Article
Gastroenterology & Hepatology
Keizo Zeze, Atsushi Hirano, Takehiro Torisu, Motohiro Esaki, Tomohiko Moriyama, Junji Umeno, Keisuke Kawasaki, Shin Fujioka, Yuta Fuyuno, Yuichi Matsuno, Takanari Kitazono
Summary: Delayed addition of thiopurine after loss of response to IFX may be an alternative strategy in treating CD, as it does not significantly affect the continuation rate of IFX but reduces the incidence of adverse events.
DIGESTIVE DISEASES AND SCIENCES
(2021)
Article
Immunology
Chenglin Ye, Sizhe Zhu, Jingping Yuan
Summary: This study analyzed the gene expression profiles of patients with Crohn's disease (CD) and identified two gene subtypes: immune and metabolic. The immune subtype was associated with leukocyte migration and cytokine interactions, while the metabolic subtype was associated with metabolic pathways. The combination of interleukin 1 beta, interleukin 6, and Toll-like receptor 4 effectively distinguished between these two gene subtypes.
FRONTIERS IN IMMUNOLOGY
(2022)
Review
Gastroenterology & Hepatology
Bing Han, Daiyuan Tang, Xiaodan Lv, Shiquan Li, Junhua Fan, Xiaofang Xu, Jiatong Zhang, Shang Xu, Weizheng Ye, Ziqian Huang, Lingling Zhan, Xiaoping Lv
Summary: Using a network meta-analysis and systematic review, this study evaluated the efficacy and safety of combination therapy and infliximab monotherapy in Crohn's disease patients. The results showed that there was no statistical difference between different combination therapies in inducing and maintaining remission. For inducing remission, infliximab + enteral nutrition ranked highest; for maintaining remission, infliximab + azathioprine ranked highest. There was no treatment that was significantly safer than the others.
INTERNATIONAL JOURNAL OF COLORECTAL DISEASE
(2023)
Review
Gastroenterology & Hepatology
Siddharth Singh, Deborah Proctor, Frank Scott, Yngve Falck-Ytter, Joseph D. Feuerstein
Summary: The global incidence and prevalence of Crohn's disease (CD) is increasing, with patients at high risk for complications, surgery, and hospitalization. Optimal management of moderate to severe CD often requires immunomodulators and/or biologic therapies, but guidelines on comparative efficacy are limited, leading to variability in practice.
Article
Computer Science, Artificial Intelligence
Xuehua Li, Yingkui Zhong, Chenglang Yuan, Jinjiang Lin, Xiaodi Shen, Minyi Guo, Baolan Lu, Jixin Meng, Yangdi Wang, Naiwen Zhang, Zixin Luo, Guimeng Hu, Ren Mao, Minhu Chen, Canhui Sun, Ziping Li, Qing-hua Cao, Baili Chen, Zhihui Chen, Bingsheng Huang, Shi-Ting Feng
Summary: This study developed and validated a radiomic signature based on computed tomography enterography for identification of Crohn's disease patients at high risk of primary nonresponse to infliximab therapy, and demonstrated its incremental value to the clinical model.
INTERNATIONAL JOURNAL OF INTELLIGENT SYSTEMS
(2022)
Article
Radiology, Nuclear Medicine & Medical Imaging
Chen Yueying, Feng Jing, Feng Qi, Shen Jun
Summary: A magnetic resonance enterography-based model was constructed in this study to predict the risk of loss of response to infliximab (IFX) in bio-naive patients with Crohn's disease (CD), providing an effective tool for the early estimation of treatment response before biological intervention.
EUROPEAN RADIOLOGY
(2023)
Article
Gastroenterology & Hepatology
Siddharth Singh, Jihoon Kim, Jiyu Luo, Paulina Paul, Vivek Rudrapatna, Sunhee Park, Kai Zheng, Gaurav Syal, Christina Ha, Phillip Fleshner, Dermot McGovern, Jenny S. Sauk, Berkeley Limketkai, Parambir S. Dulai, Brigid S. Boland, Samuel Eisenstein, Sonia Ramamoorthy, Gil Melmed, Uma Mahadevan, William J. Sandborn, Lucila Ohno-Machado
Summary: This study compared the safety and effectiveness of three drugs, tumor necrosis factor a (TNF-a) antagonists, vedolizumab, and ustekinumab, in the treatment of patients with Crohn's disease. The results showed that ustekinumab was associated with a lower risk of serious infections compared to TNF-a antagonists and vedolizumab, with no differences in hospitalization or surgery risk. Compared to vedolizumab, ustekinumab-treated patients also had a lower risk of serious infections, but no significant differences in hospitalization or surgery risk.
