Article
Pediatrics
Ozlem Kalaycik Sengul, Bilge Sahin Akkelle, Pinar Ay, Burcu Volkan, Engin Tutar, Cigdem Ataizi Celikel, Deniz Ertem
Summary: This study validates the efficacy of negative tTG-IgA and/or EMA in reflecting mucosal status in the follow-up of pediatric patients with celiac disease. However, positive serology may be misleading in reflecting mucosal status.
EUROPEAN JOURNAL OF PEDIATRICS
(2022)
Article
Medicine, General & Internal
Komal Siddiqui, Arsalan Ahmed Uqaili, Muhammad Rafiq, Muhammad Aqeel Bhutto
Summary: Celiac disease is an autoimmune enteropathy triggered by gluten, with HLA-DQ2 and -DQ8 as risk alleles. HLA typing can aid in diagnosis, and the prevalence of DQ2 and DQ8 haplotypes shows DQ2 is more common. Awareness of molecular typing for Celiac disease can help laboratories and healthcare professionals in identifying and diagnosing the disease.
Article
Multidisciplinary Sciences
Marketa Chlubnova, Asbjorn O. Christophersen, Geir Kjetil F. Sandve, Knut E. A. Lundin, Jorgen Jahnsen, Shiva Dahal-Koirala, Ludvig M. Sollid
Summary: 42 wheat gluten-reactive T cell clones with different phenotypes and no reactivity to known epitopes were screened. Synthetic peptides were identified bioinformatically from a wheat gluten protein database and tested against the T cell clones. Reactivity of 10 T cell clones was assigned, and 5 previously uncharacterized gliadin/glutenin epitopes with a 9-nucleotide oligomer core region were identified. This work represents an advance in identifying CeD-driving gluten epitopes.
Article
Nutrition & Dietetics
Rakel Nurmi, Ilma Korponay-Szabo, Kaija Laurila, Heini Huhtala, Onni Niemela, Jukka Mustonen, Satu Makela, Katri Kaukinen, Katri Lindfors
Summary: IgA-tTG deposits were found in the kidney biopsies of IgAN patients with celiac disease and non-celiac IgAN patients consuming gluten, suggesting limited specificity to celiac disease.
Article
Gastroenterology & Hepatology
Anat Guz-Mark, Michal Kori, Chani Topf-Olivestone, Ronit Weinberger, Sara Morgenstern, Nadya Ziv-Sokolovskaya, Raanan Shamir
Summary: This study investigated the real-life performance of a CD serology automated analyzer and explored the correlation between TGA levels and intestinal biopsies in children. The study found that the Multiplex TGA assay had a very high diagnostic accuracy in real-life. Adding anti-endomysial antibodies did not improve the diagnostic performance of the test in patients with positive TGA.
JOURNAL OF PEDIATRIC GASTROENTEROLOGY AND NUTRITION
(2022)
Review
Gastroenterology & Hepatology
Peter H. R. Green, Shirley Paski, Cynthia W. Ko, Alberto Rubio-Tapia
Summary: This article summarizes the diagnosis and management of refractory celiac disease, providing guidance on evaluation, nutritional support, potential therapeutic options, and surveillance for complications. The article emphasizes the importance of regular follow-up and multidisciplinary care for patients with refractory celiac disease.
Article
Medicine, Research & Experimental
Lola Giner-Perez, Ester Donat, Paula Sinisterra-Sebastian, Etna Masip, Veronica Ballester, Begona Polo, Carmen Ribes-Koninckx, Maria Roca
Summary: This study aims to analyze the decreasing dynamics of IgG anti-tTG in CD patients who start a GFD. The results show that the normalization rates of IgG anti-tTG are slower for SIgAD CD patients compared to IgA competent CD patients, while IgA anti-tTG reaches lower values in a higher proportion of IgA competent patients.
CLINICAL AND EXPERIMENTAL MEDICINE
(2023)
Review
Pediatrics
Rishi Bolia, Nikhil Thapar
Summary: Celiac disease is a chronic immune-mediated enteropathy caused by the ingestion of gluten in genetically predisposed individuals. It has a wide range of clinical manifestations and can affect people of all ages. The diagnosis is based on clinical history, serologic testing and duodenal biopsies. The management involves lifelong complete dietary avoidance of gluten, and monitoring of IgA-TGA for mucosal healing.
