Article
Pathology
Daniel J. Shepherd, Elisabeth S. Tabb, Keiko Kunitoki, M. Lisa Zhang, Marina Kem, Jaimie Barth, David A. Qualls, Meghan J. Mooradian, Justin F. Gainor, Mari Mino-Kenudson, Yin P. Hung
Summary: LAG-3 expression in non-small-cell lung carcinoma is associated with CD8(+) T-cell count and PD-L1 expression, with high LAG-3 expression linked to smoking history, high T stage, aggressive pathologic features, and lack of EGFR mutation in adenocarcinomas. High LAG-3 and LAG-3/CD8 index are associated with worse overall survival in the entire resected tumor cohort and in adenocarcinomas. High CD8 is linked to better overall survival in squamous-cell carcinomas. The predictive impact of LAG-3 in non-small-cell lung carcinoma varies by histotype.
Article
Oncology
Zhongyue Liu, Wenchao Zhang, Chao Tu, Wenyi Li, Lin Qi, Zhiming Zhang, Lu Wan, Zhimin Yang, Xiaolei Ren, Zhihong Li
Summary: This meta-analysis demonstrates that high circZFR expression is associated with unfavorable overall survival and clinicopathologic parameters including tumor size, clinical stage, lymph node metastasis, and histology grade, suggesting it as a promising prognostic factor in cancers.
WORLD JOURNAL OF SURGICAL ONCOLOGY
(2022)
Article
Oncology
Stamatios Karakatsanis, Fotios Panitsas, Maria Arapaki, Dimitrios Galopoulos, John Asimakopoulos, Athanassios Liaskas, Chrysovalantou Chatzidimitriou, Marina Belia, Elianna Konstantinou, Ioannis Vassilopoulos, Stamatis S. Papadatos, Sotirios Sachanas, Maria Efstathopoulou, Xanthoula Yiakoumis, Vassilios Pardalis, Theodoros Iliakis, Nefeli Giannakopoulou, Maria Dimou, Sevastianos Chatzidavid, George Boutsikas, Kyriaki Petevi, Alexandros Kanellopoulos, Gabriella Gainaru, Eleni Variamis, Marina P. Siakantaris, Marie-Christine Kyrtsonis, Eleni Plata, Panayiotis Tsaftaridis, Maria N. Dimopoulou, Nora-Athina Viniou, Konstantinos N. Syrigos, Gerassimos A. Pangalis, Panayiotis Panayiotidis, Kostas Konstantopoulos, Maria K. Angelopoulou, Theodoros P. Vassilakopoulos
Summary: In patients with cHL, higher SF levels are associated with markers of advanced/aggressive disease, and are significantly elevated in male, older patients, those with high BMI and mixed cellularity histology. The strongest correlation was found between SF and CRP levels, with elevated SF levels, advanced stage, and high LDH being independent prognostic factors.
LEUKEMIA & LYMPHOMA
(2022)
Article
Multidisciplinary Sciences
Pierre Pinochet, Edgar Texte, Aspasia Stamatoullas-Bastard, Pierre Vera, Sorina-Dana Mihailescu, Stephanie Becker
Summary: The study demonstrates the prognostic value of initial total metabolic tumor volume (TMTV) in predicting outcomes for patients with advanced-stage Hodgkin's lymphoma (HL). TMTV is useful for predicting 5-year progression-free survival and PET response after chemotherapy, and remains a baseline prognostic factor even when considering other treatment variables.
SCIENTIFIC REPORTS
(2021)
Article
Biochemistry & Molecular Biology
Jianrong Guo, Shoucheng Feng, Hong Liu, Zhuopeng Chen, Chao Ding, Yukai Jin, Xiaojiang Chen, Yudong Ling, Yi Zeng, Hao Long, Haibo Qiu
Summary: This study reveals the association of TRIM6 expression with prognosis in gliomas. TRIM6 promotes the viability, clonogenic potential, migration, and invasion of glioma cells. It is also linked to cytokine-cytokine receptor interaction and the abundance of immune cells.
Article
Oncology
Yeon Bi Han, Jeong Mi Yang, Hyun Jung Kwon, Jeong-Ok Lee, Jong Seok Lee, Jin Ho Paik
Summary: BTK expression in DLBCL can help stratify risk and predict disease progression, especially in patients with non-GCB subtype treated with R-CHOP. Co-expression of BTK and BCL2/MYC may independently predict shorter progression-free survival in DLBCL patients.
ANTICANCER RESEARCH
(2021)
Article
Multidisciplinary Sciences
Orlandric Miree, Sanjeev Kumar Srivastava, Mohammad Aslam Khan, Fnu Sameeta, Srijan Acharya, Harrison Ndetan, Karan Pal Singh, Kate Louise Hertweck, Santanu Dasgupta, Luciana Madeira da Silva, Rodney Paul Rocconi, James Elliot Carter, Seema Singh, Ajay Pratap Singh
Summary: The study found that aberrant MYB expression in ovarian cancer is positively correlated with tumor grades and stages, and has race-specific prognostic value for African American patients, but not for Caucasian American patients. High levels of MYB transcripts in epithelial ovarian cancer subtypes are associated with poor survival in African American patients, highlighting MYB as a potentially useful clinical biomarker for prognosis in this population.
