Article
Pharmacology & Pharmacy
Bing Han, Huan Tang, Qiming Liang, Ming Zhu, Yizhuo Xie, Jinglin Chen, Qianwen Li, Juan Jia, Yan Li, Zhihui Ren, Dengli Cong, Xiaofeng Yu, Dayun Sui, Jin Pei
Summary: The study aimed to optimize the preparation method of injectable Octreotide microspheres to reduce burst release and treat portal hypertension, modifying the double emulsion solution evaporation method. Results showed that the optimized Octreotide microspheres significantly reduced portal vein pressure and had stable drug release within 1200 h, indicating potential therapeutic effects for portal hypertension. The study also observed changes in liver tissue morphology and related indexes in vivo, demonstrating the efficacy of the optimized preparation method.
Article
Oncology
Yue Cheng, Lowell Anthony, Chris Delcher, Daniela C. Moga, Aman Chauhan, Bin Huang, Val Adams
Summary: This study evaluated the real-world utilization of long-acting release (LAR) and immediate-release (IR) in patients with neuroendocrine tumors (NETs). The results showed that a significant percentage of LAR prescriptions exceeded the recommended maximum dose, while a small percentage of LAR prescriptions had preceding IR use. Furthermore, patients with NETs or carcinoid syndrome (CS) were more likely to experience dose escalation compared to patients with an unknown diagnosis.
Article
Oncology
Yue Cheng, Lowell Anthony, Chris Delcher, Daniela C. Moga, Aman Chauhan, Bin Huang, Val Adams
Summary: This study evaluates the real-world utilization of octreotide long-acting release (LAR) and immediate-release (IR) in the treatment of neuroendocrine tumors (NETs). It found that dosing above the label-maximum dose of LAR is common and IR rescue dosing is underutilized. Patients with NETs or carcinoid syndrome (CS) are more likely to experience dose escalations and have a higher proportion of IR use before dose escalation compared to those with an unknown diagnosis.
Review
Pharmacology & Pharmacy
Anil B. Jindal, Atharva R. Bhide, Sagar Salave, Dhwani Rana, Derajram Benival
Summary: The use of long-acting parenteral drug delivery systems is a promising approach to improve the treatment of chronic conditions. These systems utilize various technologies to deliver different drugs and have shown potential in the treatment of chronic infections and diseases such as HIV/AIDS, tuberculosis, and malaria. Factors such as drug properties, formulation type, and administration route play a crucial role in the development of long-acting formulations. Recent advances in the field, including long-acting nanoformulations and products in clinical trials, have also been highlighted.
ADVANCED DRUG DELIVERY REVIEWS
(2023)
Article
Health Care Sciences & Services
Chris Worth, Paul W. Nutter, Maria Salomon-Estebanez, Sameera Auckburally, Mark J. Dunne, Indraneel Banerjee, Simon Harper
Summary: The research team has developed a system called HYPO-CHEAT to prevent hypoglycemia in children through behavior change and technology. The system successfully identified hypoglycemia patterns and effectively reduced the occurrence of hypoglycemia through behavior change and data visualization.
Article
Endocrinology & Metabolism
Paul S. Thornton, Diva D. De Leon, Susann Empting, David Zangen, David M. Kendall, Sune Birch, Eva Boge, Jelena Ivkovic, Indraneel Banerjee
Summary: This study evaluated the efficacy and safety of continuous subcutaneous infusion of dasiglucagon as an add-on treatment for children with CHI and persistent hypoglycemia. Dasiglucagon was found to significantly reduce the frequency and severity of hypoglycemic episodes, and was well tolerated.
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2023)
Review
Pharmacology & Pharmacy
Lalitkumar K. Vora, Akmal H. Sabri, Yara Naser, Achmad Himawan, Aaron R. J. Hutton, Qonita Kurnia Anjani, Fabiana Volpe-Zanutto, Deepakkumar Mishra, Mingshan Li, Aoife M. Rodgers, Alejandro J. Paredes, Eneko Larran, Raghu Raj Singh Thakur, Ryan F. Donnelly
Summary: The minimally-invasive and painless nature of microneedle (MN) application has enabled the technology to obviate many issues with injectable drug delivery. MNs not only administer therapeutics directly into the dermal and ocular space, but they can also control the release profile of the active compound over a desired period. This review discusses various MN formulations loaded with different therapeutics, the design aspects such as polymer selection and MN geometry, as well as manufacturing and regulatory hurdles that need to be overcome to bring MN technology to the market.
