Article
Clinical Neurology
Rupa G. Juthani, Anne S. Reiner, Ankur R. Patel, Aimee Cowan, Marie Roguski, Katherine S. Panageas, Eliza B. Geer, Sasan Karimi, Marc A. Cohen, Viviane Tabar
Summary: The study evaluated the safety and efficacy of iMRI for pituitary adenoma resection, comparing endoscopic transsphenoidal and microscopic transsphenoidal approaches. Results showed that iMRI can improve the extent of resection for pituitary adenomas while preserving hormone function, with low rates of postoperative complications.
JOURNAL OF NEUROSURGERY
(2021)
Article
Pediatrics
Julio Fernandez-Mendoza, Kristina P. Lenker, Susan L. Calhoun, Myra Qureshi, Anna Ricci, Elizaveta Bourchtein, Fan He, Alexandros N. Vgontzas, Jiangang Liao, Duanping Liao, Edward O. Bixler
Summary: This study examines the developmental trajectories of insomnia symptoms in childhood, their evolution into adult insomnia, and the role of objective sleep duration in this transition. The study finds that a high proportion of children with insomnia symptoms experience persistent symptoms into adulthood, and short sleep duration in childhood and adolescence increases the likelihood of worsening into adult insomnia. Early sleep interventions are crucial, and objective sleep measures may be clinically useful during adolescence.
Article
Multidisciplinary Sciences
Amanda J. Wright, Joshua J. Jackson
Summary: There has been ongoing debate on whether temperament and personality are distinct individual differences or two sides of the same coin. By examining the joint and incremental predictive validity of temperament and personality in individuals over time, this study found instances where temperament provided additional validity beyond adult personality. These findings highlight the need for a lifespan approach to fully understand life outcomes.
SCIENTIFIC REPORTS
(2022)
Article
Neurosciences
Kathryn L. Mills, Kimberly D. Siegmund, Christian K. Tamnes, Lia Ferschmann, Lara M. Wierenga, Marieke G. N. Bos, Beatriz Luna, Chun Li, Megan M. Herting
Summary: This study examined individual variability and sex differences in changes in brain structure across ages 8.0-26.0 years. Results showed considerable inter-individual variability in brain measures, with most individuals demonstrating decreases in certain areas during mid-adolescence. There were also sex differences in these patterns and an association between brain structure size and rate of change.
Article
Clinical Neurology
Mendel Castle-Kirszbaum, Yi Yuen Wang, James King, Tony Goldschlager
Summary: Surgery for pituitary adenoma is effective for relieving mass effect and controlling endocrinopathy. Preoperative factors can predict the outcome of endocrine function and visual improvement after surgery, with most patients maintaining normal endocrine function postoperatively if it was normal preoperatively. Surgery is a safe and effective therapy for pituitary adenomas, with nearly all patients experiencing improvement in visual fields.
NEUROSURGICAL REVIEW
(2022)
Article
Psychology, Developmental
Ann H. Farrell, Tracy Vaillancourt
Summary: This study explored the long-term outcomes of childhood bullying perpetration using a person-centered approach. The majority of individuals followed a low stable trajectory of bullying in childhood, while in young adulthood, most participants showed a prosocial multi-trajectory profile. Fewer individuals exhibited below average antisocial or above average antisocial profiles. Individuals with moderate bullying trajectory in childhood were more likely to exhibit above average antisocial profile in young adulthood, highlighting the importance of preventing childhood bullying to avoid antisocial behavior in later life.
JOURNAL OF YOUTH AND ADOLESCENCE
(2021)
Review
Endocrinology & Metabolism
Jiahong Sun, Bo Xi, Lili Yang, Min Zhao, Markus Juonala, Costan G. Magnussen
Summary: The study found that individuals who were obese in childhood but had normal weight in adulthood did not have a tendency to develop cardiovascular disease risk factors in adulthood, while those who were obese in adulthood or both periods had a higher likelihood of developing cardiovascular disease risk factors.
