Article
Endocrinology & Metabolism
Susmita Dutta, Soham Tarafdar, Pradip Mukhopadhyay, Nitai P. Bhattacharyya, Sujoy Ghosh
Summary: Measurement of cell-free DNA levels in plasma could be a useful tool for differentiating malignant from benign thyroid nodules, with a high sensitivity and specificity. The established cutoff value of cfDNA showed strong agreement with histopathological classification, indicating its potential clinical utility in the diagnosis of thyroid nodules.
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2021)
Article
Radiology, Nuclear Medicine & Medical Imaging
Patrick J. Navin, Scott M. Thompson, Anil N. Kurup, Robert A. Lee, Matthew R. Callstrom, M. Regina Castro, Marius N. Stan, Brian T. Welch, John J. Schmitz
Summary: Thyroid nodule treatment has evolved significantly in recent years, aiming to individualize treatment based on the cause of the nodule and patient performance status. Radiofrequency ablation (RFA) has emerged as a viable therapeutic option, particularly for symptomatic benign nodules and autonomously functioning nodules. RFA is well tolerated and safe, with minimal major complications, making it an effective treatment choice for appropriate patients.
Article
Oncology
Han Xu, Ximing Wang, Chaoqun Guan, Ru Tan, Qing Yang, Qi Zhang, Aie Liu, Qingwei Liu
Summary: The objective of this research is to explore the value of whole-thyroid CT-based radiomics in predicting benign and malignant thyroid nodules. A highly efficient CT radiomic model was constructed to differentiate between the two types of nodules based on the analysis of imaging and clinical data.
FRONTIERS IN ONCOLOGY
(2022)
Review
Endocrinology & Metabolism
Julia E. Noel, Catherine F. Sinclair
Summary: Thermal ablative techniques, such as radiofrequency ablation (RFA), are increasingly used as a first-line treatment for symptomatic benign thyroid nodules. RFA allows for gradual reduction in nodule volume while preserving thyroid function.
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2023)
Article
Radiology, Nuclear Medicine & Medical Imaging
Shengyi Huang, Weizhen Cai, Shuai Han, Yu Lin, Yu Wang, Fei Chen, Guoli Shao, Yonghong Liu, Xuefei Yu, Zhai Cai, Zenan Zou, Shun Yao, Qiaohui Wang, Zhou Li
Summary: This experiment aimed to investigate the dielectric properties of different types of thyroid nodules to detect thyroid diseases at different stages. The results showed that dielectric permittivity was a more sensitive parameter than conductivity for distinguishing between normal, benign, and malignant nodules. Different disease types could be distinguished at frequencies within 20 to 70 MHz, indicating potential application prospects for the detection and diagnosis of cancer.
Review
Endocrinology & Metabolism
Ralph P. Tufano, Pia Pace-Asciak, Jonathon O. Russell, Carlos Suarez, Gregory W. Randolph, Fernando Lopez, Ashok R. Shaha, Antti Makitie, Juan P. Rodrigo, Luiz Paulo Kowalski, Mark Zafereo, Peter Angelos, Alfio Ferlito
Summary: Thermal and chemical ablation are minimally invasive procedures targeting symptomatic nodules, with Radiofrequency ablation (RFA) being one of the most widely used techniques. Surgery remains the standard of care for most thyroid cancer, while Active Surveillance (AS) can be an option for low risk disease. Minimally invasive techniques, such as RFA, are emerging as alternative options for high risk surgery patients or those seeking more active treatment approaches than AS.
FRONTIERS IN ENDOCRINOLOGY
(2021)
Article
Oncology
Nonhlanhla Chambara, Xina Lo, Tom Chi Man Chow, Carol Man Sze Lai, Shirley Yuk Wah Liu, Michael Ying
Summary: This study assessed the diagnostic value of the combination of EU TIRADS and SWE in thyroid nodules. The results showed that the combination was effective in discriminating nodules larger than 1cm, but not ideal for cytologically-equivocal nodules.
Article
Endocrinology & Metabolism
Zejian Zhang, Karli R. Reiding, Jianqiang Wu, Zepeng Li, Xiequn Xu
Summary: This study comprehensively evaluated the plasma N-glycomic changes in patients with TC or BTN for the first time, determining several N-glycan biomarkers with potential for differential diagnosis and risk assessment of lymph node metastasis. These findings enhance the understanding of TC.
