Review
Radiology, Nuclear Medicine & Medical Imaging
Guilherme Moura Cunha, Mojgan Hosseini, Alessandro Furlan, Kathryn J. Fowler
Summary: This article provides an overview of the pathologic and radiologic TNM staging systems for hepatocellular carcinoma (HCC), emphasizing the differences between these staging systems and the limitations of radiologic-pathologic stage correlation. It reviews the prognostic value of individual features used for HCC staging and highlights significant aspects of preoperative risk stratification that could be improved to positively impact posttransplant outcomes.
AMERICAN JOURNAL OF ROENTGENOLOGY
(2022)
Review
Biochemistry & Molecular Biology
Mary-Kate Hayward, Valerie M. Weaver
Summary: Breast ductal carcinoma in situ (DCIS) is a preinvasive lesion that can potentially progress to invasive breast cancer, but not all cases do so. Current histopathological classification systems cannot reliably predict progression, resulting in potential overtreatment of women with DCIS. AI image-based analysis methods show promise in accurately identifying and potentially stratifying treatment for DCIS patients.
BIOCHIMICA ET BIOPHYSICA ACTA-REVIEWS ON CANCER
(2021)
Article
Radiology, Nuclear Medicine & Medical Imaging
Norman J. Beauchamp, R. Nick Bryan, Marilyn M. Bui, Gabriel P. Krestin, Geraldine B. McGinty, Carolyn C. Meltzer, Michael Neumaier
Summary: Enormous progress in diagnostic testing allows for more accurate diagnosis and improved clinical outcomes. However, the increasing volume and diversity of test results can overwhelm clinicians, leading to incorrect or delayed diagnoses. Integrative diagnostics, combining diagnostic and clinical data through informatics tools, has the potential to enhance treatment selection, modification, and termination, ultimately improving patient outcomes and reducing costs.
INSIGHTS INTO IMAGING
(2023)
Article
Oncology
Gustavo Moreno, Mariel Molina, Ruizhe Wu, Julie R. Sullivan, Julie M. Jorns
Summary: Breast MRI has high sensitivity but low specificity, leading to many benign biopsies. A study compared histologic findings between MRI-guided biopsies and biopsies via other imaging modalities, and identified certain features associated with malignancy in MRI cohort.
BREAST CANCER RESEARCH AND TREATMENT
(2021)
Article
Clinical Neurology
Matthew T. Carr, Gianina C. Hernandez-Marquez, Meenakshi Vij, Xing Chin, Bradley N. Delman, Melissa Umphlett, Isabelle M. Germano
Summary: This study provides a systematic review of third ventricular subependymomas (TVSE), finding that these tumors present with symptoms such as headache, memory disturbances, and vomitus. Timely diagnosis and treatment are crucial, and surgical resection of the tumor can lead to the best clinical outcomes and improvement.
WORLD NEUROSURGERY
(2023)
Article
Oncology
Aatish Thennavan, Susana Garcia-Recio, Siyao Liu, Xiaping He, Charles M. Perou
Summary: Ductal carcinoma in situ (DCIS) of the breast is a precursor of invasive ductal carcinoma (IDC). This study utilizes mouse models and human samples to identify features associated with DCIS progression. The analysis reveals malignant cells and tumor microenvironmental changes in DCIS and IDC, and suggests the existence of intrinsic subtype unique DCIS features. The findings may contribute to the identification and treatment of progression-prone DCIS in human basal-like breast cancers.
Article
Oncology
Danielle Rodin, Rinku Sutradhar, Sharon Nofech-Mozes, Sumei Gu, Neil Faught, Ezra Hahn, Cindy Fong, Sabina Trebinjac, Lawrence Paszat, Eileen Rakovitch
Summary: The lack of data on women with large DCIS tumors leads to uncertainty regarding the safety of breast-conserving surgery for these patients. This study found that larger tumor size is associated with a higher risk of local recurrence following BCS, but the addition of breast radiotherapy can achieve high long-term LRFS rates.
