Article
Chemistry, Physical
Thuany Naiara Silva Laurintino, Patricia V. de Oliveira, Jonatas L. Dias, Thairis K. S. Laurintino, Evertan A. Rebelatto, J. Vladimir Oliviera, Ariovaldo Bolzan
Summary: The encapsulation of methionine in ethyl cellulose was investigated using the GAS technique. The study evaluated the effects of methionine/polymer ratio, temperature, and pressure on particle characteristics and encapsulation efficiency. The results showed high encapsulation efficiencies of up to 99.72%.
JOURNAL OF SUPERCRITICAL FLUIDS
(2023)
Article
Chemistry, Physical
Salal Hasan Khudaida, Wei-Yang Hsieh, Yu-Zhe Huang, Wei-Yi Wu, Ming-Jer Lee, Chie-Shaan Su
Summary: The solubility of probenecid in supercritical CO2 was measured, and the use of supercritical antisolvent (SAS) process successfully obtained PLGA coated probenecid particles, which showed significantly improved dissolution rate compared to unprocessed probenecid and SAS-processed probenecid without PLGA.
JOURNAL OF SUPERCRITICAL FLUIDS
(2023)
Article
Pharmacology & Pharmacy
Jorge Sevilla Moreno, Panagiota Dima, Ioannis S. Chronakis, Ana C. Mendes
Summary: Electrosprayed ethyl cellulose core-shell microcapsules can successfully encapsulate probiotic Bifidobacterium animalis subsp. lactis and extend its viability under suitable conditions. The microcapsules have small diameter and distinct core-shell interface.
Article
Biochemistry & Molecular Biology
Shu-Fang Li, Jia-Hui Wu, Teng-Gen Hu, Hong Wu
Summary: Hydrophobic core-shell nanofibers were fabricated using ethyl cellulose as the shell and zein as the core to efficiently encapsulate quercetin via coaxial electrospinning. The encapsulation efficiency of the nanofibers reached over 97%. Quercetin was encapsulated in an amorphous state and there were interactions between quercetin and the wall materials.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2023)
Article
Engineering, Chemical
Thossaporn Wijakmatee, Yusuke Shimoyama, Yasuhiko Orita
Summary: Combination of micro-flow processes between emulsification and supercritical fluid emulsion extraction was used to fabricate stable and uniform stearic acid lipid nanoparticles dispersed in aqueous solution.
INDUSTRIAL & ENGINEERING CHEMISTRY RESEARCH
(2022)
Article
Polymer Science
Cunchuan Zheng, Fuchuan Liu, Ke Xu, Yang Wu, Jinyu Wang
Summary: In this study, a novel method of preparing microcapsules was introduced using CO2/N-2 switchable hydrophilicity solvent combined with an emulsion method. The prepared ethyl cellulose-glycerol tribenzoate microcapsules (EGM) exhibited spherical morphology and adjustable particle size. The method showed high yields and encapsulation rates, providing a new idea for microcapsule preparation and expanding the application field of switchable hydrophilicity solvents.
JOURNAL OF APPLIED POLYMER SCIENCE
(2022)
Article
Chemistry, Applied
Alicia Gil-Ramirez, Irene Rodriguez-Meizoso
Summary: This article discusses the advantages of supercritical fluids in the isolation of natural products, focusing on the extraction of polyphenols and carotenoids. It also highlights the lack of clear terminology and purpose in the field, while aiming to inspire further research in this area of study.
SEPARATION AND PURIFICATION REVIEWS
(2021)
Article
Chemistry, Physical
Lucia Baldino, Alvaro Gonzalez-Garcinuno, Antonio Tabernero, Stefano Cardea, Eva M. Martin del Valle, Ernesto Reverchon
Summary: In this study, cellulose acetate membranes loaded with the highly hydrophobic drug quercetin were produced using supercritical phase inversion, resulting in membranes with different morphologies and pore sizes by varying process parameters. The release of quercetin could be controlled by the membrane structures, with faster release from macrovoids and prolonged release from cellular structures. These membranes exhibited efficient and prolonged antifungal effects against two types of fungi, overcoming the hydrophobicity issue of quercetin.
