Article
Nutrition & Dietetics
Guanqiong Na, Jing Zhang, Dian Lv, Ping Chen, Xinyue Song, Fenfen Cai, Sicong Zheng, Wenting Wan, Yujuan Shan
Summary: This study aimed to investigate the effects of a 3-month germinated brown rice (GBR) diet on type 2 diabetes mellitus (T2DM) patients and explore the association with serum fatty acids. The results showed that GBR intervention reduced inflammation and significantly decreased blood glucose and lipid levels in T2DM patients. GBR intake also altered fatty acid composition, with increased levels of n-3 polyunsaturated fatty acids and n-3/n-6 PUFA ratio. Moreover, GBR group had higher levels of anti-inflammatory n-3 metabolites and lower levels of pro-inflammatory n-6 metabolites.
CLINICAL NUTRITION
(2023)
Article
Environmental Sciences
Jinna Zhang, Rucheng Chen, Guoqing Zhang, Yixuan Wang, Jing Peng, Ran Li, Lu Zhang, Qinghua Sun, Cuiqing Liu, Renji Hu, Weijia Gu
Summary: The study found that exposure to fine particulate matter (PM2.5) increases blood pressure and impairs vascular function through the activation of Toll-like receptor 3 (TLR3). TLR3 deficiency, on the other hand, can protect against PM2.5-induced blood pressure elevation and vascular function damage.
ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY
(2022)
Article
Nutrition & Dietetics
Lenie van Rossem, Henriette A. Smit, Martine Armand, Jonathan Y. Bernard, Hans Bisgaard, Klaus Bonnelykke, Signe Bruun, Barbara Heude, Steffen Husby, Henriette B. Kyhl, Kim F. Michaelsen, Ken D. Stark, Carel Thijs, Rebecca K. Vinding, Alet H. Wijga, Lotte Lauritzen
Summary: In this meta-analysis of seven European birth cohorts, no evidence was found to support the association between breast milk n-3 LC PUFAs and blood pressure in children.
EUROPEAN JOURNAL OF NUTRITION
(2021)
Review
Immunology
Barbora Lampova, Ivo Doskocil, Lenka Kourimska, Aneta Kopec
Summary: COVID-19 is caused by SARS-CoV-2 and serious complications are mainly due to an exaggerated immune response called a cytokine storm. Supplementation of n-3 polyunsaturated fatty acids may improve clinical outcomes in critically ill COVID-19 patients.
FRONTIERS IN IMMUNOLOGY
(2022)
Review
Biochemistry & Molecular Biology
Kamila P. Liput, Adam Lepczynski, Magdalena Ogluszka, Agata Nawrocka, Ewa Polawska, Agata Grzesiak, Brygida Slaska, Chandra S. Pareek, Urszula Czarnik, Mariusz Pierzchala
Summary: It is recommended to reduce saturated fatty acids (SFA) and increase polyunsaturated fatty acids (PUFAs) n-3 and n-6 in the diet to lower the risk of metabolic disorders. Western-type diet often contains excessive n-6 PUFAs and a high n-6/n-3 ratio. Oxylipins derived from n-3 and n-6 PUFAs play a role in inflammation, while PUFAs have varying effects on cell growth, proliferation, and neoplastic lesion progression, as observed in in vitro studies, animal models, and epidemiological studies.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Food Science & Technology
Ligang Yang, Chao Yang, Zhixiu Song, Min Wan, Hui Xia, Xian Yang, Dengfeng Xu, Da Pan, Hechun Liu, Shaokang Wang, Guiju Sun
Summary: Postprandial metabolism plays significant roles in various pathological conditions, and the n-6/n-3 polyunsaturated fatty acid ratio is closely associated with physiological disorders. This study investigated the effects of high fat meals with different n-6/n-3 PUFA ratios on postprandial metabolism in normal control and hypertriglyceridemia rats. The results showed that the n-6/n-3 PUFA ratio influenced the postprandial response of triglyceride, total cholesterol, tumor necrosis factor alpha, malondialdehyde, and reactive oxygen species in both normal control and hypertriglyceridemia rats.
