Article
Oncology
J. A. Crouzen, A. L. Petoukhova, M. L. D. Broekman, M. Fiocco, U. J. Fisscher, J. H. Franssen, C. G. M. Gadellaa-van Hooijdonk, M. Kerkhof, M. Kiderlen, M. E. Mast, C. M. van Rij, R. Nandoe Tewarie, M. A. E. van de Sande, P. P. G. van der Toorn, R. Vlasman, M. J. Vos, N. C. M. G. van der Voort van Zyp, R. G. J. Wiggenraad, L. M. Wiltink, J. D. Zindler
Summary: A multicenter prospective randomized study aims to compare the incidence of adverse local events in patients with brain metastases using fractionated stereotactic radiosurgery (fSRS) versus stereotactic radiosurgery (SRS) in one or three fractions. The study aims to reduce the risk of radionecrosis and improve the effectiveness of brain metastases treatment.
Article
Clinical Neurology
Carolina Gesteira Benjamin, Jason Gurewitz, Ami Kavi, Kenneth Bernstein, Joshua Silverman, Monica Mureb, Bernadine Donahue, Douglas Kondziolka
Summary: This study aims to explore the survival outcomes and dosimetry of Gamma Knife radiosurgery (GKRS) in patients with a large number of brain metastases. The results show that multiple courses of SRS are feasible and safe in selected patients, and in combination with new systemic therapies, they achieve satisfactory survival rates without whole-brain radiation therapy.
JOURNAL OF NEUROSURGERY
(2022)
Article
Oncology
Naoyuki Kanayama, Toshiki Ikawa, Shingo Ohira, Takero Hirata, Masahiro Morimoto, Kazuhiko Ogawa, Teruki Teshima, Koji Konishi
Summary: This study demonstrates that a significant reduction in brain metastases volume at 6 months post-SRT can predict local control. The dose of 80% of the gross tumor volume (GTV) D80 in the LQ model: alpha/beta = 20 may be a predictive factor for volume reduction.
Article
Clinical Neurology
Shoji Yomo, Kyota Oda, Kazuhiro Oguchi
Summary: This study retrospectively analyzed 233 patients with BM and CITV > 7ml who underwent upfront SRS. The results showed that systemic anticancer therapy, female sex, synchronous SRS, number of BM, controlled extracranial disease, Karnofsky performance status, and staged SRS were independently associated with OS. Additionally, post-SRS toxicities were observed in some patients, and salvage therapy was required for a portion of patients.
ACTA NEUROCHIRURGICA
(2021)
Article
Oncology
Alonso La Rosa, D. Jay J. Wieczorek, Ranjini Tolakanahalli, Yongsook C. Lee, Tugce Kutuk, Martin C. Tom, Matthew D. Hall, Michael W. McDermott, Minesh P. Mehta, Alonso N. Gutierrez, Rupesh Kotecha
Summary: The increasing incidence of patients with multiple brain metastasis has led to the need for effective treatment methods. This study evaluated the impact of lesion number and volume on mean brain dose using two dedicated intracranial SRS delivery technologies. The findings suggest that it is feasible to treat MBMs with SRS, and the number and volume of lesions are associated with the mean brain dose and radiation necrosis risk.
Article
Oncology
Michael Yan, Lori Holden, Michael Wang, Hany Soliman, Sten Myrehaug, Chia-Lin Tseng, Jay Detsky, Mark Ruschin, Michael Tjong, Eshetu G. Atenafu, Sunit Das, Nir Lipsman, Chinthaka Heyn, Arjun Sahgal, Zain Husain
Summary: This study reports the outcomes of local control and adverse radiation effects following 5-fraction GKI-HSRS for intact brain metastases. The results show that moderate total doses in 5 daily fractions of GKI-HSRS are associated with high rates of local control and a low incidence of symptomatic adverse radiation effects.