Article
Engineering, Environmental
Anran Cai, Sylvie Remy, Virissa Lenters, Bianca Cox, Greet Schoeters, Adrian Covaci, Roel Vermeulen, Lutzen Portengen
Summary: Childhood exposure to endocrine-disrupting chemicals (EDCs) may affect metabolic outcomes. Our study found associations between certain chemicals and body mass index, abdominal obesity, total cholesterol, and triglycerides. Further investigation is needed for sex-specific effects.
ENVIRONMENTAL SCIENCE & TECHNOLOGY
(2023)
Article
Psychology, Developmental
C. Bulhoes, E. Ramos, M. Severo, S. Dias, H. Barros
Summary: This study identified three trajectory classes of depressive symptoms from adolescence to young adulthood, with higher levels of symptoms associated with worse social and health outcomes. The risk of depressive symptoms in adulthood is likely to be early determined in adolescence.
EUROPEAN CHILD & ADOLESCENT PSYCHIATRY
(2021)
Article
Endocrinology & Metabolism
Kunzhe Lin, Jianping Zhang, Yinghong Lin, Zhijie Pei, Shousen Wang
Summary: This study investigated the metabolic differences between invasive and non-invasive NFPAs and found distinct metabolite profiles. It also confirmed the high expression of the M2 macrophage marker in invasive NFPAs.
FRONTIERS IN ENDOCRINOLOGY
(2022)
Article
Psychology, Clinical
Neeltje E. Blankenstein, Mark de Rooij, Joost van Ginkel, Tom F. Wilderjans, Esther L. de Ruigh, Helena C. Oldenhof, Josjan Zijlmans, Tijs Jambroes, Evelien Platje, Marjan de Vries-Bouw, Susan Branje, Wim H. J. Meeus, Robert R. J. M. Vermeiren, Arne Popma, Lucres M. C. Jansen
Summary: Across adolescence and young adulthood, individuals with antisocial behaviors are at risk for various problems. This study examined the relationship between different dimensions of antisociality and neurobiological measures, such as heart rate, pre-ejection period (PEP), respiratory sinus arrhythmia, respiration rate, skin conductance levels, testosterone, basal cortisol, and the cortisol awakening response (CAR). Three dimensions of antisociality were identified: 'callous-unemotional (CU)/manipulative traits', 'intentional aggression/conduct', and 'reactivity/impulsivity/irritability'. Shorter PEP and higher testosterone were associated with CU/manipulative traits, and a higher CAR was related to both CU/manipulative traits and intentional aggression/conduct. These effects were consistent across age.
PSYCHOLOGICAL MEDICINE
(2023)
Article
Cardiac & Cardiovascular Systems
Majid Valizadeh, Erfan Tasdighi, Maryam Barzin, Ramyar Hariri, Maryam Mahdavi, Pooneh Dehghan, Amin Momeni Moghaddam, Fereidoun Azizi, Farhad Hosseinpanah
Summary: This study investigated the association of MetS and metabolic phenotypes with a high CIMT in early adulthood. The results showed that the presence of MetS and certain metabolic phenotypes were associated with an increased risk of high CIMT.
INTERNATIONAL JOURNAL OF CARDIOLOGY
(2022)
Review
Endocrinology & Metabolism
Adi Horesh, Avishai M. Tsur, Aya Bardugo, Gilad Twig
Summary: This review summarizes the association between childhood and adolescent obesity and early-onset adverse outcomes in adulthood, emphasizing the increased risks of diabetes, cancer, and cardiometabolic outcomes in midlife. While there is mixed scientific literature regarding the independent risk of illness attributed to childhood BMI regardless of adult BMI, additional data is required to establish causality between the two.
CURRENT OBESITY REPORTS
(2021)
Article
Multidisciplinary Sciences
Margit Averdijk, Denis Ribeaud, Manuel Eisner
Summary: This study examined the relationship between early external childcare and development from age 7 to 20. The findings showed that time spent in a daycare center was associated with increased externalizing and internalizing problems, whereas external family care was related to increased prosocial behavior. Additionally, children from vulnerable backgrounds who spent time in a daycare center were more likely to experience decreased externalizing problems but increased internalizing problems and substance use, even until age 20.
