Review
Plant Sciences
Theysshana Visuvanathan, Leslie Thian Lung Than, Johnson Stanslas, Shu Yih Chew, Shalini Vellasamy
Summary: Fenugreek is a medicinal plant with therapeutic characteristics that has been utilized since ancient times. It contains various secondary metabolites which have been shown to have therapeutic effects through animal and clinical studies. Fenugreek has the potential to be used as a credible medicinal plant for deriving new drugs.
Article
Food Science & Technology
Faiza Shams, Ayesha Azeem, Ammara Shams, Abdul Tawab, Sidra Rehman, Somayya Tariq, Noreen Latief, Bushra Ijaz
Summary: The study demonstrates that Trigonella foenum-graecum flavonoid-rich leaf extract has anti-fibrotic potential in CCl4-induced hepatic fibrosis in mice by improving hepatocyte architecture, reducing collagen deposition, downregulating fibrotic markers, and regulating NF-KB and TGF-β/Smad signaling pathways.
Article
Food Science & Technology
Neetu Singh, Surender Singh Yadav, Sanjiv Kumar, Balasubramaniam Narashiman
Summary: Trigonella foenum-graecum is widely used for culinary and clinical purposes. It has pharmacological effects attributed to its diverse phytoconstituents. Nanoparticle synthesis can enhance its pharmacological efficacy. Clinical studies have validated its therapeutic potential in diabetes and reproductive health.
Article
Green & Sustainable Science & Technology
Esmaeil Rezaei-Chiyaneh, Martin Leonardo Battaglia, Amir Sadeghpour, Fahime Shokrani, Adel Dabbagh Mohammadi Nasab, Muhammad Ali Raza, Moritz von Cossel
Summary: The study showed that intercropping black cumin and fenugreek in a 66:34 ratio with bacteria fertilization can improve the essential oil and fixed oil quality and quantity of black cumin.
ADVANCED SUSTAINABLE SYSTEMS
(2021)
Article
Biochemistry & Molecular Biology
Hina Fatima, Muhammad Shahid, Chris Pruitt, Meredith A. Pung, Paul J. Mills, Muhammad Riaz, Rizwan Ashraf
Summary: This study evaluated the antioxidant and anti-inflammatory potential of hydroethanolic extract of T. foenum-graecum seeds. The extract exhibited significant antioxidant activity and was non-toxic to human and murine cells. It also showed a concentration-dependent reduction in inflammatory markers and improved antioxidant levels against oxidative stress. The hydroethanolic extract of T. foenum-graecum is a potential source of phenolic compounds with antioxidant and anti-inflammatory properties.
Article
Plant Sciences
Wiem Mnafgui, Valeria Rizzo, Giuseppe Muratore, Hicham Hajlaoui, Amine Elleuch
Summary: This study evaluated the effects of lead on the morphological and phytochemical responses of fenugreek. It found that fenugreek can be used for lead phytoremediation and remains safe for consumption after lead treatments.
Article
Biochemistry & Molecular Biology
Avinash Kumar, Vinay Kumar Singh, Arvind M. Kayastha
Summary: This study determined the three-dimensional structure of fenugreek α-amylase using homology modeling and analyzed its molecular basis and mode of action through molecular dynamics simulations and molecular docking. The study identified functional groupings and binding interactions between the enzyme and its substrate maltose. The research provides valuable insights into the atomic-level molecular underpinnings of α-amylase interaction with maltose.
JOURNAL OF BIOMOLECULAR STRUCTURE & DYNAMICS
(2023)
Article
Environmental Sciences
Javed Ahmad, Md Amjad Beg, Arlene A. Ali, Asma A. Al-Huqail, M. Irfan Qureshi
Summary: Arsenic contamination has detrimental effects on the physiology, growth, and yield of Trigonella foenum-graecum by increasing oxidative stress and decreasing photosynthetic parameters. The plant responds to arsenic toxicity by enhancing antioxidant potential and accumulating specific metabolites.
ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY
(2022)
Article
Engineering, Chemical
Manal A. Awad, Promy Virk, Awatif A. Hendi, Khalid Mustafa Ortashi, Najla Almasoud, Taghrid S. Alomar
Summary: As the human population grows, the demand for clean water is increasing. This study synthesized AgNPs using an aqueous extract of Trigonella foenum-graecum seeds. The AgNPs showed potential wastewater remediation efficacy, antimicrobial activity, and photodegradative activity. Therefore, biogenically synthesized AgNPs offer a prospective potential for use in wastewater remediation strategies.