FRONTIERS IN ENDOCRINOLOGY
(2021)
Article
Endocrinology & Metabolism
Bing Wang, Zheng Wan, Chen Li, Mingbo Zhang, YiLei Shi, Xin Miao, Yanbing Jian, Yukun Luo, Jing Yao, Wen Tian
Summary: The dynamic AI ultrasound intelligent auxiliary diagnosis system can effectively differentiate between benign and malignant thyroid nodules, with high sensitivity, specificity, and accuracy. It provides valuable guidance for surgeons in formulating individualized diagnosis and treatment strategies.
FRONTIERS IN ENDOCRINOLOGY
(2022)
Article
Multidisciplinary Sciences
Lin Zhong, Cong Wang
Summary: The objective of this meta-analysis study was to evaluate the accuracy of S-detect in distinguishing between malignant and benign thyroid nodules. A total of 17 studies were included, with 1595 benign nodules and 1118 malignant nodules analyzed. S-detect showed relatively high accuracy, with a pooled sensitivity of 0.87 and specificity of 0.74.
Article
Hematology
Alessandro Cattoni, Silvia Molinari, Alberto Gaiero, Paola De Lorenzo, Graziella Fichera, Benedetta Riva, Santo Di Marco, Chiara Tommesani, Eugenia Mariani, Francesco Medici, Fabio Pagni, Maria Laura Nicolosi, Donatella Fraschini, Sara Napolitano, Attilio Rovelli, Andrea Biondi, Maria Grazia Valsecchi, Adriana Balduzzi
Summary: Thyroid late effects are common after pediatric hematopoietic stem cell transplantation. While the detrimental effects of radiotherapy on the developing thyroid gland have been extensively studied, the role of chemotherapy-only conditioning regimens is still controversial. This study aimed to investigate the occurrence, monitoring, and management of thyroid function disorders, nodules, and volumetric changes over a 20-year period in a pediatric transplantation unit, and assess the impact of different conditioning regimens on thyroid health.
TRANSPLANTATION AND CELLULAR THERAPY
(2022)
Article
Nanoscience & Nanotechnology
Lu Xia, Jinjing Lu, Zhilin Chen, Xiaoyu Cui, Shuo Chen, Dongmei Pei
Summary: The study showed that utilizing blood serum SERS technique in combination with PLS-LDA method can effectively differentiate between healthy individuals and patients with thyroid nodules, as well as between benign and malignant nodules. This approach could potentially aid in more accurate diagnosis and treatment for patients with thyroid nodules.
NANOMEDICINE-NANOTECHNOLOGY BIOLOGY AND MEDICINE
(2021)
Article
Computer Science, Interdisciplinary Applications
Shi-Xuan Zhao, Yang Chen, Kai-Fu Yang, Yan Luo, Bu-Yun Ma, Yong-Jie Li
Summary: This study proposes a new local and global feature disentangled network (LoGo-Net) for classifying benign and malignant thyroid nodules. Experimental results show that the method achieves a high accuracy and has the potential for clinical application.
IEEE TRANSACTIONS ON MEDICAL IMAGING
(2022)
Article
Oncology
Rongqi Yi, Ting Li, Gang Xie, Kang Li
Summary: A DLCT-based nomogram was developed and tested for the preoperative classification of benign and malignant thyroid nodules. The nomogram showed good diagnostic performance and can serve as a simple and effective tool for individualized risk assessment and treatment decision-making.
FRONTIERS IN ONCOLOGY
(2023)
Article
Endocrinology & Metabolism
Rodis D. Paparodis, Evangelos Karvounis, Dimitra Bantouna, Charilaos Chourpiliadis, Hara Hourpiliadi, Sarantis Livadas, Shanawaz Imam, Juan C. Jaume
Summary: Thyroid nodule size should not be the only criterion for thyroidectomy. A study found that the risk of clinically significant thyroid cancer is small but present in patients with large or slowly growing nodules. Therefore, more precise preoperative evaluation is needed to determine which patients would benefit from thyroid surgery.
