Article
Gastroenterology & Hepatology
Ahmed Morad Asaad, Gasser El-Azab, Eman Abdelsameea, Osama Elbahr, Ahmed Kamal, Mohamed Abdel-Samiee, Ahmed Abdelfattah, Heba Abdallah, Doha Maher, Ahmed El-Refaie, Samar Ebrahim Ghanem, Shamshul Ansari, Samah Mohammed Awad
Summary: This study investigates H. pylori infection and resistance patterns in Egyptian patients, as well as the impact of H. pylori virulence genetic determinants on the success of 14-day triple therapy. The results show a low eradication rate with the triple therapy and high resistance to clarithromycin, amoxicillin, and metronidazole. Successful eradication is significantly associated with vacA s1-positive strains, while failed eradication is significantly associated with clarithromycin and amoxicillin-resistant strains.
WORLD JOURNAL OF GASTROENTEROLOGY
(2023)
Article
Medicine, Research & Experimental
Wareeporn Wattanawongdon, Theeraya Simawaranon Bartpho, Taweesak Tongtawee
Summary: This study aimed to identify Helicobacter pylori virulence factors and examine their associations with clinical outcomes in Thai patients. The cagA genotype was found to be significantly more common in patients with chronic gastritis and peptic ulcers, possibly being the main cause of serious inflammation of the gastric mucosa. The cagA gene is likely an important factor explaining gastroduodenal disease outcomes in Thai patients with H. pylori infection.
JOURNAL OF INTERNATIONAL MEDICAL RESEARCH
(2023)
Article
Food Science & Technology
Aina Ichihara, Hinako Ojima, Kazuyoshi Gotoh, Osamu Matsushita, Susumu Take, Hiroyuki Okada, Akari Watanabe, Kenji Yokota
Summary: This study aimed to explore the association between different antibody reactivities and bacterial genome organization. High-reactive strains showed high gene homology, while inversion around the vacA gene was found in the genome of poorly responsive antigen strains.
Article
Gastroenterology & Hepatology
Fidson-Juarismy Vesga, Adriana Rocio Beltran-Benavides, Ana Maria Marquez-Duque, Camilo Venegas, Alba-Alicia Trespalacios
Summary: This study identified the presence of H. pylori DNA in the Bogota River and wastewater treatment plants, demonstrating the potential risk of this pathogen in water sources.
Article
Immunology
Vignesh Shetty, Ramachandra Lingadakai, Ganesh C. Pai, Mamatha Ballal
Summary: This study validated and compared existing diagnostic methods for detecting H. pylori in biopsies from dyspeptic patients in southern India. It also revealed that different patterns of virulence gene combinations play a significant role in the progression of gastroduodenal disease.
INDIAN JOURNAL OF MEDICAL MICROBIOLOGY
(2021)
Article
Immunology
Sebastian Reuter, Jonas Raspe, Hendrik Uebner, Alexandros Contoyannis, Eva Pastille, Astrid M. Westendorf, Georgia C. Caso, Timothy L. Cover, Anne Mueller, Christian Taube
Summary: This study evaluated the therapeutic efficacy of Helicobacter pylori-derived VacA in allergic airway inflammation and found that VacA suppressed allergic airway inflammation by inducing regulatory T cells (Tregs). These findings suggest that the immunomodulatory activity of VacA could be potentially used for the prevention and treatment of allergic airway disease.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Multidisciplinary Sciences
Bui Hoang Phuc, Vo Phuoc Tuan, Ho Dang Quy Dung, Tran Thanh Binh, Pham Huu Tung, Tran Dinh Tri, Ngo Phuong Minh Thuan, Vu Van Khien, Tran Thi Huyen Trang, Junko Akada, Takeshi Matsumoto, Yoshio Yamaoka
Summary: The acquisition of tfs3/4 ICE was common in H. pylori strains in patients with gastroduodenal disease in Vietnam, and the complete cluster of tfs3 ICE was a reliable marker for the severity of disease in the H. pylori infected population.
SCIENTIFIC REPORTS
(2021)
Article
Oncology
Hyung-Suk Yoon, Xiao-Ou Shu, Hui Cai, Wei Zheng, Jie Wu, Wanqing Wen, Regina Courtney, Chris Shidal, Tim Waterboer, William J. Blot, Qiuyin Cai
Summary: This study found an association between Helicobacter pylori infection and lung cancer risk, which may be related to specific H. pylori antigens. The association between H. pylori infection and lung cancer risk may be more evident among African Americans and may be modified by smoking habits.