Article
Clinical Neurology
Kihwan Hwang, Yong Hwy Kim, Jung Hee Kim, Jung Hyun Lee, Hee Kyung Yang, Jeong-Min Hwang, Chae-Yong Kim, Jung Ho Han
Summary: The study on the natural history of asymptomatic nonfunctioning pituitary adenomas (NFPAs) with optic nerve compression showed that close follow-up and timely surgical intervention can effectively prevent visual and endocrine issues for cases with optic nerve compression, and conservative management is also acceptable for these tumors. Careful follow-up is necessary for tumors with cavernous sinus invasion.
JOURNAL OF NEUROSURGERY
(2021)
Article
Clinical Neurology
Michael Amoo, Daniel Rawluk, Rory Mcconn-Walsh, Mohsen Javadpour
Summary: We report a case of spontaneous 79% regression in the size of a vestibular schwannoma, which is the highest relative spontaneous regression recorded in the literature for vestibular schwannoma of this size.
BRITISH JOURNAL OF NEUROSURGERY
(2023)
Article
Clinical Neurology
Ronan J. Doherty, Daragh Moneley, Paul Brennan, Mohsen Javadpour
Summary: This case involves a 41-year-old male patient with an enlarging aneurysm neck one year after clipping. He underwent an IMAX-MCA bypass followed by endovascular coil occlusion, representing the first documented IMAX-MCA bypass from a European centre. Experienced neurosurgeons can safely perform IMAX-MCA bypass as long as attention is paid to anatomical landmarks and vascular anastomosis principles, with the use of CTA-based neuronavigation and micro-Doppler for identifying the IMAX.
BRITISH JOURNAL OF NEUROSURGERY
(2022)
Review
Endocrinology & Metabolism
Reuben M. Reed, Sarah J. Nevitt, Graham J. Kemp, Daniel J. Cuthbertson, Martin B. Whyte, Louise M. Goff
Summary: The study found that among populations of black African ancestry, lower visceral fat was observed despite their higher risk for type 2 diabetes. Differences in other ectopic fat depots like intrahepatic and intramyocellular lipid were found between black African ancestry populations and other ethnicities. Specifically, intrahepatic lipid was lower in black African ancestry populations compared to white European, Hispanic, and South Asian ancestry groups.
ACTA DIABETOLOGICA
(2022)
Article
Oncology
Timothy A. Ritzmann, Rebecca J. Chapman, John-Paul Kilday, Nicola Thorp, Piergiorgio Modena, Robert A. Dineen, Donald Macarthur, Conor Mallucci, Timothy Jaspan, Kristian W. Pajtler, Marzia Giagnacovo, Thomas S. Jacques, Simon M. L. Paine, David W. Ellison, Eric Bouffet, Richard G. Grundy
Summary: This study reviewed 12 years of data to evaluate treatment strategies and survival rates in children with ependymoma. Patients who underwent gross total resection had the best prognosis, while those with subtotal resection responded well to VEC chemotherapy. Biomarkers associated with poorer survival included 1q gain, H3K27me3 loss, and hTERT expression.
Review
Clinical Neurology
Michael Amoo, Jack Henry, Philip J. O'Halloran, Paul Brennan, Mohammed Ben Husien, Matthew Campbell, John Caird, Mohsen Javadpour, Gerard F. Curley
Summary: S100B showed optimal sensitivity and specificity at a threshold of 0.72 μg/L, while GFAP demonstrated 71% sensitivity and specificity at 626 pg/mL, with sensitivity peaking at 93% at 22 pg/mL. Further investigation is needed to explore the potential advantages of GFAP in the screening of mild TBI.
NEUROSURGICAL REVIEW
(2022)
Article
Endocrinology & Metabolism
Tom Waddell, Alexandre Bagur, Diogo Cunha, Helena Thomaides-Brears, Rajarshi Banerjee, Daniel J. Cuthbertson, Emily Brown, Kenneth Cusi, Jean-Pierre Despres, Michael Brady
Summary: This study used multiparametric MRI to assess differences in visceral adiposity, ectopic fat accumulation, body composition, and relevant biomarkers between individuals with and without type 2 diabetes (T2D). The results showed that participants with T2D had significantly higher liver fat and fibroinflammation than those without T2D, despite normal liver biochemistry. Additionally, participants with T2D had lower skeletal muscle index and high-density lipoprotein cholesterol levels.
