Article
Medicine, General & Internal
Sarah-Louise Gillespie, Norma C. McAvoy, Diana E. Yung, Alexander Robertson, John N. Plevris, Peter C. Hayes
Summary: Endoscopic thrombin injection is effective and safe for treating gastric varices and other portal-hypertension-related bleeding, including esophageal varices, ulcers secondary to endoscopic band ligation, and ectopic varices. Although there is a relatively high rate of rebleeding, overall mortality does not significantly differ between patient groups.
JOURNAL OF CLINICAL MEDICINE
(2021)
Article
Gastroenterology & Hepatology
Sanchit Sharma, Samagra Agarwal, Deepak Madhu, Randeep Rana, Anany Gupta, Srikanth Gopi, Deepak Gunjan, Anoop Saraya
Summary: This study compared the long-term outcomes of patients with cirrhosis with gastric variceal bleeding and esophageal variceal bleeding. It found that rebleeding was more predominant in patients with gastric variceal bleeding, while ascites was the most significant event in patients with esophageal variceal bleeding.
HEPATOLOGY INTERNATIONAL
(2023)
Article
Medicine, General & Internal
Anna Mackiewicz-Pracka, Piotr Nehring, Adam Przybylkowski
Summary: This study indicates that emergency therapeutic gastroscopy for acute upper gastrointestinal bleeding is equally effective during both day and night hours, particularly when performed after the sixth hour from symptom onset.
Article
Engineering, Multidisciplinary
Yanfei Chen, Jing Guo, Chunlei Chen, Ding Shi, Daiqiong Fang, Feng Ji, Lanjuan Li
Summary: Several studies have shown differences in oral and intestinal microbiota in patients with cirrhosis. This study analyzed the gastric mucosal microbiota of cirrhotic patients and controls, finding significantly lower H. pylori infection rates in cirrhotic patients. The non-H. pylori gastric microbiota showed heterogeneity and associations with clinical characteristics, with differences observed in composition and function among different clusters.
Article
Medicine, General & Internal
Zubia Jamil, Shahida Perveen, Samreen Khalid, Mohammed Aljuaid, Memoona Shahzad, Bashir Ahmad, Yasir Waheed
Summary: This study evaluates the validity of the CTP, MELD, and GB scoring systems in predicting the in-hospital outcome of bleeding portal hypertensive patients. The results indicate that CTP was the most efficient score as the predictor of outcome, followed by MELD and then the GB score. Platelets, albumin, CTP, and MELD scores were the independent contributors to mortality.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Gastroenterology & Hepatology
Fernanda Paixao Silveira Bello, Silvia Cardoso, Ana Cristina Tannuri, Marcela Preto-Zamperlini, Claudio Schvartsman, Sylvia Costa Lima Farhat
Summary: This study compared initial clinical and laboratory parameters, as well as outcomes of mortality and rebleeding, in pediatric patients with acute upper gastrointestinal bleeding who underwent early UGIE (<12 hours) versus late UGIE (12-24 hours). The results showed no significant differences in outcomes between the early and late UGIE groups, suggesting that UGIE can be safely performed after 12-24 hours without harming the patient and optimizing clinical stabilization and treatment.
DIGESTIVE AND LIVER DISEASE
(2022)
Article
Pharmacology & Pharmacy
Xiaoquan Huang, Ming Zhang, Yingjie Ai, Siyu Jiang, Mei Xiao, Lifen Wang, Yourong Jian, Yuzheng Zhuge, Chunqing Zhang, Shiyao Chen
Summary: In this multicenter retrospective study, the efficacy of endoscopic management of gastroesophageal variceal bleeding in MPN patients was investigated. The results showed that endoscopic treatment significantly reduced the rebleeding rate in these patients.
THERAPEUTIC ADVANCES IN CHRONIC DISEASE
(2022)
Article
Gastroenterology & Hepatology
Xu Zhang, Yan-Ying Gao, De-Zhao Song, Bao-Xin Qian
Summary: Based on a case report, this study highlights the occurrence of liver fibrosis and non-cirrhotic portal hypertension (NCPH) after oxaliplatin-based chemotherapy. The patient developed gastric variceal bleeding with splenomegaly and thrombocytopenia, but splenic size and platelet level did not accurately predict variceal formation. Liver biopsy confirmed the presence of fibrosis in the portal area, suggesting NCPH. The patient responded well to endoscopic treatment.
