Article
Oncology
Ramon Rami-Porta
Summary: The classification of lung cancer based on tumor, lymph node, and metastases has undergone several revisions since its proposal in 1966. The upcoming 9th edition is expected to combine this classification with other prognostic factors to provide a more personalized prognosis for individual patients. International collaboration is crucial in building a comprehensive database to achieve this objective.
Article
Oncology
Qingpeng Zeng, Jiagen Li, Fengwei Tan, Nan Sun, Yousheng Mao, Yushun Gao, Qi Xue, Shugeng Gao, Jun Zhao, Jie He
Summary: Novel nomograms for individual prediction of survival for resected limited-stage small cell lung cancer patients were developed and validated, performing better than the previously widely used staging system, providing clinicians with guidance.
ANNALS OF SURGICAL ONCOLOGY
(2021)
Review
Medicine, General & Internal
Lauren T. Erasmus, Taylor A. Strange, Rishi Agrawal, Chad D. Strange, Jitesh Ahuja, Girish S. Shroff, Mylene T. Truong
Summary: Lung cancer is the leading cause of cancer deaths in both men and women in the United States. Accurate staging is crucial for prognosis and treatment plans. The International Association for the Study of Lung Cancer (IASLC) has made revisions to the TNM staging system used for lung cancer, including modifications to T classification, description of regional lymph node spread in N classification, and classification of metastasis in M classification.
Article
Multidisciplinary Sciences
Michael Peer, Sharbel Azzam, Arnold Cyjon, Rivka Katsnelson, Henri Hayat, Ilan Bar, Ofer Merimsky
Summary: The study aimed to identify predictors of postoperative outcome and survival in locally advanced NSCLC. Findings showed that pre-neoadjuvant bulky mediastinal disease, persistent postoperative N2 disease, R1 resection, preoperative N2 multistation disease, and postoperative stage IIIA were negative predictive factors for survival in this patient population.
SCIENTIFIC REPORTS
(2021)
Article
Cardiac & Cardiovascular Systems
Beatrice J. Sun, Prasha Bhandari, Chi-Fu Jeffrey Yang, Mark F. Berry, Joseph B. Shrager, Leah M. Backhus, Natalie S. Lui, Douglas Z. Liou
Summary: For patients with cT4 N0 non-small cell lung cancer and tumor size >7 cm without invasion of major structures, both induction chemotherapy and primary surgery have comparable overall survival.
ANNALS OF THORACIC SURGERY
(2022)
Article
Oncology
Steinar Solberg, Yngvar Nilssen, Odd Terje Brustugun, Per Magnus Haram, Aslaug Helland, Bjorn Moller, Trond-Eirik Strand, Sissel Gyrid Freim Wahl, Lars Fjellbirkeland
Summary: This study investigated the concordance between clinical and pathology staging of lung cancer patients and found a disappointingly low precision and concordance. There were significant differences in tumor diameter and staging categories reported, with some patients being upstaged or downstaged. These results highlight the need for improvement in lung cancer staging.
Article
Oncology
Chengxiang Yi, Jie Dai, Nan Song, Chunxiao Wu, Liping Zhang, Yuming Zhu, Gening Jiang, Helin Zhang, Peng Zhang
Summary: A new pathological staging system for neuroendocrine tumors of the lung has been developed and shown to have better prognostic value than the traditional TNM staging system. This system can potentially guide postoperative treatment decisions for patients with NETL.
ANNALS OF TRANSLATIONAL MEDICINE
(2021)
Article
Oncology
Meinoshin Okumura, Mirella Marino, Vanessa Cilento, Emily Goren, Enrico Ruffini, Daniel Dibaba, Usman Ahmad, Sarit Appel, Andrea Bille, Souheil Boubia, Cecilia Brambilla, Ayten Kayi Cangir, Frank Detterbeck, Conrad Falkson, Wentao Fang, Pier Luigi Filosso, Giuseppe Giaccone, Nicolas Girard, Francesco Guerrera, James Huang, Maurizio Infante, Dong Kwan Kim, Marco Lucchi, Edith M. Marom, Andrew G. Nicholson, Ramon Rami-Porta, Andreas Rimner, Charles B. Simone, Hisao Asamura
Summary: This article presents the proposed definitions for the T categories for the ninth edition TNM stage classification of thymic malignancies. The study analyzed data from a worldwide collective database of patients with thymic epithelial tumors and found that the proposed T categories provide good discrimination in outcome for the T component of the TNM-based stage system of thymic epithelial tumors.
