregui, Partha Mukhopadhyay, Jiyang Yu, David Llobet-Navas, Jose Silva
Summary: The miR-424/503 cluster plays a crucial role in regulating Wnt signaling, MaSC fate, and breast cancer development, with its function involving targeting the LRP6 co-receptor to reduce its expression.
Article
Oncology
Hanqing Wang, Sidi Zhao, Yang Liu, Fengyuan Sun, Xiaoming Huang, Tong Wu
Summary: This study demonstrates that downregulation of SOST promotes the malignant progression of uveal melanoma by activating the Wnt/beta-catenin signaling pathway. Mechanistically, SOST may exert this function by interacting with LRP5/LRP6 membrane receptors.
FRONTIERS IN ONCOLOGY
(2022)
Article
Pharmacology & Pharmacy
Sapna Sayed, Jiaxing Song, Ling Wang, Tobias Achu Muluh, Boxin Liu, Zhixian Lin, Yun Tang, Zijie Su, Huan Li, Vivian Weiwen Xue, Shanshan Liu, Xianxiong Chen, Guangqian Zhou, Qi Sun, Desheng Lu
Summary: In this study, ISX9 was identified as a novel agonist of the Wnt/beta-catenin pathway, which activates hair regrowth and may be a potential treatment for alopecia.
BRITISH JOURNAL OF PHARMACOLOGY
(2023)
Article
Cell & Tissue Engineering
Quan-Wen Liu, Yan-Min Ying, Jia-Xin Zhou, Wen-Jie Zhang, Zhao-Xiao Liu, Bing-Bing Jia, Hao-Cheng Gu, Chu-Yu Zhao, Xiao-Hui Guan, Ke-Yu Deng, Hong-Bo Xin
Summary: This study demonstrated that human amniotic mesenchymal stem cells (hAMSCs) attenuated liver fibrosis by inhibiting the activation of hepatic stellate cells (HSCs) through the depression of the Wnt/β-catenin signaling pathway.
STEM CELL RESEARCH & THERAPY
(2022)
Article
Immunology
Jian Chen, Jia Liu, Shimin Chen, Ruijun Lai, Chuanchuan Zheng, Jialiang Lu, Xinshao Jiang, Feng He, Chengliang Yang, Kai Li, Kegong Xie, Yujin Tang, Liqiang Wang
Summary: Salinomycin may be a promising therapeutic drug for osteoarthritis (OA) as it has shown protective effects on cartilage cells, reduces disease-associated changes, and delays cartilage destruction and osteophyte formation. Its mechanism of action may involve regulating cell synthesis and inhibiting degradation.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2022)
Article
Oncology
Wei-Tao Zhang, Ji-Jun Zhang, Quan Shao, Ying-Kai Wang, Jie-Peng Jia, Bo Qian, Xiao-Wen Tian, Wen-Ji Yan
Summary: This study reveals that the upregulated expression of FGD5-AS1 in pancreatic cancer activates the Wnt/β-catenin signaling pathway and promotes cancer cell proliferation, migration, and invasion by suppressing miR-577.
Article
Cell Biology
Huifang Zhu, Zijie Su, Jiong Ning, Liang Zhou, Lifeng Tan, Sapna Sayed, Jiaxing Song, Zhongyuan Wang, Huan Li, Qi Sun, Shanshan Liu, Ou Sha, Feng Leng, Xianxiong Chen, Desheng Lu
Summary: TMEM97 upregulation is associated with poor outcome in multiple human cancers, including breast cancer, by enhancing LRP6-mediated Wnt signaling. TMEM97 interacts with LRP6 to promote CK1 delta/epsilon-dependent phosphorylation of LRP6, leading to stabilization of beta-catenin. In breast cancer cells, TMEM97 deficiency attenuated Wnt/beta-catenin signaling and suppressed tumorigenic properties, suggesting that targeting TMEM97 could be a promising therapeutic strategy for breast cancer.
CELL DEATH & DISEASE
(2021)
Article
Gastroenterology & Hepatology
Caroline Gest, Sandra Sena, Lydia Dif, Veronique Neaud, Robin Loesch, Nathalie Dugot-Senant, Lisa Paysan, Leo Piquet, Terezinha Robbe, Nathalie Allain, Doulaye Dembele, Catherine Guettier, Paulette Bioulac-Sage, Anne Rullier, Brigitte Le Bail, Christophe F. Grosset, Frederic Saltel, Valerie Lagree, Sabine Colnot, Violaine Moreau
Summary: Frequent oncogenic mutations of β-catenin in pediatric liver primary tumors affect hepatocyte differentiation and expression of fascin-1, suggesting fascin-1 as a potential therapeutic target for hepatoblastoma.
Article
Oncology
Shaojian Lin, Weiwei Zhang, Ziwen Shi, Langping Tan, Yue Zhu, Honghao Li, Xinzhi Peng
Summary: The study revealed the transcriptional regulation of LINC01278 by beta-catenin/LEF-1 transcription factor and its negative feedback regulation on beta-catenin signal in papillary thyroid carcinoma (PTC) cells. This negative regulation inhibits downstream target gene expression activated by the Wnt/beta-catenin pathway.
