Review
Cardiac & Cardiovascular Systems
Mahmoud Abdelshafy, Hagar Elsherbini, Ahmed Elkoumy, Andrew J. Simpkin, Hesham Elzomor, Kadir Caliskan, Osama Soliman
Summary: Left ventricular assist device (LVAD) therapy is crucial for saving lives of patients with end-stage heart failure (HF). However, a significant number of patients develop life-threatening right-sided HF (RHF) after LVAD implantation. Levosimendan (LEVO) is a non-conventional inotropic agent that can mitigate RHF and improve hemodynamics.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2022)
Article
Biochemistry & Molecular Biology
Mihir Parikh, Saumya Shah, Ratnadeep Basu, Konrad S. Famulski, Daniel Kim, John C. Mullen, Philip F. Halloran, Gavin Y. Oudit
Summary: The use of LVAD in patients with DCM can lead to differential responses in the LV and RV, with RV failure being the most common complication post-LVAD insertion. Transcriptomic analysis revealed changes in gene expression and regulation following LVAD, showing improvements in immune response genes in both ventricles and in oxygen homeostasis and ECM remodeling genes in the LV. LVAD appears to induce chamber-specific transcriptomic changes as part of reverse ventricular remodeling.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Review
Cardiac & Cardiovascular Systems
Takeshi Shinkawa, Yuki Ichihara, Satoshi Saito, Mikiko Ishido, Kei Inai, Hiroshi Niinami
Summary: With the improvement of long-term surgical outcome of congenital heart disease, most pediatric patients are able to reach adulthood. However, adult patients with congenital heart disease have increased risk of various complications and may require mechanical circulatory support. Ventricular assist device therapy has shown promising results in this patient population, although there are challenges specific to adult congenital heart disease patients.
JOURNAL OF CARDIOLOGY
(2023)
Article
Medicine, General & Internal
Jia-Lin Chen, Yi-Ting Tsai, Chih-Yuan Lin, Hong-Yan Ke, Yi-Chang Lin, Hsiang-Yu Yang, Chien-Ting Liu, Shih-Ying Sung, Jui-Tsung Chang, Ying-Hsiang Wang, Tso-Chou Lin, Chien-Sung Tsai, Po-Shun Hsu
Summary: Combined ECLS and t-BiVAD could be a salvage treatment for patients with severe cardiogenic shock, especially for those already having prolonged CPR.
JOURNAL OF CLINICAL MEDICINE
(2022)
Review
Cardiac & Cardiovascular Systems
K. Candis Jones-Ungerleider, Angela Rose, Kevin Knott, Sarah Comstock, Jonathan. W. W. Haft, Francis. D. D. Pagani, Paul. C. C. Tang
Summary: Women with advanced heart failure receive advanced surgical therapies at a lower rate compared to men, and the reasons for this disparity are largely unknown. Existing research indicates that females have higher mortality and experience bleeding, clotting, and right ventricular failure more frequently following LVAD implantation. However, there is limited understanding of the pre-operative factors that contribute to the lower-than-expected LVAD implant rates in this population. More focused research is needed to identify and address disparities in advanced heart failure therapy delivery for women and other underserved populations.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2022)
Article
Cardiac & Cardiovascular Systems
Karsten Heusser, Judith Wittkoepper, Christoph Bara, Axel Haverich, Andre Diedrich, Benjamin D. Levine, Jan D. Schmitto, Jens Jordan, Jens Tank
Summary: LVAD implantation can significantly improve heart function in patients with heart failure, but does not consistently normalize sympathetic activity.
EUROPEAN JOURNAL OF HEART FAILURE
(2021)
Article
Cardiac & Cardiovascular Systems
Dominic Emerson, Joanna Chikwe, Pedro Catarino, Mohamed Hassanein, Luqin Deng, Ryan S. Cantor, Amy Roach, Robert Cole, Fardad Esmailian, Jon Kobashigawa, Jaime Moriguchi, James K. Kirklin
Summary: In contemporary practice, elderly patients receiving LVADs showed improved survival, increased functional capacity, enhanced quality of life, and fewer complications compared with younger patients.
JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY
(2021)
Review
Medicine, General & Internal
Alessia Gambaro, Gianmarco Lombardi, Francesco Onorati, Leonardo Gottin, Flavio Luciano Ribichini
Summary: LVAD implantation has complex effects on the kidneys, particularly regarding renal function. Creatinine-based eGFR formulas help in assessing patient prognosis, while deterioration in renal function in LVAD patients negatively impacts outcomes.
EUROPEAN JOURNAL OF CLINICAL INVESTIGATION
(2021)
Article
Engineering, Biomedical
Mehmet H. Akay, Ismael Salas De Armas, Manish K. Patel, Sriram Nathan, Biswajit Kar, Igor D. Gregoric
Summary: This article describes a case of remission from heart failure lasting for over a decade, treated with the implantation of a left ventricular assist device (LVAD). After the initial LVAD implantation, the patient demonstrated myocardial recovery, allowing for explantation of the LVAD. Years later, the patient experienced a recurrence of heart failure and required a second LVAD implantation.
Article
Cardiac & Cardiovascular Systems
Anubodh S. Varshney, Ersilia M. DeFilippis, Jennifer A. Cowger, Ivan Netuka, Sean P. Pinney, Michael M. Givertz
Summary: With the increasing prevalence of advanced heart failure, treatment options such as heart transplantation and LVAD support have shown to improve quality of life and extend survival. Recent advancements, including the use of HeartMate 3 in clinical practice and revisions to the organ allocation system, have led to better management of LVAD-related complications. Although contemporary LVAD recipients have higher illness severity preoperatively, they have higher survival rates and lower adverse event rates compared to previous eras. However, challenges such as bleeding, infection, neurologic events, and right ventricular failure still limit the wider implementation of LVAD support. Ongoing efforts to optimize management of current LVAD devices and develop next-generation devices are expected to further enhance outcomes for patients with advanced heart failure.
JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY
(2022)
Review
Cardiac & Cardiovascular Systems
Claudio A. Bravo, Andrew G. Navarro, Karanpreet K. Dhaliwal, Maziar Khorsandi, Jeffrey E. Keenan, Parvathi Mudigonda, Kevin D. O'Brien, Claudius Mahr
Summary: Left ventricular assist device (LVAD) therapy is a life-saving option for patients with advanced heart failure who do not respond to medical treatment. However, a significant percentage of LVAD patients develop right heart failure (RHF), which is associated with poor outcomes. The mechanisms of RHF are complex, involving patient factors, surgical factors, and hemodynamic factors. Despite advances in surgical techniques and LVAD technology, RHF remains a major cause of morbidity and mortality among LVAD patients. Current medical therapies for RHF are limited, and cardiac transplantation or supportive management are the only options for these patients. Efforts to predict the risk of RHF in LVAD patients have been challenging, with varying definitions of RHF in different studies. Additionally, most research in this field has focused on early-onset RHF, while late-onset RHF is increasingly recognized as a significant problem. This review aims to describe the unique physiology of the right ventricle and the changes caused by LVADs that may contribute to both early- and late-onset RHF. The available treatments for RHF, including mechanical circulatory support and medical therapies, will also be analyzed.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2022)
Article
Cardiac & Cardiovascular Systems
Ofer Havakuk, Aviram Hochstadt, Sapir Sadon, Michal Laurel Perl, Ben Sadeh, Assi Milwidsky, Orly Ran Sapir, Yoav Granot, Lior Lupu, Erez Levi, Ariel Farkash, Yanai Ben Gal, Shmuel Banai, Yan Topilsky
Summary: This study demonstrates that long-term stabilization of patients entering a left ventricular assist device (LVAD) program is possible with the use of aggressive conservative therapy.