FOOD SCIENCE AND HUMAN WELLNESS
(2023)
Article
Agriculture, Dairy & Animal Science
Ana C. M. Vitor, Jorge J. Correia, Susana P. Alves, Rui J. B. Bessa
Summary: This study aimed to evaluate the fatty acid composition of lamb brain and retina tissues after feeding them with three experimental diets supplemented with EPA-rich microalgae. The results demonstrated that the brain EPA content remained unchanged after supplementation, while the retinal tissues showed a high response to microalgae supplementation.
Article
Agriculture, Multidisciplinary
Ligang Yang, Chao Yang, Chu Chu, Min Wan, Dengfeng Xu, Da Pan, Hui Xia, Shao Kang Wang, Guofang Shu, Shiqing Chen, Guiju Sun
Summary: MUFA-rich blended oils have beneficial effects on glucolipid metabolism, inflammation, oxidative stress, and bone quality in rats.
JOURNAL OF THE SCIENCE OF FOOD AND AGRICULTURE
(2022)
Article
Food Science & Technology
Amruta Kulkarni, Ai Zhao, Baoru Yang, Yumei Zhang, Kaisa M. Linderborg
Summary: The intake of fatty acids affects the composition of lipids in the body. In this study, rats were fed a peanut-oil-based diet for 33 days after weaning to investigate the effects of mild (n-3) deficiency on the lipid composition of various organs and feces. Results showed a lower level of docosahexaenoic acid (DHA) in the (n-3) deficient group compared to the control group, but no difference in DHA content was observed in the eyes and feces. This study highlights the importance of adequate maternal nutrition for a healthy fatty acid balance in rats.
Article
Clinical Neurology
Yuxi Jia, Ping Li, Fei Wu, Fanjie Zeng, Beilin Zhang, Jinpeng Wang
Summary: This study investigated the potential influences of n-3/n-6 polyunsaturated fatty acids (PUFAs) as supplements in VPA-induced autistic rat model. The results showed that supplementation with n-3/n-6 PUFA (1:5) reduced repetitive stereotyped behaviors and social deficits in neonatal rats exposed to VPA, likely due to improved inflammatory responses through the alteration of STAT3 signaling. This study provides evidence for the use of n-3/n-6 PUFAs in the treatment of autism in humans.
NEUROPSYCHIATRIC DISEASE AND TREATMENT
(2022)
Article
Chemistry, Medicinal
Hong-Yu Zou, Hui-Juan Zhang, Ying-Cai Zhao, Xiao-Yue Li, Yu-Ming Wang, Tian-Tian Zhang, Chang-Hu Xue
Summary: It has been reported that dietary n-3 polyunsaturated fatty acids (n-3 PUFAs) have therapeutic potential for preserving functional beta-cell mass. This study aimed to investigate the effect of n-3 PUFA deficiency on pancreatic injury and whether n-3 PUFA supplementation could prevent the development of pancreatic injury. The results showed that n-3 PUFA deficiency exacerbated streptozotocin-induced pancreas injury, but pre-intervention with DHA and EPA alleviated the damage by increasing insulin levels and reversing islet area.
Review
Nutrition & Dietetics
Gary P. Zaloga
Summary: Fish oil supplementation, rich in n-3 polyunsaturated fatty acids, has immunomodulatory effects on immune functions, potentially suppressing inflammation and cellular immune responses while increasing lipid peroxidation.
Review
Chemistry, Medicinal
Atiporn Therdyothin, Nacharin Phiphopthatsanee, Masoud Isanejad
Summary: Sarcopenia, a disease that affects the aging population worldwide, can be prevented by nutritional strategies such as omega-3 polyunsaturated fatty acid (n-3 PUFA) supplementation. This review examines the effect and mechanism of n-3 PUFA on muscle health. Despite conflicting evidence, n-3 PUFA is suggested to benefit muscle mass, strength, physical performance, and muscle protein synthesis. Proposed mechanisms include anti-inflammatory properties, increased expression of mTORC1 pathway, decreased protein breakdown, improved mitochondrial function, enhanced amino acid transport, and modulation of neuromuscular junction activity. However, the interpretation of findings is limited by small sample sizes, heterogeneity of supplementation regimens, and different measuring protocols.