JOURNAL OF NEURO-ONCOLOGY
(2022)
Article
Clinical Neurology
Georgios Mantziaris, Stylianos Pikis, Zhiyuan Xu, Reed Mullen, Juan Alzate, Kenneth Bernstein, Douglas Kondziolka, Zhishuo Wei, Ajay Niranjan, L. Dade Lunsford, Roman Liscak, Jaromir May, Cheng-chia Lee, Huai-che Yang, Francois-Louis Coupe, David Mathieu, Kimball Sheehan, Darrah Sheehan, Joshua D. Palmer, Haley K. Perlow, Selcuk Peker, Yavuz Samanci, Jennifer Peterson, Daniel M. Trifiletti, Matthew J. Shepard, Shahed Elhamdani, Rodney E. Wegner, Herwin Speckter, Wenceslao Hernandez, Ronald E. Warnick, Jason Sheehan
Summary: This retrospective study showed that stereotactic radiosurgery (SRS) is an effective treatment option for intraventricular metastases (IVMs), with a comparable local control rate to SRS for parenchymal brain metastases. However, careful follow-up is needed to detect leptomeningeal spread and hydrocephalus in patients with IVMs.
Review
Oncology
Raees Tonse, Martin C. Tom, Minesh P. Mehta, Manmeet S. Ahluwalia, Rupesh Kotecha
Summary: In modern times, brain metastasis requires multi-modal management and interdisciplinary care. Traditionally, treatment strategies have focused on local treatments alone due to limited efficacy of cytotoxic chemotherapy. However, with the availability of molecular-based therapies with central nervous system penetration, individualized selection of tailored systemic therapies can now be used alongside local treatments. Moreover, the introduction of immune checkpoint inhibitors has further revolutionized the management of brain metastasis patients.
Article
Clinical Neurology
Adomas Bunevicius, Karen Lavezzo, Leah Shabo, Jesse McClure, Jason P. Sheehan
Summary: The study evaluated the quality of life in patients treated with stereotactic radiosurgery for brain metastases, finding that the quality of life remained largely stable post-treatment. Factors such as the patient's RPA class, upfront whole-brain radiation therapy, and the number of intracranial lesions were identified as independent predictors of post-treatment quality of life deterioration. Additionally, a lower pre-treatment quality of life was associated with shorter survival independently of other clinical and demographic variables.
JOURNAL OF NEUROSURGERY
(2021)
Article
Oncology
Raphael Bodensohn, Anna -Lena Kaempfel, Anne-Laure Boulesteix, Anna Maria Orzelek, Stefanie Corradini, Daniel Felix Fleischmann, Robert Forbrig, Sylvia Garny, Indrawati Hadi, Jan Hofmaier, Giuseppe Minniti, Ulrich Mansmann, Montserrat Pazos Escudero, Niklas Thon, Claus Belka, Maximilian Niyazi
Summary: This prospective nonrandomized controlled trial aimed to compare whole-brain radiotherapy (WBRT) and stereotactic radiosurgery (SRS) in the treatment of multiple brain metastases. Propensity-score matching was performed to compare the efficacy between SRS and historical WBRT control groups. The results showed no significant differences in overall survival and intracranial progression-free survival between the two groups, and no grade III toxicities were observed in the SRS group. The trial did not meet its primary endpoint, and further prospective randomized trials are needed in the era of immunotherapy and targeted therapies.
RADIOTHERAPY AND ONCOLOGY
(2023)
Article
Clinical Neurology
Stylianos Pikis, Adomas Bunevicius, Cheng-Chia Lee, Huai-Che Yang, Brad E. Zacharia, Roman Liscak, Gabriela Simonova, Manjul Tripathi, Narendra Kumar, David Mathieu, Remi Perron, Selcuk Peker, Yavuz Samanci, Jason Gurewitz, Kenneth Bernstein, Douglas Kondziolka, Ajay Niranjan, L. Dade Lunsford, Nikolaos Mantziaris, Jason P. Sheehan
Summary: This multicenter study evaluated the safety and efficacy of stereotactic radiosurgery (SRS) in the management of intracranial prostate cancer metastases. The results showed that SRS was a safe, well-tolerated, and effective treatment option for these patients.
JOURNAL OF NEUROSURGERY
(2022)
Article
Oncology
Alejandro Bugarini, Evan Meekins, Joshua Salazar, Andrea L. Berger, Michel Lacroix, Edward A. Monaco III, Andrew R. Conger, Anand Mahadevan
Summary: Neoadjuvant stereotactic radiosurgery (SRS) may reduce the incidence of radionecrosis (RN) and decrease radiation to normal tissue in patients with cerebral metastatic disease. A retrospective analysis of 47 brain metastases patients showed that neoadjuvant SRS was associated with reduced radiotherapy doses, improved conformality profile, and decreased radiation to normal tissue, supporting its use in the treatment of brain metastases.