Review
Medicine, General & Internal
Jaskamal Padda, Khizer Khalid, Ayden Charlene Cooper, Gutteridge Jean-Charles
Summary: Gastric carcinoma is the third leading cause of cancer mortality worldwide, with a noticeable increase in new cases in Eastern Asia. Helicobacter pylori is responsible for the increased incidence of gastric cancer, utilizing multiple strains to survive chronically in the host cell epithelium.
CUREUS JOURNAL OF MEDICAL SCIENCE
(2021)
Article
Chemistry, Multidisciplinary
Yun Lu, Jing Pang, Genzhu Wang, Xinxin Hu, Xue Li, Guoqing Li, Xiukun Wang, Xinyi Yang, Congran Li, Xuefu You
Summary: Helicobacter pylori, a Gram-negative bacterium related to gastric diseases, can develop antibiotic resistance. Daphnetin, a traditional Chinese medicine, shows antibacterial activity without resistance. A proteomics study identified protein changes in H. pylori under daphnetin pressure.
Article
Microbiology
Judit Alarcon-Millan, Jose Bonilla-Delgado, Gloria Fernandez-Tilapa, Nayeli Goreti Nieto-Velazquez, Monica Sierra-Martinez, Victor Manuel Alvarado-Castro, Enoc Mariano Cortes-Malagon
Summary: This study investigated the prevalence of clarithromycin resistance-associated mutations in Mexican patients infected with Helicobacter pylori. The results showed a high prevalence of H. pylori infection (84.3%) among patients with gastric diseases, with the vacA s1m1/cagA+ genotype being the most frequent (44.8%). The prevalence of clarithromycin resistance-associated mutations was 19.8%, with the A2143G and A2142C mutations being the most common. Furthermore, a significant association was found between the A2142G mutation and the vacA s1m1/cagA+ genotype.
Article
Microbiology
Xiaoyan Zhu, Chaohui Zhu, Yajiao Zhao, Xiaochuan Liu, Rina Sa, Yaxuan Wang, Kai Wu, Jianrong Su
Summary: This study investigated the correlation between Helicobacter pylori virulence genes and chronic gastritis. The results showed significant differences in certain virulence genes among different strains, and the detection of these genes is crucial for screening high-risk populations for precancerous lesions and the early prevention and control of gastric cancer.
CURRENT MICROBIOLOGY
(2023)
Editorial Material
Multidisciplinary Sciences
Benjamin Plackett
Summary: Sickle-cell disease is prevalent in the Middle East, with 2.6% of the population in some areas affected by this genetic disorder. Adlette Inati, a specialist in clinical haematology at the Lebanese American University, and president of a foundation supporting sickle-cell disease patients in Lebanon, discusses the potential benefits of genetic screening in this region.
Article
Gastroenterology & Hepatology
Dogukan Ozbey, Suleyman Demiryas, Seher Akkus, Nuray Kepil, Harika Oyku Dinc, Nesrin Gareayaghi, Mehmet Demirci, Enes Ali Kurt, Omer Uysal, Suat Saribas, Hrisi Bahar Tokman, Bekir Kocazeybek
Summary: This study evaluated the associations between the polymorphisms of the cagL gene of Helicobacter pylori (H. pylori) and gastroduodenal pathologies, as well as the associations between vacA genotypes and cagL polymorphisms. PCR amplification and sequencing were performed to analyze the cagL and cagA, vacA genes, and the amino acid sequences were translated. The results showed that the D58 and D58/K59 amino acid polymorphisms were significantly higher in gastric cancer cases compared to duodenal ulcer cases, and the D58/K59 polymorphism in gastric cancer cases was associated with the vacA genotype s1/m2. Multivariate logistic regression analysis demonstrated a significant Odds Ratio for the D58/K59 amino acid polymorphism.
TURKISH JOURNAL OF GASTROENTEROLOGY
(2023)
Review
Physiology
Akriti Prashar, Mariana Capurro, Nicola L. Jones
Summary: This article discusses how Helicobacter pylori overcomes gastric epithelial host defense responses to promote its long-term survival and establish a chronic infection through the secretion of virulence factors, immune evasion, and manipulation of cellular mechanisms.