Review
Plant Sciences
Pushpa Ruwali, Niharika Pandey, Khusboo Jindal, Rahul Vikram Singh
Summary: Fenugreek, a herb with medicinal and nutraceutical values, contains various bioactive compounds and possesses antibiotic, antioxidant, anti-carcinogenic properties, as well as the ability to control hyperglycemia in diabetic patients.
SOUTH AFRICAN JOURNAL OF BOTANY
(2022)
Article
Chemistry, Applied
Thierry Hellebois, Claire Gaiani, Jennyfer Fortuin, Alexander Shaplov, Christos Soukoulis
Summary: Cryotropic gelation is a common method to design novel hydrogels with multifaceted functionalities. This study focused on the formation of physically crosslinked hydrogels using highly galactosyl-substituted galactomannans like fenugreek and alfalfa gum via cryogenic processing. Results showed that alfalfa gum-based cryogels had higher elasticity and stiffness compared to fenugreek counterparts, and blending with locust bean gum enhanced the mechanical properties without altering microstructural aspects significantly.
CARBOHYDRATE POLYMERS
(2021)
Article
Environmental Sciences
Javed Ahmad, Rubina Yasmeen, Mohammad Irfan, Asma A. Al-Huqail, Mohammad Irfan Qureshi
Summary: Traces of arsenic in vegetables and crops cultivated in arsenic-polluted soils are a global concern due to its carcinogenic properties and harmful effects on the food chain. This study focused on the accumulation and defense mechanisms of fenugreek plants exposed to arsenic stress. The findings showed increased oxidative stress and DNA damage at higher arsenic concentrations.
ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH
(2023)
Article
Plant Sciences
Eun-Young Kim, Hoyeon Park, Eom Ji Kim, Seung Hoon Lee, Jun Won Choi, Jonghyun Kim, Hyuk-Sang Jung, Youngjoo Sohn
Summary: This study demonstrates the efficacy of Trigonella foenum-graecum Linne (TFG) in alleviating PM-induced inflammatory response in bronchial epithelial cells and an animal model of asthma exacerbation.
JOURNAL OF ETHNOPHARMACOLOGY
(2024)
Article
Plant Sciences
Reda E. Abdelhameed, Arafat Abdel Hamed Abdel Latef, Rania S. Shehata
Summary: Foliar application of salicylic acid improves salt tolerance of fenugreek plants by increasing chlorophyll content index and reducing malondialdehyde content, while promoting accumulation of proline, total phenolics, and flavonoids. Additionally, it enhances total free amino acids and shikimic acid, and activates antioxidant enzymes such as ascorbate peroxidase, peroxidase, polyphenol oxidase, and catalase.
Article
Biochemistry & Molecular Biology
Hafssa Ouattar, Otmane Zouirech, Mohammed Kara, Amine Assouguem, Saeedah Musaed Almutairi, Fahad M. Al-Hemaid, Rabab Ahmed Rasheed, Riaz Ullah, Arshad Mehmood Abbasi, Mahjoub Aouane, Karima Mikou
Summary: The current study aims to investigate the biological activities of Nigella sativa and Lepidium sativum and found that both plants exhibited high antioxidant potential and medicinal value.
Article
Chemistry, Medicinal
Ebtehal M. Dorgham, Gamal M. El Maghraby, Ebtessam A. Essa, Mona F. Arafa
Summary: This study aimed to enhance the dissolution rate of eslicarbazepine acetate (ESL) by forming eutectic systems with tartaric acid or citric acid. The eutectic system formation with both tartaric and citric acid was confirmed, with the optimum molar ratio being 1:1 for both substances. The co-processing of ESL with either citric acid or tartaric acid resulted in significantly enhanced dissolution rate, attributed to the combined effect of eutexia and pH modification.
DRUG DEVELOPMENT AND INDUSTRIAL PHARMACY
(2023)
Article
Pharmacology & Pharmacy
Amal A. Sultan, Ghada A. Saad, Gamal M. El Maghraby
Summary: This study investigated the use of bilosomes encapsulating absorption enhancers as carriers for enhancing the oral absorption and cytotoxicity of doxorubicin. The bilosomes were found to significantly improve the intestinal absorption and cytotoxicity of doxorubicin against breast cancer cells.