RADIOTHERAPY AND ONCOLOGY
(2023)
Article
Oncology
David J. Carpenter, Brahma Natarajan, Muzamil Arshad, Divya Natesan, Olivia Schultz, Michael J. Moravan, Charlotte Read, Kyle J. Lafata, Will Giles, Peter Fecci, Trey C. Mullikin, Zachary J. Reitman, John P. Kirkpatrick, Scott R. Floyd, Steven J. Chmura, Julian C. Hong, Joseph K. Salama
Summary: This study validates a previously published nomogram for predicting intracranial progression risk after stereotactic radiosurgery (SRS) in patients with brain metastases. The nomogram successfully stratifies patients into low- and high-risk groups for post-SRS intracranial progression. The results support the use of this nomogram as a quick and simple tool for surveillance and risk stratification in SRS-treated patients.
Article
Oncology
Pauline Roussille, Marie Auvray, Damien Vansteene, Thierry Lecomte, Eugenie Rigault, Marianne Maillet, Christophe Locher, Marie Dior, Vincent Hautefeuille, Pascal Artru, May Mabro, Yann Touchefeu, Lysiane Marthey, Valerie Moulin, Samy Louafi, Cedric Lecaille, Romain Chautard, Astrid Lievre, Aziz Zaanan, Jaafar Bennouna, Antoine Berger, Sheik Emambux, Violaine Randrian, David Tougeron
Summary: This study evaluated prognostic factors of brain metastases from colorectal cancer and found that ECOG performance status, number of brain metastases, and number of chemotherapy lines are the most relevant factors in the management of patients with this condition.
RADIOTHERAPY AND ONCOLOGY
(2021)
Article
Oncology
Angela Barillaro, Mara Caroprese, Laura Cella, Anna Viggiano, Francesca Buccelli, Chiara Daponte, Chiara Feoli, Caterina Oliviero, Stefania Clemente, Antonio Farella, Manuel Conson, Roberto Pacelli
Summary: Brain metastases are severe events in patients with solid tumors. Stereotactic radiation therapy is an effective treatment for brain metastases, but it may lead to radiation necrosis, which can impact patient's quality of life. Prompt recognition and treatment are necessary for managing radiation necrosis.
Article
Clinical Neurology
Joel R. Martin, Paolo G. Gabriel, Jeffrey J. Gold, Richard Haas, Suzanne L. Davis, David D. Gonda, Cynthia Sharpe, Scott B. Wilson, Nicolas C. Nierenberg, Mark L. Scheuer, Sonya G. Wang
Summary: This study used computer vision technology to quantify neonatal movements and trained a binary patting detection algorithm, which successfully reduced false-positive automated seizure detections and improved the accuracy of detecting true seizure activity.
JOURNAL OF CLINICAL NEUROPHYSIOLOGY
(2022)
Article
Clinical Neurology
Jeffrey A. Steinberg, Michael G. Brandel, Keiko M. Kang, Robert C. Rennert, J. Scott Pannell, Scott E. Olson, David D. Gonda, Alexander A. Khalessi, Michael L. Levy
Summary: This retrospective study analyzed 89 pediatric patients who underwent microsurgical resection of cerebral AVMs at a children's hospital from 2002 to 2019. The results showed a high rate of radiographic obliteration post-surgery, relatively low incidence of neurological complications and AVM recurrence, with good neurological outcomes for the majority of patients at last follow-up.
CHILDS NERVOUS SYSTEM
(2021)
Article
Clinical Neurology
Mihir Gupta, Tiffany M. Chan, David R. Santiago-Dieppa, Anudeep Yekula, Carlos E. Sanchez, Jennifer D. Elster, John R. Crawford, Michael L. Levy, David D. Gonda
Summary: Robotic stereotactic biopsies of pediatric brainstem and thalamic tumors using the ROSA platform were successful with a high diagnostic success rate of 91.3%. The ROSA system enabled rapid acquisition of lesional tissue without major adverse outcomes. This experience represents the largest clinical series dedicated to this type of robot-assisted biopsies.
JOURNAL OF NEUROSURGERY-PEDIATRICS
(2021)
Article
Surgery
Alicia G. Sykes, William B. Sisson, David D. Gonda, Karen M. Kling, Romeo C. Ignacio, Hariharan Thangarajah, Stephen W. Bickler, Michael L. Levy, David A. Lazar
Summary: Laparoscopic-assisted VPS placement in reoperative abdomen reduces shunt-related complications, prolongs shunt patency, and shortens operative times.
