Article
Oncology
Zijian Tian, Lingfeng Meng, Xin Wang, Tongxiang Diao, Maolin Hu, Miao Wang, Yaqun Zhang, Ming Liu
Summary: This study identified clinicopathological factors associated with lymph node metastasis in bladder cancer and developed a nomogram for predicting prognosis. The nomogram showed high accuracy in predicting LNM, assisting in optimal treatment selection for patients.
FRONTIERS IN ONCOLOGY
(2021)
Article
Mathematical & Computational Biology
Jiaping Wang
Summary: This study identified hub genes related to the progression of SKCM through comprehensive analysis of RNA sequencing datasets. By constructing predictive and nomogram models, independent clinicopathologic factors were identified, and a predictive model for estimating individual survival probabilities was developed.
MATHEMATICAL BIOSCIENCES AND ENGINEERING
(2021)
Article
Oncology
Mengting Wang, Min Ma, Liju Yang, Chengtong Liang
Summary: This study investigated the risk factors and prognosis of lymph node metastasis (LNM) in cervical cancer patients using data from the SEER database. Predictive nomogram models were established and their performance was evaluated. The study provides clinicians with a reference for diagnosis and treatment.
FRONTIERS IN ONCOLOGY
(2022)
Article
Medicine, General & Internal
Min-Hao Lyu, You-Zhao Ma, Pei-Qi Tian, Hui-Hui Guo, Chao Wang, Zhen-Zhen Liu, Xiu-Chun Chen
Summary: In this study, a novel nomogram was developed to predict the overall survival of breast cancer patients with ISLNM but without distant metastasis. The nomogram showed good predictive accuracy and discriminative ability in both the training and validation cohorts. It can help clinicians estimate prognosis more accurately and make personalized therapeutic decisions for individual patients.
CHINESE MEDICAL JOURNAL
(2021)
Article
Oncology
Jinzhou Li, Ting Cui, Zeping Huang, Yanxi Mu, Yalong Yao, Wei Xu, Kang Chen, Haipeng Liu, Wenjie Wang, Xiao Chen
Summary: This study explored the risk factors and independent prognostic factors of lymph node metastasis (LNM) in early gastric cancer (EGC) patients and developed a clinical prediction model to predict LNM. The study has clinical significance for the risk assessment and prognosis prediction of LNM in EGC patients.
FRONTIERS IN ONCOLOGY
(2023)
Article
Oncology
Shuai Li, Yicun Wang, Xiaopeng Hu
Summary: This study compared the prognostic value of multiple lymph node metastasis indicators and developed prognostic nomograms for bladder cancer patients. The nomograms were validated in three cohorts and demonstrated good predictive accuracy and clinical utility. Additionally, the nomograms were able to differentiate between two risk groups and reveal differences in biological function and tumor immunity.
Article
Otorhinolaryngology
Wanpeng Li, Hanyu Lu, Huan Wang, Li Hu, Xicai Sun, Hongmeng Yu, Dehui Wang
Summary: This study developed and validated a nomogram to predict overall survival in nasopharyngeal carcinoma patients with lymph node metastasis. Seven prognostic factors were identified and the nomogram demonstrated good predictive capability.
HEAD AND NECK-JOURNAL FOR THE SCIENCES AND SPECIALTIES OF THE HEAD AND NECK
(2021)
Article
Oncology
Zhenghao Chen, Chuan Qin, Gang Wang, Donghao Shang, Ye Tian, Lushun Yuan, Rui Cao
Summary: This study developed a nomogram that included an StrLNM signature to predict the lymph node metastasis status in bladder cancer patients. The nomogram showed good performance in prediction and was validated in multiple independent cohorts.