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2022)
Article
Urology & Nephrology
Marie-Sophie Meuleman, Sophie Guilmin-Crepon, Aurelie Hummel, Eric Daugas, Agnes Dumas, Fallou Leye, Jacques Dantal, Claire Rigothier, Francois Provot, Dominique Chauveau, Stephane Burtey, Alexandre Hertig, Karine Dahan, Antoine Durrbach, Claire Dossier, Alexandre Karras, Dominique Guerrot, Vincent Esnault, Philippe Remy, Ziad A. Massy, Isabelle Tostivint, Marie-Pascale Morin, Philippe Zaoui, Olivier Fritz, Moglie Le Quintrec, Alain Wynckel, Aurelie Bourmaud, Olivia Boyer, Dil Sahali, Corinne Alberti, Vincent Audard, Helene Mellerio
Summary: The study found that pediatric-onset frequently relapsing or steroid-dependent idiopathic nephrotic syndrome may have long-term negative impact on mental health-related quality of life in adulthood. Fatigue, which is often overlooked in routine care, plays a significant role in psychosocial well-being in these patients.
JOURNAL OF NEPHROLOGY
(2022)
Article
Pediatrics
Morgane Michel, Corinne Alberti, Jean-Claude Carel, Karine Chevreul
Summary: This study found that preterm infants with lower socioeconomic status were less likely to be born in level III maternity hospitals, had a higher risk of mortality, and were more likely to be born in unsuitable maternity hospitals. Newborns from the lowest socioeconomic status had a 40% increase in mortality compared to those from the highest socioeconomic status.
ARCHIVES OF DISEASE IN CHILDHOOD-FETAL AND NEONATAL EDITION
(2022)
Article
Pharmacology & Pharmacy
Nicolas Pages, Anissa Bounabi, Inesse Boussaha, Marietou Ndiaye, Aurelie Portefaix, Gaelle Simeon, Claire Guy, Jean Stagnara, Nathalie Paret, Thierry Vial, Pirayeh Eftekhari, Daniel Floret, Vincent Gajdos, Jean-Paul Langhendries, Nathalie Bleyzac, Corinne Alberti, Evelyne Jacqz-Aigrain, Kim An Nguyen, Behrouz Kassai, Eremi Group
Summary: This study assessed the agreement between RPC and AC in the evaluation of ADRs and found significant discrepancies, particularly in severe ADRs and drug causality.
Article
Endocrinology & Metabolism
Caroline de Gouveia Buff Passone, Gaelle Vermillac, Willem Staels, Alix Besancon, Dulanjalee Kariyawasam, Cecile Godot, Cecile Lambe, Cecile Talbotec, Muriel Girard, Christophe Chardot, Laureline Berteloot, Taymme Hachem, Alexandre Lapillonne, Amelie Poidvin, Caroline Storey, Mathieu Neve, Cosmina Stan, Emmanuelle Dugelay, Anne-Laure Fauret-Amsellem, Yline Capri, Helene Cave, Marina Ybarra, Vikash Chandra, Raphael Scharfmann, Elise Bismuth, Michel Polak, Jean Claude Carel, Benedicte Pigneur, Jacques Beltrand
Summary: This study presents the clinical management and analysis of four new cases of Mitchell-Riley syndrome (MRS), a rare genetic disorder caused by mutations in the RFX6 transcription factor gene. The study highlights the impact of these mutations on RFX6 function and discusses the multidisciplinary approach to treatment that has improved the prognosis for these patients. The findings suggest that further understanding of RFX6 function could lead to new therapeutic interventions for MRS.
FRONTIERS IN ENDOCRINOLOGY
(2022)
Article
Medicine, General & Internal
Zein Assad, Morgane Michel, Zaba Valtuille, Andrea Lazzati, Priscilla Boizeau, Fouad Madhi, Jean Gaschignard, Luu-Ly Pham, Marion Caseris, Robert Cohen, Florentia Kaguelidou, Emmanuelle Varon, Corinne Alberti, Albert Faye, Francois Angoulvant, Berengere Koehl, Naim Ouldali
Summary: This study found that the implementation of PCV13 is associated with a significant reduction in the incidence of ACS in children with SCD. This vaccine research provides new evidence for the key role of S pneumoniae in ACS and should be considered when evaluating the potential benefits of current and next-generation PCVs in children with SCD.