ADVANCED DRUG DELIVERY REVIEWS
(2023)
Review
Pharmacology & Pharmacy
Smrithi Padmakumar, Mansoor M. Amiji
Summary: Despite advancements in therapeutic strategies and research progress, a cure for glioma remains elusive due to the tumor's heterogeneity, immunosuppressive state, and the presence of the blood-brain barrier. Long-acting depot formulations, such as injectables and implantables, are being explored as viable options for drug delivery to the brain. Combining nanoparticulates within these systems enhances their pharmaceutical advantages. Clinical studies have shown that utilizing long-acting depots as monotherapy or in combination with existing strategies can significantly improve patient survival rates and prevent glioma recurrences.
ADVANCED DRUG DELIVERY REVIEWS
(2023)
Article
Radiology, Nuclear Medicine & Medical Imaging
Lisa J. States, J. Christopher Davis, Steven M. Hamel, Susan A. Becker, Hongming Zhuang
Summary: Congenital hyperinsulinism is a condition characterized by persistent hypoglycemia due to excessive insulin secretion, with varying clinical course and potential cure through surgical resection of focal lesions.F-18-6-fluoro-L-dopa PET/CT plays a vital role in detection and management of this condition.
JOURNAL OF NUCLEAR MEDICINE
(2021)
Article
Instruments & Instrumentation
Thomas Tice
Summary: Long-acting injectables have had a significant impact on clinical medicine, with contributions from various fields and pioneers who envisioned and implemented new drug delivery concepts over 50 years ago.
DRUG DELIVERY AND TRANSLATIONAL RESEARCH
(2023)
Article
Chemistry, Multidisciplinary
Wenjie Qiu, Weiwei Zhao, Ludan Zhang, Haimang Wang, Ningyu Li, Kexin Chen, Hongyu Zhang, Yuguang Wang
Summary: This study developed a solid-liquid composite lubricating nano-snowboard that combines anti-inflammatory and high-performance lubrication to effectively treat osteoarthritis.
ADVANCED FUNCTIONAL MATERIALS
(2022)
Review
Nanoscience & Nanotechnology
Wei Li, Jie Tang, Dennis Lee, Thomas R. Tice, Steven P. Schwendeman, Mark R. Prausnitz
Summary: Long-acting drug delivery formulations enable sustained and prolonged drug release, improving patient compliance. This review discusses FDA-approved long-acting drug delivery formulations, including different slow-release mechanisms and materials, and provides a comprehensive summary of their clinical applications and product information.
NATURE REVIEWS MATERIALS
(2022)
Review
Endocrinology & Metabolism
Mirjam E. van Albada, Pratik Shah, Terry G. J. Derks, Sabine Fuchs, Judith J. M. Jans, Valerie Mclin, Hubert P. J. van der Doef, IRCPSS
Summary: In physiological glucose homeostasis, the liver plays a crucial role in glucose extraction and storage, as well as insulin elimination. Patients with a congenital porto-systemic shunt provide important insights into the role of the portal circulation and hepatic function in different phases of glucose homeostasis.
FRONTIERS IN ENDOCRINOLOGY
(2023)
Editorial Material
Radiology, Nuclear Medicine & Medical Imaging
Han Chung Low, Young Soon Tay, Simon Yew Kuang Ong, Wei Ying Tham, Sean Xuexian Yan
Summary: This case report presents a 68-year-old man with metastatic small bowel neuroendocrine tumor who underwent peptide receptor radionuclide therapy. Despite a miscommunication in scheduling, the tumoral uptake was not reduced after the fourth cycle of therapy, suggesting that stopping somatostatin analogs before the therapy may not be necessary.
CLINICAL NUCLEAR MEDICINE
(2023)
Article
Medicine, General & Internal
Emily B. Schroeder, Romain Neugebauer, Kristi Reynolds, Julie A. Schmittdiel, Linda Loes, Wendy Dyer, Noel Pimentel, Jay R. Desai, Gabriela Vazquez-Benitez, P. Michael Ho, Jeffrey P. Anderson, Patrick J. O'Connor
Summary: This study compared cardiovascular events and mortality in adults with type 2 diabetes receiving long-acting insulin with or without short-acting insulin. The findings suggested an increased risk of all-cause mortality and a decreased risk of acute myocardial infarction for those adding short-acting insulin. However, there was no increased risk of congestive heart failure, stroke, or cardiovascular mortality associated with the combination treatment.
