Article
Nutrition & Dietetics
Xinting Jiang, Liang Cui, Lin Huang, Yihan Guo, Gaozhong Huang, Qihao Guo
Summary: This study examines the relationship between beverage consumption and cognitive impairment. It shows that the consumption of green tea, coffee, and pure milk can protect cognitive function, while low water intake increases the risk of cognitive impairment. These associations are influenced by baseline cognitive status, gender, and A beta deposition.
Article
Endocrinology & Metabolism
Liang Pan, Qianqian Xu, Jianmin Liu, Yang Gao, Jun Li, Hongye Peng, Linli Chen, Miyuan Wang, Gang Mai, Shuo Yang
Summary: The study revealed a close association between CVAI and the risk of T2DM, suggesting that CVAI may be a potential marker in predicting T2DM development. It is recommended to maintain CVAI within an appropriate range.
FRONTIERS IN ENDOCRINOLOGY
(2022)
Article
Environmental Sciences
Jinqiu Yao, Fei Wang, Ying Zhang, Zefang Zhang, Jiao Bi, Jia He, Peiwen Li, Xu Han, Yue Wei, Xiaomin Zhang, Huan Guo, Meian He
Summary: The study found that serum BPA concentration was associated with changes in blood lipid levels and dyslipidemia risk in middle-elderly Chinese adults. Serum BPA levels were positively related to total cholesterol, LDL-c, and Non-HDL-c levels. Increased Ln-BPA was associated with increased Delta TC, Delta Non-HDL-c, Delta TC/HDL-c, and Delta Non-HDL-c/HDL-c. The associations were observed in females but not in males.
ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY
(2022)
Article
Cardiac & Cardiovascular Systems
Mengyuan Qu, Chenzhao Feng, Xiaotong Wang, Yiqun Gu, Xuejun Shang, Yuanzhong Zhou, Chengliang Xiong, Honggang Li
Summary: The study found that the decline in sex hormone levels due to aging may be an important factor in male aging and cardiovascular diseases. Testosterone levels were inversely associated with hypertension prevalence, but factors like age, weight, smoking, and family history can impact this association.
JOURNAL OF THE AMERICAN HEART ASSOCIATION
(2021)
Article
Urology & Nephrology
Jun Ho Lee, Sung Won Lee
Summary: The study found that serum testosterone levels in middle-aged men vary monthly, with a nadir in May (4.4 ng/ml) and a peak in January (6.0 ng/ml). After adjusting for confounders, this monthly variation still exists, with testosterone levels showing a negative relationship with daylight duration and outdoor temperature.
JOURNAL OF UROLOGY
(2021)
Article
Biochemistry & Molecular Biology
Sol Mochon-Benguigui, Almudena Carneiro-Barrera, Manuel Dote-Montero, Manuel J. Castillo, Francisco J. Amaro-Gahete
Summary: Sleep quality is not related to levels of plasma anabolic hormones, but to levels of catabolic hormones, in sedentary middle-aged adults. Changes in aging markers associated with sleep disturbances may be mediated by age-related changes in the catabolic endocrine system.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Endocrinology & Metabolism
Gang Wei, Feng Lin, Changchun Cao, Haofei Hu, Yong Han
Summary: This study investigated the relationship between BMI and stroke risk in a middle-aged and elderly Chinese population. The findings revealed a specific non-linear association and saturation effect of BMI with stroke in men, with an inflection point of 25.94 kg/m(2). The risk of stroke in men was significantly and positively associated with BMI when it was below 25.94 kg/m(2).
FRONTIERS IN ENDOCRINOLOGY
(2023)
Article
Peripheral Vascular Disease
Lauren C. Chasland, Louise H. Naylor, Bu B. Yeap, Andrew J. Maiorana, Daniel J. Green
Summary: Exercise training improves endothelium-dependent vasodilator function in middle-to-older-aged men with central adiposity and low/normal testosterone levels, while administration of testosterone at therapeutic doses does not directly impact vascular function and does not add to the benefits of exercise.
