Review
Endocrinology & Metabolism
Carlos Perez-Vega, Shashwat Tripathi, Ricardo A. Domingo, Andres Ramos-Fresnedo, Seung J. Lee, Kaisorn L. Chaichana, Alfredo Quinones-Hinojosa, Susan L. Samson
Summary: Postoperative fluid restriction after transsphenoidal surgery is found to be effective in preventing hyponatremia and hospital readmission, with the potential to decrease healthcare costs, as shown in a meta-analysis and systematic review of the literature.
ENDOCRINE PRACTICE
(2021)
Article
Medicine, General & Internal
Toru Hamada, Katsuyuki Matsuki, Seiji Kondou, Shinya Furukawa, Morikazu Onji
Summary: Duloxetine can cause syndrome of inappropriate secretion of antidiuretic hormone (SIADH), leading to hyponatremia. Elderly patients are more susceptible, with lower doses and earlier onset. Duloxetine-induced SIADH should be considered in high-risk elderly patients when hyponatremia occurs.
Article
Oncology
Marcus Skribek, Benedek Bozoky, Georgios Tsakonas
Summary: Asian patients with EGFR-mutated NSCLC have a higher prevalence and may develop SIADH with osimertinib treatment, which can be significantly improved after discontinuation. Further studies are needed to evaluate the potential mechanisms of osimertinib-induced SIADH.
Review
Medicine, General & Internal
Pajaree Krisanapan, Supawit Tangpanithandee, Charat Thongprayoon, Pattharawin Pattharanitima, Andrea Kleindienst, Jing Miao, Iasmina M. Craici, Michael A. Mao, Wisit Cheungpasitporn
Summary: This meta-analysis evaluates the safety and efficacy of vaptans in treating chronic hyponatremia in adult SIADH patients. The results indicate that vaptans effectively raise serum sodium concentration in the short-term, but caution is needed due to the risk of overcorrection.
JOURNAL OF CLINICAL MEDICINE
(2023)
Review
Medicine, General & Internal
Ralph Wendt, Andrew Z. Fenves, Benjamin P. Geisler
Summary: Urea may be an effective, safe, and inexpensive treatment modality for hyponatremia and the syndrome of inappropriate secretion of antidiuretic hormone (SIADH).
Article
Pediatrics
Ankit Kumar Meena, Pamali Mahasweta Nanda, Rajni Sharma, Biswaroop Chakrabarty, Sheffali Gulati
Summary: Syndrome of inappropriate antidiuretic hormone secretion (SIADH) is a common cause of euvolemic hyponatremia in hospitalized children. It is characterized by increased serum ADH, leading to water retention through V2 receptors in the distal renal tubules. The conventional treatment for SIADH includes fluid restriction and salt supplementation, but pharmacological therapy may be required in some cases. Limited experience exists with the use of V2-receptor antagonists in the pediatric population. In this case report, a girl with corpus callosum agenesis and severe symptomatic hyponatremia due to SIADH was successfully managed with the V2-receptor antagonist tolvaptan.
INDIAN JOURNAL OF PEDIATRICS
(2023)
Article
Endocrinology & Metabolism
Rebecca Jane Moon, Maisara Soliman, Lieke Hoogenboom, Rodney D. Gilbert, Georgina Bird-Lieberman, Jaspal Singh, Detlef Bockenhauer, Anitha Kumaran
Summary: This article describes a case of a 6-week-old infant presenting with seizures and life-threatening hyponatremia. A hypothalamic hamartoma (HH) was identified on magnetic resonance imaging. Clinical examination and biochemistry were consistent with the syndrome of inappropriate secretion of anti-diuretic hormone (SIADH). Successful management of hyponatremia was achieved using tolvaptan.
JOURNAL OF PEDIATRIC ENDOCRINOLOGY & METABOLISM
(2023)
Article
Immunology
Wen Li, Shu Teng, Shi-Yong Zhao, Zheng-Hong Qi
Summary: This article reports a case of SIADH secondary to varicella in a 9-year-old girl with remarkable hyponatremia. The patient's serum sodium returned to the normal level under appropriate treatment and no evidence of hyponatremia was found at a 3-month follow-up. The authors suggest that the existence of SIADH should be considered when treating patients with varicella who present with severe hyponatremia.
PEDIATRIC INFECTIOUS DISEASE JOURNAL
(2022)
Article
Medicine, General & Internal
Muhammad M. Javaid, Jocelyn Shan, Rachel Frederick, Reinhardt Dreyer, James J. Gome
Summary: Hyponatremia is a common complication in COVID-19-positive patients and is often caused by Syndrome of Inappropriate Secretion of Antidiuretic Hormone (SIADH). However, COVID-19-related hyponatremia can have diverse underlying causes similar to non-COVID-19 hyponatremia and requires a thorough assessment for accurate diagnosis and appropriate management.
CUREUS JOURNAL OF MEDICAL SCIENCE
(2022)
Review
Medicine, General & Internal
Lei Tian, Li-Ya He, Hong-Zhen Zhang
Summary: This case report describes a rare occurrence of SIADH induced by nedaplatin in a 54-year-old female with nasopharyngeal carcinoma. The side effects were effectively managed with fluid restriction and sodium supplementation, emphasizing the importance of cautiously treating life-threatening hyponatremia in patients receiving nedaplatin treatment.
WORLD JOURNAL OF CLINICAL CASES
(2021)
Review
Medicine, General & Internal
Fatma Dilek Dellal, Gulsum Karaahmetli, Serdar Can Guven, Cevdet Aydin, Oya Topaloglu, Reyhan Ersoy, Bekir Cakir
Summary: This article reports a rare case of SIADH secondary to EGPA. Effective treatment of EGPA resulted in the resolution of SIADH, suggesting a causality between the two conditions.
IRISH JOURNAL OF MEDICAL SCIENCE
(2023)
Article
Clinical Neurology
Masahiro Oishi, Yasuhiko Hayashi, Yasuo Sasagawa, Nozomu Oikawa, Mitsutoshi Nakada
Summary: Although rare, syndrome of inappropriate secretion of antidiuretic hormone (SIADH) may present as an initial sign of hypothalamic PCNSL.
ACTA NEUROLOGICA BELGICA
(2023)
Editorial Material
Clinical Neurology
Manabu Takano, Tsuyoshi Okada, Toshiyuki Kobayashi, Shiro Suda
Summary: This case report highlights a 77-year-old man with type 2 diabetes who developed hyponatremia (SIADH) 12 days after starting suvorexant for major depression treatment. The hyponatremia improved within 6 days of discontinuing suvorexant, suggesting a possible association between suvorexant and SIADH. Clinicians should be aware of this potential adverse effect despite the drug generally being considered relatively safe.
JOURNAL OF CLINICAL SLEEP MEDICINE
(2021)
Article
Medicine, General & Internal
Mari Mori, Satoru Takeshita, Nami Nakamura, Yuki Mizuno, Akiko Tomita, Mineyoshi Aoyama, Hiroki Kakita, Yasumasa Yamada
Summary: This report demonstrates the safety and efficacy of tolvaptan in an infant with HPE-associated SIADH.
WORLD JOURNAL OF CLINICAL CASES
(2023)
Review
Clinical Neurology
Mendel Castle-Kirszbaum, Tony Goldschlager, Margaret D. Y. Shi, Jeremy Kam, Peter J. Fuller
Summary: Prophylactic postoperative fluid restriction is a cheap and easily implemented intervention that can reduce the incidence of postoperative hyponatremia, but may not necessarily decrease readmission rates.
JOURNAL OF CLINICAL NEUROSCIENCE
(2022)