Review
Nutrition & Dietetics
Malgorzata Piecuch, Jagoda Garbicz, Martyna Waliczek, Jolanta Malinowska-Borowska, Piotr Rozentryt
Summary: This paper extensively discusses the nutritional recommendations for patients with endometriosis, emphasizing the importance of nutrients like polyphenols, vitamins, and various diets for managing the disease.
Article
Oncology
Arianna Di Napoli, Daniele Greco, Giorgia Scafetta, Francesca Ascenzi, Alessandro Gulino, Luigi Aurisicchio, Fabio Santanelli Di Pompeo, Adriana Bonifacino, Enrico Giarnieri, John Morgan, Rita Mancini, Marshall E. Kadin
Summary: BI-ALCL is a rare peripheral T cell lymphoma commonly presenting as delayed peri-implant effusion, requiring cytological examination, CD30 immunostaining, and T-cell clonality assessment for diagnosis. A Th2-type cytokine profile characterized by high levels of IL-10, IL-13, and Eotaxin distinguishes BI-ALCL from reactive seromas, with an IL10/IL-6 ratio cutoff of 0.104 showing high specificity and sensitivity in identifying BI-ALCL effusions. This study identifies potential biomarkers for early screening of late seromas to aid in prompt BI-ALCL diagnosis.
CANCER IMMUNOLOGY IMMUNOTHERAPY
(2021)
Article
Nutrition & Dietetics
Ching-Hung Lin, Yi-An Lin, Shu-Li Chen, Mei-Chich Hsu, Cheng-Chen Hsu
Summary: Short-term supplementation with American ginseng can alleviate exercise-induced muscle damage (EIMD) by reducing lipid peroxidation and promoting inflammatory adaptation.
Review
Nutrition & Dietetics
Emilia Vassilopoulou, George Guibas, Nikolaos G. Papadopoulos
Summary: The second wave of the allergy epidemic is currently affecting both affluent societies and developing countries. Changes in lifestyle and diet, including the consumption of processed foods, may contribute to the increase in prevalence of atopy/asthma. The Mediterranean diet has been studied as a potential protective factor against asthma/atopy, but the evidence is inconclusive.
Article
Medical Laboratory Technology
Gongbo Zeng, Dong Chen, Renxi Zhou, Xinfeng Zhao, Cuiying Ye, Huiting Tao, Wenbin Sheng, Yidong Wu
Summary: Combining CRP, PCT, and IL-6 can accurately diagnose the hyperinflammatory state of pediatric sepsis and increase the diagnostic specificity. Early diagnosis of organ dysfunction requires a combination of PCT, IL-8, and IL-10.
JOURNAL OF CLINICAL LABORATORY ANALYSIS
(2022)
Review
Fisheries
Marco A. Hernandez de-Dios, Dariel Tovar-Ramirez, Deneb Maldonado Garcia, Mario A. Galaviz-Espinoza, Milton Spanopoulos Zarco, Minerva C. Maldonado-Garcia
Summary: This article reviews the use of functional food additives affecting marine fish reproductive performance, with a focus on vitamins, carotenes, fatty acids, and proteins of animal origin.
Review
Biochemistry & Molecular Biology
Alexandros Mavrommatis, Eleni Tsiplakou, Anastasia Zerva, Panagiota D. Pantiora, Nikolaos D. Georgakis, Georgia P. Tsintzou, Panagiotis Madesis, Nikolaos E. Labrou
Summary: Microalgae are a renewable source with beneficial effects on nutrition and health. They have been explored as feed additives in livestock animals, improving their health, product quality, and environmental impact. However, the cost-effective production and use of microalgae remains a challenge.
