Article
Allergy
Youping Tian, Ying Ye, Yi Zhang, Limin Dou, Yalan Dou, Piaoping Zhao, Yuan Jiang, Xiaohua Gao, Xiaohua Zhang, Jun Huang, Liping Xiao, Liuhui Wang, Weili Yan
Summary: Higher maternal serum 25(OH)D levels during pregnancy were associated with increased risks of infant AD before 1 year of age, but the clinical significance of the findings should be limited to those with blood levels over the recommendations.
PEDIATRIC ALLERGY AND IMMUNOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Shufei Zeng, Chang Chu, Cornelia Doebis, Volker von Baehr, Berthold Hocher
Summary: There is a strong positive linear correlation between free 25(OH)D (f25(OH)D) and total 25(OH)D, making them useful for assessing vitamin D levels. The recommended threshold level for f25(OH)D is 8.499 pg/mL, corresponding to a target concentration of at least 30 ng/mL for t25(OH)D. The upper limit for vitamin D is still unclear, with most experts favoring a upper limit of 100 ng/mL for t25(OH)D.
JOURNAL OF STEROID BIOCHEMISTRY AND MOLECULAR BIOLOGY
(2021)
Article
Nutrition & Dietetics
Guowei Li, Likang Li, Jonathan D. Adachi, Ruoting Wang, Zebing Ye, Xintong Liu, Lehana Thabane, Gregory Y. H. Lip
Summary: This study found a quasi J-shaped relationship between serum circulating 25-hydroxyvitamin D (25(OH)D) level and risk of recurrent stroke in patients with a stroke history. The lowest risk of recurrent stroke was observed at a 25(OH)D level of approximately 60 nmol/L, which was associated with a 48% reduction in risk compared to a level of 10 nmol/L.
Article
Nutrition & Dietetics
RuTong Wang, Weijing Wang, Ping Hu, Ronghui Zhang, Xue Dong, Dongfeng Zhang
Summary: This study aimed to evaluate the association between dietary vitamin D intake and serum vitamin D concentrations with cognitive performance in older Americans. The results showed a positive association between dietary vitamin D intake, serum total 25-hydroxyvitamin D, and cognitive performance, with no significant gender differences in the associations. Further research is needed to clarify the effects of dietary vitamin D intake and specific serum D concentrations on cognitive performance.
Article
Multidisciplinary Sciences
Albertine Enjema Njie, Winstone Mokaya Nyandiko, Phinehas Ademi Ahoya, Jude Suh Moutchia
Summary: This study compared the effectiveness of APGAR scores in diagnosing birth asphyxia with the gold standard, and identified healthcare provider factors that affect the ineffective use of APGAR scores. The results showed that APGAR scores had low sensitivity and positive predictive values. Healthcare provider factors associated with ineffective use of APGAR scores included instrumental delivery, lack of access to APGAR scoring charts, and neonatal resuscitation.
Article
Nutrition & Dietetics
Spyridon N. Karras, Erdinc Dursun, Merve Alaylioglu, Duygu Gezen-Ak, Stefan Pilz, Cedric Annweiler, Fatme Al Anouti
Summary: This study aimed to evaluate the combined effect of maternal and neonatal VDBP polymorphism heterogeneity in conjunction with different maternal and neonatal 25(OH)D cutoffs on neonatal anthropometric profile at birth. The findings suggest a potential role for neonatal VDBP genotypes rs2298850 and rs4588, in conjunction with specific neonatal 25(OH)D cutoffs, in affecting neonatal growth and development. However, no significant effects were observed for maternal VDBP polymorphisms or maternal 25(OH)D concentrations at birth on neonatal anthropometry.
Article
Nutrition & Dietetics
Tomozumi Takatani, Yuzuka Kunii, Mamoru Satoh, Akifumi Eguchi, Midori Yamamoto, Kenichi Sakurai, Rieko Takatani, Fumio Nomura, Naoki Shimojo, Chisato Mori
Summary: The correlation between maternal vitamin D concentrations and birth outcomes is conflicting. This study found that the maternal vitamin D metabolite ratio, specifically VMR2, is associated with neonatal anthropometric data regardless of 25(OH)D concentrations. Accurate measurement of vitamin D metabolites can help understand the effects of vitamin D on birth outcomes.
