Article
Medicine, General & Internal
Maria Bouam, Christine Binquet, Florian Moretto, Thibault Sixt, Michele Vourc'h, Lionel Piroth, Patrick Ray, Mathieu Blot
Summary: This study aimed to investigate whether a delayed diagnosis of community-acquired pneumonia (CAP) in the emergency department (ED) is associated with worse outcome. The results showed that a delayed diagnosis was associated with a less severe clinical presentation, the absence of obvious signs of pneumonia on chest X-ray, and delayed antibiotic initiation, but was not associated with in-hospital mortality.
FRONTIERS IN MEDICINE
(2023)
Article
Infectious Diseases
Morten Hjarno Lorentzen, Flemming Schonning Rosenvinge, Annmarie Touborg Lassen, Ole Graumann, Christian B. Laursen, Christian Backer Mogensen, Helene Skjot-Arkil
Summary: This study aimed to describe the empirical antibiotic treatment of CAP patients and determine the coverage against LMC. The most commonly prescribed empirical treatments for CAP were piperacillin-tazobactam and Beta-lactamase sensitive penicillins. The empirical antibiotic treatment accuracy for LMC pneumonia was relatively low.
BMC INFECTIOUS DISEASES
(2023)
Article
Oncology
Rongmeng Jiang, Bing Han, Chang Dou, Fei Zhou, Bin Cao, Xingwang Li
Summary: The rationale for antibiotic treatment of viral community-acquired pneumonia in adults was analyzed, revealing a high rate of unreasonable antibiotic use, highlighting the need for clinicians to reduce unnecessary antibiotic use.
FRONTIERS OF MEDICINE
(2021)
Article
Emergency Medicine
Anthony J. Renzoni, Gary D. Peksa, Joshua M. DeMott
Summary: A study of 116 emergency department patients found that conducting MRSA nasal screening for pneumonia patients did not decrease the duration of anti-MRSA antibiotics. Secondary outcomes showed no significant differences either. Therefore, there is currently no need for ED providers to consider MRSA nasal screening for patients admitted to general medicine.
AMERICAN JOURNAL OF EMERGENCY MEDICINE
(2021)
Article
Immunology
Valerie M. Vaughn, Tejal N. Gandhi, Timothy P. Hofer, Lindsay A. Petty, Anurag N. Malani, Danielle Osterholzer, Lisa E. Dumkow, David Ratz, Jennifer K. Horowitz, Elizabeth S. McLaughlin, Tawny Czilok, Scott A. Flanders
Summary: In a 3-year quality improvement initiative, it was found that the appropriate use of 5-day antibiotic treatment for uncomplicated community-acquired pneumonia increased to 43.9% over time, resulting in a decrease in adverse events.
CLINICAL INFECTIOUS DISEASES
(2022)
Review
Immunology
Ilari Kuitunen, Johanna Jaaskelainen, Matti Korppi, Marjo Renko
Summary: Based on a meta-analysis of 4 randomized controlled studies, it was found that short antibiotic treatment (3-5 days) was as effective and safe as longer treatment (7-10 days) for community-acquired pneumonia in children in high-income countries.
CLINICAL INFECTIOUS DISEASES
(2023)
Article
Medicine, General & Internal
J. du Fay de Lavallaz, P. Badertscher, T. Zimmermann, T. Nestelberger, J. Walter, I Strebel, C. Coelho, O. Miro, E. Salgado, M. Christ, N. Geigy, L. Cullen, M. Than, F. Javier Martin-Sanchez, S. Di Somma, W. Frank Peacock, B. Morawiec, D. Wussler, D. Keller, D. Gualandro, E. Michou, M. Kuehne, J. Lohrmann, T. Reichlin, C. Mueller
Summary: The study demonstrates that ESCJ including a standardized syncope-specific CRF has very high diagnostic accuracy for cardiac syncope, outperforming the EGSYS score, hs-cTnI and BNP. Additionally, biomarkers significantly improve diagnostic accuracy when used in conjunction with ESCJ.
JOURNAL OF INTERNAL MEDICINE
(2021)
Article
Infectious Diseases
Lauren Puzz, Emily A. Plauche, David A. Cretella, Virginia A. Harrison, Mary Joyce B. Wingler
Summary: This study evaluated the impact of an antimicrobial stewardship intervention on antibiotic prescribing in pediatric patients admitted for community-acquired pneumonia. The intervention resulted in improved antibiotic selection and duration, providing valuable data for further education of providers.