Article
Immunology
Elisa Toppi, Laura Sireno, Micaela Lembo, Nerisa Banaj, Beatrice Messina, Sedigheh Golesorkhtafti, Gianfranco Spalletta, Paola Bossu
Summary: Homotaurine is a potential therapeutic compound for Alzheimer's disease (AD) and has anti-inflammatory properties. This study suggests that supplementation of homotaurine in patients with mild cognitive impairment (MCI) increases the levels of anti-inflammatory cytokines IL-10 and IL-33, while decreasing the levels of pro-inflammatory cytokine IL-18. The elevation of IL-10 and IL-33 is associated with improved episodic memory in treated patients.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Oncology
Gang Liu, Xiang-Ting Chen, Hao Zhang, Xin Chen
Summary: This study investigated the relationship between changes in peripheral blood VEGF, IL-5, IL-6, IL-8, and IL-17 concentrations in breast cancer patients and their significance in breast cancer staging and invasive metastasis. The results showed that IL-6, IL-17, and VEGF were strongly associated with breast cancer development and could be used as reference indicators for diagnosis and postoperative follow-up.
FRONTIERS IN ONCOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Michal Tomaszewski, Paulina Mertowska, Martyna Janczewska, Agnieszka Styczen, Sebastian Mertowski, Kamil Jonas, Ewelina Grywalska, Grzegorz Kopec
Summary: Pulmonary arterial hypertension (PAH) is a complex disorder where cytokines play a crucial role in deregulation of the immune system. This study found that PAH patients have abnormal immune function with decreased percentages of immune cell subpopulations and changes in cytokine concentration. Furthermore, significant differences were observed between PAH subtypes and immunological parameters, suggesting the important role of the immune system in the pathogenesis of PAH.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Oncology
Nicoletta Nastasi, Amada Pasha, Gennaro Bruno, Angela Subbiani, Laura Pietrovito, Angela Leo, Lucia Scala, Lorena de Simone, Gabriella Casazza, Federica Lunardi, Maria Letizia Taddei, Angela Tamburini, Annalisa Tondo, Claudio Favre, Maura Calvani
Summary: Osteosarcoma is a common malignant bone tumor that mainly affects children and adolescents. Standard treatment includes surgery and chemotherapy, but the effectiveness is limited for metastatic or recurrent cases. This study investigates the efficacy of mifamurtide and identifies interleukin-10 as a possible target to improve its effectiveness. The synergistic use of mifamurtide and an anti-IL-10 antibody significantly increases cell death and reduces metastasis in a mouse model. The findings suggest that combining mifamurtide with an anti-IL-10 antibody may improve outcomes for osteosarcoma patients.
Article
Medicine, General & Internal
Magdalena Kutwin, Monika Migdalska-Sek, Ewa Brzezianska-Lasota, Piotr Zelga, Anna Wozniacka
Summary: Psoriasis is an immune disease characterized by elevated expression of IL-17A and IL-23R in the skin of patients, while IL-10 expression is lower. The study found a positive correlation between IL-23A expression levels and PASI index in psoriasis patients. Further research is needed to understand the exact role of these cytokines in the pathogenesis of psoriasis.
JOURNAL OF CLINICAL MEDICINE
(2021)
Article
Immunology
Sandeep R. Kaushik, Sukanya Sahu, Hritusree Guha, Sourav Saha, Ranjit Das, Rukuwe-u Kupa, Wetetsho Kapfo, Trinayan Deka, Rumi Basumatary, Asunu Thong, Arunabha Dasgupta, Bidhan Goswami, Amit Kumar Pandey, Lahari Saikia, Vinotsole Khamo, Anjan Das, Ranjan Kumar Nanda
Summary: This study monitored the levels of cytokines, trace metals, and iron-related proteins in tuberculosis (TB) patients and control populations. The results showed that TB patients had low iron and selenium levels, high copper and aluminum levels, and altered iron metabolism. After 6 months of anti-TB therapy, the iron metabolism partially normalized. These findings are important for the development of host-directed adjunct therapeutics.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Nutrition & Dietetics
Farhad Vahid, Wena Rahmani, Sayed Hossein Davoodi, Torsten Bohn
Summary: There is a significant association between mental health issues, such as depression and stress, and the risk of gastric cancer. Consuming a healthy diet rich in vitamins and minerals may lower the odds of developing gastric cancer, possibly due to reduced levels of anxiety and depression.