JOURNAL OF THORACIC ONCOLOGY
(2023)
Article
Oncology
Hisao Asamura, Katherine K. Nishimura, Dorothy J. Giroux, Kari Chansky, Antje Hoering, Valerie Rusch, Ramon Rami-Porta
Summary: [
JOURNAL OF THORACIC ONCOLOGY
(2023)
Review
Biochemistry & Molecular Biology
Laura Banias, Ioan Jung, Rebeca Chiciudean, Simona Gurzu
Summary: This historical review covers the evolution of colorectal carcinoma staging systems, from classical classifications to molecular classifications, including the author's contributions in IHC-based molecular classification of CRC. The latest prognostic biomarkers play a crucial role in targeted therapy decisions.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Oncology
Lauren N. Krumeich, Robert E. Roses, Lindsay E. Kuo, Brenessa M. Lindeman, Matthew A. Nehs, Ali Tavakkoli, Sareh Parangi, Richard A. Hodin, Douglas L. Fraker, Benjamin C. James, Tracy S. Wang, Carmen C. Solorzano, Carrie C. Lubitz, Heather Wachtel
Summary: The aim of this study was to evaluate the clinical benefit of adrenal metastasectomy for all lung cancer subtypes. The results showed that patients undergoing adrenal metastasectomy had longer disease-free survival and overall survival. Adrenal metastasectomy should be considered for isolated adrenal metastases of non-small cell lung cancer, while small cell histology and extra-adrenal metastases are relative contraindications.
ANNALS OF SURGICAL ONCOLOGY
(2022)
Article
Oncology
Frank C. Detterbeck, Katherine K. Nishimura, Vanessa J. Cilento, Meredith Giuliani, Mirella Marino, Raymond U. Osarogiagbon, Ramon Rami-Porta, Valerie W. Rusch, Hisao Asamura, Advisory Boards
Summary: Stage classification is fundamental in cancer management as it enables reporting results, comparing treatments, and assessing clinical relevance. The International Association for the Study of Lung Cancer (IASLC) is refining the stage classification for thoracic malignancies, using a sophisticated approach and a large international database for analysis. The goal is to ensure consistent discrimination and clinical applicability across different settings, treatments, and patients.
JOURNAL OF THORACIC ONCOLOGY
(2022)
Review
Oncology
Jamie E. Chaft, Andreas Rimner, Walter Weder, Christopher G. Azzoli, Mark G. Kris, Tina Cascone
Summary: The treatment goal for early-stage lung cancer patients is cure, with surgical resection or radiotherapy as definitive local treatments along with adjuvant therapy to improve the likelihood of cure. New therapies lag behind due to inefficient trial designs and lengthy follow-ups, despite efforts to study surrogate endpoints to shorten trial durations.
NATURE REVIEWS CLINICAL ONCOLOGY
(2021)
Review
Oncology
Todd William Mudd Jr, Mansoor Khalid, Achuta Kumar Guddati
Summary: The evolution of cancer treatment has led to the development of new classes of anticancer therapies, resulting in exciting survival benefits for patients. However, these therapies also come with various side effects, with cardiotoxicity emerging as a major concern. Management of these cardiotoxic side effects is crucial for patient care.
AMERICAN JOURNAL OF CANCER RESEARCH
(2021)
Article
Public, Environmental & Occupational Health
Xianghui Yang, Liyong Deng, Min Li, Yongjie Zhou, Guihua Wang
Summary: This study evaluated the association between socioeconomic status (SES) factors and cancer-specific survival (CSS) in patients with non-small cell lung cancer (NSCLC). A novel TNM-SES staging system was proposed, which showed superior predictive value compared to the traditional TNM stage.
FRONTIERS IN PUBLIC HEALTH
(2022)
Article
Oncology
Cecile Le Pechoux, Nicolas Pourel, Fabrice Barlesi, Delphine Lerouge, Delphine Antoni, Bruno Lamezec, Ursula Nestle, Pierre Boisselier, Eric Dansin, Amaury Paumier, Karine Peignaux, Francois Thillays, Gerard Zalcman, Jeannick Madelaine, Eric Pichon, Anne Larrouy, Armelle Lavole, Delphine Argo-Leignel, Marc Derollez, Corinne Faivre-Finn, Matthew Q. Hatton, Oliver Riesterer, Emilie Bouvier-Morel, Ariane Dunant, John G. Edwards, Pascal Alexandre Thomas, Olaf Mercier, Aurelie Bardet
Summary: This study aimed to investigate whether three-dimensional conformal radiotherapy (3D PORT) should be part of the standard treatment for patients with non-small-cell lung cancer (NSCLC) with N2 involvement. The results showed that 3-year disease-free survival was slightly higher in patients with PORT compared to those without, but the difference was not significant.