CANCER CELL INTERNATIONAL
(2021)
Article
Oncology
Yanqiu Bao, Jingshu Cui, Yuyang Yue, Shuxia Cao, Xiangdan Li, Lan Liu
Summary: Ebp1 is highly expressed in malignant melanoma and is associated with clinical stage and lymph node metastases. Knockdown of Ebp1 inhibits cell proliferation, migration, and invasion in melanoma. Ebp1 may promote the proliferation and metastasis of melanoma cells through activation of the Wnt/β-catenin pathway.
CANCER CELL INTERNATIONAL
(2022)
Review
Cell Biology
Qian Ren, Jiongcheng Chen, Youhua Liu
Summary: LRP5 and LRP6 are crucial in mediating Wnt signaling, with similar functions but also distinct characteristics, as they interact with different protein partners, each possessing its own unique functions. Understanding the precise roles of LRP5 and LRP6 may help in identifying and refining therapeutic targets for various human diseases.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Article
Medicine, Research & Experimental
Zheng Qin, Yupei Li, Jiameng Li, Luojia Jiang, Zhuyun Zhang, Kaixi Chang, Qinbo Yang, Shanshan Chen, Ruoxi Liao, Baihai Su
Summary: This study found that exosomal STAT1 derived from HP-treated HUVECs can promote VSMC calcification. Activation of the Wnt/beta-catenin pathway may be a potential mechanism of exosome-promoted VSMC calcification.
INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE
(2022)
Article
Biochemistry & Molecular Biology
Byeong-Yun Ahn, Myong-Ho Jeong, Jung-Hoon Pyun, Hyeon-Ju Jeong, Tuan Anh Vuong, Ju-Hyeon Bae, Subin An, Su Woo Kim, Yong Kee Kim, Dongryeol Ryu, Hyun-Ji Kim, Hana Cho, Gyu-Un Bae, Jong-Sun Kang
Summary: PRMT7 plays an important role in cardiac hypertrophy and fibrosis. Overexpression of PRMT7 can alleviate cellular hypertrophic response, while depletion of PRMT7 exacerbates hypertrophic response. Transcriptome analysis reveals altered gene expression profile related to Wnt signaling pathway in PRMT7-deficient hearts.
CELLULAR AND MOLECULAR LIFE SCIENCES
(2022)
Article
Biochemistry & Molecular Biology
Irina Giralt, Gabriel Gallo-Oller, Natalia Navarro, Patricia Zarzosa, Guillem Pons, Ainara Magdaleno, Miguel F. Segura, Constantino Sabado, Raquel Hladun, Diego Arango, Jose Sanchez de Toledo, Lucas Moreno, Soledad Gallego, Josep Roma
Summary: The study demonstrates the therapeutic potential of DKK-1 pharmaceutical inhibition in rhabdomyosarcoma, resulting in beta-catenin activation and modulation of focal adhesion kinase, with positive effects on myogenic marker expression and a reduction in proliferation and invasion. In addition, the chemical inhibitor WAY-262611 was able to impair tumor cell survival in vivo, suggesting DKK-1 as a potential molecular target for novel therapeutic strategies in RMS patients, especially those with high DKK-1 expression.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Meeting Abstract
Biochemistry & Molecular Biology
Rajesh Kumar Gandhirajan, Sanjeev Kumar Sagwal, Yana Bodnar, Sander Bekeschus
FREE RADICAL BIOLOGY AND MEDICINE
(2017)
Article
Multidisciplinary Sciences
Rajesh Kumar Gandhirajan, Katrin Roedder, Yana Bodnar, Gabriella Pasqual-Melo, Steffen Emmert, Corinne E. Griguer, Klaus-Dieter Weltmann, Sander Bekeschus
SCIENTIFIC REPORTS
(2018)
Article
Cell Biology
Sanjeev Kumar Sagwal, Gabriella Pasqual-Melo, Yana Bodnar, Rajesh Kumar Gandhirajan, Sander Bekeschus
CELL DEATH & DISEASE
(2018)
Article
Chemistry, Multidisciplinary
Katrin Roedder, Juliane Moritz, Vandana Miller, Klaus-Dieter Weltmann, Hans-Robert Metelmann, Rajesh Gandhirajan, Sander Bekeschus
APPLIED SCIENCES-BASEL
(2019)
Article
Biochemistry & Molecular Biology
Gabriella Pasqual-Melo, Sanjeev Kumar Sagwal, Eric Freund, Rajesh Kumar Gandhirajan, Benjamin Frey, Thomas von Woedtke, Udo Gaipl, Sander Bekeschus
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2020)
Article
Biochemistry & Molecular Biology
Sander Bekeschus, Sebastian Eisenmann, Sanjeev Kumar Sagwal, Yana Bodnar, Juliane Moritz, Broder Poschkamp, Ingo Stoffels, Steffen Emmert, Muniswamy Madesh, Klaus-Dieter Weltmann, Thomas von Woedtke, Rajesh Kumar Gandhirajan
Article
Oncology
Gabriella Pasqual-Melo, Thiago Nascimento, Larissa Juliani Sanches, Fernanda Paschoal Blegniski, Julya Karen Bianchi, Sanjeev Kumar Sagwal, Julia Berner, Anke Schmidt, Steffen Emmert, Klaus-Dieter Weltmann, Thomas von Woedtke, Rajesh Kumar Gandhirajan, Alessandra Lourenco Cecchini, Sander Bekeschus
Article
Physics, Applied
Rajesh K. Gandhirajan, Nicole Endlich, Sander Bekeschus
Summary: Zebrafish larvae serve as a fast, reliable, and relevant model for testing the toxicity of plasma sources. Research revealed that plasma exposure reduced hedging rates and viability in fish in a dose-dependent manner, accompanied by an increase in reactive oxygen species and a decrease in glutathione in plasma-treated fish.
