Article
Nutrition & Dietetics
Xi Pan, Hong Liu, Guo Feng, Jie Xiao, Meng Wang, Hua Liu, Xueyi Xie, Zhipeng Rong, Jinru Wu, Min Liu
Summary: This study reveals that traditional nutritional assessment methods cannot accurately identify muscle mass loss in patients with locally advanced NPC. FFMI and ASMI can detect muscle mass reduction that other assessment parameters cannot identify.
FRONTIERS IN NUTRITION
(2021)
Article
Oncology
Yun Du, Ruimei Feng, Ellen T. Chang, Li Yin, Tingting Huang, Yancheng Li, Xiang Zhou, Yi Huang, Feng Zhou, Canqiong Su, Xue Xiao, Weihua Jia, Yuming Zheng, Hans-Olov Adami, Yixin Zeng, Yonglin Cai, Zhe Zhang, Miao Xu, Weimin Ye
Summary: This study found that overweight NPC patients at diagnosis had a 25% lower all-cause mortality and NPC-specific mortality compared to normal-weight patients. Lean body shapes 1 and 2 at diagnosis were associated with a 68% and 23% higher all-cause mortality, respectively, compared to normal body shape 3. Associations with BMI and body shape 10 years before diagnosis were similar but attenuated, while body size and shape at age 20 were not associated with mortality.
INTERNATIONAL JOURNAL OF CANCER
(2023)
Article
Oncology
Erkan Topkan, Efsun Somay, Busra Yilmaz, Berrin Pehlivan, Ugur Selek
Summary: This study aimed to assess the predictive significance of the H-Index for radiation-induced trismus (RIT) and osteoradionecrosis of the jaw (ORNJ) in patients with locally advanced nasopharyngeal carcinoma (LA-NPC) receiving concurrent chemoradiotherapy (C-CRT). The results showed that a pre-C-CRT H-Index > 5.5 was associated with significantly increased rates of RIT and ORNJ.
Article
Engineering, Biomedical
Yuxun Ding, Xiaohui Xiao, Lingli Zeng, Qiuping Shang, Wei Jiang, Sha Xiong, Xiaohui Duan, Jun Shen, Ruibing Wang, Jinshan Guo, Yue Pan
Summary: By developing RGD-targeted platinum-based nanoparticles, targeted chemoradiotherapy for NPC can be achieved with improved delivery efficiency of cisplatin. RPNs act as radiotherapy sensitizer and chemotherapy agents, leading to remarkable therapeutic outcome in synergistic chemoradiotherapy for NPC.
BIOACTIVE MATERIALS
(2021)
Article
Oncology
Xiang Li, Gui-Fen Fu, Yu-Ying Huang, Qing-Yu Jiang, Xiao-Yan Huang, Jin-Tao Zhang, Shen-Hong Qu
Summary: This study investigated the incidence of complications and types of symptom clusters induced by chemoradiotherapy in patients with nasopharyngeal carcinoma (NPC) who were discharged from hospital. Exploratory factor analysis identified six symptom clusters, including painful eating, social difficulties, psychological disorders, symptomatic shame, teeth/throat injuries, and sensory abnormalities. The authors recommended evaluating patients' symptoms before discharge and providing targeted health education services to reduce complications and improve the quality of life at home.
FRONTIERS IN ONCOLOGY
(2023)
Letter
Medicine, General & Internal
David A. Gorelick
Summary: This comprehensive review of human adipose tissue fails to mention the role of the endocannabinoid system in fat metabolism. The endogenous cannabinoids and their receptors, found in both white and brown fat, have been recognized as key players in adipose tissue metabolism. Rimonabant, an inverse agonist of cannabinoid receptor type 1, has shown promising effects as a therapeutic target for obesity, dyslipidemia, and insulin resistance, although its clinical use was discontinued due to neuropsychiatric side effects.
NEW ENGLAND JOURNAL OF MEDICINE
(2022)
Article
Nutrition & Dietetics
Yilin Yu, Haishan Wu, Jianjian Qiu, Dongmei Ke, Yahua Wu, Mingqiang Lin, Tianxiu Liu, Qunhao Zheng, Hongying Zheng, Jun Yang, Zhiping Wang, Hui Li, Lingyun Liu, Qiwei Yao, Jiancheng Li, Wenfang Cheng, Xiaohui Chen
Summary: This study found that lower BMI and PNI levels are associated with worse survival outcomes in patients with locally advanced esophageal squamous cell carcinoma undergoing chemoradiotherapy. BMI and PNI can be used to stratify risk factors and guide treatment for these patients.