JOURNAL OF SURGICAL RESEARCH
(2022)
Review
Clinical Neurology
Karol Wisniewski, Michael G. Brandel, David D. Gonda, John R. Crawford, Michael L. Levy
Summary: Diffuse leptomeningeal glioneuronal tumor (DLGNT) is a rare tumor with challenging diagnosis and prognosis. This systematic review identified Ki-67 ≥ 7% as the most important prognostic factor for overall survival (OS) in DLGNT patients, while symptoms of elevated intracranial pressure, age, and the presence of contrast-enhancing intraparenchymal tumor were also associated with poor OS.
CHILDS NERVOUS SYSTEM
(2022)
Article
Biochemical Research Methods
Abdulwahab Alasfour, Paolo Gabriel, Xi Jiang, Isaac Shamie, Lucia Melloni, Thomas Thesen, Patricia Dugan, Daniel Friedman, Werner Doyle, Orin Devinsky, David Gonda, Shifteh Sattar, Sonya Wang, Eric Halgren, Vikash Gilja
Summary: In this study, the authors analyzed neural activity from two patients using electrocorticography (ECoG) and stereo-electroencephalography (sEEG) recordings. They found multiple neural signal characteristics that discriminate between unstructured and naturalistic behavioral states. The high gamma amplitude and Gaussian process factor analysis (GPFA) were used to demonstrate the discriminability of these features.
PLOS COMPUTATIONAL BIOLOGY
(2022)
Article
Orthopedics
Jessica H. Heyer, Jason B. Anari, Keith D. Baldwin, Stuart L. Mitchell, Scott J. Luhmann, Peter F. Sturm, John M. Flynn, Patrick J. Cahill
Summary: The study found that the law of diminishing returns applies to magnetically controlled growing rods in patients with early-onset scoliosis, with only 21.7% of rods expanding to within 80% of the maximum excursion.
JOURNAL OF BONE AND JOINT SURGERY-AMERICAN VOLUME
(2022)
Article
Genetics & Heredity
Changuk Chung, Xiaoxu Yang, Taejeong Bae, Keng Ioi Vong, Swapnil H. Mittal, Catharina Donkels, H. Westley Phillips, Zhen Li, Ashley P. L. Marsh, Martin Breuss, Laurel Ball, Camila Araujo Bernardino Garcia, Renee George, Jing Gu, Mingchu Xu, Chelsea Barrows, Kiely James, Valentina Stanley, Anna Nidhiry, Sami Khoury, Gabrielle Howe, Emily Riley, Xin Xu, Brett Copeland, Yifan G. Wang, Se Hoon L. Kim, Hoon-Chul W. Kang, Andreas Schulze-Bonhage, Carola Haas, Horst Urbach, Marco Prinz, David A. Limbrick, Christina Gurnett, Matthew C. Smyth, Shifteh M. Sattar, Mark B. Nespeca, David V. Gonda, Katsumi Y. Imai, Yukitoshi E. Takahashi, Hsin-Hung B. Chen, Jin-Wu Tsai, Valerio Conti, Renzo Guerrini, Orrin Devinsky, Wilson Silva, Helio M. Machado, Gary Mathern, Alexej Abyzov, Sara Baldassari, Stephanie Baulac, Joseph G. Gleeson
Summary: Malformations of cortical development (MCD) are neurological disorders caused by somatic mosaic mutations during embryogenesis, leading to intractable epilepsy. This study identified 69 mutated genes from 283 brain resections and investigated their functional roles using various techniques. Genotype-phenotype correlation analysis revealed specific gene sets associated with different pathophysiological and clinical phenotypes of MCD. The spatiotemporal expression patterns of mutated genes in control and patient brains suggest their critical roles in excitatory neurogenesis and neuronal hyperexcitability.
Article
Emergency Medicine
Naomi Abe, Michael Gardiner, Christopher Dory, David Gonda, Helen Harvey, Mary Hilfiker, Kathryn Hollenbach, John T. Kanegaye
Summary: Among children with traumatic intracranial epidural hematomas admitted for observation, larger hematoma size, mass effect, headaches, and prolonged prothrombin time were associated with delayed surgical intervention.
