Article
Clinical Neurology
Paola Solis-Pazmino, Ioana Baiu, Eddy Lincango-Naranjo, Winston Trope, Larry Prokop, Oscar J. Ponce, Joseph B. Shrager
Summary: In patients with MG, different surgical techniques for thymectomy showed similar rates of CSR at 3 years. The only significant difference was seen at 10 years between traditional open and minimally invasive approaches. Extended minimally invasive approaches appear to be equivalent to extended transsternal approaches in achieving CSR.
Review
Clinical Neurology
Jakob Rath, Bernhard Moser, Fritz Zimprich
Summary: Thymectomy is an effective treatment option for adult patients with early onset acetylcholine-receptor positive myasthenia gravis, but there is still uncertainty regarding certain patient subgroups.
CURRENT OPINION IN NEUROLOGY
(2023)
Article
Surgery
Ahmed AL-Bulushi, Issa Al Salmi, Fatma Al Rahbi, AbdulAziz Al Farsi, Suad Hannawi
Summary: This study investigated the epidemiology of patients with myasthenia gravis who underwent thymectomy at the Royal Hospital in Muscat, Oman over the past three decades. The results showed that post-thymectomy, most patients experienced significant clinical improvement, with a small percentage achieving complete clinical remission.
ASIAN JOURNAL OF SURGERY
(2021)
Editorial Material
Clinical Neurology
Steven Karceski
Summary: The study examines the impact of different surgical approaches on thymectomy in Myasthenia Gravis patients, aiming to determine the most effective method with the lowest risk and highest benefit. Modern surgical techniques, including minimally invasive approaches with robotic assistance, have revolutionized treatment options and outcomes for MG patients. The question of which surgical approach is best for MG may seem simple but entails complex considerations and evaluations.
Editorial Material
Radiology, Nuclear Medicine & Medical Imaging
Kailash Chaurasiya, Elena Kireeva, Tatyana Shamanskaya, Denis Kachanov, Yury Likar
Summary: Primary neuroblastoma is the most common extracranial solid tumor in children, usually found in the abdominal/retroperitoneal region or thorax. This case report presents an extremely rare occurrence of primary neuroblastoma in the thymus of a pediatric patient.
CLINICAL NUCLEAR MEDICINE
(2023)
Article
Oncology
Virginie Joubert, Lara Chalabreysse, Delphine Gamondes, Francois Tronc, Jean-Michel Maury, Nicolas Girard
Summary: Non-neoplastic thymic lesions are rare findings that can be difficult to differentiate from thymic malignancies. A multidisciplinary approach that integrates clinical and imaging features, as well as follow-up, can help in the management and selection of patients for surgery.
Review
Oncology
Doaa Alqaidy, Cesar A. Moran
Summary: The diagnosis of thymic carcinoma can be challenging due to difficulties in determining its specific origin and the lack of a definitive immunohistochemical stain. This article discusses the challenges encountered by diagnostic surgical pathologists in assessing thymic carcinoma and staging these tumors.
FRONTIERS IN ONCOLOGY
(2022)
Article
Health Care Sciences & Services
Hyun-Joung No, Young Chul Yoo, Young Jun Oh, Hye Sun Lee, Soyoung Jeon, Ki Hong Kweon, Na Young Kim
Summary: This study retrospectively analyzed the effects of sugammadex compared with neostigmine on postoperative recovery in patients with myasthenia gravis who underwent video-assisted thoracoscopic surgery. The study found that patients who received sugammadex had a significantly shorter postoperative hospital stay compared to those who received neostigmine.
JOURNAL OF PERSONALIZED MEDICINE
(2023)
Article
Medicine, General & Internal
Huayang Zhang, Ting Chen, Xuesong Zhang, Peng Zhang, Yuan Chen
Summary: This article reports a rare case of thymoma combined with SLE and immune-related anemia, providing references for the clinical diagnosis and treatment of thymoma combined with SLE, and attempting to explain the potential clinical remission of SLE after thymoma resection. It should raise the attention of clinicians when diagnosing and treating related diseases.
Article
Oncology
Florit Marcuse, Monique Hochstenbag, Janneke G. J. Hoeijmakers, Myrurgia Abdul Hamid, Jan Damoiseaux, Jos Maessen, Marc De Baets
Summary: Subclinical myasthenia gravis (MG) was found in a proportion of thymoma patients, with the majority of these patients developing clinical MG within six years after thymectomy. Analyzing anti-AChR antibodies in suspected thymoma patients before thymectomy is recommended.
Review
Medicine, General & Internal
Doaa Alqaidy
Summary: This article discusses the naming, classification, and staging of thymomas, which are one of the most common types of mediastinal epithelial tumors. There is controversy over the significance of thymoma histologic classifications, and the challenges that diagnostic surgical pathologists may face in evaluating the histopathology of these tumors and staging them are presented. The clinical characteristics and current management strategy of these distinct tumors are also briefly reviewed.
Article
Clinical Neurology
Jakob Rath, Manuela Taborsky, Bernhard Moser, Gudrun Zulehner, Rosa Weng, Martin Krenn, Hakan Cetin, Jose Ramon Matilla, Leonhard Muellauer, Fritz Zimprich
Summary: This study investigated the short- and long-term outcomes of thymectomy in patients with acetylcholine receptor antibody-positive myasthenia gravis (MG). The results showed that the sustained long-term clinical response after thymectomy is lower than the initial response rates would suggest. None of the evaluated clinical factors predicted a worse outcome, supporting the current clinical practice of patient selection for thymectomy. The relative decline of AChR-Abs after surgery appears to be a promising prognostic marker.
EUROPEAN JOURNAL OF NEUROLOGY
(2022)
Review
Oncology
Mingbo Tang, Yifeng Shao, Junxue Dong, Xinliang Gao, Shixiong Wei, Jianzun Ma, Yang Hong, Zhiqin Li, Taiyu Bi, Yipeng Yin, Wenyu Zhang, Wei Liu
Summary: This study used a meta-analysis to examine the incidence of postoperative myasthenia gravis (PMG) and risk factors in patients with non-MG thymoma. The results showed that the incidence of PMG in preoperative patients with non-MG thymoma was 8%. Preoperative seropositive acetylcholine receptor antibody, open thymectomy, non-R0 resection, WHO type B, and postoperative inflammation were identified as risk factors for PMG.
FRONTIERS IN ONCOLOGY
(2023)
Article
Endocrinology & Metabolism
Giovanna Rotondo Dottore, Marenza Leo, Roberta Ricciardi, Michelangelo Maestri, Ilaria Bucci, Marco Lucchi, Franca Melfi, Melania Guida, Anna De Rosa, Loredana Petrucci, Ilaria Ionni, Giulia Lanzolla, Francesca Nicoli, Michele Mantuano, Debora Ricci, Francesco Latrofa, Stefano Mariotti, Claudio Marcocci, Michele Marino
Summary: This study investigated the role of the thymus in thyroid autoimmunity and found that the prevalence of serum anti-thyroid autoantibodies significantly decreased in patients who underwent thymectomy, suggesting a potential role of the thymus in maintaining humoral thyroid autoimmunity.
EUROPEAN THYROID JOURNAL
(2021)
Article
Pathology
Annikka Weissferdt, Cesar A. Moran
Summary: Five cases of primary thymic carcinoma with distinct histopathological features resembling chromophobe car-cinomas are presented. Clinically, the patients presented with non-specific symptoms of dyspnea and chest pain. Diagnostic imaging revealed the presence of anterior mediastinal masses.
PATHOLOGY RESEARCH AND PRACTICE
(2023)