Article
Nutrition & Dietetics
Sonja Soininen, Aino-Maija Eloranta, Ursula Schwab, Timo A. Lakka
Summary: The purpose of this study was to investigate the intake and sources of vitamin D, as well as the determinants of serum 25-hydroxyvitamin D (S-25(OH)D) in Finnish adolescents. The results showed that most adolescents had vitamin D intake at the recommended level, although a quarter did not meet the recommended intake and almost a third had low levels of S-25(OH)D. The main determinants of S-25(OH)D were vitamin D intake from supplements, consumption of milk products, consumption of meat products, travels to sunny countries, and average daylight time.
EUROPEAN JOURNAL OF NUTRITION
(2023)
Article
Nutrition & Dietetics
Naoko Tsugawa, Mayu Nishino, Akiko Kuwabara, Honami Ogasawara, Maya Kamao, Shunjiro Kobayashi, Junichi Yamamura, Satoshi Higurashi
Summary: The study found that the low vitamin D status in recent lactating mothers may have decreased the concentrations of vitamin D and 25OHD in breast milk, compared to the 1980s. This has important implications for improving the vitamin D status of lactating mothers and infants.
Article
Nutrition & Dietetics
Zhenyu Zhong, Guannan Su, Liping Du, Qingyun Zhou, Fuzhen Li, Wei Chi, Shengyun Liu, Meifen Zhang, Xianbo Zuo, Peizeng Yang
Summary: This study using Mendelian randomization found that genetically increased serum 25-hydroxyvitamin D levels were associated with a higher risk of Behcet's disease, with data from Chinese and Turkish cohorts supporting this conclusion. The contribution to Behcet's disease risk may increase with higher levels of vitamin D.
CLINICAL NUTRITION
(2021)
Article
Biochemistry & Molecular Biology
Frank Z. Stanczyk, Intira Sriprasert, Rachel Danis, Raj Pandian, Harpreet Matharu, Nicole Bender, Melissa Natavio
Summary: This study compared the effects of two combined oral contraceptive formulations on 25(OH)D levels and VDBP levels, revealing different impacts. LNG may have a suppressive effect on VDBP. Further research is needed to understand the influence of hormonal contraceptive formulations on vitamin D status and women's health.
JOURNAL OF STEROID BIOCHEMISTRY AND MOLECULAR BIOLOGY
(2021)
Article
Endocrinology & Metabolism
Rebecca J. Moon, Laura D. F. Cooke, Stefania D'Angelo, Elizabeth M. Curtis, Philip Titcombe, Justin H. Davies, Keith M. Godfrey, Jane K. Cleal, Rohan M. Lewis, Cyrus Cooper, Nicholas C. Harvey
Summary: There is an association between specific single nucleotide polymorphisms (SNPs) in genes related to vitamin D metabolism pathway and cord blood 25(OH)D in both mothers and offspring, indicating a potential role of genetic factors in this relationship.
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2022)
Article
Multidisciplinary Sciences
Hsin-Ya Tang, Wang-Sheng Ko, Yuan-Horng Yan, Su-Chen Yu, Ya-ling Chiou
Summary: Shift nurses in Taiwan often experience 25(OH)D deficiency, sleep disturbances, depression, and fatigue. However, no significant correlation was found between 25(OH)D levels and mental health.
SCIENTIFIC REPORTS
(2022)
Article
Pediatrics
Simei Wang, Quanmei Xu, Anqi Wang, Fang Yuan, Xiaona Luo, Yilin Wang, Miao Guo, Yuanfeng Zhang, Wenjing Zhang, Xiaobing Ji, Yun Ren, Yucai Chen
Summary: This study found a correlation between 25-hydroxyvitamin D deficiency and tic disorders (TD) in Chinese children, but no correlation between 25-hydroxyvitamin D deficiency and the severity of TD. Additionally, the deficiency of 25-hydroxyvitamin D was most pronounced in children over the age of 9.