Article
Surgery
Marie Courbebaisse, Aurelie Bourmaud, Jean-Claude Souberbielle, Rebecca Sberro-Soussan, Valerie Moal, Yannick Le Meur, Nassim Kamar, Laetitia Albano, Antoine Thierry, Jacques Dantal, Clement Danthu, Karine Moreau, Emmanuel Morelon, Anne-Elisabeth Heng, Dominique Bertrand, Nadia Arzouk, Peggy Perrin, Marie-Pascale Morin, Philippe Rieu, Claire Presne, Philippe Grimbert, Didier Ducloux, Matthias Buchler, Moglie Le Quintrec, Nacera Ouali, Vincent Pernin, Nicolas Bouvier, Antoine Durrbach, Eric Alamartine, Christine Randoux, Virginie Besson, Marc Hazzan, Justine Pages, Sandra Colas, Marie-Liesse Piketty, Gerard Friedlander, Dominique Prie, Corinne Alberti, Eric Thervet
Summary: Vitamin D sufficiency is associated with reduced risk of complications such as fractures, diabetes, cardiovascular events, and cancers after renal transplantation. However, a study called VITALE found that high-dose cholecalciferol supplementation does not reduce extraskeletal complications in kidney transplant recipients.
AMERICAN JOURNAL OF TRANSPLANTATION
(2023)
Article
Genetics & Heredity
Apolline Imbard, Artemis Toumazi, Sophie Magreault, Nuria Garcia-Segarra, Dimitri Schlemmer, Florentia Kaguelidou, Isabelle Perronneau, Jeremie Haignere, Helene Ogier de Baulny, Alice Kuster, Francois Feillet, Corinne Alberti, Sophie Guilmin-Crepon, Jean-Francois Benoist, Manuel Schiff
Summary: This study suggests that increasing betaine dosage higher than 100 mg/kg/day does not lower tHcy concentrations in pnrCBS and cblC deficiencies. However, increasing betaine up to 250 mg/kg/d could benefit cblC patients through the increase of methionine and SAM concentrations, as low Met and SAM concentrations are involved in the pathophysiology of this disease. In contrast, in pnrCBS deficiency, betaine doses higher than 100 mg/kg/day could be harmful to these patients with pre-existing hypermethioninemia.
ORPHANET JOURNAL OF RARE DISEASES
(2022)
Article
Pediatrics
Margaux Laulhe, Cecile Dumaine, Didier Chevenne, Fallou Leye, Albert Faye, Blandine Dozieres, Marion Strullu, Jerome Viala, Julien Hogan, Veronique Houdouin, Juliane Leger, Dominique Simon, Jean-Claude Carel, Caroline Storey, Sophie Guilmin-Crepon, Laetitia Martinerie
Summary: Morning cortisol values can predict the results of the Low Dose Short Synacthen Test (LD-SST) for glucocorticoid-induced adrenal insufficiency, providing a convenient tool for diagnosis.
FRONTIERS IN PEDIATRICS
(2022)
Editorial Material
Obstetrics & Gynecology
Mary E. Norton
OBSTETRICAL & GYNECOLOGICAL SURVEY
(2023)
Article
Health Care Sciences & Services
Philippe Martin, Boris Chapoton, Aurelie Bourmaud, Agnes Dumas, Joelle Kivits, Clara Eyraud, Capucine Dubois, Corinne Alberti, Enora Le Roux
Summary: This study aims to collect and describe proposals for delivering health promotion through existing web-based community games among young people. It found that integrating health promotion interventions into existing web-based community games can improve the health and well-being of young people.
JMIR SERIOUS GAMES
(2023)
Article
Multidisciplinary Sciences
Maeva Cotinat, Isabelle Boquet, Moreno Ursino, Cecile Brocard, Elisabeth Jouve, Corinne Alberti, Laurent Bensoussan, Jean-Michel Viton, Frederic Brocard, Olivier Blin
Summary: This clinical trial aims to assess the safety and efficacy of riluzole in reducing spasticity in patients with chronic spinal cord injury. Through a double-blind randomized trial, the impact of riluzole on spasticity will be observed and its safety and pharmacokinetics will be evaluated. This study is the first to systematically investigate the effectiveness of riluzole in reducing spasticity in patients with chronic spinal cord injury.