Article
Pharmacology & Pharmacy
S. N. Bahcecioglu, N. Kokturk, A. Baha, D. Yapar, F. N. B. Aksakal, C. Gunduz, S. Tasbakan, A. Sayiner, A. S. Coskun, F. Yaman, A. Cilli, B. Celenk, O. Kilinc, S. S. Mersin, A. Hazar, F. Tokgoz
Summary: The study aimed to investigate the diagnostic value of adding oxygenation parameters to CURB-65 in predicting mortality in CAP patients. It was found that using CURBS-65 scoring instead of CURB-65 scoring may be more useful in predicting mortality.
EUROPEAN REVIEW FOR MEDICAL AND PHARMACOLOGICAL SCIENCES
(2023)
Article
Infectious Diseases
Markus Fally, Emma Diernaes, Simone Israelsen, Britta Tarp, Thomas Benfield, Lilian Kolte, Pernille Ravn
Summary: The stewardship program significantly reduced overall antibiotic exposure and increased the proportion of patients treated with recommended antibiotics, without a significant reduction in exposure to intravenous antibiotics.
INTERNATIONAL JOURNAL OF INFECTIOUS DISEASES
(2021)
Article
Microbiology
Dariusz Kawecki, Anna Majewska, Jaroslaw Czerwinski
Summary: This is a single-centre observational study of adult patients with severe pneumonia requiring hospitalization conducted at the emergency department. The study found that the average length of hospitalization for these patients was 15.8 days, and the majority of patients received treatment with beta-lactam antibiotics. Among the patients who died, the average age was 79 years.
Article
Emergency Medicine
Monique Payne-Cardona, Valerie A. San Luis, Roshanak Aazami, Mira Dermendjieva, Melissa Erin, Jason Kirkwood, Christopher Tong, Gregory Marks, Ethan A. Smith, Sam S. Torbati, James F. Gilmore
Summary: The study showed that expanding the scope of emergency medicine pharmacists significantly reduced major delays in subsequent antibiotic administration for emergency department patients, leading to a decreased incidence of in-hospital mortality.
AMERICAN JOURNAL OF EMERGENCY MEDICINE
(2021)
Article
Infectious Diseases
Benjamin Schleenvoigt, Juliane Ankert, Grit Barten-Neiner, Florian Voit, Norbert Suttorp, Christoph Boesecke, Christian Hoffmann, Daiana Stolz, Mathias Pletz, Gernot Rohde, Martin Witzenrath, Marcus Panning, Andreas Essig, Jan Rupp, Olaf Degen, Christoph Stephan, M. Dreher
Summary: The objective of this study was to identify the pathogen spectrum of community acquired pneumonia in people living with HIV (PLWH), and to compare it with a matched HIV negative group in order to reassess therapeutic strategies for PLWH. The study used various methods to identify pathogens, and found that pneumococci were the most common pathogen among both PLWH and controls. The mortality rate was higher for PLWH compared to controls.
Article
Microbiology
Nathaniel J. Rhodes, Caroline C. Jozefczyk, W. Justin Moore, Paul R. Yarnold, Karolina Harkabuz, Robert Maxwell, Sarah H. Sutton, Christina Silkaitis, Chao Qi, Richard G. Wunderink, Teresa R. Zembower
Summary: This study developed and tested clinical decision rules for identifying Clostridioides difficile infection (CDI) risk in hospitalized patients with community-acquired pneumonia (CAP). Findings showed that antibiotic use increased the risk of CDI in this patient population, highlighting the importance of antibiotic stewardship.
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY
(2021)
Article
Medicine, General & Internal
Hung Do Tran, Yen Thi Bach Nguyen, Trung Thanh Tran, Trang Thi Thu Le, Ha Thi Thu Nguyen, Chau Minh Nguyen, Hop Thi Bach Le, Tham Thi Ngoc Phan, Tuyen Thi Thanh Vo, Hieu Thi Ngoc Bui, Vi Tuong Mai, Navy Yong, Thang Nguyen, Hung Gia Tran
Summary: Due to the overuse of antibiotics and regional variation in disease factors, community-acquired pneumonia (CAP) has a relatively high morbidity and mortality rate. This study investigated the prevalence of bacteria causing CAP and their antibiotic resistance. The results showed that Streptococcus pneumoniae was the leading cause, with the age group of 60s being the most affected and showing increased resistance to certain antibiotics.
Article
Health Care Sciences & Services
Oscar Miro, Miguel Benito-Lozano, Pedro Lopez-Ayala, Sergio Rodriguez, Pere Llorens, Ana Yufera-Sanchez, Javier Jacob, Lissete Traveria, Ivo Strebel, Victor Gil, Josep Tost, Maria de los Angeles Lopez-Hernandez, Aitor Alquezar-Arbe, Begona Espinosa, Christian Mueller, Guillermo Burillo-Putze
Summary: The study found that there is a relationship between ambient temperature and atmospheric pressure with the severity of heart failure decompensations. Temperature and AP are independently associated with the need for hospitalization and in-hospital mortality, with possible different effects.
