4.2 Article

Wine consumption and colorectal cancer risk: a meta-analysis of observational studies

Journal

EUROPEAN JOURNAL OF CANCER PREVENTION
Volume 28, Issue 3, Pages 151-158

Publisher

LIPPINCOTT WILLIAMS & WILKINS
DOI: 10.1097/CEJ.0000000000000444

Keywords

colorectal cancer; meta-analysis; relative risk; wine intake

Categories

Ask authors/readers for more resources

There were inconsistent results with respect to the correlation between consumption of wine and the development of colorectal cancer ( CRC). We carried out a meta- analysis to investigate this issue. We included observational studies on the aforementioned relationship according to a literature search of Embase and Pubmed from inception till 28 February 2017. The summary relative risk ( SRR) and 95% confidence intervals ( CI) were calculated using a random- effects model. A total of eight case- control and nine cohort studies were identified, involving 12 110 CRC cases. The study showed that wine drinking was not associated with any greater risk for CRC ( SRR= 0.99, 95% CI: 0.89- 1.10; P-heterogeneity< 0.001) compared with nondrinkers. The subgroup analyses indicated that null associations were observed in men and women for colon and rectal cancer. Neither light to moderate (< 2 drinks/ day; SRR= 0.93, 95% CI: 0.80- 1.08, I-2 = 69.2%) nor heavy (>= 2 drinks/ day; SRR= 1.00, 95% CI: 0.86- 1.16, I-2 = 39.9%) consumption of wine was associated statistically with CRC risk. This meta- analysis suggests that any wine consumption was not associated with the risk of CRC. Null associations were shown in men and women for colon and rectal cancer. Copyright (c) 2018 Wolters Kluwer Health, Inc. All rights reserved.

Authors

I am an author on this paper
Click your name to claim this paper and add it to your profile.

Reviews

Primary Rating

4.2
Not enough ratings

Secondary Ratings

Novelty
-
Significance
-
Scientific rigor
-
Rate this paper

Recommended

Article Pathology

Runt-related transcription factor 2 (RUNX2) inhibits apoptosis of intestinal epithelial cells in Crohn's disease

Liugen Gu, Juan Zhao, Shiqing Zhang, Weisong Xu, Runzhou Ni, Xiaojuan Liu

PATHOLOGY RESEARCH AND PRACTICE (2018)

No Data Available