BREAST CANCER RESEARCH AND TREATMENT
(2022)
Article
Medicine, General & Internal
M. Luke Marinovich, Elizabeth Wylie, William Lotter, Alison Pearce, Stacy M. Carter, Helen Lund, Andrew Waddell, Jiye G. Kim, Gavin F. Pereira, Christoph Lee, Sophia Zackrisson, Meagan Brennan, Nehmat Houssami
Summary: This study aims to compare the accuracy of an AI algorithm and radiologists in a real-world population breast cancer screening program. The study addresses limitations in previous research by using data from a consecutive cohort and provides accurate estimates of cancer detection and recall rates.
Article
Radiology, Nuclear Medicine & Medical Imaging
Dexter P. Mendoza, Milena Petranovic, Avik Som, Markus Y. Wu, Esther Y. Park, Eric W. Zhang, John M. Archer, Shaunagh McDermott, Melin Khandekar, Michael Lanuti, Justin F. Gainor, Inga T. Lennes, Jo-Anne O. Shepard, Subba R. Digumarthy
Summary: This study aimed to evaluate the frequency of cancer among Lung-RADS category 3 and 4 nodules in clinical practice and to identify factors affecting the cancer frequency within each category. The results showed that the cancer frequency of these nodules was higher than previously estimated. Furthermore, almost all endobronchial category 4A nodules were benign.
AMERICAN JOURNAL OF ROENTGENOLOGY
(2022)
Article
Oncology
Phuong Dung (Yun) Trieu, Natacha Borecky, Tong Li, Patrick C. Brennan, Melissa L. Barron, Sarah J. Lewis
Summary: This study investigated the diagnostic efficacy of radiologists when reading screening mammograms without previous images (NP), with prior images from the same vendor (SP), and from different vendors (DP). The results showed that radiologists had higher sensitivity in NP and DP compared to SP, as well as higher ROC AUC values. The odds ratio of true positive for NP and DP was also higher than SP, indicating improved cancer detection. Radiologists were more likely to detect architectural distortion and calcifications in DP compared to SP. These findings suggest the importance of a mixed reading strategy to enhance diagnostic accuracy in the digital era.
Review
Oncology
Alexander Bartram, Fiona Gilbert, Alastair Thompson, G. Bruce Mann, Amit Agrawal
Summary: The utility of MRI in predicting tumor size accurately in DCIS patients is noted, with no significant difference in surgical outcomes between pre-operative MRI and conventional imaging groups. However, there is a lack of data on the usefulness of pre-operative MRI in oncoplastic breast surgery.
CANCER TREATMENT REVIEWS
(2021)
Article
Critical Care Medicine
Michael B. Weykamp, Katherine E. Stern, Scott C. Brakenridge, Bryce R. H. Robinson, Charles E. Wade, Erin E. Fox, John B. Holcomb, Grant E. O'Keefe
Summary: Although blood product resuscitation is favored, crystalloid resuscitation remains a common practice in prehospital care. This study investigated the relationship between prehospital crystalloid (PHC) volume and clinical outcomes, and found that higher PHC volume is associated with worse coagulopathy and increased risk of ARDS, but lower risk of AKI.
Review
Medicine, General & Internal
Rebecca Mottram, Wendy Lynn Knerr, Daniel Gallacher, Hannah Fraser, Lena Al-Khudairy, Abimbola Ayorinde, Sian Williamson, Chidozie Nduka, Olalekan A. Uthman, Samantha Johnson, Alexander Tsertsvadze, Christopher Stinton, Sian Taylor-Phillips, Aileen Clarke
Summary: The study found that factors associated with attending breast cancer screening include higher socioeconomic status, higher income, home ownership, non-immigrant status, being married or cohabiting, and medium level of education. Women with previous false-positive results were less likely to reattend. Age group and rural versus urban residence did not show significant differences.
Review
Medicine, General & Internal
Kareem Mahmoud Diab, Jamie Deng, Yusen Wu, Yelena Yesha, Fernando Collado-Mesa, Phuong Nguyen
Summary: Natural Language Processing (NLP) has emerged as a valuable tool in diagnostic radiology, particularly in breast imaging. This comprehensive review discusses the recent advances in NLP for breast imaging, including techniques for extracting relevant information from clinical notes, radiology reports, and pathology reports. It also explores the potential impact of NLP on the accuracy and efficiency of breast imaging and highlights the challenges and opportunities for NLP in this field. Overall, this review emphasizes the potential of NLP in enhancing breast imaging care and provides valuable insights for clinicians and researchers.