Article
Biochemistry & Molecular Biology
Mengli Li, Hang Yun, Jie Huang, Jian Wang, Wansheng Wu, Remmei Guo, Li Wang
Summary: The study found that the median hair Se content of middle-aged and elderly Chinese was 0.36 μg/g, ranging from 0.08 to 20.04 μg/g. Participants from Guangdong and Hunan provinces had the highest Se levels, while those from Henan and Shaanxi provinces had the lowest levels. Males had higher Se content than females, with no significant differences between different ages and BMIs.
BIOLOGICAL TRACE ELEMENT RESEARCH
(2021)
Review
Food Science & Technology
Shirin Amini, Sima Jafarirad, Behnaz Abiri
Summary: This systematic review provides preliminary evidence for the relationship between vitamin D deficiency and depression in middle-aged and elderly men, and suggests a positive association between vitamin D and testosterone, indicating that vitamin D may play a protective role in depression through its effect on testosterone.
CRITICAL REVIEWS IN FOOD SCIENCE AND NUTRITION
(2023)
Article
Nutrition & Dietetics
Vladimir Vidic, Vladimir Ilic, Lazar Toskic, Nenad Jankovic, Dusan Ugarkovic
Summary: This study compared the effects of a ketogenic diet and a non-ketogenic diet on middle-aged men, finding that both diets were effective in maintaining muscle strength, improving body composition, and hormonal levels under hypocaloric conditions. Additionally, there were no significant differences in lipid profile and blood sugar levels between the two groups.
CLINICAL NUTRITION
(2021)
Article
Endocrinology & Metabolism
Adrian Heald, Michael J. Cook, Leen Antonio, Jos Tournoy, Parisa Ghaffari, Fahmida Mannan, Helene Fachim, Dirk Vanderschueren, Ian Laing, Geoff Hackett, Felipe F. Casanueva, Ilpo T. Huhtaniemi, Mario Maggi, Giulia Rastrelli, Jolanta Slowikowska-Hilczer, Fred Wu, Terence W. O'Neill
Summary: This study found no association between androgen receptor CAG repeat number and mortality in European men. However, a post-hoc analysis showed a potential association in men with lower baseline testosterone concentrations, which requires further investigation.
CLINICAL ENDOCRINOLOGY
(2023)
Article
Medicine, General & Internal
Bu B. Yeap, Ross J. Marriott, Leen Antonio, Suchitra Raj, Girish Dwivedi, Christopher M. Reid, Bradley D. Anawalt, Shalender Bhasin, Adrian S. Dobs, David J. Handelsman, Graeme J. Hankey, Robin Haring, Alvin M. Matsumoto, Paul E. Norman, Terence W. O'Neill, Claes Ohlsson, Eric S. Orwoll, Dirk Vanderschueren, Gary A. Wittert, Frederick C. W. Wu, Kevin Murray
Summary: The study aimed to analyze the associations of serum total testosterone and SHBG with incident cardiovascular events in men. The results showed that men with lower total testosterone concentrations were not at increased risk for cardiovascular events, while calculated free testosterone may be associated with risk for adverse cardiovascular events.
ANNALS OF INTERNAL MEDICINE
(2022)
Article
Public, Environmental & Occupational Health
Liang Pan, Yu Gao, Jing Han, Ling Li, Miyuan Wang, Hongye Peng, Juan Liao, Hua Wan, Guohua Xiang, Yangyun Han
Summary: This study aimed to compare the changes in four surrogate indexes for predicting T2DM in middle-aged and elderly Chinese. The results showed that TyG-D was the best predictor and could help identify individuals at high risk.
