Article
Agriculture, Dairy & Animal Science
Richard Ducatelle, Evy Goossens, Venessa Eeckhaut, Filip Van Immerseel
Summary: Intestinal health is crucial for digestion and nutrient absorption, which directly impacts performance. High performing poultry lines often face intestinal health issues due to high feed intake, putting pressure on the digestive system. Excess undigested nutrients can lead to dysbiosis and inflammation, causing gut leakage. This paper reviews key factors and nutritional tools to support intestinal health.
Review
Food Science & Technology
Diogo Carregosa, Catarina Pinto, Maria Angeles Avila-Galvez, Paulo Bastos, David Berry, Claudia Nunes Santos
Summary: Numerous epidemiological studies have confirmed the health benefits of consuming fruits, vegetables, and beverages rich in (poly)phenols, especially in preventing and treating cardiovascular and neurological diseases. However, the role of phenolic acids has been overlooked in previous research. This review focuses on two main aspects of low molecular weight phenolic metabolites: the microbiota responsible for their production and their analysis and pharmacokinetics in the human circulation. The aim is to advance scientific understanding of the ubiquitous roles of low molecular weight phenolic metabolites in physiologically relevant concentrations and (patho)physiologically relevant conditions in humans.
COMPREHENSIVE REVIEWS IN FOOD SCIENCE AND FOOD SAFETY
(2022)
Article
Biochemistry & Molecular Biology
Tiantian Zhao, Chen Zhang, Saiyi Zhong, Qirong Chen, Shuo Liu, Wenjuan Jiao, Weifeng Liu, Lihua Huang, Yehui Zhang, Yousheng Zhang
Summary: Anchovy protein hydrolysates (APH) and catechin (CA) have been shown to improve memory. This study investigated the effects of APH-CA conjugates on memory enhancement, gut microbiota, fecal metabolites, and neurotransmitters in mice. The results showed that APH-CA regulated various biomarkers and had better alleviating effects than APH and CA alone. The study also revealed possible connections between gut microbiota, fecal metabolites, and brain neurotransmitters. These findings suggest that the regulation of the microbiota-metabolites-brain-neurotransmitters axis may be one of the mechanisms for the cognitive enhancement effects of APH-CA, and the synergic effects of APH and CA were partially confirmed.
Review
Nutrition & Dietetics
Dae Yong Yi, Su Yeong Kim
Summary: Human breast milk provides essential nutrients for early human growth and development, as well as immunologic components that support infant immunity. Its unique microbiome contributes to infant gut colonization, while extracellular vesicles and microRNA play important roles in infant development. Overall, the various components in human breast milk have significant health effects and potential applications in human health.
Review
Gastroenterology & Hepatology
Renate A. A. A. Ruigrok, Rinse K. Weersma, Arnau Vich Vila
Summary: The review highlights the importance of studying the microbial communities in the small intestine, which has been largely overlooked compared to the fecal microbiota. It provides an overview of methods for studying the composition and dynamics of the small intestinal microbiota and discusses its role in maintaining physiological functions and the development of diseases. Understanding and characterizing the small intestinal microbiota has the potential to advance gut microbiome research and the development of diagnostic and therapeutic approaches for diseases.
Article
Biochemical Research Methods
Qingfeng Zhang, Kai Yu, Shihua Li, Xiaolong Zhang, Qi Zhao, Xia Zhao, Zekun Liu, Han Cheng, Ze-Xian Liu, Xiaoxing Li
Summary: The study introduced gutMEGA, a comprehensive database curating and hosting quantitative gut microbiota datasets from Homo sapiens. It integrated 59,132 quantification events for 6457 taxa under 776 conditions, providing users with a fast and simple way to access relative abundances of intestinal microbes through various browsing and search functions. GutMEGA is a convenient and comprehensive resource for gut metagenome research, available for free access at http://gutmega.omicsbio.info.
BRIEFINGS IN BIOINFORMATICS
(2021)
Article
Biochemical Research Methods
Andrea Anesi, Kirsten Berding, Gerard Clarke, Catherine Stanton, John F. Cryan, Noel Caplice, R. Paul Ross, Andrea Doolan, Urska Vrhovsek, Fulvio Mattivi
Summary: The modulation of host and dietary metabolites by gut microbiota is crucial for maintaining host physiology and understanding various pathologies. A new chromatography-mass spectrometry method was developed to quantitate 89 metabolites resulting from human-gut microbial cometabolism in plasma, serum, and urine. This method provides accurate and efficient measurement of metabolite concentrations in biological fluids, making it a valuable tool for studying changes in human-gut microbial cometabolism in health and disease.