INDIAN JOURNAL OF PEDIATRICS
(2023)
Article
Multidisciplinary Sciences
Hoda Gad, Ibrahim Mohammed, Saras Saraswathi, Bara Al-Jarrah, Maryam Ferdousi, Ioannis N. Petropoulos, Georgios Ponirakis, Adnan Khan, Parul Singh, Souhaila Al Khodor, Mamoun Elawad, Wesam Almasri, Hatim Abdelrahman, Khalid Hussain, Mohamed A. Hendaus, Fatma Al-Mudahka, Khaled Abouhazima, Anthony K. Akobeng, Rayaz A. Malik
Summary: This study aims to investigate whether quantification of corneal Langerhans cells (LCs) using corneal confocal microscopy (CCM) can serve as a surrogate marker for antigen presenting cell status and disease activity in children with CeD. The results showed no difference in LC density between the CeD group and the control group, but LC density correlated with anti-TtG levels.
SCIENTIFIC REPORTS
(2022)
Article
Endocrinology & Metabolism
Xuan Chen, Alison H. Affinati, Yungchun Lee, Adina F. Turcu, Norah Lynn Henry, Elena Schiopu, Angel Qin, Megan Othus, Dan Clauw, Nithya Ramnath, Lili Zhao
Summary: This study found that the risk of developing ICI-T1DM is associated with the type of ICI therapy, patient age, and preexisting non-T1DM diabetes. The development of ICI-T1DM does not seem to significantly impact patient survival.
Article
Immunology
Tong Yue, Huiling Tan, Chaofan Wang, Ziyu Liu, Daizhi Yang, Yu Ding, Wen Xu, Jinhua Yan, Xueying Zheng, Jianping Weng, Sihui Luo
Summary: This study aimed to investigate the characteristics of gut microbiota, serum metabolites, and lipids in type 1 diabetes (T1D) patients with different human leukocyte antigen (HLA) genotypes.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Pediatrics
Juan-juan Zhang, Jun-qi Wang, Xu Xu, Li-dan Zhang, Cai-ping Zhang, Wen-li Lu, Wei-qiong Gu, Zhi-ya Dong, Yuan Xiao, Zhen-wei Xia
Summary: This study found a high frequency of celiac disease autoantibodies (CDAbs) in Chinese children with type 1 diabetes (T1D). The expression profile of circRNAs in T1D children with CDAbs was different from that of general T1D patients. Hsa_circ_0004564 and its parental gene RAPH1 may be new targets for studying immune mechanisms in children with T1D and celiac disease (CD).
FRONTIERS IN PEDIATRICS
(2022)
Review
Gastroenterology & Hepatology
Melis G. Celdir, Claire L. Jansson-Knodell, Isabel A. Hujoel, Larry J. Prokop, Zhen Wang, M. Hassan Murad, Joseph A. Murray
Summary: This meta-analysis reveals that higher latitudes are associated with a greater prevalence of serology-based celiac disease.
CLINICAL GASTROENTEROLOGY AND HEPATOLOGY
(2022)
Review
Medicine, General & Internal
Gabriela V. Flores Monar, Hamza Islam, Sri Madhurima Puttagunta, Rabia Islam, Sumana Kundu, Surajkumar B. Jha, Ana P. Rivera, Ibrahim Sange
Summary: Type 1 diabetes mellitus and celiac disease are two common related autoimmune disorders that share a common genetic background, and celiac disease has been found to be an independent risk factor for diabetes. Celiac disease is often asymptomatic but can lead to growth retardation and anemia. Gluten may be the primary trigger for these autoimmune responses.
CUREUS JOURNAL OF MEDICAL SCIENCE
(2022)
Article
Immunology
Rita D. Jores, Davide Baldera, Enrico Schirru, Sandro Muntoni, Rossano Rossino, Maria F. Manchinu, Maria F. Marongiu, Cristian A. Caria, Carlo Ripoli, Maria R. Ricciardi, Francesco Cucca, Mauro Congia
Summary: This study investigated the T cell proliferation responses of peripheral blood mononuclear cells (PBMCs) from early-onset type 1 diabetes (T1D) pediatric patients and HLA-matched controls in response to preproinsulin (PPI) and glutamate decarboxylase 65 (GAD65)-derived peptides. Significant T cell responses against specific peptide epitopes were found in HLA-DR4, -DQ8 and -DR3, -DQ2 T1D children.
FRONTIERS IN IMMUNOLOGY
(2023)