FRONTIERS IN PUBLIC HEALTH
(2022)
Article
Immunology
Marie Lachatre, Armelle Pasquet, Faiza Ajana, Benoit Soudan, Yann Quertainmont, Georges Lion, Emmanuel Durand, Laurence Bocket, Martine Mole, Pauline Cornavin, Pilartxo Catalan, Eric Senneville, Cecile Goujard, Faroudy Boufassa, Antoine Cheret
Summary: This study examines the prevalence and predictive factors for male hypogonadism in young-to-middle-aged people with HIV on effective combined antiretroviral therapy. Age, total body fat percentage, and treatment including efavirenz are potential risk factors for male hypogonadism in this population. Early screening for this condition could improve care for patients requiring testosterone replacement.
Article
Cardiac & Cardiovascular Systems
Yang Yang, Nianchun Peng, Gang Chen, Qin Wan, Li Yan, Guixia Wang, Yingfen Qin, Zuojie Luo, Xulei Tang, Yanan Huo, Ruying Hu, Zhen Ye, Guijun Qin, Zhengnan Gao, Qing Su, Yiming Mu, Jiajun Zhao, Lulu Chen, Tianshu Zeng, Xuefeng Yu, Qiang Li, Feixia Shen, Li Chen, Yinfei Zhang, Youmin Wang, Huacong Deng, Chao Liu, Shengli Wu, Tao Yang, Mian Li, Yu Xu, Min Xu, Zhiyun Zhao, Tiange Wang, Jieli Lu, Yufang Bi, Weiqing Wang, Guang Ning, Qiao Zhang, Lixin Shi
Summary: Smoking and diabetes interact with each other in relation to increased risk of cardiovascular disease events, and the beneficial effect of risk factor management on cardiovascular disease risk among participants with diabetes is attenuated by smoking.
CARDIOVASCULAR DIABETOLOGY
(2022)
Article
Engineering, Multidisciplinary
Yafei Wu, Guijun Qin, Guixia Wang, Libin Liu, Bing Chen, Qingbo Guan, Zhongshang Yuan, Xu Hou, Ling Gao, Chao Xu, Haiqing Zhang, Xu Zhang, Qiu Li, Yongfeng Song, Fei Jing, Shizhan Ma, Shanshan Shao, Meng Zhao, Qingling Guo, Nanwei Tong, Hongyan Zhao, Xiaomin Xie, Chao Liu, Zhongyan Shan, Zhifeng Cheng, Xuefeng Yu, Shulin Chen, Tao Yang, Yangang Wang, Dongmei Li, Zhaoli Yan, Lixin Guo, Qiuhe Ji, Wenjuan Wang, Jiajun Zhao
Summary: The aim of this study was to explore the associations of moderate-to-vigorous-intensity physical activity (MVPA) time and sedentary (SED) time with a history of cardiovascular disease (CVD) and multifactorial control status among type 2 diabetes mellitus (T2DM) patients in China. The study found that higher MVPA time was associated with lower odds of CVD risk, regardless of SED time, among patients with T2DM. Rating: 8/10.
Article
Medicine, General & Internal
Xiaoshan Feng, Ruirui Xuan, Yingchun Dong, Xiaoqin Wu, Yiping Cheng, Zinuo Yuan, Hang Dong, Junming Han, Fang Zhong, Jiajun Zhao, Xiude Fan
Summary: As the diagnostic criteria for metabolic dysfunction-associated fatty liver disease (MAFLD) do not exclude alcohol consumption, some patients initially diagnosed with alcoholic fatty liver disease (AFLD) may be diagnosed with dual-etiology fatty liver disease (AFLD&MAFLD). It is important to explore the impact of this classification change on clinical manifestations.
Article
Health Care Sciences & Services
Jing Du, Shizhan Ma, Li Fang, Meng Zhao, Zhongshang Yuan, Yiping Cheng, Jiajun Zhao, Xiude Fan, Qingling Guo, Zhongming Wu
Summary: This study found a correlation between muscle distribution and nonalcoholic fatty liver disease (NAFLD). Higher muscle mass in the lower limbs, extremities, and trunk was associated with a lower risk of NAFLD. Furthermore, a decrease in muscle mass in the lower limbs and trunk was linked to increased severity of NAFLD.