JOURNAL OF PROTEOME RESEARCH
(2022)
Review
Pharmacology & Pharmacy
Stephen C. Emencheta, Chinasa V. Olovo, Osita C. Eze, Chisom F. Kalu, Dinebari P. Berebon, Ebele B. Onuigbo, Marta M. D. C. Vila, Victor M. Balcao, Anthony A. Attama
Summary: Bacteriophages are nano-sized viruses that can live off bacteria and interact with bacterial cells in the gut microbiota, which has implications for human health.
Review
Biochemistry & Molecular Biology
Maria Garcia-Ricobaraza, Jose Antonio Garcia-Santos, Mireia Escudero-Marin, Estefania Dieguez, Tomas Cerdo, Cristina Campoy
Summary: Human milk is considered the most complete food for infants, providing important nutrients and bioactive components for infant health. Interest in human milk as a potential source of probiotics and commensal bacteria has been growing, which may influence infant gut colonization and immune system maturation. Research on microbial communities in human breast milk samples and the impact of HM microbiota dysbiosis on maternal and infant health provides valuable insights into the role of breast milk-related bacteria as a novel probiotic strategy.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Review
Immunology
Pei Zhou, Yawen Hu, Xiaoyan Wang, Luxuan Shen, Xinghao Liao, Yajuan Zhu, Jiadong Yu, Fulei Zhao, Yi Zhou, Hengshui Shen, Jiong Li
Summary: Microorganisms play a crucial role in the occurrence, development, and treatment of tumors, and are closely related to immunotherapy. This review article summarizes the contributions of microbiota to cancer and its impact on cancer immunotherapy, highlighting the potential mechanisms of their interaction and outlining their potential application in tumor immunotherapy.
FRONTIERS IN IMMUNOLOGY
(2022)
Review
Microbiology
Muhammad Afzaal, Farhan Saeed, Yasir Abbas Shah, Muzzamal Hussain, Roshina Rabail, Claudia Terezia Socol, Abdo Hassoun, Mirian Pateiro, Jose M. Lorenzo, Alexandru Vasile Rusu, Rana Muhammad Aadil
Summary: The human gut contains a complex microbial community, which forms a connecting axis with other organs and plays a vital role in host-microbe interactions. Dysbiosis of the gut microbiota is linked to various human diseases. Understanding the role of gut microbiota in health and disease is crucial for maintaining health and treating diseases.
FRONTIERS IN MICROBIOLOGY
(2022)
Review
Biochemistry & Molecular Biology
Kevin D. Seely, Cody A. Kotelko, Hannah Douglas, Brandon Bealer, Amanda E. Brooks
Summary: The gut microbiota has been shown to play a role in bone metabolism and the pathogenesis of osteoporosis. Despite the established connection between a healthy microbiome and bone homeostasis, the specific mechanisms underlying this relationship are not fully understood. Studying the interactions between the microbiome, osteoblasts, osteoclasts, and RANKL may offer insights into potential therapeutic targets for promoting bone health.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Microbiology
Bich Vu Thi Ngoc, Hai Ho Bich, Gianluca Galazzo, Dung Vu Tien Viet, Melissa Oomen, Trang Nghiem Nguyen Minh, Hoang Tran Huy, Hindrik Rogier van Doorn, Heiman F. L. Wertheim, John Penders
Summary: This study investigated the microbiota composition in humans, domestic animals, water, and processed food in northern Vietnam with a history of antibiotic use. It found lower microbial diversity in individuals who used antibiotics in the past 4 months, with human fecal microbiota being more diverse than nonhuman samples and sharing some amplicon sequence variants with feces from animals, water, and food. There was also a correlation between certain Enterobacteriaceae ASVs and the presence of extended-spectrum beta-lactamase CTX-M-group-2 encoding genes in feces from humans and animals, suggesting exchange of antimicrobial-resistant strains.
Review
Microbiology
Kelly M. Herremans, Andrea N. Riner, Miles E. Cameron, Kelley L. McKinley, Eric W. Triplett, Steven J. Hughes, Jose G. Trevino
Summary: Pancreatic cancer patients have oral microbial shifts that may indicate their risk years before diagnosis, and pathogenic bacteria have been found in pancreatic tumors. Understanding the interaction between the oral microbiome and pancreatic cancer could lead to improved diagnostic and therapeutic approaches, reducing healthcare disparities.
Review
Biochemistry & Molecular Biology
Yu Ri Woo, Sang Hyun Cho, Jeong Deuk Lee, Hei Sung Kim
Summary: Skin cancer is a prevalent form of cancer worldwide. In addition to UV radiation, emerging evidence suggests that the microbiota may also play a role in its development. While the link between microbiota and skin cancer is not well understood, the connection between microbial dysbiosis, inflammation, and modulation of UV-induced immunosuppression suggests a potential association.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