SCIENTIFIC REPORTS
(2021)
Article
Oncology
Chong Wei, Wei Li, Liping Qin, Shan Liu, Chang Xue, Kexing Ren, Zirong Zhang, Caili Liu, Fang Bao, Huilai Zhang, Hui Zhou, Zhiming Li, Huijing Wu, Liqun Zou, Lihong Liu, Hongmei Jing, Wei Zhang
Summary: This study aimed to characterize the clinicopathologic features, prognosis, and prognostic factors of AITL in China. The majority of Chinese AITL patients were treated with anthracycline-based regimens, but the outcomes were still unsatisfactory. A novel prognostic model (the Chinese AITL score) was developed to better identify patients at different risks for alternative therapies.
Article
Hematology
Pablo Mozas, Andrea Rivero, Alfredo Rivas-Delgado, Aleix Fabregat, Juan A. Pineyroa, Juan G. Correa, Ferran Nadeu, Aina Oliver, Alex Bataller, Eva Gine, Julio Delgado, Neus Villamor, Maria T. Cibeira, Carlos Fernandez de Larrea, Laura Rosinol, Elias Campo, Juan I. Arostegui, Joan Blade, Laura Magnano, Armando Lopez-Guillermo
Summary: The presence of a serum monoclonal component, particularly in follicular lymphoma, is associated with poorer outcomes such as a higher risk of early relapse, shorter progression-free survival, and shorter overall survival. This finding is especially significant in patients over 60 years old, where a positive serum immunofixation electrophoresis is an independent predictor of overall survival. Further investigation into the relationship between serum monoclonal components and B-cell biology and the tumor microenvironment is encouraged.
BRITISH JOURNAL OF HAEMATOLOGY
(2021)
Article
Oncology
Danian Nie, Xiaohui Xiao, Jiaoting Chen, Shuangfeng Xie, Jie Xiao, Wenjuan Yang, Hongyun Liu, Jieyu Wang, Liping Ma, Yumo Du, Kezhi Huang, Yiqing Li
Summary: This study found that high expression of XPO1 is associated with poor prognosis in T-cell lymphoma and demonstrated the anti-tumor activity of the selective nuclear export inhibitor KPT-8602 in TCL cells.
EXPERIMENTAL CELL RESEARCH
(2022)
Article
Multidisciplinary Sciences
May Sadik, Jesus Lopez-Urdaneta, Johannes Ulen, Olof Enqvist, Armin Krupic, Rajender Kumar, Per-Ola Andersson, Elin Tragardh
Summary: An AI-based method was developed for the detection of focal skeleton/bone marrow uptake in Hodgkin's lymphoma patients undergoing staging with FDG-PET/CT. The study found high agreement between the AI and independent physicians in interpreting the results, indicating the potential for more accurate diagnoses for patients.
SCIENTIFIC REPORTS
(2021)
Article
Pathology
Tomoko Tamaki, Kennosuke Karube, Shugo Sakihama, Yuma Tsuruta, Ryoko Awazawa, Masaki Hayashi, Norihiro Nakada, Hirofumi Matsumoto, Nobutake Yagi, Kazuiku Ohshiro, Iwao Nakazato, Sakiko Kitamura, Yukiko Nishi, Takuya Miyagi, Sayaka Yamaguchi, Sawako Nakachi, Satoko Morishimaj, Hiroaki Masuzakij, Kenzo Takahashik, Takuya Fukushimac, Naoki Wadaa
Summary: Adult T-cell leukemia/lymphoma (ATLL) is a mature T-cell tumor caused by HTLV-1. The typical ATLL immunophenotypes include positive expression of CD2, CD3, CD5, CD4, and CD25, and negative or partially positive expression of other markers. This study performed immunohistochemical stains and identified some new findings regarding the immunophenotypic profile of ATLL.
Article
Medicine, Research & Experimental
Mahmut Bakir Koyuncu, Erkan Guler, Tolga Koseci, Mehmet Ali Ucar, Anil Tombak, Aydan Akdeniz, Eyup Naci Tiftik, Cagatay Cavusoglu
Summary: This study evaluated the impact of low muscle mass on Hodgkin's lymphoma patients and found that patients with low muscle mass had significantly lower survival rates. The integration of low muscle mass into the IPS scoring system improved the system's ability to predict patient outcomes.
BIOMARKERS IN MEDICINE
(2022)
Article
Medicine, General & Internal
Yang Dong, Lai-Jun Deng, Mi-Mi Li
Summary: The development of PTCL after HL chemotherapy is rare, and in this case, a patient initially diagnosed with CHL later developed T-cell leukemia/lymphoma, with unsuccessful treatment leading to a refractory state and death.
WORLD JOURNAL OF CLINICAL CASES
(2021)
Article
Multidisciplinary Sciences
Caixia Jing, Yuhuan Zheng, Yu Feng, Xia Cao, Caigang Xu
Summary: The study revealed that TP53 mutations in MCL patients have a negative impact on their survival, and patients with triple-positive expression of p53/Sox11/Pax5 have a higher risk. This risk stratification is independent of other prognostic indicators and may help identify high-risk MCL patients.
SCIENTIFIC REPORTS
(2021)