Article
Nutrition & Dietetics
Estefania Aparicio, Carla Martin-Grau, Cristina Bedmar, Nuria Serrat Orus, Josep Basora, Victoria Arija
Summary: This study found that factors such as high education levels, older age, consumption of fish and seafood, and non-smoking are significantly associated with serum fatty acid concentrations in pregnant women, leading to a better omega-3 fatty acid profile. Further research is needed to explore the health consequences of these findings.
Review
Hematology
Irina Portier, Robert A. Campbell
Summary: Platelets, traditionally viewed as essential in hemostasis and thrombosis, have recently been recognized for their role in modulating the immune response during infectious diseases. Through the release of antimicrobial proteins upon activation, platelets can directly limit pathogen growth and aid in pathogen clearance by activating immune cells. However, abnormal platelet activation may lead to inflammation and thrombotic events.
ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY
(2021)
Review
Hematology
Ruchika Goel, Evan M. Bloch, France Pirenne, Arwa Z. Al-Riyami, Elizabeth Crowe, Laetitia Dau, Kevin Land, Mary Townsend, Thachil Jecko, Naomi Rahimi-Levene, Gopal Patidar, Cassandra D. Josephson, Satyam Arora, Marion Vermeulen, Hans Vrielink, Celina Montemayor, Adaeze Oreh, Salwa Hindawi, Karin van den Berg, Katherine Serrano, Cynthia So-Osman, Erica Wood, Dana V. Devine, Steven L. Spitalnik
Summary: Growing evidence suggests that ABO blood group may play a role in the immunopathogenesis of SARS-CoV-2 infection, with group O individuals less likely to test positive and group A conferring a higher susceptibility to infection and propensity to severe disease. The mechanisms behind these associations are not fully understood and more research is needed to confirm these findings.
Article
Hematology
Gopal K. Patidar, Kevin J. Land, Hans Vrielink, Naomi Rahimi-Levene, Eldad J. Dann, Hind Al-Humaidan, Steven L. Spitalnik, Yashaswi Dhiman, Cynthia So-Osman, Salwa I. Hindawi
Summary: Cytokine release syndrome in COVID-19 is caused by an inflammatory response of raised cytokines. Therapeutic plasma exchange (TPE) may help improve clinical outcomes by removing toxic cytokines and viral particles or correcting coagulopathy. Early initiation of TPE treatment can increase the chances of recovery for COVID-19 patients.
Editorial Material
Hematology
Laura Green, Simon Stanworth, Zoe McQuilten, Victor Lin, Harriet Tucker, Bryon Jackson, Maha Badawi, Salwa Hindawi, Rahul Chaurasia, Gopal Patidar, Hem Chandra Pandey, Foluke Fasola, Shigeki Miyata, Masanori Matsumoto, Tadashi Matsushita, Naomi Rahimi-Levene, Victoria Peer, Katerina Pavenski, Jeannie Callum, Troy Thompson, Michael Murphy, Julie Staves, Marc Maegele, Chathuri Abeyakoon, Kylie Rushford, Erica Wood, Maria Antonieta Nunez, Sandra Mellado, Edgardo Saa, Teguh Triyono, Bhirowo Pratomo, Torunn Oveland Apelseth, Nancy Dunbar
Editorial Material
Hematology
Laura Green, Simon Stanworth, Zoe McQuilten, Victor Lin, Harriet Tucker, Bryon Jackson, Maha Badawi, Salwa Hindawi, Rahul Chaurasia, Gopal Patidar, Hem Chandra Pandey, Foluke Fasola, Shigeki Miyata, Masanori Matsumoto, Tadashi Matsushita, Naomi Rahimi-Levene, Victoria Peer, Katerina Pavenski, Jeannie Callum, Troy Thompson, Michael Murphy, Julie Staves, Marc Maegele, Chathuri Abeyakoon, Kylie Rushford, Erica Wood, Maria Antonieta Nunez, Sandra Mellado, Edgardo Saa, Teguh Triyono, Bhirowo Pratomo, Torunn Oveland Apelseth, Nancy Dunbar
Article
Hematology