PEDIATRIC EMERGENCY CARE
(2023)
Article
Clinical Neurology
Elsa Arocho-Quinones, Sean M. Lew, Michael H. Handler, Zulma Tovar-Spinoza, Matthew D. Smyth, Robert J. Bollo, David Donahue, M. Scott Perry, Michael Levy, David Gonda, Francesco T. Mangano, Benjamin C. Kennedy, Phillip B. Storm, Angela Price, Daniel E. Couture, Chima Oluigbo, Ann-Christine Duhaime, Gene H. Barnett, Carrie R. Muh, Michael D. Sather, Aria Fallah, Anthony C. Wang, Sanjiv Bhatia, Daniel Eastwood, Sergey Tarima, Sarah Graber, Sean Huckins, Daniel Hafez, Kavelin Rumalla, Laurie Bailey, Sabrina Shandley, Ashton Roach, Erin Alexander, Wendy Jenkins, Deki Tsering, George Price, Antonio Meola, Wendi Evanoff, Eric M. Thompson, Nicholas Brandmeir
Summary: The safety and efficacy of stereotactic laser ablation (SLA) for drug-resistant epilepsy (DRE) in children were evaluated in this study. Retrospective data from pediatric patients with DRE who underwent SLA treatment between 2008 and 2018 were reviewed. The results showed that SLA is an effective and well-tolerated treatment option for children with DRE.
JOURNAL OF NEUROSURGERY-PEDIATRICS
(2023)
Article
Medicine, General & Internal
Joshua Loya, Nolan J. Brown, David Gonda, Michael Levy
Summary: This case study reports on the repair of a giant occipital encephalocele and highlights important methods to reduce the risk of blood loss and other complications.
CLINICAL CASE REPORTS
(2023)
Article
Clinical Neurology
Sujay Rajkumar, Daniel S. S. Ikeda, Michaela Scanlon, Margaret Shields, John R. R. Kestle, Jillian Plonsker, Michael Brandel, David D. D. Gonda, Michael Levy, Donald J. J. Lucas, Pamela M. M. Choi, Vijay M. M. Ravindra
Summary: This study examined the concurrent complications and predictive factors in syndromic children after multi-suture craniosynostosis surgery. It found that cardiac and pulmonary risk factors, along with preoperative nutritional support, were independently associated with concurrent complications. This information can be used to guide presurgical counseling and risk assessment.
CHILDS NERVOUS SYSTEM
(2023)
Article
Immunology
Claudia Z. Han, Rick Z. Li, Emily Hansen, Samantha Trescott, Bethany R. Fixsen, Celina T. Nguyen, Cristina M. Mora, Nathanael J. Spann, Hunter R. Bennett, Olivier Poirion, Justin Buchanan, Anna S. Warden, Bing Xia, Johannes C. M. Schlachetzki, Martina P. Pasillas, Sebastian Preissl, Allen Wang, Carolyn O'Connor, Shreya Shriram, Roy Kim, Danielle Schafer, Gabriela Ramirez, Jean Challacombe, Samuel A. Anavim, Avalon Johnson, Mihir Gupta, Ian A. Glass, Birth Defects Research Birth Defects Res Lab, Michael L. Levy, Sharona Ben Haim, David D. Gonda, Louise Laurent, Jennifer F. Hughes, David C. Page, Mathew Blurton-Jones, Christopher K. Glass, Nicole G. Coufal
Summary: This study characterized the transcriptomes and epigenetic landscapes of fetal and postnatal human microglia, as well as in induced pluripotent stem cell-derived microglia and cerebral organoids, and after engraftment into humanized mice. Computational approaches were developed to predict gene regulatory networks associated with the maturation of microglia. The results suggest that many features of the fetal-to-postnatal transition can be replicated in a time-dependent manner following engraftment.
Article
Neurosciences
Vijay M. Ravindra, Lucia Ruggieri, Nisha Gadgil, Angela P. Addison, Ilana Patino, David D. Gonda, Jason Chu, Laura Whitehead, Anne Anderson, Gloria Diaz-Medina, Kimberly Houck, Akshat Katyayan, Laura Masters, Audrey Nath, Michael Quach, James John Riviello, Elaine Seto, Krystal Elizabeth Sully, Latanya Agurs, Sonali Sen, Maureen Handoko, Rohini Coorg, Irfan Ali, Daniel Ikeda, Howard Weiner, Daniel J. Curry
Summary: We have demonstrated the feasibility of completing hemispherotomy using MRgLITT, which can achieve both disconnection and seizure control.