JOURNAL OF GENERAL INTERNAL MEDICINE
(2023)
Article
Endocrinology & Metabolism
Clara O. O. Sailer, Jill M. Kuehne, Ismael da Conceicao, Julie Refardt, Mirjam Christ-Crain, Bettina Winzeler
Summary: This study found no difference in HPA axis activity between patients with primary polydipsia and healthy controls, but there was a significant difference in salivary cortisol levels, which may be attributed to a dilution effect in saliva.
CLINICAL ENDOCRINOLOGY
(2023)
Review
Cardiac & Cardiovascular Systems
Oriol Aguilo, Xavier Castells, Oscar Miro, Christian Mueller, Ovidiu Chioncel, Joan Carles Trullas
Summary: This study aimed to conduct a meta-analysis on prospective studies to assess the relationship between bundle branch block (BBB) or wide QRS and the risk of all-cause mortality in patients with acute heart failure (AHF). The findings indicate a significant increase in the risk of all-cause mortality among patients with wide QRS, regardless of the type of BBB (left or right).
CLINICAL RESEARCH IN CARDIOLOGY
(2023)
Article
Biotechnology & Applied Microbiology
Melissa Amrein, Stephanie Meier, Ibrahim Schafer, Sabine Schaedelin, Eline Willemse, Pascal Benkert, Joan Walter, Christian Puelacher, Tobias Zimmermann, Daniela Median, Caroline Egli, David Leppert, Raphael Twerenbold, Michael Zellweger, Jens Kuhle, Christian Mueller
Summary: sNfL concentration is not a reliable diagnostic biomarker for fCAD, but it can predict adverse cardiovascular outcomes, including all-cause death, cardiovascular death, and stroke/TIA.
Article
Cardiac & Cardiovascular Systems
Christian Puelacher, Danielle M. Gualandro, Noemi Glarner, Giovanna Lurati Buse, Andreas Lampart, Daniel Bolliger, Luzius A. Steiner, Mario Grossenbacher, Katrin Burri-Winkler, Hatice Gerhard, Elisabeth A. Kappos, Olivier Clerc, Laura Biner, Zaza Zivzivadze, Christoph Kindler, Angelika Hammerer-Lercher, Miodrag Filipovic, Martin Clauss, Lorenz Gurke, Thomas Wolff, Edin Mujagic, Murat Bilici, Francisco A. Cardozo, Stefan Osswald, Bruno Caramelli, Christian Mueller
Summary: Perioperative myocardial infarction/injury (PMI) following non-cardiac surgery is a common cardiac complication. This study found that the etiologies of PMIs include both extra-cardiac diseases and cardiac diseases, and the outcomes vary greatly according to these etiologies. Most PMIs have high rates of major adverse cardiac events (MACE) and all-cause death at 1 year, indicating the urgent need for more intensive treatments.
EUROPEAN HEART JOURNAL
(2023)
Article
Physiology
Johanna Sieland, Daniel Niederer, Tobias Engeroff, Lutz Vogt, Christian Troidl, Thomas Schmitz-Rixen, Winfried Banzer, Kerstin Troidl
Summary: The acute effects of aerobic walking and anaerobic walking on miRNA parameters related to vascular collateral formation were compared in patients with peripheral arterial disease. The study found that moderate-intensity walking was more suitable for inducing changes in blood flow and miRNA in patients with peripheral arterial disease than vigorous exercise.
EUROPEAN JOURNAL OF APPLIED PHYSIOLOGY
(2023)
Article
Cardiac & Cardiovascular Systems
Eleni Michou, Desiree Wussler, Maria Belkin, Cornelia Simmen, Ivo Strebel, Albina Nowak, Nikola Kozhuharov, Samyut Shrestha, Pedro Lopez-Ayala, Zaid Sabti, Constantin Mork, Matthias Diebold, Tiffany Pequignot, Katharina Rentsch, Arnold von Eckardstein, Danielle M. Gualandro, Tobias Breidthardt, Christian Mueller
Summary: We assessed the role of systemic inflammation in the pathophysiology, phenotyping, and risk stratification of patients with acute heart failure (AHF) using a novel Interleukin-6 immunoassay. The study found that systemic inflammation levels were associated with the type of heart failure and risk of death.
EUROPEAN JOURNAL OF HEART FAILURE
(2023)
Article
Endocrinology & Metabolism
Sophie Monnerat, Cihan Atila, Julie Refardt, Mirjam Christ-Crain
Summary: This retrospective analysis found no significant difference in the prevalence of hyponatremia between patients with type 2 diabetes treated with SGLT2 inhibitors and those without.