Arwa Z. Al-Riyami, Thierry Burnouf, Erica M. Wood, Dana V. Devine, Adaeze Oreh, Torunn Oveland Apelseth, Ruchikha Goel, Evan M. Bloch, Karin van den Berg, Mahrukh Getshen, Vernon Louw, Ai Leen Ang, Cheuk Kwong Lee, Naomi Rahimi-Levene, Susan L. Stramer, Ralph Vassallo, Torsten J. Schulze, Gopal Kumar Patidar, Hem Chandra Pandey, Rounak Dubey, Maha Badawi, Salwa Hindawi, Abdullah Meshi, Tadashi Matsushita, Enrico Sorrentino, Rada M. Grubovic Rastvorceva, Renee Bazin, Marion Vermeulen, Susan Nahirniak, Hamilton C. Tsang, Hans Vrielink, Teguh Triyono, Marcelo Addas-Carvalho, Ana Hecimovic, Oscar W. Torres, Samclide M. Mutindu, Jesper Bengtsson, Diego Dominguez, Ahmed Sayedahmed, Rozi Hanisa Musa, Bipul Gautam, Eszter Herczenik, Cynthia So-Osman
Summary: This study investigated the challenges faced by blood systems worldwide during the COVID-19 pandemic, including blood supplies, collection and use of COVID-19 convalescent plasma (CCP), transfusion demands, and operational challenges. The survey results showed decreases in blood donations, donor fear and refusal of blood drives as major factors contributing to the challenges. The study highlights the importance of guidance, harmonization, and strengthening of the preparedness and capacity of blood systems against future infectious threats.
Editorial Material
Ophthalmology
Asaf Shemer, Naomi Rahimi-Levene, Nadav Shoshany
JAMA OPHTHALMOLOGY
(2022)
Article
Multidisciplinary Sciences
Naomi Rahimi-Levene, Jonathan Shapira, Irma Tzur, Eli Shiloah, Victoria Peer, Ella Levin, Marina Izak, Eilat Shinar, Tomer Ziv-Baran, Miriam Weinberger, Oren Zimhony, Jacob Chen, Yasmin Maor
Summary: This study aimed to describe the survival of severe COVID-19 patients treated with convalescent COVID plasma (CCP) and identify predictors of in-hospital mortality. The study found that diabetes mellitus, mechanical ventilation, and lower albumin levels during treatment were significantly associated with increased in-hospital mortality.
Review
Hematology
Thierry Burnouf, Birgit Gathof, Evan M. Bloch, Renee Bazin, Vincenzo de Angelis, Gopal Kumar Patidar, Rada M. Grubovic Rastvorceva, Adaeze Oreh, Ruchika Goel, Naomi Rahimi-Levene, Salwa Hindawi, Arwa Z. Al-Riyami, Cynthia So-Osman
Summary: The COVID-19 pandemic has highlighted the potential therapeutic value of early passive polyclonal immunotherapy using high-titer convalescent plasma (CCP). Human polyclonal hyperimmune immunoglobulin (HIG) has several advantages over CCP, such as standardized antibody content, viral safety, and preserved immunoglobulin neutralization capacity. This document provides an overview of current practices and guidance for the collection and testing of plasma rich in antibodies against SARS-CoV-2 and its fractionation for the manufacture of quality-assured and safe HIG. Considerations are also given to the production of HIG preparations in low- and middle-income countries.
TRANSFUSION MEDICINE REVIEWS
(2022)
Article
Hematology
Arwa Z. Al-Riyami, David Peterson, Jana Vanden Broeck, Soumya Das, Ben Saxon, Yulia Lin, Naomi Rahimi-Levene, Cynthia So-Osman, Simon Stanworth
Summary: This survey aimed to assess the use of e-learning courses in blood establishments and transfusion services internationally. The results showed that approximately two-thirds of the courses were developed in-house and most of them were available to learners outside the host institutions. The survey also revealed that one-third of the institutions established these courses during the COVID-19 pandemic. Physicians, laboratory scientists/technologists, and transfusion practitioners were the primary target audiences.