ANNUAL REVIEW OF PHYSIOLOGY
(2022)
Article
Microbiology
Kiarash Ghazvini, Yoshio Yamaoka, Mohsen Karbalaei, Masoud Keikha
Summary: This study aims to assess the relationship between H. pylori infection and alopecia areata, and found a significant association between H. pylori infection and susceptibility to alopecia areata.
REVIEWS AND RESEARCH IN MEDICAL MICROBIOLOGY
(2022)
Article
Gastroenterology & Hepatology
Adi Wasis Prakosa, Muhammad Miftahussurur, Juniastuti Juniastuti, Langgeng Agung Waskito, Dalla Doohan, Kartika Afrida Fauzia, Yudith Annisa Ayu Rezkitha, Titong Sugihartono, Ari Fahrial Syam, Tomohisa Uchida, Yoshio Yamaoka
DIGESTIVE DISEASES
(2022)
Editorial Material
Microbiology
Filipa F. Vale, Philippe Lehours, Yoshio Yamaoka
FRONTIERS IN MICROBIOLOGY
(2022)
Article
Genetics & Heredity
Yuanhai You, Kaisa Thorell, Lihua He, Koji Yahara, Yoshio Yamaoka, Jeong-Heon Cha, Kazunari Murakami, Yukako Katsura, Ichizo Kobayashi, Daniel Falush, Jianzhong Zhang
Summary: The East Asian region, including China, Japan and Korea, has high gastric cancer death rates. The population structure of Helicobacter pylori in this region is unknown. This study analyzed H. pylori genomes from different areas in these countries and discovered genetic differences associated with gastric cancer risk. These findings have important implications for understanding the variation in gastric cancer incidence between geographical areas in East Asia.
MICROBIAL GENOMICS
(2022)
Article
Microbiology
Phawinee Subsomwong, Dalla Doohan, Kartika Afrida Fauzia, Junko Akada, Takashi Matsumoto, Than Than Yee, Kyaw Htet, Langgeng Agung Waskito, Vo Phuoc Tuan, Tomohisa Uchida, Takeshi Matsuhisa, Yoshio Yamaoka
Summary: The prevalence of H. pylori infection and its resistance to metronidazole is high in Myanmar. Classical triple therapy remains effective as a first-line treatment. Next-generation sequencing is a powerful tool for identifying mutations and monitoring the spread of antibiotic-resistant strains.
Article
Nutrition & Dietetics
Farapti Farapti, Annas Buanasita, Dominikus R. Atmaka, Stefania W. Setyaningtyas, Merryana Adriani, Purwo S. Rejeki, Yoshio Yamaoka, Muhammad Miftahussurur
Summary: Increasing potassium and reducing sodium intake are identified as important interventions to reduce non-communicable diseases. This study examined the association between potassium intake and nutritional contents and diet cost in low sodium high potassium (LSHP) diets compared to usual diets. The LSHP diet had higher nutritional quality and cost but lower fat and energy density compared to the usual diet. There was a strong positive correlation between fibre, potassium, and diet cost.
JOURNAL OF NUTRITIONAL SCIENCE
(2022)
Review
Microbiology
Shamshul Ansari, Yoshio Yamaoka
Summary: Despite the decrease in H. pylori infection rates, gastric cancer morbidity and mortality rates remain high, fueled by antimicrobial resistance and treatment failure. Accurate diagnosis is crucial for effective treatment and eradication of infections. This article provides a comprehensive description of available diagnostic methods, aiding clinicians and researchers in selecting appropriate approaches and emphasizing the importance of clinical settings, patient factors, and clinical factors in diagnosis and evaluating eradication efficacy.
CLINICAL MICROBIOLOGY REVIEWS
(2022)
Article
Microbiology
Nicole Tegtmeyer, Bodo Linz, Yoshio Yamaoka, Steffen Backert
Summary: The genomes of the gastric bacterial pathogen Helicobacter pylori contain multiple type-IV secretion systems, with the cag T4SS playing a crucial role in chronic infection and gastric disease development. This study reveals a unique T4SS-dependent mechanism of TLR9 stimulation by H. pylori, which is different from other bacteria.
