Letter
Medicine, General & Internal
Olivier C. Manintveld, Stefan Roest, Yannick J. H. J. Taverne
Summary: In the study by Suverein et al., the use of extracorporeal cardiopulmonary resuscitation (CPR) in patients with refractory out-of-hospital cardiac arrest was examined. The results showed similar survival rates with a favorable neurologic outcome between extracorporeal CPR and conventional CPR. This raises questions about the role of extracorporeal CPR as an adjunct to conventional CPR.
NEW ENGLAND JOURNAL OF MEDICINE
(2023)
Article
Multidisciplinary Sciences
Benjamin Nyholm, Laust Obling, Christian Hassager, Johannes Grand, Jacob Moller, Marwan Othman, Daniel Kondziella, Jesper Kjaergaard
Summary: This study investigates the repeatability, reliability, and reproducibility of quantitative pupillometry in comatose patients after out-of-hospital cardiac arrest. The results show that automated quantitative pupillometry has excellent reliability and twice the reproducibility and repeatability compared to manual pupillometry.
Article
Multidisciplinary Sciences
Martin Hermann, Markus Isser, Valentin Bilgeri, Andreas Klinger, Wolfgang Lederer
Summary: This experimental study investigates the characteristics of blood drops dispersed on four different foil surfaces and finds differences in the characteristics compared to paper towel. Delayed clotting is associated with larger areas of contamination, indicating a higher likelihood of coming into contact with potential germs but a lower chance of contracting an infection. Space blankets, as obligatory components of first aid kits, serve as a mechanical barrier between rescuers and patients during resuscitation.
SCIENTIFIC REPORTS
(2022)
Article
Education & Educational Research
Jesus Lopez-Herce, Angel Carrillo, Javier Urbano, Gema Manrique, Santiago Mencia
Summary: Pediatric and neonatal CPR instructor courses are essential for training quality and homogeneity. Most participants passed the tests and evaluated the course positively.
BMC MEDICAL EDUCATION
(2021)
Review
Medicine, General & Internal
Cheng-Ying Chiang, Ket-Cheong Lim, Pei Chun Lai, Tou-Yuan Tsai, Yen Ta Huang, Ming-Jen Tsai
Summary: This study conducted a meta-analysis comparing the effects of mechanical and manual CPR applied in the pre-hospital stage on clinical outcomes after OHCA in adults. The results showed that compared to manual CPR, pre-hospital use of mechanical CPR had a positive effect in achieving ROSC and survival to admission. However, the difference in survival to discharge and discharge with favorable neurological status remains inconclusive.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Medicine, General & Internal
Stig Nikolaj Blomberg, Helle Collatz Christensen, Freddy Lippert, Annette Kjaer Ersboll, Christian Torp-Petersen, Michael R. Sayre, Peter J. Kudenchuk, Fredrik Folke
Summary: This randomized clinical trial found that using machine learning model to identify out-of-hospital cardiac arrest in emergency calls did not significantly improve dispatchers' ability to recognize cardiac arrest, despite artificial intelligence surpassing human recognition.
Article
Critical Care Medicine
Yohei Okada, Nur Shahidah, Yih Yng Ng, Michael Y. C. Chia, Han Nee Gan, Benjamin S. H. Leong, Desmond R. Mao, Wei Ming Ng, Nausheen Edwin, Takeyuki Kiguchi, Norihiro Nishioka, Tetsuhisa Kitamura, Taku Iwami, Marcus Eng Hock Ong
Summary: This study evaluated the outcomes of OHCA patients with initial shockable rhythm in Singapore and Osaka, and found that the outcomes for patients without prehospital ROSC in Singapore were worse than expected based on Osaka data, even when using population-based databases.
Article
Pediatrics
Megan O'Reilly, Tze-Fun Lee, Po-Yin Cheung, Georg M. Schmolzer
Summary: Machine chest compression leads to significant improvements in hemodynamic parameters during resuscitation of asphyxiated neonatal piglets, including greater stroke volume and left ventricular contractility, compared to manual compression techniques. This suggests that mechanical chest compression devices may offer better outcomes in neonatal and pediatric asphyxia-induced cardiac arrest.