JOURNAL OF PERSONALIZED MEDICINE
(2023)
Review
Cell Biology
Yashuang Yang, Quanshu Wang, Ling Gao, Sijin Liu, Jiajun Zhao, Guoliang Liu, Shuping Zhang
Summary: Many indicators, including RDW and iron metabolism, are sensitive to various risk factors and are associated with pathological alterations and disease onset. Increased RDW indicates various conditions such as iron deficiency anemia and chronic inflammation. Understanding the factors affecting RDW, such as disordered iron metabolism and oxidative stress, can be valuable in diagnosing and monitoring pathological conditions.
CELL BIOLOGY INTERNATIONAL
(2023)
Article
Cell Biology
Xiude Fan, Junming Han, Enfa Zhao, Jiansong Fang, Dawei Wang, Yiping Cheng, Yingzhou Shi, Zhen Wang, Zhenyu Yao, Peng Lu, Tianbao Liu, Qihang Li, Kyle L. Poulsen, Zhongshang Yuan, Yongfeng Song, Jiajun Zhao
Summary: Breakthrough SARS-CoV-2 infections of vaccinated individuals are increasing the risk of hospitalization and death. It is crucial to identify modifiable risk factors and initiate early interventions.
Article
Immunology
Yunyun Xu, Xu Hou, Honglin Guo, Zhenyu Yao, Xiude Fan, Chao Xu, Guimei Li, Yanzhou Wang, Yan Sun, Ling Gao, Yongfeng Song, Jiajun Zhao
Summary: Patients with Prader-Willi syndrome (PWS) show hyper-inflammatory state in their peripheral immune cells, characterized by increased CD16(+) monocytes. These monocytes transmit chemokine and cytokine signaling to drive inflammatory process in other cell types. This study provides insights into the characteristics of peripheral immune cells in PWS at the single cell level and suggests potential targets for immunotherapy in the future.
FRONTIERS IN IMMUNOLOGY
(2023)
Review
Oncology
Chao Xu, Zhao He, Yongfeng Song, Shanshan Shao, Guang Yang, Jiajun Zhao
Summary: It has been traditionally believed that pituitary hormones act on their cognate receptors in classical target glands to carry out their various functions. However, recent studies have revealed that multiple types of pituitary hormone receptors are widely expressed in non-classical target organs. This article summarizes the additional biological functions of pituitary hormones (thyroid-stimulating hormone, follicle-stimulating hormone, luteinizing hormone, adrenocorticotrophic hormone, and prolactin) when they act on non-classical organs, defining them as part of an atypical pituitary hormone-target tissue axis. This novel concept provides insight into the mechanisms behind metabolic diseases and offers potential novel therapeutic targets.
FRONTIERS OF MEDICINE
(2023)
Article
Medicine, General & Internal
Jie Jiang, Chao Xu, Zinuo Yuan, Junming Han, Zhixiang Wang, Yang Tian, Yingchun Dong, Weibo Xia, Xiude Fan, Jiajun Zhao
Summary: This study aimed to evaluate the impact of different metabolic obesity phenotypes on the burden of postmenopausal hospitalized patients with osteoporosis. It found that metabolic abnormalities were associated with elevated rates and risks of 30- or 90-day readmission among these patients, while obesity did not seem to be innocent. The combination of these factors led to an additional burden on healthcare systems and individuals.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Oncology
Mengzhu Li, Yizhan Zhang, Jiajun Zhao, Dawei Wang
Summary: This study conducted a bibliometric analysis to reveal the research trends and new frontiers in phase separation-related cancer research. The results showed an increasing trend in this field, and future research hotspots were related to tumor microenvironments, immunotherapy, prognosis, p53, and cell death.
