☆ 4.5 Article

Staphylococcus lugdunensis strain with a modified PBP1A/1B expressing resistance to β-lactams

EUROPEAN JOURNAL OF CLINICAL MICROBIOLOGY & INFECTIOUS DISEASES (2012)

Journal

EUROPEAN JOURNAL OF CLINICAL MICROBIOLOGY & INFECTIOUS DISEASES

Volume 31, Issue 2, Pages 169-172

Publisher

SPRINGER

DOI: 10.1007/s10096-011-1289-8

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Infectious Diseases Microbiology

Funding

Medical School of the University of Thessalia [3917]

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Abstract

We describe for the first time the emergence of an mecA-negative Staphylococcus lugdunensis strain with a modified PBP1A/1B that expresses resistance to all beta-lactams. A duplication of the tetrapeptide S(569)AYG, which is part of the transpeptidase domain of PBP1A/1B and closely located to the K(583)TG catalytic motif, was associated with this unusual phenotype.

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