Journal
EUROPEAN JOURNAL OF CANCER
Volume 49, Issue 9, Pages 2179-2186Publisher
ELSEVIER SCI LTD
DOI: 10.1016/j.ejca.2013.01.018
Keywords
HPV; Screening; Triage; Cervical disease
Categories
Funding
- Cancer Research UK [C569/A10404, C8162/A10406]
- Qiagen
- Gen-Probe Incorporated
- Abbott Molecular
- BD Diagnostics
- NorChip
- mtm laboratories
- Roche Diagnostics
- Genera
- BD Diagnostics Roche Diagnostics
- Ventana
- Hologic
- Merck
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Aim: To compare triage strategies using different human papillomavirus (HPV) consensus and genotyping tests and a p16(INK4a) test. Methods: 1228 women referred with a borderline or single mildly dyskaryotic smear. Samples were taken at colposcopy using PreservCyt. Tests included Hybrid Capture 2, Abbott Real-Time PCR, BD HPV, CobasW 4800, PreTect HPV-Proofer, APTIMA and p16(INK4a). Results were based on the worst histology within 9 months. Results: 97/1228 (7.9%) women had CIN3+ (203/1228 (17%) CIN2+). HPV testing alone using Hybrid Capture 2, Abbott RealTime PCR, BD HPV, Cobas 4800 or APTIMA had a sensitivity for CIN3+ ranging from 99.0% to 100.0% and specificity for
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