STEREOTACTIC AND FUNCTIONAL NEUROSURGERY
(2023)
Article
Clinical Neurology
Robert C. Rennert, Michael G. Brandel, Jeffrey A. Steinberg, David D. Gonda, Rick A. Friedman, Takanori Fukushima, John D. Day, Alexander A. Khalessi, Michael L. Levy
Summary: This study analyzed the morphometrics of the anterior petrous apex (APA) region in children and found that APA development is largely complete by the ages of 8-11 years. Understanding these growth patterns may assist in approach selection and APA removal in pediatric patients.
JOURNAL OF NEUROSURGERY
(2022)
Article
Oncology
Diego de Miguel-Perez, Edward M. Pickering, Umberto Malapelle, William Grier, Francesco Pepe, Pasquale Pisapia, Gianluca Russo, Joseph A. Pinto, Alessandro Russo, Giancarlo Troncone, Melissa J. Culligan, Katherine A. Scilla, Ranee Mehra, Pranshu Mohindra, Oscar Arrieta, Andres F. Cardona, Marzia Del Re, Ashutosh Sachdeva, Fred R. Hirsch, Andrea Wolf, Joseph S. Friedberg, Christian Rolfo
Summary: In this study, genetic alterations in resectable pleural mesothelioma tissues and blood samples were analyzed, and it was found that high tissue tumor mutational burden, tissue median minor allele frequency, blood tumor mutational burden, and specific mutations were correlated with outcomes in patients with resected PM. These findings suggest that molecular profiling could help identify longer survivors in patients with resected PM.
EUROPEAN JOURNAL OF CANCER
(2024)
Article
Oncology
Davide Melisi, Camilla Zecchetto, Valeria Merz, Giuseppe Malleo, Luca Landoni, Alberto Quinzii, Simona Casalino, Federica Fazzini, Marina Gaule, Camilla Pesoni, Luca Casetti, Alessandro Esposito, Giovanni Marchegiani, Cristiana Piazzola, Mirko D'Onofrio, Riccardo de Robertis, Armando Gabbrielli, Laura Bernardoni, Stefano F. Crino, Silvia Pietrobono, Claudio Luchini, Camillo Aliberti, Guido Martignoni, Stefano Milleri, Giovanni Butturini, Aldo Scarpa, Roberto Salvia, Claudio Bassi
Summary: This study evaluated the safety and activity of liposomal irinotecan in the perioperative treatment of resectable pancreatic ductal adenocarcinoma (rPDAC) patients. The results showed that NALIRIFOX has manageable and active outcomes, and should be further investigated in randomized trials comparing it to standard upfront surgery followed by adjuvant therapy.
EUROPEAN JOURNAL OF CANCER
(2024)
Article
Oncology
Eric Jonasch, Todd M. Bauer, Kyriakos P. Papadopoulos, Elizabeth R. Plimack, Jaime R. Merchan, David F. Mcdermott, M. Dror Michaelson, Leonard J. Appleman, Ananya Roy, Rodolfo F. Perini, Yanfang Liu, Toni K. Choueiri
Summary: After a median follow-up of 41.2 months, belzutifan monotherapy demonstrated durable antitumor activity in patients with advanced ccRCC and acceptable safety.
EUROPEAN JOURNAL OF CANCER
(2024)
Article
Oncology
Patricia A. H. Hamers, Geraldine R. Vink, Marloes A. G. Elferink, Leon M. G. Moons, Cornelis J. A. Punt, Anne M. May, Miriam Koopman
Summary: Screen-detection of the primary tumor is associated with longer overall survival after metachronous metastasis.
EUROPEAN JOURNAL OF CANCER
(2024)
Article
Oncology
Camilla Nero, Nicolo Bizzarri, Stefano Di Berardino, Francesca Sillano, Giuseppe Vizzielli, Francesco Cosentino, Virginia Vargiu, Pierandrea De Iaco, Anna Myriam Perrone, Enrico Vizza, Benito Chiofalo, Stefano Uccella, Fabio Ghezzi, Luigi Carlo Turco, Giacomo Corrado, Diana Giannarelli, Tina Pasciuto, Gian Franco Zannoni, Anna Fagotti, Giovanni Scambia
Summary: This study evaluates the sensitivity and specificity of sentinel-lymph-node mapping compared to systematic lymphadenectomy in detecting lymph node metastasis in early stage ovarian cancer. The results show that sentinel-lymph-node mapping did not reach the expected sensitivity, but ultra-staging protocol improved the accuracy of diagnosis for patients.