FRONTIERS IN PEDIATRICS
(2022)
Article
Endocrinology & Metabolism
Zhuohui Chen, Menghui Liu, Xingfeng Xu, Lixiang He, Peng Wang, Xiaojie Cai, Rihua Huang, Shaozhao Zhang, Xinghao Xu, Yuhui Lai, Yiquan Huang, Miaohong Li, Yifen Lin, Peihan Xie, Xinxue Liao, Xiaodong Zhuang, Yue Guo
Summary: This study investigated the joint association of serum 25-hydroxyvitamin D [25(OH)D] and klotho with mortality risk in American community-dwelling adults. The results showed that vitamin D-associated mortality risk is observed only with concurrently decreasing klotho, indicating that vitamin D metabolism dysfunction increases the risk of mortality.
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2023)
Article
Endocrinology & Metabolism
Jens Bollerslev, Evelina Sjostedt, Lars Rejnmark
Summary: PTH plays a crucial role in regulating calcium and phosphate balance in adults, with various clinical manifestations and cardiovascular risks associated with parathyroid disorders. While most PHPT patients are asymptomatic, they still face cardiovascular risks; Ps-HypoPT patients show resistance to PTH with unclear CV risks; HypoPT patients often develop hormonal deficiency syndrome post-surgery, leading to increased CV risk.
ANNALES D ENDOCRINOLOGIE
(2021)
Article
Endocrinology & Metabolism
Etki A. R. Hartogsohn, Aliya A. Khan, Line Underbjerg Kjaersulf, Tanja Sikjaer, Sharjil Hussain, Lars Rejnmark
CLINICAL ENDOCRINOLOGY
(2020)
Article
Endocrinology & Metabolism
Neil J. Gittoes, Sherwin Criseno, Natasha M. Appelman-Dijkstra, Jens Bollerslev, Ernesto Canalis, Lars Rejnmark, Zaki Hassan-Smith
EUROPEAN JOURNAL OF ENDOCRINOLOGY
(2020)
Article
Nutrition & Dietetics
Lise Sofie Bislev, Ulrik Kraemer Sundekilde, Ece Kilic, Trine Kastrup Dalsgaard, Lars Rejnmark, Hanne Christine Bertram
Review
Endocrinology & Metabolism
Lars Rejnmark, Henriette Ejlsmark-Svensson
CURRENT OSTEOPOROSIS REPORTS
(2020)
Article
Endocrinology & Metabolism
Giovanna Mantovani, Murat Bastepe, David Monk, Luisa De Sanctis, Susanne Thiele, S. Faisal Ahmed, Roberto Bufo, Timothee Choplin, Gianpaolo De Filippo, Guillemette Devernois, Thomas Eggermann, Francesca M. Elli, Aurora Garcia Ramirez, Emily L. Germain-Lee, Lionel Groussin, Neveen A. T. Hamdy, Patrick Hanna, Olaf Hiort, Harald Jueppner, Peter Kamenicky, Nina Knight, Elvire Le Norcy, Beatriz Lecumberri, Michael A. Levine, Outi Maekitie, Regina Martin, Gabriel Angel Martos-Moreno, Manasori Minagawa, Philip Murray, Arrate Pereda, Robert Pignolo, Lars Rejnmark, Rebeca Rodado, Anya Rothenbuhler, Vrinda Saraff, Ashley H. Shoemaker, Eileen M. Shore, Caroline Silve, Serap Turan, Philip Woods, M. Carola Zillikens, Guiomar Perez de Nanclares, Agnes Linglart
HORMONE RESEARCH IN PAEDIATRICS
(2020)
Article
Multidisciplinary Sciences
Tilman A. Grunewald, Marianne Liebi, Nina K. Wittig, Andreas Johannes, Tanja Sikjaer, Lars Rejnmark, Zirui Gao, Martin Rosenthal, Manuel Guizar-Sicairos, Henrik Birkedal, Manfred Burghammer
Article
Multidisciplinary Sciences
Christine Rohr Thomsen, Ioanna Milidou, Lone Hvidman, Mohammed Rohi Khalil, Lars Rejnmark, Niels Uldbjerg
Article
Multidisciplinary Sciences
Aline Clabaut, Celine Grare, Gaelle Rolland-Valognes, Jean-Guillaume Letarouilly, Chantal Bourrier, Thomas L. Andersen, Tanja Sikjaer, Lars Rejnmark, Charlotte Ejersted, Philippe Pastoureau, Pierre Hardouin, Massimo Sabatini, Odile Broux
Summary: Preliminary findings suggest that bone marrow adipocyte secretions may contribute to bone loss by inducing transdifferentiation of osteoblasts into adipocytes. This phenomenon was confirmed in elderly subjects, indicating a potential mechanism for decreased bone mass with aging.