Article
Oncology
Jarushka Naidoo, Johan F. Vansteenkiste, Corinne Faivre-Finn, Mustafa Ozguroglu, Shuji Murakami, Rina Hui, Xavier Quantin, Helen Broadhurst, Michael Newton, Piruntha Thiyagarajah, Scott J. Antonia
Summary: This study provides detailed characterization and analysis of immune-mediated adverse events (imAEs) in patients with non-small cell lung cancer treated with the PACIFIC regimen. The incidence of immune-mediated pneumonitis and non-pneumonitis imAEs was low, but higher in patients receiving durvalumab. Most imAEs occurred within 3 months after starting durvalumab, but were well managed with appropriate clinical intervention.
Article
Oncology
Matthew Craddock, Ursula Nestle, Jochem Koenig, Tanja Schimek-Jasch, Stephanie Kremp, Stefan Lenz, Kathryn Banfill, Angela Davey, Gareth Price, Ahmed Salem, Corinne Faivre-Finn, Marcel van Herk, Alan McWilliam
Summary: This study analyzes the overall survival of patients with inoperable stage II or III NSCLC treated with radiotherapy, and for the first time includes left ventricular ejection fraction as a metric of cardiac function. The results indicate that there is a region within the base of the heart that is significantly associated with worse overall survival, and an interaction between baseline cardiac health and heart base dose was identified.
JOURNAL OF THORACIC ONCOLOGY
(2023)
Article
Respiratory System
Torsten Gerriet Blum, Rebecca L. Morgan, Valerie Durieux, Joanna Chorostowska-Wynimko, David R. Baldwin, Jeanette Boyd, Corinne Faivre-Finn, Francoise Galateau-Salle, Fernando Gamarra, Bogdan Grigoriu, Georgia Hardavella, Michael Hauptmann, Erik Jakobsen, Dragana Jovanovic, Paul Knaut, Gilbert Massard, John McPhelim, Anne-Pascale Meert, Robert Milroy, Riccardo Muhr, Luciano Mutti, Marianne Paesmans, Pippa Powell, Paul Martin Putora, Janette Rawlinson, Anna L. Rich, David Rigau, Dirk de Ruysscher, Jean-Paul Sculier, Arnaud Schepereel, Dragan Subotic, Paul Van Schil, Thomy Tonia, Clare Williams, Thierry Berghmans
Summary: This guideline provides good quality recommendations in lung cancer care, based on systematic reviews and evidence syntheses. The recommendations cover various quality improvement measures, such as avoiding delays in diagnosis and treatment, integrating multidisciplinary teams, adhering to guidelines, and using specific tools for decision-making. The recommendations should be periodically updated as new evidence becomes available.
EUROPEAN RESPIRATORY JOURNAL
(2023)
Article
Oncology
Alan McWilliam, Azadeh Abravan, Kathryn Banfil, Corinne Faivre-Finn, Marcel van Herk
Summary: The dose to the base of the heart is associated with overall survival, explaining the worse survival in the high-dose arm of lung cancer treatment. By avoiding the heart subregion dose, future dose escalation trials may be feasible.
JOURNAL OF THORACIC ONCOLOGY
(2023)
Letter
Oncology
Marina C. Garassino, Corinne Faivre-Finn
JOURNAL OF THORACIC ONCOLOGY
(2023)
Article
Oncology
Saskia A. Cooke, Dirk de Ruysscher, Bart Reymen, Maarten Lambrecht, Gitte Fredberg Persson, Corinne Faivre-Finn, Edith M. T. Dieleman, Rolf Lewensohn, Judi N. A. van Diessen, Karolina Sikorska, Ferry Lalezari, Wouter Vogel, Wouter van Elmpt, Eugene M. F. Damen, Jan -Jakob Sonke, Jose S. A. Belderbos
Summary: This study aimed to evaluate the ability of radiation dose escalation to improve local control in patients with locally advanced non-small-cell lung cancer. The results showed that both whole primary tumour dose escalation and PET-defined subvolume dose escalation can improve local control. However, both strategies also led to unexpected high rates of toxicity. Therefore, it is recommended to improve dose escalation strategies by considering dose differentiation, better patient selection, and improved protection of central structures.