FRONTIERS IN NUTRITION
(2022)
Article
Oncology
Mi Na Kim, Kyungdo Han, Juhwan Yoo, Yeonjung Ha, Young Eun Chon, Ju Ho Lee, Seong Gyu Hwang
Summary: This study investigated the impact of short-term changes in general and central fatness on the risk of hepatocellular carcinoma (HCC). The results showed that both incident and persistent general and central fatness were associated with an increased risk of HCC. This emphasizes the importance of preventing and reversing body fatness to reduce the incidence of HCC.
INTERNATIONAL JOURNAL OF CANCER
(2022)
Article
Radiology, Nuclear Medicine & Medical Imaging
Jun Liu, Juan Zhu, Yaxian Wang, Fei Wang, Hualin Yang, Nan Wang, Qingyun Chu, Qing Yang
Summary: This study demonstrates the value of arterial spin labeling (ASL) perfusion imaging in assessing the early efficacy of chemoradiotherapy for nasopharyngeal carcinoma (NPC). By investigating tumor blood flow parameters and their correlation with tumor atrophy rate, it is possible to predict the sensitivity to chemoradiotherapy and the presence of residual tumors.
INSIGHTS INTO IMAGING
(2022)
Article
Gastroenterology & Hepatology
Nicole E. Rich, Samuel Phen, Nirali Desai, Sukul Mittal, Adam C. Yopp, Ju Dong Yang, Jorge A. Marrero, Puneeth Iyengar, Rodney E. Infante, Amit G. Singal
Summary: This study finds that nearly 1 in 4 patients with hepatocellular carcinoma (HCC) present with cancer cachexia, which is associated with worse outcomes in HCC patients. The presence of cancer-associated weight loss appears to be an early and independent predictor of reduced survival in HCC patients.
CLINICAL GASTROENTEROLOGY AND HEPATOLOGY
(2022)
Review
Medicine, General & Internal
Ying He, Xiaoyu Chen, Tong Yang, Yan Li, Sitao Tan, Xiaoxia Liu
Summary: Compared with conventional diets, nutritional interventions can improve serum nutritional parameters, nutritional status, treatment tolerance, and prognosis of patients undergoing radiotherapy for nasopharyngeal carcinoma.
Article
Oncology
Xiang Lin, Bingyi Wang, Fei Zheng, Zhaodong Fei, Chuanben Chen
Summary: This study assessed the impact of pretreatment body mass index (BMI) and change in BMI during treatment on the outcomes of nasopharyngeal carcinoma (NPC) patients receiving volumetric modulated arc therapy (VMAT). The results indicated that the change in BMI during treatment may significantly affect the prognosis of NPC patients receiving VMAT.
Article
Oncology
Enkelejda Lamaj, Erwin Vu, Janita E. van Timmeren, Chiara Leonardi, Louise Marc, Izabela Pytko, Matthias Guckenberger, Panagiotis Balermpas
Summary: Re-optimized treatment plans using VMAT significantly improved cochlea sparing without compromising PTV dose coverage in nasopharyngeal carcinoma patients. This method can reduce the risk of hearing impairment and should be considered for future treatment planning.
RADIATION ONCOLOGY
(2021)
Review
Oncology
Fubin Zhu, Yidan Wu, Hua Wang
Summary: Translation: The Importance of Platinum-Based Therapies for Nasopharyngeal Carcinoma
Nasopharyngeal carcinoma (NPC) is a malignant tumor characterized by the transformation of nasopharyngeal epithelial cells. Radiotherapy is the primary treatment modality, but it often fails to achieve desirable outcomes for locally advanced NPC (LA-NPC). Therefore, combining radiotherapy with chemotherapy, particularly concurrent chemoradiotherapy (CCRT) using platinum-based drugs, has become an effective strategy. The extensive use of platinum drugs in clinical settings highlights their therapeutic potential and emphasizes the importance of developing novel platinum-based complexes for anticancer therapy.
