Article
Medicine, General & Internal
Vadim V. Klimontov, Elena A. Koroleva, Rustam S. Khapaev, Anton I. Korbut, Alexander P. Lykov
Summary: This study aimed to identify risk factors and biomarkers of subclinical carotid atherosclerosis (CA) and carotid artery stenosis (CAS) in individuals with type 2 diabetes (T2D). Carotid ultrasonography and evaluation of various clinical parameters were conducted on 389 patients. The results showed that age, sex, glycemic control, complications, and comorbidities were associated with subclinical CA, while factors such as blood pressure, insulin dosage, and kidney function were associated with CAS.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Multidisciplinary Sciences
Chibo Liu, Susu Wu, Xiao Pan
Summary: The study found an association between clustering of CMRFs and pre-diabetes among U.S. adolescents, suggesting the need for effective strategies and measures targeting adolescents with clustering of CMRFs.
SCIENTIFIC REPORTS
(2021)
Article
Endocrinology & Metabolism
Anita Morandi, Claudia Piona, Massimiliano Corradi, Marco Marigliano, Alice Giontella, Silvia Orsi, Federica Emiliani, Angela Tagetti, Denise Marcon, Cristiano Fava, Claudio Maffeis
Summary: This study aimed to assess the association between overall oxidative stress, oxidized lipoproteins, and glycemic variability with early macro-vascular damage in type 1 diabetes (T1D), in addition to traditional risk factors. The results showed that oxidative stress, gender, insulin dose, diabetes duration, and changes in lipids and blood pressure contributed to the variance of early vascular damage in young patients with T1D.
DIABETES RESEARCH AND CLINICAL PRACTICE
(2023)
Article
Public, Environmental & Occupational Health
April P. Carson, D. Leann Long, Andrea L. Cherrington, Gareth R. Dutton, Virginia J. Howard, Todd M. Brown, George Howard, Monika M. Safford, Mary Cushman
Summary: The study found that in adults aged 45 and older, the incidence of diabetes is significantly higher among Black individuals compared to White individuals. Adjusting for age and prediabetes, Black women had a higher risk of diabetes compared to White women, and Black men had a higher risk compared to White men. The individual factors that had the most impact on attenuating the racial disparity were dietary patterns and neighborhood socioeconomic environment for men, and BMI and waist circumference for women. Overall, after considering all factors, the racial disparity in diabetes incidence was similar for men and attenuated for women.
AMERICAN JOURNAL OF PREVENTIVE MEDICINE
(2021)
Article
Medicine, General & Internal
David R. Jacobs, Jessica G. Woo, Alan R. Sinaiko, Stephen R. Daniels, Johanna Ikonen, Markus Juonala, Noora Kartiosuo, Terho Lehtimaki, Costan G. Magnussen, Jorma S. A. Viikari, Nanhua Zhang, Lydia A. Bazzano, Trudy L. Burns, Ronald J. Prineas, Julia Steinberger, Elaine M. Urbina, Alison J. Venn, Olli T. Raitakari, Terence Dwyer
Summary: This prospective cohort study found that childhood cardiovascular risk factors, including BMI, systolic blood pressure, lipid levels, and smoking, were associated with cardiovascular events in adulthood. Childhood risk factors and the change in risk score between childhood and adulthood were associated with midlife cardiovascular events.
NEW ENGLAND JOURNAL OF MEDICINE
(2022)
Article
Health Care Sciences & Services
Yeong Chan Lee, Jiho Cha, Injeong Shim, Woong-Yang Park, Se Woong Kang, Dong Hui Lim, Hong-Hee Won
Summary: In this study, an artificial intelligence model was developed to identify cardiovascular disease using multimodal data including clinical risk factors and fundus photographs. The model achieved high accuracy in both validation datasets and suggested that fundus photography can serve as a possible predictive marker for CVD.
NPJ DIGITAL MEDICINE
(2023)
Editorial Material
Medicine, General & Internal
Julie R. Ingelfinger
Summary: While atherosclerosis has been found on postmortem examination of youths, there is a lack of direct evidence linking childhood cardiovascular risk factors to adult cardiovascular disease outcomes.
NEW ENGLAND JOURNAL OF MEDICINE
(2022)
Review
Biochemistry & Molecular Biology
Elham Hasheminasabgorji, Jay C. Jha
Summary: Diabetes prevalence is increasing rapidly, leading to various complications and premature mortality. Atherosclerosis, a major macro-vascular complication of diabetes, can be mitigated by controlling dyslipidemia and reducing inflammation and oxidative stress with pharmacological agents.