JOURNAL OF THE ENDOCRINE SOCIETY
(2023)
Article
Medical Laboratory Technology
Flavia K. Borges, Emmanuelle Duceppe, Diane Heels-Ansdell, Ameen Patel, Daniel Sessler, Vikas Tandon, Matthew Chan, Rupert Pearse, Sadeesh Srinathan, Amit X. Garg, Robert J. Sapsford, Sandra N. Ofori, Maura Marcucci, Peter A. Kavsak, Shirley Pettit, Jessica Spence, Emilie Belley-Cote, Michael McGillion, Richard Whitlock, Andre Lamy, David Conen, Sabu Thomas, Christian Mueller, Allan S. Jaffe, P. J. Devereaux
Summary: By measuring high-sensitivity troponin I (hsTnI) levels, we identified the thresholds associated with major adverse cardiovascular events (MACE) within 30 days after non-cardiac surgery. The results showed that hsTnI levels of 75 ng/L and above were significantly associated with an increased risk of MACE.
CLINICAL CHEMISTRY
(2023)
Article
Cardiac & Cardiovascular Systems
Laila Widmann, Stanislav Keranov, Leili Jafari, Christoph Liebetrau, Till Keller, Christian Troidl, Steffen Kriechbaum, Sandra Voss, Mani Arsalan, Manuel J. J. Richter, Khodr Tello, Henning Gall, Hossein A. A. Ghofrani, Stefan Guth, Werner Seeger, Christian W. W. Hamm, Oliver Doerr, Holger Nef
Summary: This study investigated the role of fibroblast growth factor 23 (FGF-23) as a biomarker for right ventricular (RV) function in patients with pulmonary hypertension (PH). The results showed that PH patients had higher levels of FGF-23 compared to healthy controls. Higher FGF-23 levels were associated with worse renal function and RV dysfunction. Therefore, FGF-23 may serve as a biomarker for maladaptive RV remodeling in patients with PH.
CLINICAL RESEARCH IN CARDIOLOGY
(2023)
Article
Endocrinology & Metabolism
Sophie Monnerat, Julie Refardt, Laura Potasso, Christian Meier, Mirjam Christ-Crain
Summary: This study investigated the impact of increasing sodium levels on bone turnover in outpatients with chronic SIAD. The results showed a positive correlation between sodium levels and bone formation index (P1NP/CTX), suggesting that an increase in sodium is associated with enhanced bone formation.
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2023)
Article
Endocrinology & Metabolism
Laura Potasso, Sophie Monnerat, Julie Refardt, Gregor Lindner, Volker Burst, Bettina Winzeler, Mirjam Christ-Crain
Summary: This study evaluated the role of simplified apparent strong ion difference in serum, urine chloride and potassium score, and fractional uric acid excretion in the differential diagnosis of thiazide-associated hyponatremia (TAH). The results showed that these markers can help identify patients with volume-depleted TAH requiring fluid substitution vs patients with SIAD-like TAH requiring fluid restriction.
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2023)
Editorial Material
Endocrinology & Metabolism
Sophie Monnerat, Mirjam Christ-Crain, Julie Refardt
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2023)
Article
Medicine, Research & Experimental
Sophia Lengsfeld, Thilo Burkard, Andrea Meienberg, Nica Jeanloz, David Coynel, Deborah R. Vogt, Lars G. Hemkens, Benjamin Speich, Davide Zanchi, Tobias E. Erlanger, Mirjam Christ-Crain, Bettina Winzeler
Summary: This study aims to evaluate the GLP-1 analogue dulaglutide as a new therapy for smoking cessation. The results show that dulaglutide treatment can alleviate nicotine withdrawal symptoms and reduce post-cessation weight gain, potentially improving quit rates.
Article
Medicine, General & Internal
Sophia Lengsfeld, Thilo Burkard, Andrea Meienberg, Nica Jeanloz, Tanja Vukajlovic, Katja Bologna, Michelle Steinmetz, Cemile Bathelt, Clara O. Sailer, Deborah R. Vogt, Lars G. Hemkens, Benjamin Speich, SandrineA. Urwyler, Jill Kuehne, Fabienne Baur, Linda N. Lutz, Tobias E. Erlanger, Mirjam Christ-Crain, Bettina Winzeler
Summary: This study aimed to investigate the effects of the GLP-1 analogue dulaglutide on smoking cessation and post-cessation weight gain. The results showed that dulaglutide had no effect on abstinence rates but prevented weight gain and decreased HbA1c levels. These findings suggest that GLP-1 analogues may play a role in future cessation therapy targeting metabolic parameters.