Article
Immunology
Qiuhua Zhu, Huan Li, Shanshan Zheng, Bin Wang, Mingjie Li, Wenbin Zeng, Lanlan Zhou, Zebing Guan, Hong Wang, Yanan Liu, Yanmin Gao, Shiqiu Qiu, Chaolun Chen, Shimei Yang, Yuemei Yuan, Hanling Zhang, Guanqiao Ruan, Xueyi Pan
Summary: This study investigates the Th1/Th2 cytokine profile in patients with lymphoma during the myelosuppression stage of infection and proposes a rapid diagnostic method to determine the type of infection and anti-infective effect. IL-6 and IL-10 are closely associated with the severity and treatment efficacy in lymphoma patients who develop infections after chemotherapy, and can help distinguish between Gram-negative and Gram-positive bacterial infections at an early stage.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Nutrition & Dietetics
Laura Cristina Tibiletti Balieiro, Cristiana Araujo Gontijo, Luisa Pereira Marot, Gabriela Pereira Teixeira, Walid Makin Fahmy, Yara Cristina de Paiva Maia, Cibele Aparecida Crispim
Summary: This study aimed to investigate the effects of sleep timing on dietary intake and weight gain during pregnancy. The results showed that pregnant women with an eveningness chronotype tended to have a later breakfast, higher energy and carbohydrate intake at dinner, and inadequate weight gain in the third trimester. These findings emphasize the importance of considering sleep timing variables in prenatal nutritional guidelines.
Article
Biophysics
Rafael da Fonseca Alves, Isabella Castro Martins, Diego Leoni Franco, Adriane das Gracas Silva, Paula de Souza Santos, Luiz Ricardo Goulart, Yara Cristina de Paiva Maia, Alinne Tatiane Faria Silva, Thaise Goncalves Araujo, Maria Del Pilar Taboada Sotomayor
Summary: In this study, a new electrochemical biosensor was developed using peptides selected by Phage Display as bio-recognition phase for Breast Cancer (BC) characterization. The peptides were validated and found to have stronger reactivity to a specific type of BC. A new matrix for immobilizing biomolecules was generated through electrochemical modification of graphite electrodes. The biosensor was developed by immobilizing the peptides in the system for the detection of BC tumor markers in serological samples. The biosensor showed better performance compared to ELISA test.
BIOSENSORS & BIOELECTRONICS
(2022)
Review
Virology
Thaise Yasmine Vasconcelos de Lima Cavalcanti, Mylena Ribeiro Pereira, Sergio Oliveira de Paula, Rafael Freitas de Oliveira Franca
Summary: Chikungunya virus (CHIKV) is a mosquito-borne alphavirus that has recently re-emerged, causing large-scale outbreaks worldwide. The infection mainly presents as severe joint pain and myalgia, but can also lead to severe complications such as neurological disorders and even death. Factors such as virus evolution, globalization, and climate change contribute to the spread of CHIKV, while the lack of preventive vaccines and effective antiviral treatments make it a major global health threat.
Article
Nutrition & Dietetics
Catarina Mendes Silva, Bruno Simao Teixeira, Kenneth P. Wright, Yara Cristina de Paiva Maia, Cibele Aparecida Crispim
Summary: The study investigated the association between time-related eating patterns and daily calorie and macronutrient intake in Brazilian male military police officers. The findings showed that night shift workers had later eating times, longer eating durations, and later caloric midpoint than day workers. Late eaters consumed more energy, fat, and protein, but less carbohydrates, compared to early eaters. The time of the first and last meal was correlated with energy and macronutrient intake, with different patterns observed for day and night shift workers. Eating duration was positively correlated with energy and carbohydrate intake in both groups. Therefore, eating later at night was associated with increased daily energy and macronutrient intake.