PEDIATRIC RESEARCH
(2023)
Editorial Material
Cardiac & Cardiovascular Systems
Laurie-Anne Boivin-Proulx, Amelie Doherty, Nicolas Rousseau-Saine, Serge Doucet, Hung Q. Ly, Patrick Lavoie, Nicolas Thibodeau-Jarry
Summary: Cardiac arrest is common in critically ill patients with COVID-19 and often leads to poor survival rates. Simulation training for code teams can help improve outcomes, but there are still challenges in adhering to guidelines and maintaining the efficacy of resuscitation efforts.
CANADIAN JOURNAL OF CARDIOLOGY
(2021)
Article
Medicine, Research & Experimental
Patrick Bernhard, Berit Amelie Bretthauer, Sam Joe Brixius, Hannah Buegener, Johannes Elias Groh, Christian Scherer, Domagoj Damjanovic, Joerg Haberstroh, Georg Trummer, Christoph Benk, Friedhelm Beyersdorf, Oliver Schilling, Jan-Steffen Pooth
Summary: This study investigated the effects of cardiac arrest (CA), conventional cardiopulmonary resuscitation (CPR), and extracorporeal cardiopulmonary resuscitation (ECPR) on the serum proteome profiles in a pig model. The results showed significant changes in the serum proteome during resuscitation, including haemolysis, coagulation, inflammation, and cell-death processes. These findings contribute to a better understanding of the underlying mechanisms and may help improve therapeutic options for CA and resuscitation.
JOURNAL OF TRANSLATIONAL MEDICINE
(2022)
Article
Medicine, General & Internal
Michel Le May, Christina Osborne, Juan Russo, Derek So, Aun Yeong Chong, Alexander Dick, Michael Froeschl, Christopher Glover, Benjamin Hibbert, Jean-Francois Marquis, Sophie De Roock, Marino Labinaz, Jordan Bernick, Shawn Marshall, Ronnen Maze, George Wells
Summary: This study compared the clinical outcomes of comatose survivors of out-of-hospital cardiac arrest with target temperatures of 31 degrees C and 34 degrees C, and found that there was no significant difference in all-cause mortality or poor neurologic outcome between the two groups.
JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION
(2021)
Review
Medicine, General & Internal
Amelia Xin Chun Goh, Jie Cong Seow, Melvin Yong Hao Lai, Nan Liu, Yi Man Goh, Marcus Eng Hock Ong, Shir Lynn Lim, Jamie Sin Ying Ho, Jun Wei Yeo, Andrew Fu Wah Ho
Summary: Care at high-volume centers is associated with improved survival outcomes for patients with nontraumatic out-of-hospital cardiac arrest, while there is no association between center volume and improved neurological outcomes.
Article
Critical Care Medicine
James Knox Russell, Mikel Leturiondo, Digna M. Gonzalez-Otero, Jose Julio Gutierrez, Mohamud Ramzan Daya, Sofia Ruiz de Gauna
Summary: The study characterized the dynamics of release and recoil in chest compressions during prolonged CPR efforts, finding that while depth waveforms changed minimally, force waveforms exhibited substantial variations. Peak force decreased monotonically, while recoil velocity and interval remained within limited ranges. Despite adjustments in force application to compensate for changes in chest stiffness, interference between release of force and recoil of depth was limited.
Article
Critical Care Medicine
Deborah Wagner, S. L. Kronick, H. Nawer, J. A. Cranford, S. M. Bradley, R. W. Neumar
Summary: This retrospective cohort study compared the use of amiodarone and lidocaine in adult patients with in-hospital cardiac arrest from VT/VF. The study found that compared to amiodarone, lidocaine therapy was associated with significantly higher rates of ROSC, 24 h survival, survival to hospital discharge, and favorable neurologic outcome.
Article
Critical Care Medicine
Carl-Henrik Olander, Per Vikholm, Petter Schiller, Laila Hellgren
Summary: The study found that the level of ETCO2 at the end of mechanical CPR is inversely associated with the extent of brainstem and renal injury following ECPR. The group with higher ETCO2 levels showed better carotid blood pressure, oxygen delivery index, and brain injury at the end of ECPR.
Article
Health Care Sciences & Services
Dimitra S. Mouliou, Ioannis Pantazopoulos, Konstantinos I. Gourgoulianis
Summary: A web-based questionnaire was used to assess the factors influencing the response to COVID-19 vaccination in Greece, and the results showed that women, younger people, and university graduates were more likely to accept the vaccine. Internet, work, and social life were found to be the main influencing factors for the decision to vaccinate.