Editorial Material
Clinical Neurology
Hilary Humphreys, Binu Dinesh, Stephen MacNally, Mohsen Javadpour
BRITISH JOURNAL OF NEUROSURGERY
(2022)
Letter
Critical Care Medicine
Mohsen Javadpour, Michael Amoo, David P. O'Brien, Donncha F. O'Brien, Pierce Geoghegan, Ger Curley
INJURY-INTERNATIONAL JOURNAL OF THE CARE OF THE INJURED
(2023)
News Item
Clinical Neurology
Jack Henry, Michael Amoo, Matthew T. Crockett, Mohsen Javadpour
WORLD NEUROSURGERY
(2023)
Article
Oncology
Michael Amoo, Jack Henry, Michael Farrell, Mohsen Javadpour
Summary: Meningiomas are the most common primary brain tumors, accounting for 40% of all cases. The incidence of meningioma increases with age and is higher in older patients. Most of the increase in cases is due to incidental and asymptomatic diagnoses, which have a low risk of progression in the elderly. Surgery is the first-line treatment for symptomatic cases, but radiotherapy can be considered when surgery is not possible or as adjuvant therapy. The role of radiotherapy in cases of gross total resection of atypical meningioma is unclear and needs further evaluation. Older patients have a higher risk of complications, so management decisions need to be tailored to individual circumstances to achieve good outcomes.
NEURO-ONCOLOGY ADVANCES
(2023)
Article
Clinical Neurology
Cathal John Hannan, Bharti Kewlani, Steven Browne, Mohsen Javadpour
Summary: This study reviewed a large series of endoscopic skull base cases and found that the adoption of a standardized multi-layer repair technique significantly reduced the post-operative CSF leak rate, without the use of nasal packing or lumbar drains.
ACTA NEUROCHIRURGICA
(2023)
Article
Clinical Neurology
Jack Henry, Michael Amoo, Mohamed O. Dablouk, Paula Corr, Deirdre Nolan, Deirdre Coffey, Mohsen Javadpour
Summary: The study examined the incidence and risk factors of spontaneous subarachnoid hemorrhage (SAH) in a nationally representative sample. Smoking, hypertension, increasing age, and female sex were identified as risk factors. Smoking had the strongest association with SAH, and there was a synergistic interaction between smoking and hypertension in increasing the risk of SAH.
ACTA NEUROCHIRURGICA
(2023)
Review
Clinical Neurology
Ronan J. Doherty, Jack Henry, David Brennan, Mohsen Javadpour
Summary: Rebleeding before intervention in aneurysmal subarachnoid hemorrhage (aSAH) can be caused by various factors, such as increased systolic blood pressure, poorer clinical grades, and higher radiological grades. Awareness of these potential risk factors is crucial for evaluating patients and ensuring timely management.
NEUROSURGICAL REVIEW
(2022)
Review
Clinical Neurology
Divya Elizabeth Sunny, Michael Amoo, Maryam Al Breiki, Elite Dong Wen Teng, Jack Henry, Mohsen Javadpour
Summary: Incidental findings are common in brain MRI, especially vascular abnormalities and neoplastic abnormalities. These incidental findings may result in substantial resource expenditure and patient anxiety but are often of little clinical significance.
ACTA NEUROCHIRURGICA
(2022)
Review
Clinical Neurology
Conor Brosnan, Michael Amoo, Mohsen Javadpour
Summary: This systematic review evaluated the role of preoperative embolisation in the treatment of brain arteriovenous malformations (bAVMs). The existing studies assessing this intervention were of poor quality, and there was insufficient evidence to recommend preoperative embolisation of bAVMs based on the published literature.
NEUROSURGICAL REVIEW
(2022)