FRONTIERS IN ONCOLOGY
(2022)
Article
Endocrinology & Metabolism
Bo Chen, Yuan Zeng, Bo Liu, Gaoxiang Lu, Zhouxia Xiang, Jiyang Chen, Yan Yu, Ziyi Zuo, Yangjun Lin, Jinfeng Ma
Summary: This study identified independent risk factors for distant metastasis (DM) and established two nomograms to predict the occurrence and prognosis of DM in osteosarcoma patients. The nomograms were validated using various analysis methods and were found to be effective tools for predicting the risk of DM and personalized prognosis prediction for patients with DM.
FRONTIERS IN ENDOCRINOLOGY
(2021)
Article
Oncology
Yu Du, Caili Li, Lili Mao, Xiaoting Wei, Xue Bai, Zhihong Chi, Chuanliang Cui, Xinan Sheng, Bin Lian, Bixia Tang, Xuan Wang, Xieqiao Yan, Siming Li, Li Zhou, Jun Guo, Lu Si
Summary: This study found that the expression of Ki67 is associated with the progression and prognosis of acral melanoma (AM). Among 314 AM patients analyzed, those with high Ki67 expression had lower melanoma-specific survival. A predictive model incorporating Ki67 and other clinical factors was constructed to predict the prognosis of AM.
JOURNAL OF CANCER RESEARCH AND CLINICAL ONCOLOGY
(2023)
Article
Oncology
Jiajia Tang, Shitao Jiang, Luying Gao, Xuehua Xi, Ruina Zhao, Xingjian Lai, Bo Zhang, Yuxin Jiang
Summary: LODDS is an independent prognostic factor for MTC, showing superior prognostic efficiency over N status and PLNN, and its prediction model performs better than the AJCC TNM system in predicting CSS for MTC after surgery.
ANNALS OF SURGICAL ONCOLOGY
(2021)
Article
Immunology
Rui Mao, Fan Yang, Tongtong Zhang, Ji Li
Summary: The incidence of cutaneous melanoma is rising, and better markers are needed to predict prognosis and immunotherapy effectiveness. By analyzing TCGA data and developing a signature based on immune checkpoint proteins, researchers were able to accurately predict prognosis and response to therapy in melanoma patients. The signature was found to be an independent prognostic factor and a nomogram based on the signature was more effective than the signature alone.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Endocrinology & Metabolism
Zheyu Yang, Yu Heng, Qiwu Zhao, Zichao Cao, Lei Tao, Weihua Qiu, Wei Cai
Summary: The study identified differences in clinical characteristics between skip metastasis and other types of lymph node metastasis, and established a nomogram that effectively predicts the risk of skip metastasis.
FRONTIERS IN ENDOCRINOLOGY
(2021)
Article
Endocrinology & Metabolism
Mei Tao, Shuyan Luo, Xiaoming Wang, Meng Jia, Xiubo Lu
Summary: This study aimed to develop a visual model for predicting the prognosis of patients with parathyroid carcinoma (PC) and analyze related biochemistries in different stage groups. Nomograms were constructed based on independent prognostic factors, and they showed good predictive value in both training and validation sets. Lower albumin levels and higher postoperative parathyroid hormone levels were associated with distant metastasis in PC patients.
FRONTIERS IN ENDOCRINOLOGY
(2022)
Review
Biochemistry & Molecular Biology
Mina Alimohammadi, Ali Rahimi, Fatemeh Faramarzi, Reza Alizadeh-Navaei, Alireza Rafiei
Summary: The results indicate that CXCR4 overexpression is significantly associated with ulceration, tumor thickness, and lymph node metastasis in melanoma, suggesting its involvement in disease progression and metastasis, which may warrant further clinical studies to explore its potential as a diagnostic and therapeutic biomarker for melanoma cancer.
Article
Environmental Sciences
Kyoko Miura, Minas Coroneo, Jean Claude Dusingize, Catherine M. Olsen, Rick Tinker, Ken Karipidis, Ian Hosegood, Adele C. Green
Summary: This study estimated the prevalence of cataract in pilots by analyzing medical records of commercial airline pilots diagnosed with cataract between 2011 and 2016. The results showed that the prevalence of cataract in pilots aged 60 and above was 11.6%, while it was only 0.5% in pilots aged below 60. The study also found that there was no significant difference in cataract prevalence based on the ambient ultraviolet radiation levels, although the lowest prevalence was observed in the low-UV state of Victoria. Furthermore, cataracts in pilots aged 60 and above were mostly bilateral and mild, while cataracts in pilots below 60 were more likely to be unilateral and severe.