Review
Endocrinology & Metabolism
Chaoqun Wang, Jin Chen, Pin Wang, Shengli Qing, Wenwen Li, Jin Lu
Summary: Imbalance between injury and endogenous protective factors is believed to be the cause of vascular complications in patients with diabetes. Glucagon-like peptide-1 based drugs have been proven to be effective and recommended for the treatment of diabetic patients with high risks or established arteriosclerotic cardiovascular disease. Multiple endogenous protective factors play an important role in combating injury factors and maintaining vascular homeostasis in diabetes.
FRONTIERS IN ENDOCRINOLOGY
(2022)
Article
Cardiac & Cardiovascular Systems
Laurits Juhl Heinsen, Gokulan Pararajasingam, Thomas Rueskov Andersen, Soren Auscher, Hussam Mahmoud Sheta, Helle Precht, Jess Lambrechtsen, Kenneth Egstrup
Summary: This study found a high prevalence of HRP in asymptomatic T2D patients, with HRP detection associated with specific patient characteristics. HRP was not correlated with high CACS, as HRP could be found even in patients with zero CACS.
CARDIOVASCULAR DIABETOLOGY
(2021)
Review
Cell Biology
Giulia Germena, Laura Cecilia Zelarayan, Rabea Hinkel
Summary: Exosomes are small membranous vesicles that contain biological material and can mediate cell-to-cell communication, maintaining homeostasis or modulating disease processes. They play a crucial role in cardiovascular diseases and have potential diagnostic value, although their specific physiological and pathophysiological functions in the cardiovascular system are still not fully understood.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2022)
Article
Health Care Sciences & Services
Marija Majda Perisic, Klemo Vladimir, Sarah Karpov, Mario Storga, Ali Mostashari, Raya Khanin
Summary: A polygenic risk score for GDM was developed to investigate its genetic architecture and its relation to genetically constructed risk factors and biomarkers. The polygenic risk score can be used as an early screening tool to identify women at higher risk of GDM for comprehensive monitoring and preventative programs.
JOURNAL OF PERSONALIZED MEDICINE
(2022)
Review
Peripheral Vascular Disease
Jan Skrha
Summary: In addition to glucose management, there are effective pharmacologic tools for significant reduction of cardiovascular risk. New treatments targeting both hyperglycemia and disorders of lipid metabolism have shown promising results in reducing the risk of cardiovascular disease.
CURRENT ATHEROSCLEROSIS REPORTS
(2021)
Review
Cardiac & Cardiovascular Systems
Antonio Ceriello, Francesco Prattichizzo
Summary: Studies suggest that variability of risk factors such as blood pressure, plasma lipids, and weight may play a role in diabetes complications, with potential additive effects. While causality of variability is uncertain, monitoring risk factor variability in clinical practice could improve quality of care.
CARDIOVASCULAR DIABETOLOGY
(2021)
Review
Immunology
Maria Teresa Palano, Martina Cucchiara, Matteo Gallazzi, Federica Riccio, Lorenzo Mortara, Gian Franco Gensini, Gaia Spinetti, Giuseppe Ambrosio, Antonino Bruno
Summary: Atherosclerosis, the leading cause of cardiovascular disease worldwide, is influenced not only by dyslipidemia but also chronic inflammation and immune system abnormalities. Natural killer cells, an understudied immune cell type, may play a role in vascular homeostasis and offer potential for new therapies. Understanding the pathophysiology of natural killer cells in atherosclerosis and associated risk factors could lead to preventive and treatment strategies.
