Article
Microbiology
Anamika Yadav, Peeyush Jain, Kusum Jain, Yue Wang, Aditi Singh, Ashutosh Singh, Jianping Xu, Anuradha Chowdhary
Summary: This article reports an outbreak of fungemia caused by Lodderomyces elongisporus in a neonatal intensive care unit (NICU) in Delhi, India. The outbreak affected 10 preterm, low-birthweight neonates, with nine of them surviving after treatment. Whole-genome sequencing showed that patient isolates grouped into two clusters, one from stored apples and the other from patients, clinical environments, and stored apples. Recombination was found in all samples, and there was significant genome divergence between the clinical and apple surface strains. The study highlights the diversity, recombination, and evolution of L. elongisporus in the hospital setting.
Article
Microbiology
Atsushi Miyake, Kenji Gotoh, Jun Iwahashi, Akinobu Togo, Rie Horita, Miho Miura, Masahiro Kinoshita, Keisuke Ohta, Yushiro Yamashita, Hiroshi Watanabe
Summary: This study investigates the transmission route and biofilm of Candida parapsilosis in a neonatal intensive care unit (NICU). Microsatellite analysis confirms that the C. parapsilosis strains in the three inpatients and two environmental cultures are the same. Dry weight measurements and electron microscopy confirm the formation of biofilms by C. parapsilosis. The outbreak is attributed to horizontal transfer through the incubator's humidifier, and the biofilm produced by C. parapsilosis is linked to its invasive and infectious properties.
Article
Public, Environmental & Occupational Health
C. Sartor, I. Ligi, P. R. Petit, I. Grandvuillemin, C. Zandotti, A. Nougairede, S. Schipani, F. Fenollar, R. N. Charrel
Summary: This study describes an outbreak of adenovirus (ADV) D8 in a neonatal intensive care unit (NICU), associated with ophthalmologic equipment used for screening retinopathy of prematurity (ROP). The outbreak was significantly attributed to ROP examination, inadequate disinfection protocol, and transmission from parents to neonates and between parents.
JOURNAL OF HOSPITAL INFECTION
(2023)
Article
Environmental Sciences
Randall Jenkins, Devlynne Ondusko, Luke Montrose, Ryan Forbush, David Rozansky
Summary: The study shows that in a neonatal unit, infants receive 98% of DEHP exposure from respiratory devices, with bubble CPAP accounting for 95% of the total exposure. By avoiding the use of IV tubing containing DEHP and modifying respiratory equipment appropriately, DEHP exposure can be significantly reduced.
Article
Public, Environmental & Occupational Health
A. Muyldermans, F. Crombe, P. Bosmans, F. Cools, D. Pierard, I Wybo
Summary: Analysis of a Serratia marcescens outbreak in an NICU from 2018-2019 revealed that replacing siphons and weekly decontamination with acetic acid were key infection control measures. Whole-genome sequencing (WGS) enabled faster recognition and accurate mapping of the outbreak, facilitating the implementation of control measures. Additionally, WGS provided valuable insights into the spread of antibiotic resistance and virulence genes.
JOURNAL OF HOSPITAL INFECTION
(2021)
Article
Public, Environmental & Occupational Health
A. Rahal, A. Andreo, F. Le Gallou, C. Bourigault, C. Bouchand, C. Ferriot, S. Corvec, A. Guillouzouic, C. Gras-Leguen, E. Launay, C. Flamant, D. Lepelletier
Summary: The report discusses the investigation of an Enterobacter cloacae complex outbreak in a neonatal intensive care unit from November 2020 to February 2021. Pulsed-field gel electrophoresis revealed that five out of eight cases were infected with a clonal strain, potentially due to the shared breast pumps among mothers in the unit. Copyright 2021 The Healthcare Infection Society. Published by Elsevier Ltd.
JOURNAL OF HOSPITAL INFECTION
(2021)
Article
Multidisciplinary Sciences
Lu Lin, Weiqin Liu, Jing Mu, Enmei Zhan, Hong Wei, Siqi Hong, Ziyu Hua
Summary: The establishment of NNICU has gradually improved and standardized neuroprotective therapy and clinical follow-up to improve neurodevelopmental prognosis of NE patients. The unit focused on neonatal neurocritical care for babies susceptible to NE with evidence-based medicine guidance.