FRONTIERS IN ONCOLOGY
(2023)
Article
Oncology
Maimouna Mane, Sofian Benkhaled, Tatiana Dragan, Marianne Paesmans, Sylvie Beauvois, Yassine Lalami, Petr Szturz, P. Macoumba Gaye, Jan B. Vermorken, Dirk Van Gestel
Summary: The study found that adding induction chemotherapy (ICT) followed by concurrent chemoradiotherapy (CCRT) to treatment for locally advanced nasopharyngeal carcinoma (LA-NPC) significantly improved overall survival and progression-free survival compared to CCRT alone.
Article
Oncology
Diego de Miguel-Perez, Edward M. Pickering, Umberto Malapelle, William Grier, Francesco Pepe, Pasquale Pisapia, Gianluca Russo, Joseph A. Pinto, Alessandro Russo, Giancarlo Troncone, Melissa J. Culligan, Katherine A. Scilla, Ranee Mehra, Pranshu Mohindra, Oscar Arrieta, Andres F. Cardona, Marzia Del Re, Ashutosh Sachdeva, Fred R. Hirsch, Andrea Wolf, Joseph S. Friedberg, Christian Rolfo
Summary: In this study, genetic alterations in resectable pleural mesothelioma tissues and blood samples were analyzed, and it was found that high tissue tumor mutational burden, tissue median minor allele frequency, blood tumor mutational burden, and specific mutations were correlated with outcomes in patients with resected PM. These findings suggest that molecular profiling could help identify longer survivors in patients with resected PM.
EUROPEAN JOURNAL OF CANCER
(2024)
Article
Oncology
Davide Melisi, Camilla Zecchetto, Valeria Merz, Giuseppe Malleo, Luca Landoni, Alberto Quinzii, Simona Casalino, Federica Fazzini, Marina Gaule, Camilla Pesoni, Luca Casetti, Alessandro Esposito, Giovanni Marchegiani, Cristiana Piazzola, Mirko D'Onofrio, Riccardo de Robertis, Armando Gabbrielli, Laura Bernardoni, Stefano F. Crino, Silvia Pietrobono, Claudio Luchini, Camillo Aliberti, Guido Martignoni, Stefano Milleri, Giovanni Butturini, Aldo Scarpa, Roberto Salvia, Claudio Bassi
Summary: This study evaluated the safety and activity of liposomal irinotecan in the perioperative treatment of resectable pancreatic ductal adenocarcinoma (rPDAC) patients. The results showed that NALIRIFOX has manageable and active outcomes, and should be further investigated in randomized trials comparing it to standard upfront surgery followed by adjuvant therapy.
EUROPEAN JOURNAL OF CANCER
(2024)
Article
Oncology
Eric Jonasch, Todd M. Bauer, Kyriakos P. Papadopoulos, Elizabeth R. Plimack, Jaime R. Merchan, David F. Mcdermott, M. Dror Michaelson, Leonard J. Appleman, Ananya Roy, Rodolfo F. Perini, Yanfang Liu, Toni K. Choueiri
Summary: After a median follow-up of 41.2 months, belzutifan monotherapy demonstrated durable antitumor activity in patients with advanced ccRCC and acceptable safety.
EUROPEAN JOURNAL OF CANCER
(2024)
Article
Oncology
Patricia A. H. Hamers, Geraldine R. Vink, Marloes A. G. Elferink, Leon M. G. Moons, Cornelis J. A. Punt, Anne M. May, Miriam Koopman
Summary: Screen-detection of the primary tumor is associated with longer overall survival after metachronous metastasis.
EUROPEAN JOURNAL OF CANCER
(2024)
Article
Oncology
Camilla Nero, Nicolo Bizzarri, Stefano Di Berardino, Francesca Sillano, Giuseppe Vizzielli, Francesco Cosentino, Virginia Vargiu, Pierandrea De Iaco, Anna Myriam Perrone, Enrico Vizza, Benito Chiofalo, Stefano Uccella, Fabio Ghezzi, Luigi Carlo Turco, Giacomo Corrado, Diana Giannarelli, Tina Pasciuto, Gian Franco Zannoni, Anna Fagotti, Giovanni Scambia
Summary: This study evaluates the sensitivity and specificity of sentinel-lymph-node mapping compared to systematic lymphadenectomy in detecting lymph node metastasis in early stage ovarian cancer. The results show that sentinel-lymph-node mapping did not reach the expected sensitivity, but ultra-staging protocol improved the accuracy of diagnosis for patients.