PLASMA PROCESSES AND POLYMERS
(2021)
Article
Oncology
Rajesh Kumar Gandhirajan, Dorothee Meyer, Sanjeev Kumar Sagwal, Klaus-Dieter Weltmann, Thomas von Woedtke, Sander Bekeschus
Summary: Recent studies have highlighted the significant role of amino acids in cancer metabolism. Cold physical plasma can target tumor cells by introducing reactive oxygen species (ROS). The study found that amino acid influx plays a crucial role in driving metabolic reprogramming in tumor cells following physical plasma exposure, influencing the extent of cell death.
BRITISH JOURNAL OF CANCER
(2021)
Review
Biochemistry & Molecular Biology
Jeyasree M. Ganesh, P. Prerana, Arun Dharmarajan, Sudha Warrier, Rajesh Kumar Gandhirajan
Summary: Oxidation-reduction reactions have played a significant role in the chemical evolution of life forms. Reactive oxygen species (ROS) play an important role in cellular signaling, but high levels of ROS can cause severe damage to tissues. Elevated and chronic levels of ROS are associated with carcinogenesis, and some therapies rely on altering ROS levels to eliminate tumor cells. The effective modulation of ROS levels has been a focal point in recent research.
FREE RADICAL RESEARCH
(2022)
Review
Biochemistry & Molecular Biology
Roopak Murali, Vaishnavi Balasubramaniam, Satish Srinivas, Sandhya Sundaram, Ganesh Venkatraman, Sudha Warrier, Arun Dharmarajan, Rajesh Kumar Gandhirajan
Summary: Ovarian cancers are a type of tumor that originates from different cells of the ovary and account for around 4% of all cancers in women worldwide. There are more than 30 identified tumor types based on cellular origins, with epithelial ovarian cancer (EOC) being the most common and deadly type. EOC can be further categorized into different subtypes. The development of ovarian cancer has long been associated with endometriosis, a chronic inflammation leading to the accumulation of mutations. Recent studies have elucidated the role of somatic mutations and their impact on altered tumor metabolism. Several oncogenes and tumor suppressor genes have been implicated in ovarian cancer progression. This review highlights the genetic alterations and their impact on metabolic networks in ovarian cancer, providing insights into potential personalized therapies.
Article
Cell Biology
B. S. Soumya, V. P. Shreenidhi, Apoorvaa Agarwal, Rajesh Kumar Gandhirajan, Arun Dharmarajan, Sudha Warrier
Summary: Amyotrophic lateral sclerosis (ALS) is a devastating neurodegenerative disease characterized by the degeneration of upper and lower motor neurons, resulting in muscle wasting, paralysis, and death. The Wnt signaling pathway has been implicated in the progression of ALS and is involved in oxidative stress, mitochondrial dysfunction, autophagy, and apoptosis. Mutations in ALS-associated genes disrupt neuronal integrity and homeostasis, leading to motor neuron demise. Dysregulated canonical and non-canonical Wnt pathways play a role in multiple motor neuron disease models, highlighting the potential of targeting Wnt signaling in ALS treatment.
CELLULAR SIGNALLING
(2023)
Article
Radiology, Nuclear Medicine & Medical Imaging
Sander Bekeschus, Ramona Clemen, Lyubomir Haralambiev, Felix Niessner, Piotr Grabarczyk, Klaus-Dieter Weltmann, Jonas Menz, Matthias Stope, Thomas von Woedtke, Rajesh Gandhirajan, Anke Schmidt
Summary: The study reveals that leukemia cell death induced by cold physical plasma is influenced by the ROS chemistry, the HO-1/CXCL8 axis, and IL8-mediated signal transduction.
IEEE TRANSACTIONS ON RADIATION AND PLASMA MEDICAL SCIENCES
(2021)
Article
Medicine, Research & Experimental
Gabriella Pasqual-Melo, Rajesh Kumar Gandhirajan, Ingo Stoffels, Sander Bekeschus
CLINICAL PLASMA MEDICINE
(2018)
Article
Biochemistry & Molecular Biology
Sander Bekeschus, Eric Freund, Kristian Wende, Rajesh Kumar Gandhirajan, Anke Schmidt