Article
Cardiac & Cardiovascular Systems
Andrew N. Rosenbaum, Bradley W. Ternus, Siddharth Pahwa, John M. Stulak, Alfredo L. Clavell, Sarah D. Schettle, Atta Behfar, Jacob C. Jentzer
Summary: In patients undergoing left ventricular assist device implantation, right ventricular stroke work index, right heart catheterization, cardiopulmonary bypass time, and ultrafiltration are strongly associated with incident INT-LD and decreased 1-year survival. Optimization of these factors may reduce the risk of liver dysfunction but further validation is needed.
ANNALS OF THORACIC SURGERY
(2021)
Article
Medicine, General & Internal
Alexander A. Brescia, Tessa M. F. Watt, Francis D. Pagani, Thomas M. Cascino, Min Zhang, Jeffrey S. McCullough, Supriya Shore, Donald S. Likosky, Keith D. Aaronson, Michael P. Thompson
Summary: The study found that a significant proportion of LVAD recipients are ineligible for clinical trials, and that mortality rates are higher among those who are ineligible compared to those who are eligible. The results suggest that criteria for clinical trial eligibility should be more reflective of real-world experience.
Article
Cardiac & Cardiovascular Systems
Maryam Ajmal, Aisha Ajmal, Maryam Rizvi, Umar Salim, Lei Huang
Summary: This study aimed to investigate the changes in myocardial gene expression profile after LVAD implantation and their molecular biological significance. The results showed that inflammatory signaling pathway is crucial for the pathophysiology after LVAD implantation and chemokines mediate cardiac inflammatory response and tissue remodeling through GPCR-ligand binding.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2022)
Article
Cardiac & Cardiovascular Systems
Kaveh Eghbalzadeh, Elmar W. Kuhn, Anton Sabashnikov, Carolyn Weber, Cherif Sahyoun, Tanja Rudolph, Stephan Baldus, Thorsten C. W. Wahlers, Navid Mader
THORACIC AND CARDIOVASCULAR SURGEON
(2020)
Article
Cardiac & Cardiovascular Systems
Christopher Gaisendrees, Navid Mader, Anton Sabashnikov, Georg Schlachtenberger, Laura Suhr, Thorsten Wahlers
Editorial Material
Cardiac & Cardiovascular Systems
Ilija Djordjevic, Parwis Rahmanian, Mohamed Zeriouh, Kaveh Eghbalzadeh, Sassan Sangsari, Julia Merkle, Elmar Kuhn, Antje-Christin Deppe, Carolyn Weber, Anton Sabashnikov, Oliver Liakopoulos, Thorsten Wahlers
JOURNAL OF CARDIAC SURGERY
(2020)
Article
Cardiac & Cardiovascular Systems
Ilija Djordjevic, Kaveh Eghbalzadeh, Anton Sabashnikov, Antje C. Deppe, Elmar W. Kuhn, Joon Seo, Carolyn Weber, Julia Merkle, Christoph Adler, Parwis B. Rahmanian, Oliver J. Liakopoulos, Navid Mader, Ferdinand Kuhn-Regnier, Mohamed Zeriouh, Thorsten Wahlers
JOURNAL OF CARDIAC SURGERY
(2020)
Article
Cardiac & Cardiovascular Systems
Anton Sabashnikov, Julia Merkle, Farid Azizov, Ilija Djordjevic, Kaveh Eghbalzadeh, Irawati Tunggal, Carolyn Weber, Viktoria Weixler, Christian Rustenbach, Mohamed Zeriouh, Axel Kroener, Thorsten Wahlers, Gerardus Bennink
Article
Surgery