ARCHIVES OF ENVIRONMENTAL & OCCUPATIONAL HEALTH
(2023)
Article
Gastroenterology & Hepatology
Swathikan Chidambaram, Nikhil M. Patel, Viknesh Sounderajah, Rita Alfieri, Luigi Bonavina, Edward Cheong, Andy Cockbain, Xavier Benoit D'Journo, Lorenzo Ferri, Ewen A. Griffiths, Peter Grimminger, Caroline Gronnier, Christian Gutschow, Jakob Hedberg, Joonas H. Kauppila, Sjoerd Lagarde, Donald Low, Philippe Nafteux, Grard Nieuwenhuijzen, Magnus Nilsson, Riccardo Rosati, Wolfgang Schroeder, B. Mark Smithers, Mark I. van Berge Henegouwen, Richard van Hillegesberg, David Watson, Ravinder Vohra, Nick Maynard, Sheraz R. Markar
Summary: Currently, there is a lack of evidence-based guidelines for surveillance of recurrence after esophageal and gastric (OG) cancer surgical resection. This study used a modified Delphi consensus process to identify eight symptoms that should prompt further investigations for suspected recurrent malignancy.
DISEASES OF THE ESOPHAGUS
(2023)
Editorial Material
Dermatology
Tricia Tay, Martin G. Cook, Kyoko Miura, Megan Grant, Richard Marais, Adele C. Green
ACTA DERMATO-VENEREOLOGICA
(2023)
Article
Dermatology
Alexander James Tedman, Upekha E. Liyanage, Sharene Chong, Casey Rowe, Lena A. von Schuckmann, Maryrose Malt, Adele C. Green, B. Mark Smithers, Kiarash Khosrotehrani
Summary: By analyzing data of patients with stage IB to IIIA melanomas in Queensland, Australia, it was found that tumor characteristics such as thickness and ulceration, along with SLN status, significantly influenced the 10-year survival rate after diagnosis at 1 and 2 years, but only SLN status remained predictive after 5 years.
AUSTRALASIAN JOURNAL OF DERMATOLOGY
(2023)
Article
Dermatology
Ashley Ahimbisibwe, Morten Valberg, Adele C. Green, Reza Ghiasvand, Corina S. Rueegg, Raju Rimal, Elisabete Weiderpass, Torkjel M. Sandanger, Trude E. Robsahm, Marit B. Veierod
Summary: This study investigated the association between nevus count and pigmentary characteristics with melanoma-specific mortality. The study found that in patients with thicker melanoma, darker pigmentary characteristics were associated with a higher risk of melanoma death. However, in women with thicker melanoma, lighter pigmentary characteristics and asymmetrical nevi may be associated with lower melanoma-specific mortality.