RADIOTHERAPY AND ONCOLOGY
(2023)
Article
Oncology
Jarushka Naidoo, Scott Antonia, Yi-Long Wu, Byoung Chul Cho, Piruntha Thiyagarajah, Helen Mann, Michael Newton, Corinne Faivre-Finn
Summary: This study examined the efficacy of immunotherapy in patients with EGFR-mutant NSCLC. The results showed that durvalumab had similar PFS and OS compared to placebo, but due to small sample size and lack of prospective studies, further research is needed to determine the optimal treatment for EGFR-mutant NSCLC.
JOURNAL OF THORACIC ONCOLOGY
(2023)
Letter
Oncology
Alan McWilliam, Azadeh Abravan, Kathryn Banfill, Corinne Faivre-Finn, Marcel van Herk
JOURNAL OF THORACIC ONCOLOGY
(2023)
Review
Oncology
Erik Claes, Reinier Wener, Arne P. Neyrinck, Axelle Coppens, Paul E. Van Schil, Annelies Janssens, Therese S. Lapperre, Annemiek Snoeckx, Wen Wen, Hanne Voet, Stijn E. Verleden, Jeroen M. H. Hendriks
Summary: Lung cancer is the leading cause of cancer-related deaths, and surgery is the preferred treatment for early-stage cancer. However, for more advanced stages, a multimodal treatment approach consisting of chemotherapy, radiotherapy, and/or immunotherapy is recommended. Loco-regional techniques have gained interest due to their potential advantages over current therapies. This article provides an overview of established and promising invasive loco-regional techniques categorized by route of administration (endobronchial, endovascular, and transthoracic), along with their implementation and effectiveness. Further clinical studies are needed to ensure the efficacy and safety of these techniques before they can be widely used.
Article
Oncology
Romaana Mir, Nicki Groom, Hitesh B. Mistry, Elena Wilson, Corinne Faivre-Finn
Summary: This study conducted comprehensive contouring, dosimetry, and treatment delivery quality assurance in radiotherapy, and examined the impact of protocol variations on patient outcomes. Non-compliant heart contours were associated with increased dose delivered to the heart organ at risk (OAR), but unacceptable variations did not affect toxicity or survival outcomes.
CLINICAL AND TRANSLATIONAL RADIATION ONCOLOGY
(2023)
Article
Health Care Sciences & Services
Amelia Payne, Ashley Horne, Neil Bayman, Fiona Blackhall, Layla Bostock, Clara Chan, Joanna Coote, Marie Eaton, Jacqueline Fenemore, Fabio Gomes, Emma Halkyard, Margaret Harris, Colin Lindsay, Delyth McEntee, Hilary Neal, Laura Pemberton, Hamid Sheikh, David Woolf, James Price, Janelle Yorke, Corinne Faivre-Finn
Summary: This study investigates the experiences of patients and clinicians using the ePROMs service at Christie NHS Foundation Trust in the UK. The results show that the use of ePROMs improves communication and increases patient involvement in their care, as reported by both patients and clinicians. This study demonstrates the acceptability and positive impact of incorporating ePROMs into routine cancer care.
JOURNAL OF PATIENT-REPORTED OUTCOMES
(2023)
Article
Oncology
I. Fornacon-Wood, K. Banfill, S. Ahmad, A. Britten, C. Carson, N. Dorey, M. Hatton, C. Hiley, K. Thippu Jayaprakash, A. Jegannathen, A. C. Kidd, P. Koh, N. Panakis, C. Peedell, A. Peters, A. Pope, C. Powell, C. Stilwell, B. Thomas, E. Toy, K. Wicks, V. Wood, S. Yahya, G. Price, C. Faivre-Finn
Summary: This study aims to analyze the impact of changes in radiotherapy and chemotherapy during the COVID-19 pandemic on patient outcomes. The results show that these changes did not significantly affect distant relapse or survival, but increased the odds of grade >= 3 acute toxicity.
Article
Cardiac & Cardiovascular Systems
Alyaa M. Ajabnoor, Rosa Parisi, Salwa S. Zghebi, Darren M. Ashcroft, Corinne Faivre-Finn, Charlotte Morris, Mamas A. Mamas, Evangelos Kontopantelis
Summary: The study examines the association between certain types of cancer and the balance between stroke and bleeding risk in patients with atrial fibrillation.