EUROPEAN JOURNAL OF CANCER
(2024)
Article
Oncology
Adriana Hepner, Judith M. Versluis, Roslyn Wallace, Clara Allayous, Lauren Julia Brown, Claudia Trojanielloh, Camille Lea Gerardi, Yanina J. L. Jansenj, Prachi Bhave, Bart Neyns, Andrew Haydon, Olivier Michielin, Joanna Manganan Oliver Klein, Alexander N. Shoushtari, Allison Betof Warner, Paolo Antonio Ascierto, Jennifer Leigh McQuade, Matteo S. Carlino, Lisa Zimmer, Celeste Lebbe, Douglas B. Johnson, Shahneen Sandhu, Victoria Atkinson, Christian U. Blank, Serigne N. Lo, Georgina V. Long, Alexander M. Menzies
Summary: Acquired resistance to PD-1 therapy in melanoma is mainly oligometastatic, and patients may have a favorable survival outcome following salvage treatment.
EUROPEAN JOURNAL OF CANCER
(2024)
Article
Oncology
Savannah Roy, Stephanie Lakritz, Anna R. Schreiber, Elizabeth Molina Kuna, Cathy J. Bradley, Lavanya Kondapalli, Jennifer R. Diamond
Summary: This study evaluates major adverse cardiovascular events (MACE) in older women with TNBC treated with anthracycline and taxane-based chemotherapy (ATAX) compared to taxane-based chemotherapy (TAX). The results show that ATAX does not increase the risk of MACE and there is no difference in survival between patients who received TAX and ATAX.
EUROPEAN JOURNAL OF CANCER
(2024)
Letter
Oncology
Pei-Chun Weng, Yau-Li Huang, Chun-Yu Cheng
EUROPEAN JOURNAL OF CANCER
(2024)
Article
Oncology
Philipp Jansen, Jean Le 'Clerc Arrastia, Daniel Otero Baguer, Maximilian Schmidt, Jennifer Landsberg, Joerg Wenzel, Michael Emberger, Dirk Schadendorf, Eva Hadaschik, Peter Maass, Klaus Georg Griewank
Summary: This study highlights the enormous potential of artificial intelligence in pathology, showing that it can aid in the identification of rare cutaneous adnexal tumors and potentially become a standard tool in routine diagnostics.
EUROPEAN JOURNAL OF CANCER
(2024)
Article
Oncology
Casper W. F. van Eijck, Gaby Strijk, Eveline E. Vietscha, Fleur van der Sijde, Maaike Verheij, Dana A. M. Mustafa, Madelief Vinkc, Joachim G. J. V. Aerts, Casper H. J. van Eijck, Marcella Willemsen
Summary: The study reveals that FOLFIRINOX has immunomodulatory effects, suggesting its potential in immune-based combination therapies for pancreatic cancer. Additionally, certain plasma proteins hold promise as circulating predictive biomarkers for early prediction of FOLFIRINOX response in patients with pancreatic cancer.
EUROPEAN JOURNAL OF CANCER
(2024)
Article
Oncology
Marwan Fakih, Chongkai Wang, Jaideep Sandhu, Jian Ye, Colt Egelston, Xiaochen Li
Summary: This study explores the impact of metastatic sites on treatment outcomes for chemotherapy-refractory colorectal cancer patients. It found that patients with liver or peritoneal metastases had poor treatment outcomes, while those with lung-only metastases showed significant response. The presence of concurrent lymph node or other extrahepatic metastatic disease diminished treatment response in patients with lung metastases. Future checkpoint inhibitor trials should stratify patients based on metastatic locations.
EUROPEAN JOURNAL OF CANCER
(2024)
Article
Oncology
Georgios Christos Tsiatsianis, Candace S. Y. Chan, Ioannis Mouratidis, Nikol Chantzi, Anna Maria Tsiatsiani, Nelson S. Yee, Apostolos Zaravinos, Verena Kantere, Ilias Georgakopoulos-Soares
Summary: The study reveals that nullpeptides can serve as biomarkers for cancer detection and treatment, particularly in highly recurrent cancer patients. These nullpeptides primarily occur in highly expressed genes, particularly in specific loci of oncogenes and tumor suppressors. Recurrent nullpeptides are more likely to be found in neoantigens, which play a significant role in immunotherapy.
EUROPEAN JOURNAL OF CANCER
(2024)