JOURNAL OF SUPERCRITICAL FLUIDS
(2021)
Review
Polymer Science
Karol Tutek, Anna Masek, Anna Kosmalska, Stefan Cichosz
Summary: This article reviews the use of fluids under supercritical conditions in processes related to the modern and innovative polymer industry. The focus is on extraction, micronization, particle formation, and encapsulation, emphasizing the importance of ecological and efficient processes. Advanced technological solutions using less toxic fluids under supercritical conditions are becoming more prevalent in the chemical industry, creating new opportunities for materials with specialized applications.
Review
Engineering, Chemical
Tariqul Islam, Abdullah Al Ragib, Sahena Ferdosh, A. B. M. Helal Uddin, Md. Jahurul Haque Akanda, Md. Abdur Rashid Mia, Reddy D. M. Prasad, Bin Yunus Kamaruzzaman, Md. Zaidul Islam Sarker
Summary: This review discusses the synthesis of nanoparticles and particle size design using supercritical fluid technology in pharmaceutical formulations. The environmentally friendly supercritical CO2 fluid is highlighted as a common and cost-effective component for the formation of nanomedicine in drug delivery. Various supercritical approaches are described, offering insights into the principles, advantages, and challenges in creating nanoparticles.
CHEMICAL ENGINEERING COMMUNICATIONS
(2022)
Article
Energy & Fuels
Qiang Lu, Yuefang Chen, Weipeng Song, Chaonan Tao, Junhua Zhang, Yong Sun, Lincai Peng, Huai Liu
Summary: The addition of β-valerolactone (GVL) co-solvent during the acid-catalyzed conversion of cellulose in ethanol improves the reaction rate and catalytic activity for producing ethyl levulinate (EL). GVL not only aids in the dissolution and depolymerization of cellulose, but also enhances the acidity and catalytic activity of the Al species, resulting in higher yields and faster reaction rates for EL production.
Article
Biochemistry & Molecular Biology
Shu-Fang Li, Teng-Gen Hu, Hong Wu
Summary: A colon-targeted delivery system was developed using gelatin as a regulator to efficiently deliver and release quercetin. The nanofibers had good stability in acidic and aqueous foods, and achieved less than 3% quercetin release in simulated gastrointestinal fluid. Nanofibers with an EC to GN ratio of 1:3 exhibited more preferable release performance.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2023)
Article
Chemistry, Physical
Aaron O'Sullivan, Kevin M. Ryan, Luis Padrela
Summary: The inability of many biopharmaceutical formulations to retain their structure and integrity when in solution is a major issue. Producing dried solid dosage forms, such as proteins and nucleic acids, improves their storage, transport, and administration. Spray drying and supercritical fluid drying are promising drying techniques that offer different particle sizes and morphologies, enhancing the stability of the final product.
JOURNAL OF SUPERCRITICAL FLUIDS
(2022)
Article
Chemistry, Multidisciplinary
R. Vallejo, J. Gonzalez-Valdivieso, M. Santos, S. Rodriguez-Rojo, F. J. Arias
Summary: This study introduces a new methodology for developing innovative drug-delivery strategies by combining genetically engineered elastin-like recombinamers with supercritical fluid techniques. The encapsulation process using a specific block copolymer ELR showed significant improvement in water solubility of the chemotherapeutic agent. Cellular assays demonstrated that the developed strategy is more precise in targeting cancer cells compared to non-selective chemotherapeutic drugs.
JOURNAL OF INDUSTRIAL AND ENGINEERING CHEMISTRY
(2021)
Article
Chemistry, Physical
Azadeh Shirafkan, Seyed Mostafa Nowee, Hossein Kamali
Summary: This study focuses on coprecipitation of pyrazinamide (PZA) with polyvinylpyrrolidone (PVP) using gas antisolvent (GAS) process, ultimately achieving high dissolution rate of PVP/PZA particles. By manipulating operating parameters, controlled morphology and particle size distribution were obtained, reducing crystallinity and enhancing drug assimilation through the organism.