JOURNAL OF THE AMERICAN HEART ASSOCIATION
(2023)
Review
Oncology
Lawek Berzenji, Wen Wen, Stijn Verleden, Erik Claes, Suresh Krishan Yogeswaran, Patrick Lauwers, Paul Van Schil, Jeroen M. H. Hendriks
Summary: In the last twenty years, minimally invasive surgery (MIS) has revolutionized surgical procedures. In thoracic surgery, video-assisted thoracoscopic surgery (VATS) and robotic-assisted thoracoscopic surgery (RATS) have become the new standards, especially for early-stage lung cancer. However, there is a lack of concrete data comparing the outcomes of these minimally invasive approaches to traditional open surgery. As lung cancer screening programs lead to the detection of more early-stage lung cancer, data on the effectiveness of VATS and RATS in treating it is needed.
Article
Oncology
Diego de Miguel-Perez, Edward M. Pickering, Umberto Malapelle, William Grier, Francesco Pepe, Pasquale Pisapia, Gianluca Russo, Joseph A. Pinto, Alessandro Russo, Giancarlo Troncone, Melissa J. Culligan, Katherine A. Scilla, Ranee Mehra, Pranshu Mohindra, Oscar Arrieta, Andres F. Cardona, Marzia Del Re, Ashutosh Sachdeva, Fred R. Hirsch, Andrea Wolf, Joseph S. Friedberg, Christian Rolfo
Summary: In this study, genetic alterations in resectable pleural mesothelioma tissues and blood samples were analyzed, and it was found that high tissue tumor mutational burden, tissue median minor allele frequency, blood tumor mutational burden, and specific mutations were correlated with outcomes in patients with resected PM. These findings suggest that molecular profiling could help identify longer survivors in patients with resected PM.
EUROPEAN JOURNAL OF CANCER
(2024)
Article
Oncology
Davide Melisi, Camilla Zecchetto, Valeria Merz, Giuseppe Malleo, Luca Landoni, Alberto Quinzii, Simona Casalino, Federica Fazzini, Marina Gaule, Camilla Pesoni, Luca Casetti, Alessandro Esposito, Giovanni Marchegiani, Cristiana Piazzola, Mirko D'Onofrio, Riccardo de Robertis, Armando Gabbrielli, Laura Bernardoni, Stefano F. Crino, Silvia Pietrobono, Claudio Luchini, Camillo Aliberti, Guido Martignoni, Stefano Milleri, Giovanni Butturini, Aldo Scarpa, Roberto Salvia, Claudio Bassi
Summary: This study evaluated the safety and activity of liposomal irinotecan in the perioperative treatment of resectable pancreatic ductal adenocarcinoma (rPDAC) patients. The results showed that NALIRIFOX has manageable and active outcomes, and should be further investigated in randomized trials comparing it to standard upfront surgery followed by adjuvant therapy.
EUROPEAN JOURNAL OF CANCER
(2024)
Article
Oncology
Eric Jonasch, Todd M. Bauer, Kyriakos P. Papadopoulos, Elizabeth R. Plimack, Jaime R. Merchan, David F. Mcdermott, M. Dror Michaelson, Leonard J. Appleman, Ananya Roy, Rodolfo F. Perini, Yanfang Liu, Toni K. Choueiri
Summary: After a median follow-up of 41.2 months, belzutifan monotherapy demonstrated durable antitumor activity in patients with advanced ccRCC and acceptable safety.
EUROPEAN JOURNAL OF CANCER
(2024)
Article
Oncology
Patricia A. H. Hamers, Geraldine R. Vink, Marloes A. G. Elferink, Leon M. G. Moons, Cornelis J. A. Punt, Anne M. May, Miriam Koopman
Summary: Screen-detection of the primary tumor is associated with longer overall survival after metachronous metastasis.
EUROPEAN JOURNAL OF CANCER
(2024)
Article
Oncology
Camilla Nero, Nicolo Bizzarri, Stefano Di Berardino, Francesca Sillano, Giuseppe Vizzielli, Francesco Cosentino, Virginia Vargiu, Pierandrea De Iaco, Anna Myriam Perrone, Enrico Vizza, Benito Chiofalo, Stefano Uccella, Fabio Ghezzi, Luigi Carlo Turco, Giacomo Corrado, Diana Giannarelli, Tina Pasciuto, Gian Franco Zannoni, Anna Fagotti, Giovanni Scambia
Summary: This study evaluates the sensitivity and specificity of sentinel-lymph-node mapping compared to systematic lymphadenectomy in detecting lymph node metastasis in early stage ovarian cancer. The results show that sentinel-lymph-node mapping did not reach the expected sensitivity, but ultra-staging protocol improved the accuracy of diagnosis for patients.