Article
Obstetrics & Gynecology
Noura Nickel, Sandra Brooks, Chris Mize, Allison Messina
Summary: Specific interventions targeting patient, provider, and environmental factors, including the implementation of a SA decolonization protocol, were successful in decreasing the incidence of SA infections in neonates.
JOURNAL OF PERINATOLOGY
(2022)
Article
Multidisciplinary Sciences
Carolin Boehne, Leonard Knegendorf, Frank Schwab, Ella Ebadi, Franz-Christoph Bange, Marius Vital, Dirk Schlueter, Gesine Hansen, Sabine Pirr, Corinna Peter, Bettina Bohnhorst, Claas Baier
Summary: This study investigated MRSA colonization and infection in a mixed tertiary neonatal intensive and intermediate care unit in Germany over an 8-year period. The study found that the burden of MRSA was low and emphasized the importance of a comprehensive infection control concept.
Article
Multidisciplinary Sciences
Maskit Bar-Meir, Shoshana Bendelac, Irina Shchors
Summary: The aim of this study was to assess the safety of 2% chlorhexidine gluconate (CHG) bathing in NICU patients. The results showed that after 661 days of treatment on 810 newborns, no skin reactions were observed and the bloodstream infection rate was similar to the control group. It was concluded that 2% CHG bathing is safe for infants >30 weeks and >3 days old.
Article
Microbiology
Jia Jie Woon, Azanna Ahmad Kamar, Cindy Shuan Ju Teh, Nuryana Idris, Rosliza Zhazali, Suzana Saaibon, Harvinderjit Kaur Basauhra Singh, Jasreena Kaur Gill Charanjeet Singh, Adeeba Kamarulzaman, Sasheela Ponnampalavanar
Summary: This study describes an epidemiological investigation into a carbapenem-resistant Acinetobacter baumannii (CRAB) outbreak in a neonatal intensive care unit (NICU) and the subsequent strengthening of infection control interventions. The investigation identified gaps in existing infection control measures and implementation of immediate actions successfully halted further CRAB transmission.
Article
Public, Environmental & Occupational Health
Lukas Bechmann, Ralf Boettger, Claas Baier, Aljoscha Tersteegen, Katja Bauer, Achim J. Kaasch, Gernot Geginat
Summary: This retrospective case-control study investigated the origin of a Serratia marcescens outbreak in a neonatal intensive care unit. The study found that the infection originated from a breast milk donor. The outbreak was controlled through the implementation of an infection control bundle and strict hygiene measures.
INFECTION CONTROL AND HOSPITAL EPIDEMIOLOGY
(2023)
Article
Public, Environmental & Occupational Health
Ghaziaa Alanezi, Alaa Almulhem, Marwh Aldriwesh, Manal Bawazeer
Summary: Gram-negative bacteria are a significant concern in neonatal intensive care units, particularly multidrug-resistant Klebsiella pneumonia. In this case series, a combination of three antimicrobials (amikacin, colistin, and meropenem) was found to effectively eradicate multidrug-resistant K. pneumonia in septic neonates. The triple regimen resulted in a complete recovery for 80% of the neonates, highlighting the potential of combination antimicrobial therapies in combating multidrug-resistant bacterial isolates.
JOURNAL OF INFECTION AND PUBLIC HEALTH
(2022)
Article
Multidisciplinary Sciences
Btissam Arhoune, Samira El Fakir, Sara Himri, Kaoutar Moutaouakkil, Salma El Hassouni, Moussa Benboubker, Fouzia Hmami, Bouchra Oumokhtar
Summary: The study revealed a high colonization rate of ESBL and CPE in neonates during their hospitalization in NICU. Risk factors significantly associated with MDR enterobacteria colonization included admission from the maternity of the university hospital and neurological distress. High rates of colonization and presence of resistance genes indicate possible cross-transmission in the NICU, emphasizing the need for active strategies to control the spread of MDR enterobacteria.
Article
Immunology
Sebastian Baier-Grabner, Susanne Equiluz-Bruck, David Endress, Marion Blaschitz, Soren Schubert, Alexander Indra, Marta Fudel, Thomas Frischer, Florian Goetzinger
Summary: This study reports an outbreak of a yersiniabactin-producing K. aerogenes strain causing invasive infection in preterm infants, possibly associated with increased iron uptake. Extended search for virulence factors and genetic sequencing could be pivotal in the management of NICU outbreaks in the future.
PEDIATRIC INFECTIOUS DISEASE JOURNAL
(2022)