Article
Radiology, Nuclear Medicine & Medical Imaging
Thabisile Simelane, David J. Ryan, Slavi Stoyanov, Deirdre Bennett, Mark McEntee, Michael M. Maher, Colm M. P. O'Tuathaigh, Owen J. O'Connor
Summary: A significant gap exists between medical school education and the practical requirements of practicing medicine. A study identified six key learning outcomes for a preparatory module in radiology through national surveys and group concept mapping. The results showed that most interns and radiologists felt undergraduate medical training did not adequately prepare interns to interact with the radiology department.
INSIGHTS INTO IMAGING
(2021)
Article
Oncology
Anthony J. Maxwell, Bridget Hilton, Karen Clements, David Dodwell, Joanne Dulson-Cox, Olive Kearins, Cliona Kirwan, Janet Litherland, Senthurun Mylvaganam, Elena Provenzano, Sarah E. Pinder, Elinor Sawyer, Abeer M. Shaaban, Nisha Sharma, Hilary Stobart, Matthew G. Wallis, Alastair M. Thompson
Summary: This cohort study aimed to investigate the natural history of ductal carcinoma in situ (DCIS) by determining the outcomes of women who did not undergo surgery after being diagnosed with screen-detected DCIS. The findings suggest that active surveillance may be a reasonable alternative to surgery for patients with low-grade DCIS, but surgery should still be considered for patients with intermediate or high-grade disease.
Article
Medicine, General & Internal
David Jenkinson, Karoline Freeman, Karen Clements, Bridget Hilton, Joanne Dulson-Cox, Olive Kearins, Nigel Stallard, Matthew G. Wallis, Nisha Sharma, Cliona Kirwan, Sarah Pinder, Elena Provenzano, Abeer M. Shaaban, Hilary Stobart, Samantha McDonnell, Alastair M. Thompson, Sian Taylor-Phillips
Summary: The National Health Service (NHS) Breast Screening Programme aims to detect cancer earlier when treatment is more effective. However, it may also harm women by over diagnosing and overtreating cancers that would never have become symptomatic. This study explores how atypia develops into breast cancer in terms of number of women, time of cancer development, cancer type and severity, and whether this varies for different types of atypia.
Article
Radiology, Nuclear Medicine & Medical Imaging
Robert Scott, Iain Lyburn, Eleanor Cornford, Pascaline Bouzy, Nicholas Stone, Charlene Greenwood, Ihsanne Bouybayoune, Sarah Pinder, Keith Rogers
Summary: This article proposes the development of a lexicon and classification system for the micromorphology of breast calcifications, aiming to ensure consistency and comparability in published research on this topic.
BRITISH JOURNAL OF RADIOLOGY
(2022)
Article
Cell Biology
Ayaka Katayama, Jane Starczynski, Michael S. Toss, Abeer M. Shaaban, Elena Provenzano, Cecily M. Quinn, Grace Callagy, Colin A. Purdie, Rebecca Millican-Slater, David Purnell, Leena Chagla, Tetsunari Oyama, Sarah E. Pinder, Steve Chan, Ian Ellis, Andrew H. S. Lee, Emad A. Rakha
Summary: The study aimed to investigate the impact of chromosome 17 alterations on the assessment of HER2 gene amplification and its correlation with neoadjuvant therapy. The results showed no significant relationship between CEP17 alterations and pCR rate in both HER2-amplified and HER2-non-amplified breast cancer. However, the histological grade of HER2-non-amplified tumors and the estrogen receptor negativity of HER2-amplified tumors were predictors of pCR.
Article
Cell Biology
Stephen B. Fox, Fluer Webster, Chih-Jung Chen, Boon Chua, Laura Collins, Maaria-Pia Foschini, G. Bruce Mann, Ewan Millar, Sarah E. Pinder, Emad Rakha, Abeer Shaaban, Benjamin Y. Tan, Gary Tse, Peter Watson, Puy Hoon Tan
Summary: The ICCR has developed a new international dataset for pathology reporting of DCIS, variants of LCIS, and low-grade lesions to improve patient outcomes and promote uniform global management of breast disease. The dataset comprises core and noncore elements, taking into account current evidence and practical considerations.