EUROPEAN JOURNAL OF CANCER
(2024)
Article
Oncology
Adriana Hepner, Judith M. Versluis, Roslyn Wallace, Clara Allayous, Lauren Julia Brown, Claudia Trojanielloh, Camille Lea Gerardi, Yanina J. L. Jansenj, Prachi Bhave, Bart Neyns, Andrew Haydon, Olivier Michielin, Joanna Manganan Oliver Klein, Alexander N. Shoushtari, Allison Betof Warner, Paolo Antonio Ascierto, Jennifer Leigh McQuade, Matteo S. Carlino, Lisa Zimmer, Celeste Lebbe, Douglas B. Johnson, Shahneen Sandhu, Victoria Atkinson, Christian U. Blank, Serigne N. Lo, Georgina V. Long, Alexander M. Menzies
Summary: Acquired resistance to PD-1 therapy in melanoma is mainly oligometastatic, and patients may have a favorable survival outcome following salvage treatment.
EUROPEAN JOURNAL OF CANCER
(2024)
Article
Oncology
Savannah Roy, Stephanie Lakritz, Anna R. Schreiber, Elizabeth Molina Kuna, Cathy J. Bradley, Lavanya Kondapalli, Jennifer R. Diamond
Summary: This study evaluates major adverse cardiovascular events (MACE) in older women with TNBC treated with anthracycline and taxane-based chemotherapy (ATAX) compared to taxane-based chemotherapy (TAX). The results show that ATAX does not increase the risk of MACE and there is no difference in survival between patients who received TAX and ATAX.
EUROPEAN JOURNAL OF CANCER
(2024)
Letter
Oncology
Pei-Chun Weng, Yau-Li Huang, Chun-Yu Cheng
EUROPEAN JOURNAL OF CANCER
(2024)
Article
Oncology
Philipp Jansen, Jean Le 'Clerc Arrastia, Daniel Otero Baguer, Maximilian Schmidt, Jennifer Landsberg, Joerg Wenzel, Michael Emberger, Dirk Schadendorf, Eva Hadaschik, Peter Maass, Klaus Georg Griewank
Summary: This study highlights the enormous potential of artificial intelligence in pathology, showing that it can aid in the identification of rare cutaneous adnexal tumors and potentially become a standard tool in routine diagnostics.
EUROPEAN JOURNAL OF CANCER
(2024)
Article
Oncology
Casper W. F. van Eijck, Gaby Strijk, Eveline E. Vietscha, Fleur van der Sijde, Maaike Verheij, Dana A. M. Mustafa, Madelief Vinkc, Joachim G. J. V. Aerts, Casper H. J. van Eijck, Marcella Willemsen
Summary: The study reveals that FOLFIRINOX has immunomodulatory effects, suggesting its potential in immune-based combination therapies for pancreatic cancer. Additionally, certain plasma proteins hold promise as circulating predictive biomarkers for early prediction of FOLFIRINOX response in patients with pancreatic cancer.
EUROPEAN JOURNAL OF CANCER
(2024)
Article
Oncology
Marwan Fakih, Chongkai Wang, Jaideep Sandhu, Jian Ye, Colt Egelston, Xiaochen Li
Summary: This study explores the impact of metastatic sites on treatment outcomes for chemotherapy-refractory colorectal cancer patients. It found that patients with liver or peritoneal metastases had poor treatment outcomes, while those with lung-only metastases showed significant response. The presence of concurrent lymph node or other extrahepatic metastatic disease diminished treatment response in patients with lung metastases. Future checkpoint inhibitor trials should stratify patients based on metastatic locations.
EUROPEAN JOURNAL OF CANCER
(2024)
Article
Oncology
Georgios Christos Tsiatsianis, Candace S. Y. Chan, Ioannis Mouratidis, Nikol Chantzi, Anna Maria Tsiatsiani, Nelson S. Yee, Apostolos Zaravinos, Verena Kantere, Ilias Georgakopoulos-Soares
Summary: The study reveals that nullpeptides can serve as biomarkers for cancer detection and treatment, particularly in highly recurrent cancer patients. These nullpeptides primarily occur in highly expressed genes, particularly in specific loci of oncogenes and tumor suppressors. Recurrent nullpeptides are more likely to be found in neoantigens, which play a significant role in immunotherapy.
EUROPEAN JOURNAL OF CANCER
(2024)