JOURNAL OF PERSONALIZED MEDICINE
(2022)
Article
Medicine, Research & Experimental
Anna Aikaterini Neri, Dimitrios Galanis, Antonis Galanos, Angeliki Eirini Pepe, Konstantinos Soultanis, Alexandros Zervas, Spyridon Zoitsis, Stavros K. Kourkoulis, Ermioni D. Pasiou, Argyro Vontzalidou, Dimitris Michailidis, Sofia Mitakou, Efstathios Chronopoulos, Georgios Karamanolis, Ismene A. Dontas, Theodore Karatzas
Summary: This study aimed to investigate the effect of Ceratonia siliqua on bone mineral density (BMD) as a nonpharmaceutical alternative treatment for postmenopausal osteoporosis. The results showed that long-term administration of C. siliqua significantly increased BMD compared to the control group and the ovariectomized group after 3 and 6 months of intervention. Therefore, C. siliqua may be considered a non-pharmaceutical alternative treatment for postmenopausal osteoporosis.
Editorial Material
Health Care Sciences & Services
Ioannis Pantazopoulos, Ourania S. S. Kotsiou
JOURNAL OF PERSONALIZED MEDICINE
(2023)
Article
Health Care Sciences & Services
Ourania S. Kotsiou, Konstantinos Tourlakopoulos, Lamprini Kontopoulou, Georgios Mavrovounis, Ioannis Pantazopoulos, Paraskevi Kirgou, Sotirios G. Zarogiannis, Zoe Daniil, Konstantinos I. Gourgoulianis
Summary: This study investigated the levels of derivatives-reactive oxygen metabolites (d-ROMs) and plasma antioxidant capacity (PAT) in severe controlled asthmatics and their correlation with lung function. The results showed that d-ROMs and PAT values were higher than normal, indicating oxidative stress in severe controlled asthmatics. Furthermore, D-ROMs were positively correlated with R20 values, suggesting an increase in central airway resistance.
JOURNAL OF PERSONALIZED MEDICINE
(2023)
Article
Health Care Sciences & Services
George Pavlidis, Vasileios Giannoulis, Maria Pirounaki, Ioannis C. Lampropoulos, Eirini Siafi, Alkippi Nitsa, Efthymia Pavlou, Anna Xanthaki, Garyfallia Perlepe, Sotirios P. Fortis, George Charalambous, Christos F. Kampolis, Ioannis Pantazopoulos
Summary: This study investigated the antibody kinetics in healthcare workers of a Greek tertiary hospital after COVID-19 vaccination. A total of 803 subjects were included, with different vaccines administered. Subjects were evaluated at various time points for antibody levels and infection outcomes. Pre-vaccine infection led to higher antibody levels and increased risk of reinfection. Vaccination resulted in lower hospitalization and reinfection rates.
JOURNAL OF PERSONALIZED MEDICINE
(2023)
Article
Agriculture, Dairy & Animal Science
Katerina A. Marinou, Ismene A. Dontas
Summary: The Directive 2010/63/EU has been in force for more than a decade, bringing significant improvements and novel requirements for animal welfare and research integrity in scientific experiments. The Directive provides clear provisions for various aspects such as scope, authorization procedures, animal welfare bodies, national committees, cost/benefit analysis, severity classification, retrospective assessment, and statistical reporting. The authors, based on their experience working in this field, have identified indicative areas in existing legislative texts and guidance documents that may impact animal welfare and scientific integrity. They discuss suggested solutions to address these areas through potential future revisions in legislation or other actions to benefit animal welfare, aiming to clarify and simplify these issues for all stakeholders involved.
Article
Biology
Smaragda Koudouna, Dimitrios S. Evangelopoulos, Michail Sarantis, Efstathios Chronopoulos, Ismene A. Dontas, Spiridon Pneumaticos
Summary: This study aims to evaluate prognostic tools for predicting patient recovery after hip fractures and investigate the correlation between pre-fracture motor and functional statuses. The study included 80 patients with hip fractures and evaluated patient history, previous falls, fracture type, and overall survival. The results showed that patients' physical and functional statuses were correlated with their postoperative recovery.