EUROPEAN JOURNAL OF CANCER
(2024)
Article
Oncology
Adriana Hepner, Judith M. Versluis, Roslyn Wallace, Clara Allayous, Lauren Julia Brown, Claudia Trojanielloh, Camille Lea Gerardi, Yanina J. L. Jansenj, Prachi Bhave, Bart Neyns, Andrew Haydon, Olivier Michielin, Joanna Manganan Oliver Klein, Alexander N. Shoushtari, Allison Betof Warner, Paolo Antonio Ascierto, Jennifer Leigh McQuade, Matteo S. Carlino, Lisa Zimmer, Celeste Lebbe, Douglas B. Johnson, Shahneen Sandhu, Victoria Atkinson, Christian U. Blank, Serigne N. Lo, Georgina V. Long, Alexander M. Menzies
Summary: Acquired resistance to PD-1 therapy in melanoma is mainly oligometastatic, and patients may have a favorable survival outcome following salvage treatment.
EUROPEAN JOURNAL OF CANCER
(2024)
Article
Oncology
Savannah Roy, Stephanie Lakritz, Anna R. Schreiber, Elizabeth Molina Kuna, Cathy J. Bradley, Lavanya Kondapalli, Jennifer R. Diamond
Summary: This study evaluates major adverse cardiovascular events (MACE) in older women with TNBC treated with anthracycline and taxane-based chemotherapy (ATAX) compared to taxane-based chemotherapy (TAX). The results show that ATAX does not increase the risk of MACE and there is no difference in survival between patients who received TAX and ATAX.
EUROPEAN JOURNAL OF CANCER
(2024)
Letter
Oncology
Pei-Chun Weng, Yau-Li Huang, Chun-Yu Cheng
EUROPEAN JOURNAL OF CANCER
(2024)
Article
Oncology
Philipp Jansen, Jean Le 'Clerc Arrastia, Daniel Otero Baguer, Maximilian Schmidt, Jennifer Landsberg, Joerg Wenzel, Michael Emberger, Dirk Schadendorf, Eva Hadaschik, Peter Maass, Klaus Georg Griewank
Summary: This study highlights the enormous potential of artificial intelligence in pathology, showing that it can aid in the identification of rare cutaneous adnexal tumors and potentially become a standard tool in routine diagnostics.
EUROPEAN JOURNAL OF CANCER
(2024)
Article
Oncology
Casper W. F. van Eijck, Gaby Strijk, Eveline E. Vietscha, Fleur van der Sijde, Maaike Verheij, Dana A. M. Mustafa, Madelief Vinkc, Joachim G. J. V. Aerts, Casper H. J. van Eijck, Marcella Willemsen
Summary: The study reveals that FOLFIRINOX has immunomodulatory effects, suggesting its potential in immune-based combination therapies for pancreatic cancer. Additionally, certain plasma proteins hold promise as circulating predictive biomarkers for early prediction of FOLFIRINOX response in patients with pancreatic cancer.
EUROPEAN JOURNAL OF CANCER
(2024)
Article
Oncology
Marwan Fakih, Chongkai Wang, Jaideep Sandhu, Jian Ye, Colt Egelston, Xiaochen Li
Summary: This study explores the impact of metastatic sites on treatment outcomes for chemotherapy-refractory colorectal cancer patients. It found that patients with liver or peritoneal metastases had poor treatment outcomes, while those with lung-only metastases showed significant response. The presence of concurrent lymph node or other extrahepatic metastatic disease diminished treatment response in patients with lung metastases. Future checkpoint inhibitor trials should stratify patients based on metastatic locations.
EUROPEAN JOURNAL OF CANCER
(2024)
Article
Oncology
Georgios Christos Tsiatsianis, Candace S. Y. Chan, Ioannis Mouratidis, Nikol Chantzi, Anna Maria Tsiatsiani, Nelson S. Yee, Apostolos Zaravinos, Verena Kantere, Ilias Georgakopoulos-Soares
Summary: The study reveals that nullpeptides can serve as biomarkers for cancer detection and treatment, particularly in highly recurrent cancer patients. These nullpeptides primarily occur in highly expressed genes, particularly in specific loci of oncogenes and tumor suppressors. Recurrent nullpeptides are more likely to be found in neoantigens, which play a significant role in immunotherapy.
EUROPEAN JOURNAL OF CANCER
(2024)