ACTA DERMATO-VENEREOLOGICA
(2023)
Letter
Oncology
John F. Thompson, John Hyngstrom, Corrado Caraco, Jonathan S. Zager, Tiina Jahkola, Tawnya L. Bowles, Elisabetta Pennacchioli, Harald J. Hoekstra, Marc Moncrieff, Christian Ingvar, Alexander van Akkooi, Michael S. Sabel, Edward A. Levine, Michael Henderson, Reinhard Dummer, Carlo Riccardo Rossi, John M. Kane, Steven Trocha, Frances Wright, David R. Byrd, Maurice Matter, Alastair MacKenzie-Ross, Mark C. Kelley, Patrick Terheyden, Tara L. Huston, Jeffrey D. Wayne, Heather Neuman, B. Mark Smithers, Darius Desai, Jeffrey E. Gershenwald, Shlomo Schneebaum, Anja Gesierich, Lisa K. Jacobs, James M. Lewis, Cristina O'Donoghue, Armando Sardi, J. Greg McKinnon, Craig L. Slingluff, Jeffrey M. Farma, Erwin Schultz, Randall P. Scheri, Sergi Vidal-Sicart, Alessandro A. E. Testori, Richard A. Scolyer, David E. Elashoff, Alistair J. Cochran, Mark B. Faries
ANNALS OF SURGICAL ONCOLOGY
(2023)
Letter
Dermatology
Reza Ghiasvand, Leon A. M. Berge, Bettina K. Andreassen, Adele C. Green, Marie Al Rahmoun, Agnes Fournier, Marina Kvaskoff, Marit B. Veierod, Trude E. Robsahm
BRITISH JOURNAL OF DERMATOLOGY
(2023)
Article
Oncology
Ibtissam Acem, Veroniek M. van Praag, Cassidy Q. B. Mostert, Robert J. P. van der Wal, Ralph M. L. Neijenhuis, Cornelis Verhoef, Dirk J. Grunhagen, Michiel A. J. van de Sande
Summary: This study aimed to assess the ability of an easy-to-use electronic nose to differentiate between patients with soft tissue sarcoma (STS) and those without STS based on their exhaled breath. It is the first pilot study to show that an electronic nose could serve as a diagnostic tool for STS detection with good performance. Future studies are needed to validate these findings in larger cohorts.
Letter
Dermatology
C. Cox, K. Fry, Y. Sivakumaran, L. Spelman, K. Khosrotehrani
JOURNAL OF THE EUROPEAN ACADEMY OF DERMATOLOGY AND VENEREOLOGY
(2023)
Article
Health Care Sciences & Services
N. J. M. C. Vrancken Peeters, Z. L. R. Kaplan, M. E. Clarijs, M. A. M. Mureau, C. Verhoef, T. van Dalen, O. Husson, L. B. Koppert
Summary: This study examined the long-term effects of axillary treatments on health-related quality of life in breast cancer patients. Except for axillary lymph node dissection (ALND) with axillary radiotherapy, other axillary treatments showed no significant impact on physical and psychosocial wellbeing. Patients who received ALND with radiotherapy experienced a significant decrease in physical and psychosocial wellbeing postoperatively.
QUALITY OF LIFE RESEARCH
(2023)
Article
Surgery
Hidde A. Galema, Tessa M. van Ginhoven, Gaston J. H. Franssen, Johannes Hofland, Claire G. O. T. Bouman, Cornelis Verhoef, Alexander L. Vahrmeijer, Merlijn Hutteman, Denise E. Hilling, Stijn Keereweer
BRITISH JOURNAL OF SURGERY
(2023)
Article
Chemistry, Multidisciplinary
Abbas Shafiee, Jane Sun, Imaan A. Ahmed, Felicia Phua, Gustavo R. Rossi, Cheng-Yu Lin, Fernando Souza-Fonseca-Guimaraes, Ernst J. Wolvetang, Jason Brown, Kiarash Khosrotehrani
Summary: This study successfully generated skin organoids with appendages from induced pluripotent stem cells, providing a valuable platform for researching human skin development, disease modeling, or reconstructive surgeries.
Article
Dermatology
M. Shakeel, Z. Jiyad, M. Grant, M. G. Cook, D. Oudit, A. C. Green
Summary: The occurrence of lower limb melanoma in women is higher, but it varies across subsites and age groups. This might be linked to the relative influence of genetic and environmental risk factors.
