Journal
EUROPEAN JOURNAL OF CELL BIOLOGY
Volume 91, Issue 1, Pages 24-30Publisher
ELSEVIER GMBH
DOI: 10.1016/j.ejcb.2011.01.005
Keywords
Central tolerance; Knockout; Virus; miRNA; Thymic epithelium; Reaggregate thymus organ culture
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Funding
- Deutsche Forschungsgemeinschaft [Sonderforschungsbereich 455]
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Thymic epithelial cells (TECs) provide a highly specialized microenvironment for the generation of a functional and self-tolerant T cell repertoire. Much of our current view of TEC biology is derived from gain- or loss-of-function approaches, which have significantly contributed to our understanding of gene function in TEC development and T cell repertoire selection. Here, we will review transgenic and viral strategies that have been used to manipulate gene expression in TECs, highlight some of the shortcomings of particular currently available tools and provide a brief outline of our own attempts to more rapidly and/or more specifically assess gene function in TECs. (C) 2011 Elsevier GmbH. All rights reserved.
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