Article
Endocrinology & Metabolism
E. Karlafti, I. Dontas, I. Lambrinoudaki, I. Vlamis, K. Lampropoulou-Adamidou, K. Makris, I. Trifonidi, A. Galanos, G. Trovas, E. Chronopoulos, S. Tournis
Summary: This study aimed to evaluate the impact of Primary Hyperparathyroidism (PHPT) on volumetric Bone Mineral Density (vBMD) and bone geometry. The study found that both trabecular and cortical bone were adversely affected in postmenopausal women with PHPT, with greater effects on cortical bone at the radius compared to the tibia, indicating attenuation of deleterious effects on weight-bearing bone.
Article
Respiratory System
Konstantinos M. Pigakis, Vasileios T. Stavrou, Ioannis Pantazopoulos, Zoe Daniil, Aggeliki K. Kontopodi-Pigaki, Konstantinos Gourgoulianis
Summary: This study aimed to investigate the effects of systemic hydration on pulmonary function and found that it has a positive effect on spirometry in professional cyclists. Particularly, it improves small airways function.
ADVANCES IN RESPIRATORY MEDICINE
(2023)
Review
Medicine, General & Internal
Smaragda Koudouna, Dimitrios S. Evangelopoulos, Michail Sarantis, Efstathios Chronopoulos, Ismene A. Dontas, Spiros Pneumaticos
Summary: Hip fractures in the elderly are a growing concern, with post-operative rehabilitation being crucial for improved outcomes. However, there is a lack of evidence-based guidelines for the most effective rehabilitation pathways. This review aims to explore these pathways and provide objective evaluation through pre-operative and post-operative scores.
CUREUS JOURNAL OF MEDICAL SCIENCE
(2023)
Article
Medicine, General & Internal
Irena Karabella, Efstathios Chronopoulos, George Panagiotakopoulos, Ismene A. Dontas
Summary: Tuberculosis is a commonly misdiagnosed infectious disease that can mimic bone tumors or metastatic lesions in the spine. In patients with cancer and signs of lymph node involvement and bone lesions, exploring other potential causes is crucial for diagnosis. This case study highlights the importance of maintaining a high level of suspicion, as a lytic lesion initially misdiagnosed as a metastatic lesion turned out to be renal cell carcinoma.
CUREUS JOURNAL OF MEDICAL SCIENCE
(2023)
Article
Medicine, General & Internal
Irena Karabella, Efstathios Chronopoulos, George Panagiotakopoulos, Ismene A. Dontas
Summary: This study retrospectively analyzed the epidemiology, characteristics, and management of bone and joint tuberculosis (BJTB) in Greece. The findings suggest that the treatment outcomes are associated with gender and duration of treatment.
CUREUS JOURNAL OF MEDICAL SCIENCE
(2022)
Article
Neurosciences
Apostolos Tsolakis, Lubna Khaldi, Aliki Rontogianni, Maria Georgaki, Isidora Christopoulou, Ismene A. Dontas
Summary: This study investigated the effect of orthodontic tooth forces on the alveolar bone distal to the loaded teeth in ovariectomized female rats. The results showed reduced bone remodeling in the alveolar bone of ovariectomized rats.
JOURNAL OF MUSCULOSKELETAL & NEURONAL INTERACTIONS
(2022)
Article
Medicine, General & Internal
Dimitrios Vasileiadis, Georgios Drosos, Georgios Charitoudis, Ismene A. Dontas, John Vlamis
Summary: The purpose of this study was to investigate the efficacy of a six-week supervised high-intensity preoperative training program on muscle strength, functional performance, and patient-reported outcomes in patients undergoing total knee arthroplasty (TKA). The study found that the training program can decrease knee pain, improve knee function, and enhance daily living activities.
CUREUS JOURNAL OF MEDICAL SCIENCE
(2022)
Article
Neurosciences
Aliki Rontogianni, Ismene A. Dontas, Demetrios Halazonetis, Konstantinos Tosios, Pavlos Lelovas, Kyriaki Venetsanou, Antonios Galanos, Apostolos I. Tsolakis
Summary: This study aimed to investigate the effect of IUGR on the bone mineral density of the mandible and tibia, as well as the quality of the mandibular and condylar bone in growing rats. The results showed that restricted nutrition during gestation can affect the BMD of the mandible and tibia in offspring animals.
JOURNAL OF MUSCULOSKELETAL & NEURONAL INTERACTIONS
(2022)