CURRENT MICROBIOLOGY
(2022)
Review
Gastroenterology & Hepatology
Langgeng Agung Waskito, Yudith Annisa Ayu Rezkitha, Ratha-korn Vilaichone, Titong Sugihartono, Syifa Mustika, I Dewa Nyoman Wibawa, Yoshio Yamaoka, Muhammad Miftahussurur
Summary: In the past decade, the development of next-generation sequencing for human microbiota has led to significant discoveries regarding the gastric microbiota. The dominance of Helicobacter pylori in the gastric microbiota is reduced as diseases progress from gastritis to precancerous lesions and gastric cancer, with other bacteria taking its place. These findings highlight the important role of gastric microbiota in the development of gastroduodenal diseases and suggest that H. pylori may not be the sole gastric pathogen.
Review
Medicine, General & Internal
Shamshul Ansari, Yoshio Yamaoka
Summary: H. pylori infection is associated with gastric mucosal diseases and gastric cancer, and animal models are useful for studying the pathophysiology of these complications.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Multidisciplinary Sciences
Rumiko Suzuki, Naruya Saitou, Osamu Matsuari, Seiji Shiota, Takashi Matsumoto, Junko Akada, Nagisa Kinjo, Fukunori Kinjo, Kuniko Teruya, Makiko Shimoji, Akino Shiroma, Mototsugu Kato, Kazuhito Satou, Takashi Hirano, Masahiro Asaka, Kirill Kryukov, Yoshan Moodley, Yoshio Yamaoka
Summary: Helicobacter pylori, a virulence bacterium, can be used as a marker for tracing human migration. This study identified indigenous H. pylori strains hspOkinawa and hpRyukyu in Okinawa, Japan and revealed their origin and divergence patterns.
Article
Gastroenterology & Hepatology
Deasy Natalia Adriana, Titong Sugihartono, Iswan Abbas Nusi, Poernomo Boedi Setiawan, Herry Purbayu, Ummi Maimunah, Ulfa Kholili, Budi Widodo, Husin Thamrin, Amie Vidyani, Hasan Maulahela, Yoshio Yamaoka, Muhammad Miftahussurur
Summary: This study showed a close relationship between fecal calprotectin levels and the severity of hypoxemia in COVID-19 patients. There were also significant differences in fecal calprotectin levels based on the severity of ARDS. A strong negative correlation between the P/F ratio and fecal calprotectin levels was found.
Article
Gastroenterology & Hepatology
Titong Sugihartono, Kartika Afrida Fauzia, Muhammad Miftahussurur, Langgeng Agung Waskito, Purwo Sri Rejeki, Reny I'tishom, Ricky Indra Alfaray, Dalla Doohan, Rizki Amalia, Camilia Metadea Aji Savitri, Yudith Annisa Ayu Rezkitha, Junko Akada, Takashi Matsumoto, Yoshio Yamaoka
Summary: We evaluated the microbiota in the stomach of GERD patients using 16S rRNA approach and found that the presence of ERD can alter microbiome diversity, while H. pylori is negatively correlated with ERD.
Article
Sport Sciences
Adi Pranoto, Maulana Bagus Adi Cahyono, Reinaldi Yakobus, Nabilah Izzatunnisa, Roy Novri Ramadhan, Purwo Sri Rejeki, Muhammad Miftahussurur, Wiwin Is Effendi, Citrawati Dyah Kencono Wungu, Yoshio Yamaoka
Summary: A sedentary lifestyle and unhealthy diet increase the risk of obesity, which leads to the production of proinflammatory cytokines and higher morbidity and mortality rates. This study examined the effects of different types of exercise on reducing proinflammatory cytokines in young adult females with obesity.
Article
Medicine, General & Internal
Muhammad Miftahussurur, Chyntia Dewi Maharani Putri, Titong Sugihartono, Ari Fahrial Syam, Herry Purbayu, Diah Priyantini, Hartono Kahar, Yudith Annisa Ayu Rezkitha, Iswan Abbas Nusi, Poernomo Boedi Setiawan, Ummi Maimunah, Langgeng Agung Waskito, Ulfa Kholili, Budi Widodo, Amie Vidyani, Husin Thamrin, Gontar Alamsyah Siregar, Reny I'tishom, Tomohisa Uchida, Yoshio Yamaoka
Summary: This study found that the urease levels were higher in patients with acute and chronic gastritis as detected by the (14C)-Urea Breath Test. However, the test was not sufficient to predict cases of atrophic gastritis.
ACTA MEDICA INDONESIANA
(2022)