WORLD JOURNAL OF GASTROENTEROLOGY
(2022)
Article
Medicine, General & Internal
Satish Mahajan, Srinivas Naik, Anamika Giri, Gaurav S. Jagtap, Sourya Acharya
Summary: Gastric diverticula are rare and potentially life-threatening anomalies in the gastrointestinal system. Most cases are asymptomatic, but some patients may experience symptoms such as upper abdominal pain and vomiting, and in severe cases, major bleeding or perforation. This article reports a case of gastric diverticula diagnosed through endoscopy and abdominal computed tomography, successfully managed with treatment.
CUREUS JOURNAL OF MEDICAL SCIENCE
(2022)
Article
Gastroenterology & Hepatology
Yong Lv, Wei Bai, Xuan Zhu, Hui Xue, Jianbo Zhao, Yuzheng Zhuge, Junhui Sun, Chunqing Zhang, Pengxu Ding, Zaibo Jiang, Xiaoli Zhu, Weixin Ren, Yingchun Kewei LiZhang, Wenguang Zhang, Kai Li, Zhengyu Wang, Bohan Luo, Xiaomei Li, Jie Yuan, Zhiping Yang, Wengang Guo, Dongdong Xia, Huahong Xie, Changbing Yang, Yanglin Pan, Zhanxin Yin, Daiming Fan, Guohong Han
Summary: This study aimed to assess the impact of portal vein thrombosis (PVT) on the outcomes of cirrhotic patients with acute variceal bleeding (AVB). The results showed that, compared to patients without PVT, patients with PVT had a similar risk of mortality, further bleeding, and new or worsening ascites after standard treatment.
HEPATOLOGY INTERNATIONAL
(2023)
Review
Gastroenterology & Hepatology
Hiroshi Yoshida, Tetsuya Shimizu, Masato Yoshioka, Nobuhiko Taniai
Summary: Portal hypertension is most commonly caused by chronic liver disease, leading to increased portal pressure and changes in portal system hemodynamics. In chronic liver disease, increased intrahepatic vascular resistance requires sufficient portal hypertension to maintain portal flow into the liver. Splanchnic and systemic arterial vasodilatations increase blood flow into the portal venous system, resulting in portal hypertension and collateral formation.
HEPATOLOGY RESEARCH
(2021)
Article
Biology
Sergiu Marian Cazacu, Daniela Elena Burtea, Vlad Florin Iovanescu, Dan Nicolae Florescu, Sevastita Iordache, Adina Turcu-Stiolica, Victor Mihai Sacerdotianu, Bogdan Silviu Ungureanu
Summary: Upper gastrointestinal bleeding (UGIB) is an emergency condition that requires endoscopic assessment for appropriate treatment. The impact of COVID-19 on UGIB patients may be related to respiratory failure, severe bleeding, and possible delays or reductions in endoscopic procedures.
Article
Gastroenterology & Hepatology
Cosmos L. T. Guo, Sunny H. Wong, Louis H. S. Lau, Rashid N. S. Lui, Joyce W. Y. Mak, Raymond S. Y. Tang, Terry C. F. Yip, William K. K. Wu, Grace L. H. Wong, Francis K. L. Chan, James Y. W. Lau, Joseph J. Y. Sung
Summary: The study found that early endoscopy after admission for acute upper gastrointestinal bleeding was associated with better outcomes compared to urgent or late endoscopy, especially in patients with non-variceal bleeding. This suggests that patients with non-variceal AUGIB should receive endoscopy within 24 hours, while also highlighting the importance of prior resuscitation and pharmacotherapy.
Article
Gastroenterology & Hepatology
Yijie Yan, Yue Li, Chunlei Fan, Yuening Zhang, Shibin Zhang, Zhi Wang, Tehui Huang, Zhenjia Ding, Keqin Hu, Lei Li, Huiguo Ding
Summary: This study developed a novel machine learning-based radiomic model for diagnosing high bleeding risk esophageal varices in patients with cirrhosis. The model showed good performance and accuracy.
HEPATOLOGY INTERNATIONAL
(2022)
Review
Medicine, General & Internal
Socrate Pallio, Giuseppinella Melita, Endrit Shahini, Alessandro Vitello, Emanuele Sinagra, Barbara Lattanzi, Antonio Facciorusso, Daryl Ramai, Marcello Maida
Summary: Acute variceal bleeding is a serious complication of portal hypertension and a common cause of acute upper gastrointestinal bleeding. It represents a major economic and population health issue.