Review
Endocrinology & Metabolism
Elvira O. Gosmanova, Pascal Houillier, Lars Rejnmark, Claudio Marelli, John P. Bilezikian
Summary: Patients with chronic hypoparathyroidism managed with conventional therapy, including oral calcium and active vitamin D, may have a higher risk of renal complications such as nephrolithiasis and nephrocalcinosis compared to the general population. Studies show an increased risk of chronic kidney disease in these patients, with rates varying depending on the duration of disease and treatment.
REVIEWS IN ENDOCRINE & METABOLIC DISORDERS
(2021)
Article
Endocrinology & Metabolism
Rasmus Espersen, Lars Rejnmark
Summary: This study aimed to investigate the immediate effects of milk intake on cardiovascular function. The results showed that milk intake significantly increased ionized calcium levels, but did not have acute effects on cardiovascular health indices.
CLINICAL ENDOCRINOLOGY
(2022)
Article
Endocrinology & Metabolism
Lise Sofie Bislev, Louise Wamberg, Lars Rolighed, Diana Grove-Laugesen, Lars Rejnmark
Summary: Supplementation of vitamin D did not have a significant impact on muscle health or quality of life overall. However, there was a potential beneficial effect on muscle strength in severely obese individuals and on quality of life in vitamin D deficient individuals.
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2022)
Article
Endocrinology & Metabolism
Lars Rejnmark, Olulade Ayodele, Angela Lax, Fan Mu, Elyse Swallow, Elvira O. Gosmanova
Summary: This study found that adult patients with chronic hypoparathyroidism treated with rhPTH(1-84) had a significantly lower risk of developing chronic kidney disease (CKD) compared to patients not treated with rhPTH(1-84).
CLINICAL ENDOCRINOLOGY
(2023)
Article
Endocrinology & Metabolism
Aliya A. Khan, John P. Bilezikian, Maria Luisa Brandi, Bart L. Clarke, Neil J. Gittoes, Janice L. Pasieka, Lars Rejnmark, Dolores M. Shoback, John T. Potts, Gordon H. Guyatt, Michael Mannstadt
Summary: This clinical practice guideline provides evidence-based recommendations for the prevention, diagnosis, and management of hypoparathyroidism. Evaluating serum PTH within 12 to 24 hours post total thyroidectomy can predict the development of permanent postsurgical hypoparathyroidism. Genetic testing may be helpful for individuals with nonsurgical hypoparathyroidism.
JOURNAL OF BONE AND MINERAL RESEARCH
(2022)
Article
Endocrinology & Metabolism
Elvira O. Gosmanova, Olulade Ayodele, Kristina Chen, Erin E. Cook, Fan Mu, Joshua A. Young, Lars Rejnmark
Summary: This study found an association between elevated serum calcium levels and the development of CKD in patients with chronic hypoparathyroidism.
INTERNATIONAL JOURNAL OF ENDOCRINOLOGY
(2022)