Journal
EUROPEAN JOURNAL OF CELL BIOLOGY
Volume 87, Issue 8-9, Pages 507-515Publisher
ELSEVIER GMBH, URBAN & FISCHER VERLAG
DOI: 10.1016/j.ejcb.2008.01.011
Keywords
podosome; invadopodia; immune synapse
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Funding
- NCI NIH HHS [R01 CA085862, R01 CA085862-09] Funding Source: Medline
- NIGMS NIH HHS [T32 GM008692] Funding Source: Medline
- NATIONAL CANCER INSTITUTE [R01CA085862] Funding Source: NIH RePORTER
- NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES [T32GM008692] Funding Source: NIH RePORTER
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Podosomes and the immune synapse are integrin-mediated adhesive structures that share a common ring-like morphology. Both podosomes and immune synapses have a central core surrounded by a peripheral ring containing talin, vinculin and paxillin. Recent progress suggests significant parallels between the regulatory mechanisms that contribute to the formation of these adhesive structures. In this review. we compare the Structures, functions and regulation of podosomes and the immune synapse. (C) 2008 Elsevier GmbH. All rights reserved.
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