Article
Cardiac & Cardiovascular Systems
Philippe Menasche, Valerie Vanneaux, Albert Hagege, Alain Bel, Bernard Cholley, Isabelle Cacciapuoti, Alexandre Parouchev, Nadine Benhamouda, Gerard Tachdjian, Lucie Tosca, Jean-Hugues Trouvin, Jean-Roch Fabreguettes, Valerie Bellamy, Romain Guillemain, Caroline Suberbielle Boissel, Eric Tartour, Michel Desnos, Jerome Larghero
EUROPEAN HEART JOURNAL
(2015)
Article
Biochemistry & Molecular Biology
Martina Nemethova, Jan Radvanszky, Ludevit Kadasi, David B. Ascher, Douglas E. V. Pires, Tom L. Blundell, Berardino Porfirio, Alessandro Mannoni, Annalisa Santucci, Lia Milucci, Silvia Sestini, Gianfranco Biolcati, Fiammetta Sorge, Caterina Aurizi, Robert Aquaron, Mohammed Alsbou, Charles Marques Lourenco, Kanakasabapathi Ramadevi, Lakshminarayan R. Ranganath, James A. Gallagher, Christa van Kan, Anthony K. Hall, Birgitta Olsson, Nicolas Sireau, Hana Ayoob, Oliver G. Timmis, Kim-Hanh Le Quan Sang, Federica Genovese, Richard Imrich, Jozef Rovensky, Rangan Srinivasaraghavan, Shruthi K. Bharadwaj, Ronen Spiegel, Andrea Zatkova
EUROPEAN JOURNAL OF HUMAN GENETICS
(2016)
Review
Endocrinology & Metabolism
Jean-Baptiste Arnoux, Kim-Hanh Le Quan Sang, Anais Brassier, Coraline Grisel, Aude Servais, Julien Wippf, Sandrine Dubois, Nicolas Sireau, Chantal Job-Deslandre, Lakshminarayan Ranganath, Pascale de Lonlay
JOURNAL OF INHERITED METABOLIC DISEASE
(2015)
Meeting Abstract
Endocrinology & Metabolism
Simon A. Jones, Dominique Plantaz, Roshni Vara, Stephen Eckert, Kim-Hanh Le Quan Sang, Anais Brassier, Jean-Baptiste Arnoux, Catherine Breen, J. Jay Gargus, Anthony G. Quinn, Sandra Rojas-Caro, Vassili Valayannopoulos
MOLECULAR GENETICS AND METABOLISM
(2015)
Article
Genetics & Heredity
Nina Boegershausen, Vincent Gatinois, Vera Riehmer, Huelya Kayserili, Jutta Becker, Michaela Thoenes, Pelin OEzlem Simsek-Kiper, Mouna Barat-Houari, Nursel H. Elcioglu, Dagmar Wieczorek, Sigrid Tinschert, Guillaume Sarrabay, Tim M. Strom, Aurelie Fabre, Gareth Baynam, Elodie Sanchez, Gudrun Nuernberg, Umut Altunoglu, Yline Capri, Bertrand Isidor, Didier Lacombe, Carole Corsini, Valerie Cormier-Daire, Damien Sanlaville, Fabienne Giuliano, Kim-Hanh Le Quan Sang, Honorine Kayirangwa, Peter Nuernberg, Thomas Meitinger, Koray Boduroglu, Barbara Zoll, Stanislas Lyonnet, Andreas Tzschach, Alain Verloes, Nataliya Di Donato, Isabelle Touitou, Christian Netzer, Yun Li, David Genevieve, Goekhan Yigit, Bernd Wollnik
Article
Genetics & Heredity
Genevieve Baujat, Remy Choquet, Stephane Bouee, Viviane Jeanbat, Laurene Courouve, Amelie Ruel, Caroline Michot, Kim-Hanh Le Quan Sang, David Lapidus, Claude Messiaen, Paul Landais, Valerie Cormier-Daire
ORPHANET JOURNAL OF RARE DISEASES
(2017)
Article
Genetics & Heredity
Simon A. Jones, Sandra Rojas-Caro, Anthony G. Quinn, Mark Friedman, Sachin Marulkar, Fatih Ezgu, Osama Zaki, J. Jay Gargus, Joanne Hughes, Dominique Plantaz, Roshni Vara, Stephen Eckert, Jean-Baptiste Arnoux, Anais Brassier, Kim-Hanh Le Quan Sang, Vassili Valayannopoulos
ORPHANET JOURNAL OF RARE DISEASES
(2017)
Article
Cardiac & Cardiovascular Systems
Philippe Menasche, Valerie Vanneaux, Albert Hagege, Alain Bel, Bernard Cholley, Alexandre Parouchev, Isabelle Cacciapuoti, Reem Al-Daccak, Nadine Benhamouda, Helene Blons, Onnik Agbulut, Lucie Tosca, Jean-Hugues Trouvin, Jean-Roch Fabreguettes, Valerie Bellamy, Dominique Charron, Eric Tartour, Gerard Tachdjian, Michel Desnos, Jerome Larghero
JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY
(2018)
Article
Clinical Neurology
Massimo Pandolfo, Javier Arpa, Martin B. Delatycki, Kim Hanh Le Quan Sang, Caterina Mariotti, Arnold Munnich, Irene Sanz-Gallego, Geneieve Tai, Mark A. Tarnopolsky, Franco Taroni, Michael Spino, Fernando Tricta
ANNALS OF NEUROLOGY
(2014)
Article
Rheumatology
Lakshminarayan R. Ranganath, Anna M. Milan, Andrew T. Hughes, John J. Dutton, Richard Fitzgerald, Michael C. Briggs, Helen Bygott, Eftychia E. Psarelli, Trevor F. Cox, James A. Gallagher, Jonathan C. Jarvis, Christa van Kan, Anthony K. Hall, Dinny Laan, Birgitta Olsson, Johan Szamosi, Mattias Rudebeck, Torbjorn Kullenberg, Arvid Cronlund, Lennart Svensson, Carin Junestrand, Hana Ayoob, Oliver G. Timmis, Nicolas Sireau, Kim-Hanh Le Quan Sang, Federica Genovese, Daniela Braconi, Annalisa Santucci, Martina Nemethova, Andrea Zatkova, Judith McCaffrey, Peter Christensen, Gordon Ross, Richard Imrich, Jozef Rovensky
ANNALS OF THE RHEUMATIC DISEASES
(2016)
Article
Cardiac & Cardiovascular Systems
Philippe Menasche, Valerie Vanneaux, Jean-Roch Fabreguettes, Alain Bel, Lucie Tosca, Sylvie Garcia, Valerie Bellamy, Yohan Farouz, Julia Pouly, Odile Damour, Marie-Cecile Perier, Michel Desnos, Albert Hagege, Onnik Agbulut, Patrick Bruneval, Gerard Tachdjian, Jean-Hugues Trouvin, Jerome Larghero
EUROPEAN HEART JOURNAL
(2015)
Article
Chemistry, Analytical
R. Rotival, M. Bernard, T. Henriet, M. Fourgeaud, J. R. Fabreguettes, E. Surget, F. Guyon, B. Do
JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS
(2014)
Article
Clinical Neurology
Stephane Haik, Gabriella Marcon, Alain Mallet, Mauro Tettamanti, Arlette Welaratne, Giorgio Giaccone, Shohreh Azimi, Vladimir Pietrini, Jean-Roch Fabreguettes, Daniele Imperiale, Pierre Cesaro, Carlo Buffa, Christophe Aucan, Ugo Lucca, Laurene Peckeu, Silvia Suardi, Christine Tranchant, Ingo Zerr, Caroline Houillier, Veronica Redaelli, Herve Vespignani, Angela Campanella, Francois Sellal, Anna Krasnianski, Danielle Seilhean, Uta Heinemann, Frederic Sedel, Mara Canovi, Marco Gobbi, Giuseppe Di Fede, Jean-Louis Laplanche, Maurizio Pocchiari, Mario Salmona, Gianluigi Forloni, Jean-Philippe Brandel, Fabrizio Tagliavini
Meeting Abstract
Endocrinology & Metabolism
Vassili Valayannopoulos, Dominique Plantaz, Roshni Vara, Stephen Eckert, Radhika Tripuraneni, Eugene Schneider, Anthony G. Quinn, Kim-Hanh Le Quan Sang, Anais Brassier, Jean-Baptiste Arnoux, Fiona White, Catherine Breen, Simon A. Jones
MOLECULAR GENETICS AND METABOLISM
(2014)
Article
Medicine, Research & Experimental
Marianne Delville, Fabien Touzot, Chloe Couzin, Isabelle Hmitou, Lounes Djerroudi, Amani Ouedrani, Francois Lefrere, Caroline Tuchman-Durand, Chloe Mollet, Jean-Roth Fabreguettes, Nicolas Ferry, Laurent Laganier, Alessandra Magnani, Elisa Magrin, Valerie Jolaine, Asier Saez-Cirion, Orit Wolstein, Geoffrey Symonds, Pierre Frange, Helene Moins-Teisserenc, Marie-Laure Chaix-Baudier, Antoine Toubert, Jerome Larghero, Nathalie Parquet, Anne C. Brignier, Francoise Barre-Sinoussi, Eric Oksenhendler, Marina Cavazzana
MOLECULAR THERAPY-METHODS & CLINICAL DEVELOPMENT
(2019)