FRONTIERS IN ONCOLOGY
(2023)
Article
Cell Biology
Ruizhi Zheng, Yu Xu, Mian Li., Zhengnan Gao, Guixia. Wang, Xinguo Hou, Li Chen, Yanan Huo, Guijun Qin, Li Yan, Qin Wan, Tianshu Zeng, Lulu Chen, Lixin Shi, Ruying Hu, Xulei Tang, Qing Su, Xuefeng Yu, Yingfen Qin, Gang Chen, Xuejiang Gu, Feixia Shen, Zuojie Luo, Yuhong Chen, Yinfei Zhang, Chao Liu, Youmin Wang, Shengli Wu, Tao Yang, Qiang Li, Yiming Mu, Jiajun Zhao, Chunyan Hu, Xiaojing Jia, Min Xu, Tiange Wang, Zhiyun Zhao, Shuangyuan Wang, Hong Lin, Guang Ning, Weiqing Wang, Jieli Lu, Yufang Bi
Summary: By analyzing 12 variables related to body fat, glycemic measures, pancreatic b cell function, insulin resistance, blood lipids, and liver enzymes, the study examined the cluster characteristics of prediabetes and their associations with the development of diabetes and its complications. Significant differences in the risks of diabetes and its complications were observed among different clusters. Prediabetes in cluster 4, characterized by obesity and insulin resistance, had a higher risk of cardiovascular diseases compared to other clusters. This subcategorization has the potential to develop more precise strategies for targeted prediabetes prevention and treatment.
CELL REPORTS MEDICINE
(2023)
Article
Medicine, Research & Experimental
Wei Zhang, Jing Du, Hang Dong, Yiping Cheng, Fang Zhong, Zinuo Yuan, Yingchun Dong, Rong Wang, Shumin Mu, Jiajun Zhao, Wenxia Han, Xiude Fan
Summary: This study investigated the relationship between obesity, metabolic abnormalities, and hospitalizations related to diabetic kidney disease (DKD). The findings showed that both metabolic abnormalities and obesity were independently associated with increased readmission risk and hospitalization costs for DKD.
ARCHIVES OF MEDICAL RESEARCH
(2023)
Article
Multidisciplinary Sciences
Moke Liu, Luna Liu, Honglin Guo, Xiude Fan, Tianbao Liu, Chao Xu, Zhao He, Yongfeng Song, Ling Gao, Shanshan Shao, Jiajun Zhao, Peng Lu
Summary: In this study, a mouse model carrying the HNF1a P291fsinsC mutation was established, and it was found that this mutation led to liver steatosis. Further analysis revealed changes in innate immune response and lipid metabolism pathways. The study also showed that HNF1a inhibited the expression of CFD in hepatocytes, and that CFD regulated hepatocyte lipid deposition.
Article
Endocrinology & Metabolism
Zhenyu Yao, Ying Gong, Wenbin Chen, Shanshan Shao, Yongfeng Song, Honglin Guo, Qihang Li, Sijin Liu, Ximing Wang, Zhenhai Zhang, Qian Wang, Yunyun Xu, Yingjie Wu, Qiang Wan, Xinya Zhao, Qiuhui Xuan, Dawei Wang, Xiaoyan Lin, Jiawen Xu, Jun Liu, Christopher G. Proud, Xuemin Wang, Rui Yang, Lili Fu, Shaona Niu, Junjie Kong, Ling Gao, Tao Bo, Jiajun Zhao
Summary: In this study, it is shown that WDR6 promotes hepatic de novo lipogenesis during insulin resistance by interacting with PPP1CB. A small natural compound, XLIX, is also identified as an inhibitor of the WDR6-PPP1CB interaction, reducing hepatic steatosis in insulin resistance.
Article
Gastroenterology & Hepatology
Mengzhu Li, Xiude Fan, Jiajun Zhao, Dawei Wang
Summary: In this study, a predictive signature based on stress granule-related genes was established as an independent prognostic tool for hepatocellular carcinoma (HCC). The signature demonstrated strong predictive power, with the identified genes affecting HCC cell proliferation and metastasis by regulating stress granule formation.
JOURNAL OF CLINICAL AND TRANSLATIONAL HEPATOLOGY
(2023)