ARCHIVES OF DERMATOLOGICAL RESEARCH
(2023)
Article
Oncology
Diego de Miguel-Perez, Edward M. Pickering, Umberto Malapelle, William Grier, Francesco Pepe, Pasquale Pisapia, Gianluca Russo, Joseph A. Pinto, Alessandro Russo, Giancarlo Troncone, Melissa J. Culligan, Katherine A. Scilla, Ranee Mehra, Pranshu Mohindra, Oscar Arrieta, Andres F. Cardona, Marzia Del Re, Ashutosh Sachdeva, Fred R. Hirsch, Andrea Wolf, Joseph S. Friedberg, Christian Rolfo
Summary: In this study, genetic alterations in resectable pleural mesothelioma tissues and blood samples were analyzed, and it was found that high tissue tumor mutational burden, tissue median minor allele frequency, blood tumor mutational burden, and specific mutations were correlated with outcomes in patients with resected PM. These findings suggest that molecular profiling could help identify longer survivors in patients with resected PM.
EUROPEAN JOURNAL OF CANCER
(2024)
Article
Oncology
Davide Melisi, Camilla Zecchetto, Valeria Merz, Giuseppe Malleo, Luca Landoni, Alberto Quinzii, Simona Casalino, Federica Fazzini, Marina Gaule, Camilla Pesoni, Luca Casetti, Alessandro Esposito, Giovanni Marchegiani, Cristiana Piazzola, Mirko D'Onofrio, Riccardo de Robertis, Armando Gabbrielli, Laura Bernardoni, Stefano F. Crino, Silvia Pietrobono, Claudio Luchini, Camillo Aliberti, Guido Martignoni, Stefano Milleri, Giovanni Butturini, Aldo Scarpa, Roberto Salvia, Claudio Bassi
Summary: This study evaluated the safety and activity of liposomal irinotecan in the perioperative treatment of resectable pancreatic ductal adenocarcinoma (rPDAC) patients. The results showed that NALIRIFOX has manageable and active outcomes, and should be further investigated in randomized trials comparing it to standard upfront surgery followed by adjuvant therapy.
EUROPEAN JOURNAL OF CANCER
(2024)
Article
Oncology
Eric Jonasch, Todd M. Bauer, Kyriakos P. Papadopoulos, Elizabeth R. Plimack, Jaime R. Merchan, David F. Mcdermott, M. Dror Michaelson, Leonard J. Appleman, Ananya Roy, Rodolfo F. Perini, Yanfang Liu, Toni K. Choueiri
Summary: After a median follow-up of 41.2 months, belzutifan monotherapy demonstrated durable antitumor activity in patients with advanced ccRCC and acceptable safety.
EUROPEAN JOURNAL OF CANCER
(2024)
Article
Oncology
Patricia A. H. Hamers, Geraldine R. Vink, Marloes A. G. Elferink, Leon M. G. Moons, Cornelis J. A. Punt, Anne M. May, Miriam Koopman
Summary: Screen-detection of the primary tumor is associated with longer overall survival after metachronous metastasis.
EUROPEAN JOURNAL OF CANCER
(2024)
Article
Oncology
Camilla Nero, Nicolo Bizzarri, Stefano Di Berardino, Francesca Sillano, Giuseppe Vizzielli, Francesco Cosentino, Virginia Vargiu, Pierandrea De Iaco, Anna Myriam Perrone, Enrico Vizza, Benito Chiofalo, Stefano Uccella, Fabio Ghezzi, Luigi Carlo Turco, Giacomo Corrado, Diana Giannarelli, Tina Pasciuto, Gian Franco Zannoni, Anna Fagotti, Giovanni Scambia
Summary: This study evaluates the sensitivity and specificity of sentinel-lymph-node mapping compared to systematic lymphadenectomy in detecting lymph node metastasis in early stage ovarian cancer. The results show that sentinel-lymph-node mapping did not reach the expected sensitivity, but ultra-staging protocol improved the accuracy of diagnosis for patients.