JOURNAL OF SUPERCRITICAL FLUIDS
(2021)
Article
Chemistry, Physical
Claudia Maya, M. Teresa Fernandez-Ponce, Lourdes Casas, Casimiro Mantell, Enrique J. Martinez de la Ossa
Summary: This study examined the use of supercritical impregnation technology in the production of polypropylene films with insecticide properties. Experimental design was used to determine the impact of impregnation time, sample amount, pressure, and temperature on the impregnation loading of pyrethrins in PP. Two experimental procedures (batch and semi-continuous modes) were evaluated, with batch mode providing higher impregnation at 55 degrees C and 10 MPa, but facing difficulties in scaling up, while the semi-continuous mode showed adequate results at 35 degrees C.
JOURNAL OF SUPERCRITICAL FLUIDS
(2021)
Article
Biochemistry & Molecular Biology
Cristina Cejudo-Bastante, Paloma Arjona-Mudarra, Maria Teresa Fernandez-Ponce, Lourdes Casas, Casimiro Mantell, Enrique J. Martinez de la Ossa, Clara Pereyra
Summary: This study proposed natural jute fibers impregnated with RGPE as a new active food packaging material, showing high antibacterial capacity and bioactive extraction. The highest bioactive extract was obtained through PLE technique, and an efficient packaging material was prepared under specific conditions.
Article
Polymer Science
Cristina Cejudo Bastante, Marlene J. Cran, Lourdes Casas Cardoso, Casimiro Mantell Serrano, Stephen W. Bigger
Summary: In this study, a supercritical solvent impregnation technique was used to incorporate bioactive olive leaf extract into a food-grade film. The colour properties of the film were significantly modified by the addition of the olive leaf extract. The UV barrier and water permeability properties of the film were not significantly affected. The release of the extract from the polypropylene surface was faster than from the PET surface.
Article
Biochemistry & Molecular Biology
Lourdes Casas Cardoso, Cristina Cejudo Bastante, Casimiro Mantell Serrano, Enrique J. Martinez de la Ossa
Summary: In this study, efficient valorization of orange peel was investigated using green extraction, fractionation, and impregnation techniques. The extracted compounds showed strong antioxidant and moderate antimicrobial activities. The fraction obtained under specific conditions showed the strongest antioxidant and antimicrobial activities, and a high extraction yield. The impregnated plastic obtained from the best extracts demonstrated good antioxidant and antimicrobial activities.
Article
Biochemistry & Molecular Biology
Ismael Sanchez-Gomar, Josefa Benitez-Camacho, Cristina Cejudo-Bastante, Lourdes Casas, Rafael Moreno-Luna, Casimiro Mantell, Ma Carmen Duran-Ruiz
Summary: The study evaluated the potential of mango leaves, olive leaves, and red grape pomace extracts rich in polyphenols to promote ECFC reparative effects. It was found that ethanolic extracts at low concentrations improved angiogenic capacities of ECFCs and reduced proliferation, apoptosis, and the inflammatory response of these cells.
Article
Polymer Science
Cristina Cejudo-Bastante, Lidia Verano-Naranjo, Noemi Toro-Barrios, Clara Pereyra, Casimiro Mantell, Lourdes Casas
Summary: Identifying and functionalizing new polymers from natural resources can have a significant impact on biomedical devices and food preservation fields. Some natural extracts, such as mango leaf extract, have been proven to have high levels of antioxidant, antimicrobial or anti-inflammatory properties, making them suitable for controlled-release applications. This study investigates the impregnation of different types of polymers with mango leaf extract, analyzing the influence of temperature and pressure on the polymers' structure and behavior.
Article
Polymer Science
Pilar Grosso, Cristina Cejudo, Ismael Sanchez-Gomar, M. Carmen Duran-Ruiz, Rafael Moreno-Luna, Lourdes Casas, Clara Pereyra, Casimiro Mantell
Summary: The addition of natural substances with pharmacoactive properties to polymeric biomedical devices can enhance the assimilation of these implants and promote blood vessel formation. In this study, mango leaf extract (MLE) obtained through pressurized ethanol was impregnated into polylactic acid (PLA) devices. The best impregnation conditions and results were determined through in vitro culture experiments and microscopy observations.