I. Djordjevic, K. Eghbalzadeh, S. Heinen, G. Schlachtenberger, S. Gerfer, A. Sabashnikov, J. Merkle, C. Weber, E. Kuhn, M. Zeriouh, P. Rahmanian, N. Mader, O. -J. Liakopoulos, T. Wahlers
WORLD JOURNAL OF SURGERY
(2020)
Article
Cardiac & Cardiovascular Systems
Carolyn Weber, Parwis B. Rahmanian, Melanie Nitsche, Asmae Gassa, Kaveh Eghbalzadeh, Stefanie Hamacher, Julia Merkle, Antje-Christin Deppe, Anton Sabashnikov, Elmar W. Kuhn, Oliver J. Liakopoulos, Thorsten Wahlers
BMC CARDIOVASCULAR DISORDERS
(2020)
Letter
Engineering, Biomedical
Davorin Sef, Prashant Mohite, Fabio De Robertis, Alessandra Verzelloni Sef, Balakrishnan Mahesh, Ulrich Stock, Andre Simon
Article
Cardiac & Cardiovascular Systems
Simon Braumann, Felix Sebastian Nettersheim, Christopher Hohmann, Tobias Tichelbaecker, Martin Hellmich, Anton Sabashnikov, Ilija Djordjevic, Joana Adler, Richard Julius Nies, Dennis Mehrkens, Samuel Lee, Robert Stangl, Hannes Reuter, Stephan Baldus, Christoph Adler
CLINICAL RESEARCH IN CARDIOLOGY
(2020)
Article
Engineering, Biomedical
Christopher Gaisendrees, Laura Suhr, Borko Ivanov, Jonas Woermann, Ilija Djordjevic, Kaveh Eghbalzadeh, Wael Ahmad, Anton Sabashnikov, Thorsten Wahlers
JOURNAL OF ARTIFICIAL ORGANS
(2020)
Article
Cardiac & Cardiovascular Systems
Ilija Djordjevic, Kaveh Eghbalzadeh, Anton Sabashnikov, Antje-Christin Deppe, Elmar Kuhn, Julia Merkle, Carolyn Weber, Borko Ivanov, Ali Ghodsizad, Christian Rustenbach, Christoph Adler, Parwis Rahmanian, Navid Mader, Ferdinand Kuhn-Regnier, Mohamed Zeriouh, Thorsten Wahlers
JOURNAL OF CARDIAC SURGERY
(2020)
Editorial Material
Cardiac & Cardiovascular Systems
Ilija Djordjevic, Hendrik Drinhaus, Borko Ivanov, Kaveh Eghbalzadeh, Stephen Gerfer, Anton Sabashnikov, Ferdinand Kuhn-Regnier, Navid Mader, Thorsten Wahlers, Parwis Rahmanian
JOURNAL OF CARDIAC SURGERY
(2020)
Article
Engineering, Biomedical
Prashant Mohite, Rita Garda, Kabeer Umakumar, Sundip Kaul, Nandor Marczin, Bartlomiej Zych, Diana Garcia-Saez, Maria Monteagudo-Vela, Balakrishnan Mahesh, Ulrich Stock, Fabio De Robertis, Andre Simon
Summary: The study reviewed the cases of patients who required additional respiratory support under ST-VAD assistance. By combining VAD and an oxygenator (Oxy-VAD), it provides a better organ-specific support.
Article
Surgery
Davorin Sef, Alessandra Verzelloni Sef, Prashant Mohite, Ulrich Stock, Vladimir Trkulja, Binu Raj, Diana Garcia Saez, Balakrishnan Mahesh, Fabio De Robertis, Andre Simon
TRANSPLANT INTERNATIONAL
(2020)
Article
Surgery
Vitalii Poptsov, Valery Khatutskiy, Anastasiia Skokova, Ihor Krasivskyi, Anton Sabashnikov, Julia Merkle-Storms, Ekaterina Spirina
Summary: Transplanting hearts from donors with impaired left ventricular systolic function can expand the donor pool, particularly for recipients in need of urgent heart transplantation. These recipients may benefit from mechanical circulatory support pretransplantation to provide hemodynamic support in cases of early graft dysfunction post-transplantation.
CLINICAL TRANSPLANTATION
(2021)