Article
Critical Care Medicine
Emmanuel Pardo, Thomas Lescot, Jean-Charles Preiser, Pablo Massanet, Antoine Pons, Samir Jaber, Vincent Fraipont, Eric Levesque, Carole Ichai, Laurent Petit, Fabienne Tamion, Garry Taverny, Priscilla Boizeau, Corinne Alberti, Jean-Michel Constantin, Marie-Pierre Bonnet
Summary: This study investigated nutrition practices in the intensive care unit (ICU) and explored the association between early nutrition support (<48 h) in the ICU and patient mortality at day 28 (D28). The results showed that early nutrition support in the ICU was significantly associated with increased mortality at D28, particularly in younger patients with less severe disease. Only early enteral nutrition was found to be associated with increased mortality, contrasting with current guidelines.
Article
Medicine, General & Internal
Thomas Schmitz, Muriel Doret-Dion, Loic Sentilhes, Olivier Parant, Olivier Claris, Laurent Renesme, Julie Abbal, Aude Girault, Heloise Torchin, Marie Houllier, Nolwenn Le Sache, Alexandre J. Vivanti, Daniele De Luca, Norbert Winer, Cyril Flamant, Claire Thuillier, Pascal Boileau, Julie Blanc, Veronique Brevaut, Pierre-Emmanuel Bouet, Geraldine Gascoin, Gael Beucher, Valerie Datin-Dorriere, Stephane Bounan, Pascal Bolot, Christophe Poncelet, Corinne Alberti, Moreno Ursino, Camille Aupiais, Olivier Baud
Summary: Comparison between a full dose and a half dose of antenatal betamethasone for preterm delivery showed that the half dose was not non-inferior to the full dose in terms of preventing respiratory distress syndrome. Therefore, reducing the dose of antenatal betamethasone is not recommended.
Article
Genetics & Heredity
Elodie Fiot, Bertille Alauze, Bruno Donadille, Dinane Samara-Boustani, Muriel Houang, Gianpaolo De Filippo, Anne Bachelot, Clemence Delcour, Constance Beyler, Emilie Bois, Emmanuelle Bourrat, Emmanuel Bui Quoc, Nathalie Bourcigaux, Catherine Chaussain, Ariel Cohen, Martine Cohen-Solal, Sabrina Da Costa, Claire Dossier, Stephane Ederhy, Monique Elmaleh, Laurence Iserin, Helene Lengline, Armelle Poujol-Robert, Dominique Roulot, Jerome Viala, Frederique Albarel, Elise Bismuth, Valerie Bernard, Claire Bouvattier, Aude Brac, Patricia Bretones, Nathalie Chabbert-Buffet, Philippe Chanson, Regis Coutant, Marguerite de Warren, Beatrice Demaret, Lise Duranteau, Florence Eustache, Lydie Gautheret, Georges Gelwane, Claire Gourbesville, Mickael Grynberg, Karinne Gueniche, Carina Jorgensen, Veronique Kerlan, Charlotte Lebrun, Christine Lefevre, Francoise Lorenzini, Sylvie Manouvrier, Catherine Pienkowski, Rachel Reynaud, Yves Reznik, Jean-Pierre Siffroi, Anne-Claude Tabet, Maithe Tauber, Vanessa Vautier, Igor Tauveron, Sebastien Wambre, Delphine Zenaty, Irene Netchine, Michel Polak, Philippe Touraine, Jean-Claude Carel, Sophie Christin-Maitre, Juliane Leger
Summary: Turner syndrome is a rare condition characterized by the absence of all or part of one X chromosome in some or all cells. It affects female growth and gonadal development and is associated with an increased risk of various congenital and acquired diseases. The French National Diagnosis and Care Protocol aims to provide optimal management and care for patients with Turner syndrome.
ORPHANET JOURNAL OF RARE DISEASES
(2022)
Article
Pediatrics
Helene Mellerio, Agnes Dumas, Corinne Alberti, Sophie Guilmin-Crepon, Margaux Gastaldi, Loic Passini, Celine Gabarro, Maxime Morsa, Enora Le Roux, Paul Jacquin
Summary: This study assessed the value of transition preparation consultations (TPC) for adolescents with chronic conditions and healthcare providers. TPCs included face-to-face interviews and questionnaires, and the results showed that TPCs were valuable in helping adolescents reflect on their future and customize their transition preparation.
EUROPEAN JOURNAL OF PEDIATRICS
(2022)