Article
Nutrition & Dietetics
Mariana T. M. Lima, Fernanda S. M. Nunes, Isis D. D. Custodio, Kamila P. Carvalho, Paula P. L. Canto, Carlos E. Paiva, Cibele A. Crispim, Yara C. Paiva Maia
Summary: This study examines the association of eating time and frequency with diet quality, quantity of food consumption, anthropometric measurements, and body composition parameters in female breast cancer survivors. The study finds that earlier food intake time is associated with better diet quality and lower daily energy consumption. Higher frequency of eating is also associated with better diet quality. However, there are no significant associations between eating time and frequency with anthropometric measurements and body composition parameters.
JOURNAL OF THE ACADEMY OF NUTRITION AND DIETETICS
(2022)
Article
Medicine, General & Internal
John Willians Oliveira Prates, Mariana Fonseca Xisto, Joao Vitor da Silva Rodrigues, Joao Pedro Cruz Colombari, Julia Maria Alves Meira, Roberto Sousa Dias, Cynthia Canedo da Silva, E. Sergio Oliveira de Paula
Summary: In this study, the Zika virus envelope protein was successfully produced in K. phaffii KM71H cells and showed potential for diagnostic applications based on ELISA results.
Article
Oncology
Isis Danyelle Dias Custodio, Fernanda Silva Mazzutti Nunes, Mariana Tavares Miranda Lima, Kamila Pires de Carvalho, Debora Santana Alves, Juliana Freitas Chiaretto, Paula Philbert Lajolo Canto, Carlos Eduardo Paiva, Yara Cristina de Paiva Maia
Summary: This study highlights the high prevalence of vitamin D deficiency in postmenopausal women undergoing adjuvant endocrine therapy and its potential link to cancer-related fatigue. The findings suggest negative effects of lower vitamin D levels on anxiety, menopause and health, and vasomotor scores. Additionally, cancer-related fatigue was associated with negative impacts on various aspects of health-related quality of life and physical health.
Article
Nutrition & Dietetics
Fabiana Lascala, Bruna Karoline da Silva Moraes, Maria Carolina Santos Mendes, Mariluce Barbosa de Carvalho, Sandra Regina Branbilla, Ademar Dantas da Cunha Junior, Luiz Roberto Lopes, Nelson Adami Andreollo, Ligia Traldi Macedo, Carla M. Prado, Jose Barreto Campello Carvalheira
Summary: This study aimed to investigate the association between systemic inflammation and myosteatosis upon diagnosis of gastric cancer (GC) and their predictive role in survival outcomes. The study found that patients with low skeletal muscle radiodensity were more likely to be older, have a higher body mass index, and have diabetes. High skeletal muscle radiodensity was associated with better disease-free survival and overall survival. Patients with a neutrophil-to-lymphocyte ratio (NLR) > 2.3 and myosteatosis had the worst survival outcomes.
EUROPEAN JOURNAL OF CLINICAL NUTRITION
(2023)
Article
Biochemistry & Molecular Biology
Alinne T. F. Silva, Claudia M. Rodrigues, Izabella C. C. Ferreira, Leticia L. D. Santos, Donizeti W. Santos, Thaise G. Araujo, Paula P. L. Canto, Carlos E. Paiva, Luiz R. Goulart, Yara C. P. Maia
Summary: In this study, we analyzed the presence of circulating tumor cells (CTCs) in the blood to identify markers for the diagnosis and monitoring of breast cancer. By determining the transcriptional levels and flow cytometry profiles, we developed a method that shows high sensitivity and specificity for breast cancer detection and therapy monitoring.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Health Care Sciences & Services
Bruna M. M. Rocha, Ross D. Dolan, Carlos E. Paiva, Josh McGovern, Bianca S. R. Paiva, Daniel D. Preto, Donald C. McMillan, Yara C. P. Maia, Barry J. Laird
Summary: This study compares prognostic factors in two international cohorts of patients with advanced cancer and establishes a prognostic framework for treatment. The study finds that despite geographical and socio-demographic differences, similar prognostic factors are associated with long-term survival in both the European and Brazilian cohorts.