Article
Genetics & Heredity
Esther H. Lips, Tapsi Kumar, Anargyros Megalios, Lindy L. Visser, Michael Sheinman, Angelo Fortunato, Vandna Shah, Marlous Hoogstraat, Emi Sei, Diego Mallo, Maria Roman-Escorza, Ahmed A. Ahmed, Mingchu Xu, Alexandra W. Van den Belt-Dusebout, Wim Brugman, Anna K. Casasent, Karen Clements, Helen R. Davies, Liping Fu, Anita Grigoriadis, Timothy M. Hardman, Lorraine M. King, Marielle Krete, Petra Kristel, Michiel de Maaker, Carlo C. Maley, Jeffrey R. Marks, Brian A. Menegaz, Lennart Mulder, Frank Nieboer, Salpie Nowinski, Sarah Pinder, Jelmar Quist, Carolina Salinas-Souza, Michael Schaapveld, Marjanka K. Schmidt, Abeer M. Shaaban, Rana Shami, Mathini Sridharan, John Zhang, Hilary Stobart, Deborah Collyar, Serena Nik-Zainal, Lodewyk F. A. Wessels, E. Shelley Hwang, Nicholas E. Navin, P. Andrew Futreal, Alastair M. Thompson, Jelle Wesseling, Elinor J. Sawyer
Summary: A genomic analysis of ductal carcinoma in situ (DCIS) samples reveals that a significant portion of invasive breast cancer recurrences are unrelated to the initial DCIS and have distinct clonal origins. This finding is crucial for accurately assessing the risk of DCIS, developing effective treatment strategies, and identifying predictive biomarkers.
Article
Genetics & Heredity
Sue Philpott, Maria Raikou, Ranjit Manchanda, Michelle Lockley, Naveena Singh, Malcolm Scott, D. Gareth Evans, Julian Adlard, Munaza Ahmed, Richard Edmondson, Emma Roisin Woodward, Athena Lamnisos, Janos Balega, Angela F. Brady, Aarti Sharma, Louise Izatt, Anjana Kulkarni, Vishakha Tripathi, Joyce S. Solomons, Kevin Hayes, Helen Hanson, Katie Snape, Lucy Side, Steve Skates, Alistair McGuire, Adam N. Rosenthal
Summary: This study aimed to evaluate the effectiveness and cost-effectiveness of ovarian cancer surveillance in BRCA1/2-heterozygous women deferring risk-reducing surgery. The results showed that surveillance in a real-world setting was feasible and demonstrated similar performance to research trials, effectively down-staging ovarian cancer and saving costs.
JOURNAL OF MEDICAL GENETICS
(2023)
Article
Oncology
Heather J. Bax, Jitesh Chauhan, Chara Stavraka, Aida Santaolalla, Gabriel Osborn, Atousa Khiabany, Melanie Grandits, Jacobo Lopez-Abente, Lais C. G. F. Palhares, Charleen Chan Wah Hak, Alexandra Robinson, Amy Pope, Natalie Woodman, Cristina Naceur-Lombardelli, Sadek Malas, Jack E. M. Coumbe, Mano Nakamura, Roman Laddach, Silvia Mele, Silvia Crescioli, Anna M. Black, Sara Lombardi, Silvana Canevari, Mariangela Figini, Ahmad Sayasneh, Sophia Tsoka, Kevin FitzGerald, Cheryl Gillett, Sarah Pinder, Mieke Van Hemelrijck, Rebecca Kristeleit, Sharmistha Ghosh, Ana Montes, James Spicer, Sophia N. Karagiannis, Debra H. Josephs
Summary: This study investigated the potential use of sFR alpha as a biomarker for ovarian cancer. The results showed that sFR alpha levels were significantly higher in patients compared to healthy volunteers and decreased alongside tumor burden during treatment. Additionally, high concentrations of sFR alpha reduced the effectiveness of anti-FR alpha antibodies, but this effect could be overcome by increasing antibody doses.