EUROPEAN JOURNAL OF CANCER
(2024)
Article
Oncology
Adriana Hepner, Judith M. Versluis, Roslyn Wallace, Clara Allayous, Lauren Julia Brown, Claudia Trojanielloh, Camille Lea Gerardi, Yanina J. L. Jansenj, Prachi Bhave, Bart Neyns, Andrew Haydon, Olivier Michielin, Joanna Manganan Oliver Klein, Alexander N. Shoushtari, Allison Betof Warner, Paolo Antonio Ascierto, Jennifer Leigh McQuade, Matteo S. Carlino, Lisa Zimmer, Celeste Lebbe, Douglas B. Johnson, Shahneen Sandhu, Victoria Atkinson, Christian U. Blank, Serigne N. Lo, Georgina V. Long, Alexander M. Menzies
Summary: Acquired resistance to PD-1 therapy in melanoma is mainly oligometastatic, and patients may have a favorable survival outcome following salvage treatment.
EUROPEAN JOURNAL OF CANCER
(2024)
Article
Oncology
Savannah Roy, Stephanie Lakritz, Anna R. Schreiber, Elizabeth Molina Kuna, Cathy J. Bradley, Lavanya Kondapalli, Jennifer R. Diamond
Summary: This study evaluates major adverse cardiovascular events (MACE) in older women with TNBC treated with anthracycline and taxane-based chemotherapy (ATAX) compared to taxane-based chemotherapy (TAX). The results show that ATAX does not increase the risk of MACE and there is no difference in survival between patients who received TAX and ATAX.
EUROPEAN JOURNAL OF CANCER
(2024)
Letter
Oncology
Pei-Chun Weng, Yau-Li Huang, Chun-Yu Cheng
EUROPEAN JOURNAL OF CANCER
(2024)
Article
Oncology
Philipp Jansen, Jean Le 'Clerc Arrastia, Daniel Otero Baguer, Maximilian Schmidt, Jennifer Landsberg, Joerg Wenzel, Michael Emberger, Dirk Schadendorf, Eva Hadaschik, Peter Maass, Klaus Georg Griewank
Summary: This study highlights the enormous potential of artificial intelligence in pathology, showing that it can aid in the identification of rare cutaneous adnexal tumors and potentially become a standard tool in routine diagnostics.
EUROPEAN JOURNAL OF CANCER
(2024)
Article
Oncology
Casper W. F. van Eijck, Gaby Strijk, Eveline E. Vietscha, Fleur van der Sijde, Maaike Verheij, Dana A. M. Mustafa, Madelief Vinkc, Joachim G. J. V. Aerts, Casper H. J. van Eijck, Marcella Willemsen
Summary: The study reveals that FOLFIRINOX has immunomodulatory effects, suggesting its potential in immune-based combination therapies for pancreatic cancer. Additionally, certain plasma proteins hold promise as circulating predictive biomarkers for early prediction of FOLFIRINOX response in patients with pancreatic cancer.
EUROPEAN JOURNAL OF CANCER
(2024)
Article
Oncology
Marwan Fakih, Chongkai Wang, Jaideep Sandhu, Jian Ye, Colt Egelston, Xiaochen Li
Summary: This study explores the impact of metastatic sites on treatment outcomes for chemotherapy-refractory colorectal cancer patients. It found that patients with liver or peritoneal metastases had poor treatment outcomes, while those with lung-only metastases showed significant response. The presence of concurrent lymph node or other extrahepatic metastatic disease diminished treatment response in patients with lung metastases. Future checkpoint inhibitor trials should stratify patients based on metastatic locations.
EUROPEAN JOURNAL OF CANCER
(2024)
Article
Oncology
Georgios Christos Tsiatsianis, Candace S. Y. Chan, Ioannis Mouratidis, Nikol Chantzi, Anna Maria Tsiatsiani, Nelson S. Yee, Apostolos Zaravinos, Verena Kantere, Ilias Georgakopoulos-Soares
Summary: The study reveals that nullpeptides can serve as biomarkers for cancer detection and treatment, particularly in highly recurrent cancer patients. These nullpeptides primarily occur in highly expressed genes, particularly in specific loci of oncogenes and tumor suppressors. Recurrent nullpeptides are more likely to be found in neoantigens, which play a significant role in immunotherapy.
EUROPEAN JOURNAL OF CANCER
(2024)