FRONTIERS IN IMMUNOLOGY
(2022)
Review
Cardiac & Cardiovascular Systems
Kohei Takata, Stephen J. Nicholls
AMERICAN JOURNAL OF CARDIOVASCULAR DRUGS
(2019)
Article
Cardiac & Cardiovascular Systems
Stephen J. Nicholls, Adam J. Nelson
AMERICAN JOURNAL OF CARDIOVASCULAR DRUGS
(2019)
Review
Cardiac & Cardiovascular Systems
Tania S. Marin, Constance Kourbelis, Jonathon Foote, Peter Newman, Alex Brown, Mark Daniel, Neil T. Coffee, Stephen J. Nicholls, Anand Ganesan, Vincent L. Versace, Hannah Beks, Christine A. Haedtke, Robyn A. Clark
EUROPEAN JOURNAL OF PREVENTIVE CARDIOLOGY
(2019)
Review
Cardiac & Cardiovascular Systems
Stephen J. Nicholls, Adam J. Nelson
AMERICAN JOURNAL OF CARDIOVASCULAR DRUGS
(2019)
Article
Medicine, General & Internal
Brian A. Ference, John J. P. Kastelein, Kausik K. Ray, Henry N. Ginsberg, John Chapman, Chris J. Packard, Ulrich Laufs, Clare Oliver-Williams, Angela M. Wood, Adam S. Butterworth, Emanuele Di Angelantonio, John Danesh, Stephen J. Nicholls, Deepak L. Bhatt, Marc S. Sabatine, Alberico L. Catapano
JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION
(2019)
Article
Cardiac & Cardiovascular Systems
Otavio Berwanger, Renato D. Lopes, Diogo D. F. Moia, Francisco A. Fonseca, Lixin Jiang, Shaun G. Goodman, Stephen J. Nicholls, Alexander Parkhomenko, Oleg Averkov, Carlos Tajer, German Malaga, Jose F. K. Saraiva, Helio P. Guimaraes, Pedro G. M. de Barros e Silva, Lucas P. Damiani, Renato H. N. Santos, Denise M. Paisani, Tamiris A. Miranda, Nanci Valeis, Leopoldo S. Piegas, Christopher B. Granger, Harvey D. White, Jose C. Nicolau
JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY
(2019)
Article
Medicine, General & Internal
Brian A. Ference, Kausik K. Ray, Alberico L. Catapano, Thatcher B. Ference, Stephen Burgess, David R. Neff, Clare Oliver-Williams, Angela M. Wood, Adam S. Butterworth, Emanuele Di Angelantonio, John Danesh, John J. P. Kastelein, Stephen J. Nicholls
NEW ENGLAND JOURNAL OF MEDICINE
(2019)
Article
Multidisciplinary Sciences
Achini K. Vidanapathirana, Benjamin J. Pullen, Run Zhang, MyNgan Duong, Jarrad M. Goyne, Xiaozhou Zhang, Claudine S. Bonder, Andrew D. Abell, Christina A. Bursill, Stephen J. Nicholls, Peter J. Psaltis
SCIENTIFIC REPORTS
(2019)
Review
Cardiac & Cardiovascular Systems
Stephen J. Nicholls
CURRENT CARDIOLOGY REPORTS
(2019)
Editorial Material
Respiratory System
Stephen J. Nicholls, Adam J. Nelson
JOURNAL OF THORACIC DISEASE
(2019)
Article
Cardiac & Cardiovascular Systems
Preethi Mani, Rishi Puri, Gregory G. Schwartz, Steven E. Nissen, Mingyuan Shao, John J. P. Kastelein, Venu Menon, A. Michael Lincoff, Stephen J. Nicholls
Article
Cardiac & Cardiovascular Systems
Andrew Lin, Nitesh Nerlekar, Ashray Rajagopalan, Jeremy Yuvaraj, Rohan Modi, Sam Mirzaee, Ravi Kiran Munnur, Michelle Seckington, James C. G. Doery, Sujith Seneviratne, Stephen J. Nicholls, Dennis T. L. Wong
Article
Cardiac & Cardiovascular Systems
Carolyn M. Astley, Derek P. Chew, Wendy Keech, Stephen Nicholls, John Beltrame, Matthew Horsfall, Rosanna Tavella, Rosy Tirimacco, Robyn A. Clark
HEART LUNG AND CIRCULATION
(2020)
Article
Multidisciplinary Sciences
Deborah Toledo-Flores, Anna Williamson, Nisha Schwarz, Sanuja Fernando, Catherine Dimasi, Tyra A. Witt, Thao M. Nguyen, Amrutesh S. Puranik, Colin D. Chue, Sinny Delacroix, Daniel B. Spoon, Claudine S. Bonder, Christina A. Bursill, Belinda A. Di Bartolo, Stephen J. Nicholls, Robert D. Simari, Peter J. Psaltis
SCIENTIFIC REPORTS
(2019)
Review
Cardiac & Cardiovascular Systems
Kyle B. Franke, Dennis T. L. Wong, Angus Baumann, Stephen J. Nicholls, Rajiv Gulati, Peter J. Psaltis
CARDIOVASCULAR DIAGNOSIS AND THERAPY
(2019)