BRITISH JOURNAL OF CANCER
(2023)
Article
Oncology
D. Gareth Evans, Lorna McWilliams, Susan Astley, Adam R. Brentnall, Jack Cuzick, Richard Dobrashian, Stephen W. Duffy, Louise S. Gorman, Elaine F. Harkness, Fiona Harrison, Michelle Harvie, Andrew Jerrison, Matthew Machin, Anthony J. Maxwell, Sacha J. Howell, Stuart J. Wright, Katherine Payne, Nadeem Qureshi, Helen Ruane, Jake Southworth, Lynne Fox, Sarah Bowers, Gillian Hutchinson, Emma Thorpe, Fiona Ulph, Victoria Woof, Anthony Howell, David P. French
Summary: The study developed BC-Predict, a risk assessment tool that collects standard risk factor information, mammographic density, and Polygenic Risk Score (PRS) to predict the risk of breast cancer. The results showed that inviting women at high and moderate risk for additional screening and preventive measures can increase the uptake of preventive medication.
BRITISH JOURNAL OF CANCER
(2023)
Article
Oncology
Melissa Ruth Gannon, Min Hae Park, Katie Miller, David Dodwell, Kieran Horgan, Karen Clements, Jibby Medina, David Alan Cromwell
Summary: This study evaluated the consistency of cancer drug therapy (CDT) information in two data sources for early invasive breast cancer. The overall concordance between the two datasets was 94%, with improvement over time. Factors such as age, time of diagnosis, and healthcare institutions influenced the consistency. Combining these data sources provides a more comprehensive evaluation of CDT treatment.
CANCER EPIDEMIOLOGY
(2023)
Article
Oncology
K. Miller, M. R. Gannon, J. Medina, K. Clements, D. Dodwell, K. Horgan, M. H. Park, D. A. Cromwell
Summary: This study examined the variation of post-mastectomy radiotherapy (PMRT) patterns among women with early invasive breast cancer (EIBC) in England and Wales, and explored the influence of different patient factors on this variation.
Article
Oncology
Melissa Ruth Gannon, David Dodwell, Ajay Aggarwal, Min Hae Park, Katie Miller, Kieran Horgan, Karen Clements, Jibby Medina, David Alan Cromwell
Summary: Variation in the uptake of NICE-recommended oncological drugs for invasive breast cancer exists, with lowest uptake among women aged 70+ years.
BRITISH JOURNAL OF CANCER
(2023)
Article
Oncology
Holly Tovey, Orsolya Sipos, Joel S. Parker, Katherine A. Hoadley, Jelmar Quist, Sarah Kernaghan, Lucy Kilburn, Roberto Salgado, Sherene Loi, Richard D. Kennedy, Ioannis Roxanis, Patrycja Gazinska, Sarah E. Pinder, Judith Bliss, Charles M. Perou, Syed Haider, Anita Grigoriadis, Andrew Tutt, Maggie Chon U. Cheang
Summary: This study explored the predictive ability of DNA damage response (DDR) and immune markers in the treatment response of triple-negative breast cancer. High immune features predict response to docetaxel, while high DDR signature scores predict response to carboplatin. Patients can be divided into different subgroups based on their treatment sensitivity. Caution is needed when using transcriptional signatures derived from primary tumors to guide treatment.
CLINICAL CANCER RESEARCH
(2023)
Article
Multidisciplinary Sciences
James Spicer, Bristi Basu, Ana Montes, Udai Banerji, Rebecca Kristeleit, Rowan Miller, Gareth J. J. Veal, Christopher J. J. Corrigan, Stephen J. J. Till, Mariangela Figini, Silvana Canevari, Claire Barton, Paul Jones, Sarah Mellor, Simon Carroll, Chris Selkirk, George Nintos, Vineet Kwatra, Ionut-Gabriel Funingana, Gary Doherty, Hannah J. J. Gould, Giulia Pellizzari, Mano Nakamura, Kristina M. M. Ilieva, Atousa Khiabany, Chara Stavraka, Jitesh Chauhan, Cheryl Gillett, Sarah Pinder, Heather J. J. Bax, Debra H. H. Josephs, Sophia N. N. Karagiannis
Summary: The study reports the results of a phase I dose escalation trial of MOv18 IgE, a chimeric first-in-class IgE antibody, in patients with tumours expressing folate receptor-alpha. The most common toxicity observed was transient urticaria and evidence of anti-tumour activity was observed in a patient with ovarian cancer.