JOURNAL OF PAIN AND SYMPTOM MANAGEMENT
(2023)
Article
Nutrition & Dietetics
Karina Hiromoto Oikawa, Fabiana Lascala Juliani, Larissa Ariel Oliveira Carrilho, Lara Pozzuto, Daniela Morais de Hollanda Padilha, Marina Nogueira Silveira, Felipe Osorio Costa, Ligia Traldi Macedo, Ademar Dantas da Cunha, Maria Carolina Santos Mendes, Jose Barreto Campello Carvalheira
Summary: This study aimed to assess the prognostic effect of adiposity and adipose tissue radiodensities in patients with metastatic colorectal cancer (mCRC). The study found that a higher subcutaneous adipose tissue (SAT) index was associated with a lower risk for death, while higher SAT and visceral adipose tissue (VAT) radiodensities were associated with an increased risk for death.
Article
Public, Environmental & Occupational Health
Leticia Martins Okada, Catarina Machado Azeredo, Rosangela Ramos Veloso Silva, Marise Fagundes Silveira, Desiree Sant'ana Haikal, Lucineia De Pinho, Georgia das Gracas Pena
Summary: The study examines the relationship between substance use, social isolation, and food consumption in adolescents. It found that regular alcohol users were more likely to consume candies and soft drinks regularly, while regular tobacco users were less likely to consume beans regularly and more likely to consume candies regularly. Using at least one substance was negatively associated with regular bean consumption and positively associated with regular consumption of sweets and soft drinks. Socially isolated adolescents were less likely to consume beans regularly. Substance use was positively associated with an unhealthy eating score.
PSYCHOLOGY HEALTH & MEDICINE
(2023)
Article
Nutrition & Dietetics
Jordana Carolina Marques Godinho-Mota, Larissa Vaz-Goncalves, Isis Danyelle Dias Custodio, Jaqueline Schroeder de Souza, Joao Felipe Mota, Maria Cristina Gonzalez, Priscylla Rodrigues Vilella, Karine Anusca Martins, Yara Cristina de Paiva Maia, Sara Maria Moreira Lima Verde, Aline Porciuncula Frenzel, Patricia Faria Di Pietro, Eduarda da Costa Marinho, Ruffo Freitas-Junior
Summary: This study aimed to investigate the effect of chemotherapy (CT) and its different types of regimens on the anthropometry and body composition of women with breast cancer. The results showed that CT negatively impacted body composition and different regimens had different effects. The study highlights the importance of nutritional monitoring of breast cancer patients throughout the entire CT treatment.
Article
Microbiology
Jessica Duarte da Silva, Lene Bens, Adriele J. do Carmo Santos, Rob Lavigne, Jose Soares, Luis D. R. Melo, Marta Vallino, Roberto Sousa Dias, Zuzanna Drulis-Kawa, Sergio Oliveira de Paula, Jeroen Wagemans
Summary: Proteus mirabilis is a significant pathogen causing catheter-associated urinary tract infections (CAUTIs). Two phages, BigMira and MidiMira, were studied and found to have similarities with four missense mutations impacting their depolymerase activity. Analysis of clinical P. mirabilis strains revealed differences in antibiotic resistance profiles and lipopolysaccharide locus, explaining phages' host range. The presence of antimicrobial resistance genes poses challenges for treating infections caused by multidrug-resistant bacteria.
Article
Pediatrics
Nayara Cristina da Silva, Marcelo Keese Albertini, Andre Ricardo Backes, Georgia das Gracas Pena
Summary: Identifying patients at high risk of readmission is important to reduce hospital costs and provide targeted care. This study aimed to validate the use of the HOSPITAL score in predicting avoidable readmissions in a pediatric population. The results showed that the HOSPITAL score had good discrimination and can be a useful tool in predicting 30-day potentially avoidable readmissions in pediatric patients.
EUROPEAN JOURNAL OF PEDIATRICS
(2023)