TRANSFUSION MEDICINE
(2022)
Article
Hematology
Arwa Z. Al-Riyami, Lise Estcourt, Naomi Rahimi-Levene, Evan M. Bloch, Ruchika Goel, Pierre Tiberghien, Jean-Baptiste Thibert, Mie Topholm Bruun, Dana Devine, Richard R. Gammon, Silvano Wendel, Michel Toungouz Nevessignsky, Rada M. Grubovic Rastvorceva, Adaeze Oreh, Inigo Romon, Karin van den Berg, Junichi Kitazawa, Gopal Patidar, Cynthia So-Osman, Erica M. Wood
Summary: This study summarizes trials of early use of convalescent plasma in the treatment of COVID-19 and explores its feasibility in different countries. The results show that some countries are conducting trials on early convalescent plasma transfusion, and home transfusion has been implemented in several countries. However, many institutions and countries still lack such programs, and barriers to implementation include existing legislation and lack of policies and resources.
Article
Hematology
Odit Gutwein, Katrin Herzog Tzarfati, Arie Apel, Naomi Rahimi-Levene, Hani Michaeli, Liza Barki-Harrington, Maya Koren-Michowitz
Summary: The study investigated whether the COVID-19 pandemic had influenced patients' perception of home transfusions. The survey results showed a slight decrease in patients' willingness to receive home transfusions during the pandemic, along with an increased fear of adverse effects and a decreased belief that hospital transfusion would impair their quality of life. These unexpected findings may be attributed to shorter hospital arrival time during the pandemic and a greater fear of adverse effects at home.
Article
Hematology
Satyam Arora, Ruchika Goel, Arwa Z. Al-Riyami, Abdul Hakim Al-Rawas, Saif Al Hosni, Mauro Montanari, Benedetta Costantini, Christina Lee Lai Ling, Norliza Mustafa, Chan Kok Joo, Hari Krishan Dhawan, Sheetal Malhotra, Ratti Ram Sharma, Helen New, Rachel Moss, Jane Davis, Nancy Robitaille, Valerie Arsenault, Nabiha H. Saifee, Ann-Marie Taroc, Naomi Rahimi-Levene, Victoria Peer, Maha Badawi, Pauline M. Snijder, Elise J. Huisman, Josune Zubicaray Salegui, Julia Ruiz Pato, Julian Sevilla Navarro, Jose Mauro Kutner, Ana Paula Hitomi Yokoyama, Joyce Ching Mei Lam, Xin Ni Zhong, Mui Ling Heng, Oscar Walter Torres, Aggrey Dhabangi, Anel van Zyl, Nadia Mundey, Vernon Louw, Karin van den Berg, Nancy Dunbar
Article
Hematology
Satyam Arora, Ruchika Goel, Arwa Z. Al-Riyami, Abdul Hakim Al-Rawas, Saif Al Hosni, Mauro Montanari, Benedetta Costantini, Christina Lee Lai Ling, Norliza Mustafa, Chan Kok Joo, Hari Krishan Dhawan, Sheetal Malhotra, Ratti Ram Sharma, Helen New, Rachel Moss, Jane Davis, Nancy Robitaille, Valerie Arsenault, Nabiha H. Saifee, Ann-Marie Taroc, Naomi Rahimi-Levene, Victoria Peer, Maha Badawi, Pauline M. Snijder, Elise J. Huisman, Josune Zubicaray Salegui, Julia Ruiz Pato, Julian Sevilla Navarro, Jose Mauro Kutner, Ana Paula Hitomi Yokoyama, Joyce Ching Mei Lam, Xin Ni Zhong, Mui Ling Heng, Oscar Walter Torres, Aggrey Dhabangi, Anel van Zyl, Nadia Mundey, Vernon Louw, Karin van den Berg, Nancy Dunbar
Correction
Hematology
N. Rahimi-Levene, J. Chezar, V Yahalom
Article
Medicine, General & Internal
Naomi Rahimi-Levene, Yoav Preisler, Maya Koren-Michowitz, Victoria Peer, Ronit Zeidenstein, Ahuva Golik, Tomer Ziv-Baran
Summary: This study evaluated the association between hematological biomarkers and survival in patients with acute heart disease requiring RBC transfusion. The results showed that a lower PNR was significantly associated with increased mortality, while higher RDW and NLR were associated with higher mortality rates within different timeframes. Hematological biomarkers may play a role in identifying mortality risk in these patients.
AMERICAN JOURNAL OF THE MEDICAL SCIENCES
(2021)