NATURE COMMUNICATIONS
(2023)
Article
Oncology
Diego de Miguel-Perez, Edward M. Pickering, Umberto Malapelle, William Grier, Francesco Pepe, Pasquale Pisapia, Gianluca Russo, Joseph A. Pinto, Alessandro Russo, Giancarlo Troncone, Melissa J. Culligan, Katherine A. Scilla, Ranee Mehra, Pranshu Mohindra, Oscar Arrieta, Andres F. Cardona, Marzia Del Re, Ashutosh Sachdeva, Fred R. Hirsch, Andrea Wolf, Joseph S. Friedberg, Christian Rolfo
Summary: In this study, genetic alterations in resectable pleural mesothelioma tissues and blood samples were analyzed, and it was found that high tissue tumor mutational burden, tissue median minor allele frequency, blood tumor mutational burden, and specific mutations were correlated with outcomes in patients with resected PM. These findings suggest that molecular profiling could help identify longer survivors in patients with resected PM.
EUROPEAN JOURNAL OF CANCER
(2024)
Article
Oncology
Davide Melisi, Camilla Zecchetto, Valeria Merz, Giuseppe Malleo, Luca Landoni, Alberto Quinzii, Simona Casalino, Federica Fazzini, Marina Gaule, Camilla Pesoni, Luca Casetti, Alessandro Esposito, Giovanni Marchegiani, Cristiana Piazzola, Mirko D'Onofrio, Riccardo de Robertis, Armando Gabbrielli, Laura Bernardoni, Stefano F. Crino, Silvia Pietrobono, Claudio Luchini, Camillo Aliberti, Guido Martignoni, Stefano Milleri, Giovanni Butturini, Aldo Scarpa, Roberto Salvia, Claudio Bassi
Summary: This study evaluated the safety and activity of liposomal irinotecan in the perioperative treatment of resectable pancreatic ductal adenocarcinoma (rPDAC) patients. The results showed that NALIRIFOX has manageable and active outcomes, and should be further investigated in randomized trials comparing it to standard upfront surgery followed by adjuvant therapy.
EUROPEAN JOURNAL OF CANCER
(2024)
Article
Oncology
Eric Jonasch, Todd M. Bauer, Kyriakos P. Papadopoulos, Elizabeth R. Plimack, Jaime R. Merchan, David F. Mcdermott, M. Dror Michaelson, Leonard J. Appleman, Ananya Roy, Rodolfo F. Perini, Yanfang Liu, Toni K. Choueiri
Summary: After a median follow-up of 41.2 months, belzutifan monotherapy demonstrated durable antitumor activity in patients with advanced ccRCC and acceptable safety.
EUROPEAN JOURNAL OF CANCER
(2024)
Article
Oncology
Patricia A. H. Hamers, Geraldine R. Vink, Marloes A. G. Elferink, Leon M. G. Moons, Cornelis J. A. Punt, Anne M. May, Miriam Koopman
Summary: Screen-detection of the primary tumor is associated with longer overall survival after metachronous metastasis.
EUROPEAN JOURNAL OF CANCER
(2024)
Article
Oncology
Camilla Nero, Nicolo Bizzarri, Stefano Di Berardino, Francesca Sillano, Giuseppe Vizzielli, Francesco Cosentino, Virginia Vargiu, Pierandrea De Iaco, Anna Myriam Perrone, Enrico Vizza, Benito Chiofalo, Stefano Uccella, Fabio Ghezzi, Luigi Carlo Turco, Giacomo Corrado, Diana Giannarelli, Tina Pasciuto, Gian Franco Zannoni, Anna Fagotti, Giovanni Scambia
Summary: This study evaluates the sensitivity and specificity of sentinel-lymph-node mapping compared to systematic lymphadenectomy in detecting lymph node metastasis in early stage ovarian cancer. The results show that sentinel-lymph-node mapping did not reach the expected sensitivity, but ultra-staging protocol improved the accuracy of diagnosis for patients.
