Journal
EUROPEAN JOURNAL OF CANCER
Volume 49, Issue 6, Pages 1216-1225Publisher
ELSEVIER SCI LTD
DOI: 10.1016/j.ejca.2012.11.021
Keywords
Non-small cell lung cancer; Advanced disease; New systemic therapies
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The standard palliative treatment for advanced stage NSCLC remains a platinum doublet but by tailoring chemotherapy according to tumour histology the results can be improved through using pemetrexed-containing schemas in non-squamous-cell disease. In addition, maintenance chemotherapy appears to be effective in patients achieving clinical benefit by induction therapy. Targeted therapy based on the presence of activating epidermal growth factor receptor (EGFR) activating mutations or EML4-ALK gene rearrangement is becoming standard practice with high median survival rates, up to 30 months. There are still numerous other molecular targeted drugs in development. This review presents the most recent relevant progress in systemic anti-cancer therapy of advanced NSCLC in the past 5 years and delineates today's new treatment options. (C) 2012 Elsevier Ltd. All rights reserved.
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