INTERNATIONAL JOURNAL OF PHARMACEUTICS
(2023)
Article
Chemistry, Medicinal
Abdul Ahad, Mohammad Raish, Ibrahim Abdelsalam Abdelrahman, Yousef A. Bin Jardan, Mohd Aftab Alam, Abdullah M. Al-Mohizea, Fahad I. Al-Jenoobi
Summary: This study investigated the pharmacodynamics and pharmacokinetics interactions between losartan and Curcuma longa (CUR) and Lepidium sativum (LS) in hypertensive rats. Oral administration of CUR or LS showed significant antihypertensive activity and enhanced the blood pressure-lowering effects of losartan in hypertensive rats. Additionally, CUR and LS increased the plasma concentrations of losartan. These interactions suggest that dose adjustment and intermittent blood pressure monitoring are necessary when administering losartan with either CUR or LS in hypertensive patients.
Article
Microbiology
Amal Abo M. Kamer, Noha M. Amer, Ahmed A. Abdelmegeed, Gamal M. El Maghraby, Noha M. Gamaleldin
Summary: Researchers used nano-drug delivery systems to enhance the antimicrobial activity of existing antibiotics against Carbapenemase Resistant Enterobacteriaceae (CRE) and extended spectrum beta-lactamases producing bacteria (ESBL). The optimization of surfactant nanovesicles improved the efficacy of meropenem, ertapenem, and tigecycline. The results showed that the surfactant vesicles reduced the MIC values of the drugs and had potential adhesion/fusion with bacterial cells.
Article
Parasitology
Hager S. Zoghroban, Basma M. Elmansory, Yasmine Amr Issa, Amira K. Eltokhy, Hend S. Abo Safia, Gamal M. El Maghraby, Amina M. Salama
Summary: This study investigates the effects of levamisole and spiramycin on the early and late stages of experimental toxoplasmosis. The results show that the combination of spiramycin and levamisole treatment significantly decreases the burden of Toxoplasma brain cyst, increases IFN-gamma level, and improves histopathological features. Levamisole effectively modulates Toxoplasma-induced immune responses, leading to remission of chronic toxoplasmosis.
EXPERIMENTAL PARASITOLOGY
(2023)
Article
Pharmacology & Pharmacy
Rania K. Eid, Mona F. Arafa, Dalia S. Ashour, Ebtessam A. Essa, Eman S. El-Wakil, Salwa S. Younis, Gamal M. El Maghraby
Summary: This study evaluated niosomes as potential carriers for enhancing the efficacy of norfloxacin against Toxoplasma gondii. The niosomes were prepared using Span 60 and cholesterol and incorporated Gelucire 48/16 or Tween 80. In vitro and in vivo experiments showed that niosomal encapsulation of norfloxacin resulted in faster drug release and significantly reduced EC50 against tachyzoites. The mice infected with Toxoplasma showed a reduction in tachyzoite count after treatment with niosomes encapsulated norfloxacin. These results suggest the potential of surfactant vesicles for enhancing the efficacy of norfloxacin against Toxoplasma.
INTERNATIONAL JOURNAL OF PHARMACEUTICS
(2023)
Article
Pharmacology & Pharmacy
Muhammad Embaby, Gamal M. El Maghraby, Mohamed A. Osman, Amal A. Sultan
Summary: This study investigates the regional difference in linagliptin intestinal membrane transport and the effects of carvedilol, atorvastatin, and bile salts on intestinal absorption of linagliptin. The results show incomplete absorption of linagliptin from the explored intestinal segments, with absorption decreasing as movement progresses distally through the small intestine before increasing at the ascending colon. P-glycoprotein (P-gp) efflux is identified as a possible mechanism for reduced linagliptin intestinal absorption. Co-perfusion with carvedilol, atorvastatin, or bile salts significantly enhances linagliptin absorption, suggesting P-gp efflux inhibition as one possible mechanism for enhanced linagliptin intestinal membrane transport.
JOURNAL OF PHARMACY AND PHARMACOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Mohammad Raish, Ajaz Ahmad, Mudassar Shahid, Yousef A. Bin Jardan, Abdul Ahad, Mohd Abul Kalam, Mushtaq Ahmad Ansari, Muzaffar Iqbal, Naushad Ali, Khalid M. M. Alkharfy, Fahad I. I. Al-Jenoobi
Summary: Dasatinib is a drug used to treat chronic myelogenous leukemia and Ph-positive acute lymphocytic leukemia. Apigenin is a common ingredient used in food, herbs, and traditional medicine. The concomitant use of apigenin and dasatinib may result in potential herb-drug interactions.