EUROPEAN JOURNAL OF CANCER
(2024)
Article
Oncology
Adriana Hepner, Judith M. Versluis, Roslyn Wallace, Clara Allayous, Lauren Julia Brown, Claudia Trojanielloh, Camille Lea Gerardi, Yanina J. L. Jansenj, Prachi Bhave, Bart Neyns, Andrew Haydon, Olivier Michielin, Joanna Manganan Oliver Klein, Alexander N. Shoushtari, Allison Betof Warner, Paolo Antonio Ascierto, Jennifer Leigh McQuade, Matteo S. Carlino, Lisa Zimmer, Celeste Lebbe, Douglas B. Johnson, Shahneen Sandhu, Victoria Atkinson, Christian U. Blank, Serigne N. Lo, Georgina V. Long, Alexander M. Menzies
Summary: Acquired resistance to PD-1 therapy in melanoma is mainly oligometastatic, and patients may have a favorable survival outcome following salvage treatment.
EUROPEAN JOURNAL OF CANCER
(2024)
Article
Oncology
Savannah Roy, Stephanie Lakritz, Anna R. Schreiber, Elizabeth Molina Kuna, Cathy J. Bradley, Lavanya Kondapalli, Jennifer R. Diamond
Summary: This study evaluates major adverse cardiovascular events (MACE) in older women with TNBC treated with anthracycline and taxane-based chemotherapy (ATAX) compared to taxane-based chemotherapy (TAX). The results show that ATAX does not increase the risk of MACE and there is no difference in survival between patients who received TAX and ATAX.
EUROPEAN JOURNAL OF CANCER
(2024)
Letter
Oncology
Pei-Chun Weng, Yau-Li Huang, Chun-Yu Cheng
EUROPEAN JOURNAL OF CANCER
(2024)
Article
Oncology
Philipp Jansen, Jean Le 'Clerc Arrastia, Daniel Otero Baguer, Maximilian Schmidt, Jennifer Landsberg, Joerg Wenzel, Michael Emberger, Dirk Schadendorf, Eva Hadaschik, Peter Maass, Klaus Georg Griewank
Summary: This study highlights the enormous potential of artificial intelligence in pathology, showing that it can aid in the identification of rare cutaneous adnexal tumors and potentially become a standard tool in routine diagnostics.
EUROPEAN JOURNAL OF CANCER
(2024)
Article
Oncology
Casper W. F. van Eijck, Gaby Strijk, Eveline E. Vietscha, Fleur van der Sijde, Maaike Verheij, Dana A. M. Mustafa, Madelief Vinkc, Joachim G. J. V. Aerts, Casper H. J. van Eijck, Marcella Willemsen
Summary: The study reveals that FOLFIRINOX has immunomodulatory effects, suggesting its potential in immune-based combination therapies for pancreatic cancer. Additionally, certain plasma proteins hold promise as circulating predictive biomarkers for early prediction of FOLFIRINOX response in patients with pancreatic cancer.
EUROPEAN JOURNAL OF CANCER
(2024)
Article
Oncology
Marwan Fakih, Chongkai Wang, Jaideep Sandhu, Jian Ye, Colt Egelston, Xiaochen Li
Summary: This study explores the impact of metastatic sites on treatment outcomes for chemotherapy-refractory colorectal cancer patients. It found that patients with liver or peritoneal metastases had poor treatment outcomes, while those with lung-only metastases showed significant response. The presence of concurrent lymph node or other extrahepatic metastatic disease diminished treatment response in patients with lung metastases. Future checkpoint inhibitor trials should stratify patients based on metastatic locations.
EUROPEAN JOURNAL OF CANCER
(2024)
Article
Oncology
Georgios Christos Tsiatsianis, Candace S. Y. Chan, Ioannis Mouratidis, Nikol Chantzi, Anna Maria Tsiatsiani, Nelson S. Yee, Apostolos Zaravinos, Verena Kantere, Ilias Georgakopoulos-Soares
Summary: The study reveals that nullpeptides can serve as biomarkers for cancer detection and treatment, particularly in highly recurrent cancer patients. These nullpeptides primarily occur in highly expressed genes, particularly in specific loci of oncogenes and tumor suppressors. Recurrent nullpeptides are more likely to be found in neoantigens, which play a significant role in immunotherapy.
EUROPEAN JOURNAL OF CANCER
(2024)