Article
Agronomy
Beatriz Juliana Yerena-Prieto, Monserrat Gonzalez-Gonzalez, Miguel Angel Garcia-Alvarado, Lourdes Casas, Miguel Palma, Guadalupe Del Carmen Rodriguez-Jimenes, Gerardo F. Barbero, Cristina Cejudo-Bastante
Summary: Supercritical fluid extraction (SFE) using CO2 is a sustainable and efficient technique for recovering highly apolar compounds. However, the recovery of phenolic compounds requires the use of different co-solvent combinations and optimization of various variables. Pressure and temperature significantly affect the phenolic composition and concentration of the extracts.
Article
Biochemistry & Molecular Biology
Noelia D. Machado, Cristina Cejudo-Bastante, Maria L. Goni, Nicolas A. Ganan, Lourdes Casas-Cardoso, Casimiro Mantell-Serrano
Summary: The study explores the application of supercritical CO2-assisted impregnation in the preparation of biomedical devices with specific bioactivity. By using 3D-printable TPU and PLA filaments, high loading and antioxidant activity were achieved through supercritical impregnation of ethanolic olive leaf extract. The results demonstrate that temperature and pressure have significant effects on the impregnation process.
Article
Biochemistry & Molecular Biology
Lidia Verano-Naranjo, Cristina Cejudo-Bastante, Lourdes Casas, Enrique Martinez de la Ossa, Casimiro Mantell
Summary: This study proposes the use of winemaking by-products with high active properties of biomedical interest to obtain bioactive PLA by using supercritical technologies, which can effectively solve inflammation issues that might lead to rejection and promote controlled re-endothelialization of tissues. Two red grape pomace extracts obtained through high-pressure extraction with supercritical CO2 and cosolvents have been studied, along with two impregnation methods. Both extracts showed good antioxidant, anti-inflammatory, and antibacterial capacities, with the hydroethanolic extract performing better. The impregnation loadings of the extracts depended on the extract and pressure/temperature conditions, reaching up to 8% of impregnation.
Article
Food Science & Technology
Cristina Cejudo, Marta Ferreiro, Irene Romera, Lourdes Casas, Casimiro Mantell
Summary: Active packaging is an effective method to preserve perishable foods. A packaging formulation containing chitosan, starch, and mango leaf extract showed high bioactivity, reducing water solubility and water vapor permeability while increasing UV protection. This formulation demonstrated better preservation of raspberry fruit compared to a control.
Article
Chemistry, Physical
P. Belmonte, J. M. Garcia-Vargas, J. F. Rodriguez, I. Garrido, M. T. Garcia, M. J. Ramos
Summary: In this study, four polythiourethane films with different types of polyols and isocyanates were synthesized, characterized, and foamed. The results showed that the type of isocyanate greatly influenced the crystallinity and stiffness of the polymers, while the type of polyol modified the FT-IR spectra and the decomposition curve of the material with temperature. Furthermore, the choice of isocyanate also affected the properties of the foams obtained from the polymeric material.
JOURNAL OF SUPERCRITICAL FLUIDS
(2024)
Article
Chemistry, Physical
Xutao Zhu, Jianguo Yan, Shouchun Liu, Fengling Zhu
Summary: This study experimentally assessed the hydrodynamic characteristics of supercritical-pressure R134a in a horizontal circular tube. It was found that the hydrodynamic characteristic curve of R134a under supercritical pressure does not have a negative-slope region but a transition region. The transition region becomes more evident with increasing heat flux, while it weakens with increasing pressure and inlet temperature. Moreover, the onset of the transition region shifts in the direction of high mass flow rate with increasing heat flux.
JOURNAL OF SUPERCRITICAL FLUIDS
(2024)
Article
Chemistry, Physical
Stefania Mottola, Iolanda De Marco
Summary: In this study, corticosteroids were micronized with cyclodextrin using Supercritical Assisted Atomization (SAA), resulting in spherical micrometric particles with improved dissolution time.