CLINICAL GASTROENTEROLOGY AND HEPATOLOGY
(2023)
Article
Gastroenterology & Hepatology
Eun Sil Kim, Sujin Choi, So Yoon Choi, Ji Hyung Park, Byung-Ho Choe, Soo-Youn Lee, Mi Jin Kim, Yon Ho Choe, Ben Kang
Summary: NUDT15 intermediate metabolisers are associated with lower loss of response in pediatric patients with CD treated with IFX and AZA combination therapy.
ALIMENTARY PHARMACOLOGY & THERAPEUTICS
(2022)
Article
Multidisciplinary Sciences
Susree Roy, Suchandrima Ghosh, Mallica Banerjee, Sayantan Laha, Dipanjan Bhattacharjee, Rajib Sarkar, Sujay Ray, Arko Banerjee, Ranajoy Ghosh, Aniket Halder, Alakendu Ghosh, Raghunath Chatterjee, Simanti Datta, Gopal Krishna Dhali, Soma Banerjee
Summary: This study identified potential biomarkers for differentiating between intestinal tuberculosis (ITB) and Crohn's disease (CD) through analyzing miRNA and chemokines in patients. The combination of miR-375-3p + Eotaxin-1/CCL11 + SDF-1 alpha/CXCL12 + G-CSF showed better performance in distinguishing ITB from CD compared to single markers, with high specificity and positive predictive value.
SCIENTIFIC REPORTS
(2021)
Article
Pharmacology & Pharmacy
Ye Xiong, Tomoyuki Mizuno, Ruben Colman, Jeffrey Hyams, Joshua D. Noe, Brendan Boyle, Yi-Ting Tsai, Min Dong, Kimberly Jackson, Nieko Punt, Michael J. Rosen, Lee A. Denson, Alexander A. Vinks, Phillip Minar
Summary: The study identified blood biomarkers for rapid clearance and exposure targets of infliximab in pediatric Crohn's disease. Higher AUC during induction was associated with better treatment outcomes and lower surgery rates for patients.
CLINICAL PHARMACOLOGY & THERAPEUTICS
(2021)
Article
Gastroenterology & Hepatology
Neeraj Narula, Emily C. L. Wong, Parambir S. Dulai, Neil K. Sengupta, John K. Marshall, Jean-Frederic Colombel, Walter Reinisch
Summary: This post hoc analysis suggests that infliximab and ustekinumab have similar efficacy and speed of onset in biologic-naive patients with CD.
CLINICAL GASTROENTEROLOGY AND HEPATOLOGY
(2022)
Article
Gastroenterology & Hepatology
Yizhong Wang, Xuefeng Gao, Xinyue Zhang, Fangfei Xiao, Hui Hu, Xiaolu Li, Fang Dong, Mingming Sun, Yongmei Xiao, Ting Ge, Dan Li, Guangjun Yu, Zhanju Liu, Ting Zhang
Summary: The study revealed that pediatric CD patients have gut microbial dysbiosis and altered metabolism after IFX therapy, which is related to treatment outcomes. The effects of IFX treatment may be mediated by enriching bacteria taxa that produce SCFAs and BSH, thereby inhibiting inflammation and restoring bile acid metabolism. Some fecal bacteria and metabolites may serve as predictors of IFX therapy outcomes for pediatric CD patients.
Article
Biochemistry & Molecular Biology
Yiyoung Kwon, Eun-Sil Kim, Yoon-Zi Kim, Yon-Ho Choe, Mi-Jin Kim
Summary: This study aims to measure the concentration of cytokines produced during the inflammation process to investigate if there are any differences in response to treatment of pediatric Crohn's disease and to determine if the initial tumor necrosis factor-alpha (TNF-alpha) level affected the trough concentration of infliximab (IFX).
Article
Gastroenterology & Hepatology
Peter Bossuyt, Erwin Dreesen, Jordi Rimola, Sofie Devuysere, Yves De Bruecker, Ragna Vanslembrouck, Valerie Laurent, Magaly Zappa, Celine Savoye-Collet, Benjamin Pariente, Jerome Filippi, Filip Baert, Geert D'Haens, David Laharie, Laurent Peyrin-Biroulet, Severine Vermeire
Summary: This study investigated the relationship between infliximab exposure and radiologic outcomes in patients with active luminal CD. The results showed a correlation between infliximab trough levels and radiologic response and remission, highlighting the significance of drug concentration during treatment.
CLINICAL GASTROENTEROLOGY AND HEPATOLOGY
(2021)
Article
Pharmacology & Pharmacy
Shuyan Li, Yan Ma, Hongling Sun, Zijun Ni, Shurong Hu, Yan Chen, Meijuan Lan
Summary: This study investigated the adherence to Infliximab (IFX) among Chinese Crohn's disease patients and evaluated the association between medication belief and adherence. The results showed that medication concerns may be a predictive factor of adherence, and by enhancing knowledge and relieving concerns, patients' adherence to IFX can be increased.
FRONTIERS IN PHARMACOLOGY
(2023)