Article
Pharmacology & Pharmacy
Ahmed S. Kamel, Soha M. El-Masry, Haidy Abbas, Fatma Mkh Ibrahim, Hager S. Zoghroban, Gamal M. El Maghraby
Summary: The aim of this study was to improve the dissolution rate and in vivo efficacy of flubendazole against trichinella spiralis. Flubendazole nanocrystals were successfully developed through controlled anti-solvent recrystallization. The nanocrystals showed spherical shape and a size of 743.1 nm, with the formulation employing 0.2% Poloxamer 407 as a stabilizer being optimal. The optimal formulation exhibited fast dissolution and significantly improved the eradication of intestinal trichinella and larval count reduction in migrating and encysted phases compared to unprocessed flubendazole.
PHARMACEUTICAL DEVELOPMENT AND TECHNOLOGY
(2023)
Article
Pharmacology & Pharmacy
Amr Zidan, Amira A. EL Saadany, Gamal M. El Maghraby, Amany A. Abdin, Sabeha E. Hedya
Summary: The aim of this study was to investigate the potential cardioprotective and anti-cancer effects of carvedilol (CAR) either free or as loaded nano-formulated with or without doxorubicin (DOX) in solid Ehrlich carcinoma (SEC)-bearing mice. The results showed that CAR, when used in combination with DOX and loaded into PLGA or Niosomes, exhibited better cardioprotective effects and cytotoxicity against cancer cells, suggesting its potential as an adjuvant therapy.
TOXICOLOGY AND APPLIED PHARMACOLOGY
(2023)
Article
Pharmacology & Pharmacy
Asmaa M. El Shiekh Ali, Gamal M. El Maghrabyl, Abdelaziz E. Abdelaziz, Ahmed M. Soliman, Eman M. Saied, Eman A. Mazyed
Summary: The objective of this study was to improve the dissolution rate and anti-fungal activity of fluconazole by preparing solid mixtures with menthol. The developed solids were characterized using various techniques and the dissolution of fluconazole was monitored. A menthol-containing oral dispersible tablet was prepared and its prophylactic and therapeutic effects were evaluated using a mouse oral candida model. The results showed that the menthol-containing tablet exhibited improved anti-candida activity compared to fluconazole tablet.
JOURNAL OF DRUG DELIVERY SCIENCE AND TECHNOLOGY
(2023)
Article
Pharmacology & Pharmacy
Yousef A. Bin Jardan, Abdul Ahad, Mohammad Raish, Fahad I. Al-Jenoobi
Summary: Sinapic acid (SA) is a bioactive phenolic acid with diverse properties such as anti-inflammatory, antioxidant, anticancer, and antibacterial activities. This study aimed to enhance the water solubility of SA through the formulation of SA-transethosomes and evaluate their efficacy. The optimized formulation showed high entrapment efficacy, appropriate vesicle size, and smooth surface morphology, as well as enhanced antioxidant activity and penetration ability.
Article
Chemistry, Analytical
Ibrahim Abdelsalam Abdelrahman, Abdul Ahad, Mohammad Raish, Yousef A. Bin Jardan, Mohd Aftab Alam, Fahad I. Al-Jenoobi
Summary: The study aimed to investigate the influence of cumin and green tea on the pharmacodynamics and pharmacokinetics of amlodipine in hypertensive rats. The results showed that both cumin and green tea significantly decreased blood pressure, with green tea having a more prominent effect on the pharmacodynamics of amlodipine. Co-administration of green tea and cumin increased the peak concentration and half-life of amlodipine.
Article
Dermatology
Yomna Mazid El-Hamd Neinaa, Myada Abd Elmohsen Mahmoud, Gamal Mohamed El Maghraby, Zeinab Abd Elsamd Ibrahim
Summary: In recent decades, prostaglandins have been recommended as a new therapy for stable vitiligo. This study aimed to compare the effectiveness of two subtypes of prostaglandins (PGE2 and PGF2a) in combination with NB-UVB phototherapy. The study included 30 patients with stable non-segmental vitiligo who were assigned to three groups. The results showed that the therapeutic efficacy of intradermal injection of PGE2 or PGF2a, combined with NB-UVB phototherapy, was comparable and significantly higher than NB-UVB alone. However, PGE2 was associated with earlier onset of repigmentation and higher patient satisfaction compared to PGF2a. In conclusion, both PGE2 and PGF2a intradermal injections are simple and affordable techniques for the treatment of stable vitiligo with no reported side effects and good patient satisfaction.
ARCHIVES OF DERMATOLOGICAL RESEARCH
(2023)