JOURNAL OF SUPERCRITICAL FLUIDS
(2024)
Article
Chemistry, Physical
Honghai Liu, Yu Xie, Zhilan Li, Xiaokai Zhang
Summary: This study compared the effects of supercritical carbon dioxide dewatering (SCD) and conventional kiln drying (CKD) at a temperature of 55 degrees C on the dewatering rate, moisture transfer and distribution, shrinkage, and stress characteristics of bamboo strips. The results showed that SCD had a faster dewatering rate and lower shrinkage compared to CKD, but was less effective in reducing drying stress in bamboo.
JOURNAL OF SUPERCRITICAL FLUIDS
(2024)
Article
Chemistry, Physical
Tahmasb Hatami, Ozan N. Ciftci
Summary: This study fills the gap in previous research by establishing a hierarchy of significance for factors affecting SFE profitability, providing a deeper understanding of how technical and economic factors impact profitability. The findings highlight that the SFE facility becomes profitable when the extractor capacity surpasses 42 L.
JOURNAL OF SUPERCRITICAL FLUIDS
(2024)
Article
Chemistry, Physical
Tingshan Guo, Chuang He, Zhiyuan Liang, Qinxin Zhao
Summary: The initial oxidation behavior of Fe10Cr and Fe20Cr alloys in supercritical H2O and supercritical CO2 with O2 has been investigated. The results show that O2 has the highest adsorption energy on FeCr alloys and reacts faster than H2O and CO2.
JOURNAL OF SUPERCRITICAL FLUIDS
(2024)
Article
Chemistry, Physical
Vikash Chandra Roy, Jin-Seok Park, Ahmed Redwan Haque, Md Sadek Ali, Hee-Jeong Lee, Byung-Soo Chun
Summary: This research aimed to valorize brewery spent grain (BSG) using subcritical water hydrolysis (SWH) modified by six different natural deep eutectic solvents (DES) and determining their bipotentialities. The findings showed that BSG hydrolysates obtained through DES-induced SWH contained high levels of sugars, proteins, flavonoids, phenolic compounds, and essential amino acids. The hydrolysates also demonstrated antimicrobial activities, and the presence of bioactive compounds was confirmed through FT-IR analysis. This comprehensive profiling of bioactive compounds from BSG using DES-mediated SWH can contribute to the efficient valorization of BSG for industrial purposes.
JOURNAL OF SUPERCRITICAL FLUIDS
(2024)
Article
Chemistry, Physical
Kailiang Zhang, Hanyu Wang, Tong Liu, Zhu Wang, Lvxing Wang, Ping Fan, Feng Chen, Mingqiang Zhong, Bozhen Wu, Shanqiu Liu, Jintao Yang
Summary: This study investigates the influence of foam cell structure on the electromagnetic interference shielding performance of conductive polymer composite foam. The results suggest that foamed composites exhibit improved EMI shielding performance, and bimodal cell foams have higher electric conductivity but lower EMI shielding compared to uniform cell foams.
JOURNAL OF SUPERCRITICAL FLUIDS
(2024)
Article
Chemistry, Physical
Jaromir Valtr, Petr Roztocil, David Dasek, Radek Musalek, Frantisek Lukac, Jakub Klecka, Marek Janata, Mariana Arnoult-Ruzickova, Eva Mistova, Ludek Jelinek, Petr Sajdl, Jan Macak
Summary: This paper focuses on the design of an experimental facility for in-situ electrochemical testing at supercritical water conditions, including the design of the electrode system and surface insulation coating for electrode leads.
JOURNAL OF SUPERCRITICAL FLUIDS
(2024)
Article
Chemistry, Physical
Richard Djimasbe, Mikhail A. Varfolomeev, Nailya M. Khasanova, Ameen A. Al-Muntaser, Rustam R. Davletshin, Muneer A. Suwaid, Gazinur Z. Mingazov
Summary: This study confirms the capability of supercritical water to generate active hydrogen that interacts with different fractions in unconventional feedstocks, leading to synthetic oil production during hydrothermal reactions. The findings suggest that a maximum yield of 16.78% can be achieved at a temperature of 380 oC and a reaction time of 1-12 hours.
JOURNAL OF SUPERCRITICAL FLUIDS
(2024)