Article
Immunology
Dong Zhang, Xin-rui Qiao, Wen-Jing Cui, Jin-tao Zhang, Yun Pan, Xiao-fei Liu, Liang Dong
Summary: SDC-1 plays a crucial role in airway remodeling in chronic asthma by modulating the TGF beta 1/Smad3 pathway, affecting collagen I expression in airway epithelial cells and fibroblasts.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Orthopedics
Rahul G. Alenchery, Raquel E. Ajalik, Kyle Jerreld, Firaol Midekksa, Sylvia Zhong, Bashar Alkatib, Hani A. Awad
Summary: This study found that transforming growth factor-beta (TGF-beta 1) induces plasminogen activator inhibitor 1 (PAI-1) to inhibit phosphatase and tensin homolog (PTEN), suggesting that PAI-1-induced adhesions involve phosphoinositide 3-kinase/protein kinase B/mammalian target of rapamycin (mTOR) signaling. PAI-1 deletion blunted TGF-beta 1-induced myofibroblast activation in murine flexor tenocytes and increased the gene expression of Mmp-2 to confer protective effects against fibrosis. While TGF-beta 1 significantly reduced phosphorylation of PTEN in WT cells, PAI-1 deletion rescued the activation of PTEN.
JOURNAL OF ORTHOPAEDIC RESEARCH
(2023)
Article
Cell Biology
Liming Deng, Wenming Bao, Baofu Zhang, Sina Zhang, Ziyan Chen, Xuewen Zhu, Bangjie He, Lijun Wu, Xiaohu Chen, Tuo Deng, Bo Chen, Zhengping Yu, Yi Wang, Gang Chen
Summary: This study found that AZGP1 is the key target of lenvatinib in intrahepatic cholangiocarcinoma (ICC) and its low expression is associated with poor prognosis. Lenvatinib activates AZGP1 by increasing the acetylation level of H3K27Ac and inhibits ICC-EMT through the TGF-beta 1/Smad3 signaling pathway, in an AZGP1-dependent manner.
CELL DEATH & DISEASE
(2023)
Article
Cell Biology
Shan Song, Chonglin Shi, Yawei Bian, Zhaohua Yang, Lin Mu, Haijiang Wu, Huijun Duan, Yonghong Shi
Summary: The study found that Sestrin2 is low-expressed in diabetic kidney disease and can alleviate podocyte injury by modulating the activity of TSP-1/TGF-beta 1/Smad3 pathway.
CELL DEATH & DISEASE
(2022)
Review
Cell Biology
Craig E. Higgins, Jiaqi Tang, Stephen P. Higgins, Cody C. Gifford, Badar M. Mian, David M. Jones, Wenzheng Zhang, Angelica Costello, David J. Conti, Rohan Samarakoon, Paul J. Higgins
Summary: Tubulointerstitial fibrosis is a common feature in chronic renal disorders, driven by persistent TGF-beta 1 signaling. The transcriptional co-regulator p53 plays a key role in the fibrotic response induced by TGF-beta 1.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Rong Cao, Wen Su, Jingyi Sheng, Yanlin Guo, Jie Su, Cong Zhang, Honglian Wang, Yizhe Tang, Lei Chen, Rongfang Qiao, Xiaocong Chen, Xiaoru Huang, Yunfeng Zhou, Lizhen Zhu, Zirui Bai, Xiaoyan Zhang, Jan-Ake Gustafsson, Qijun Wan, Hui-yao Lan, Youfei Guan
Summary: Renal fibrosis (RF) is a common pathway leading to chronic kidney disease (CKD) and lacks effective treatment. This study investigated the role of estrogen receptor beta (ER beta) in RF progression in patients and animal models with CKD. It was found that ER beta deficiency exacerbated RF, while ER beta activation attenuated RF, indicating a protective role of ER beta in RF. Mechanistically, ER beta competitively inhibited the association of Smad3 with the Smad-binding element, leading to downregulation of fibrosis-related genes and inhibition of the TGF-beta 1/Smad3 signaling pathway.
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE
(2023)
Article
Oncology
Yuxuan Li, Pan Wang, Dongmei Ye, Xue Bai, Xuemei Zeng, Qiang Zhao, Zhiwei Zhang
Summary: This study investigated the expression of IGHG1 in gastric cancer and its effects on the proliferation, migration, invasion, and EMT of gastric cancer SGC7901 cells. High expression of IGHG1 was found in gastric cancer tissues, promoting cell proliferation, migration, and invasion. Low expression of IGHG1 reduced EMT-related protein expression and induced EMT in SGC7901 cells through the TGF-beta/SMAD3 signaling pathway.
Article
Pharmacology & Pharmacy
Yinhui Wang, Kun Yu, Chengcheng Zhao, Ling Zhou, Jia Cheng, Dao Wen Wang, Chunxia Zhao
Summary: The study revealed that Follistatin plays a cardioprotective role in attenuating diabetic cardiomyopathy by reducing cardiac fibrosis and reactive oxygen species production, and enhancing matrix metallopeptidase 9 activities.
FRONTIERS IN PHARMACOLOGY
(2021)
Article
Cell Biology
Qianwen Wang, Chenxiang Qi, Pengxiang Min, Yueyuan Wang, Fengwen Ye, Tianxiang Xia, Yujie Zhang, Jun Du
Summary: By regulating MICAL2, the migratory ability of gastric cancer cells can be influenced, and it involves changes in the E-cadherin/beta-catenin signaling pathway.
CELL COMMUNICATION AND SIGNALING
(2022)
Article
Biochemistry & Molecular Biology
Li Han, Huaiqing Luo, Wenjie Huang, Jiang Zhang, Di Wu, Jinmei Wang, Jiao Pi, Chi Liu, Xiangping Qu, Huijun Liu, Xiaoqun Qin, Yang Xiang
Summary: Persistent injury and improper repair in bronchial epithelial cells contribute to airway inflammation and remodeling in asthma. E-cadherin plays a role in regulating the balance between EMT and MET during injury repair by inhibiting EMT features, enhancing MET features, and decreasing TGF-beta 1 secretion and Snail expression, ultimately facilitating epithelial repair.
Article
Immunology
Sonia Kiran, Mousumi Mandal, Ahmed Rakib, Amandeep Bajwa, Udai P. Singh
Summary: This study investigates the role and mechanism of miR-10a-3p in adipose inflammation and adipogenesis using ex vivo and in vitro approaches. The findings suggest that miR-10a-3p mimic reduces the expression of inflammatory cells and cytokines, and induces the expression of FoxP3 in adipose tissue. In vitro experiments also show that miR-10a-3p mimic reduces the expression of inflammatory genes and lipid accumulation. This study provides a new opportunity for the development of miR-10a-3p as a novel therapeutic for adipose inflammation and its associated metabolic disorders.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Medicine, Research & Experimental
Changsheng Huang, Fuqing Hu, Da Song, Xuling Sun, Anyi Liu, Qi Wu, Xiaowei She, Yaqi Chen, Lisheng Chen, Fayong Hu, Feng Xu, Xuelai Luo, Yongdong Feng, Xiangping Yang, Junbo Hu, Guihua Wang
Summary: This study reveals the critical role of EZH2-mediated SMAD3 K53/K333 methylation in the activation of SMAD3, which is associated with cancer metastasis and poor survival outcomes.
JOURNAL OF CLINICAL INVESTIGATION
(2022)
Article
Oncology
Xiaoqing Fan, Junqi Fan, Haoran Yang, Chenggang Zhao, Wanxiang Niu, Zhiyou Fang, Xueran Chen
Summary: This study identified a mutation in isocitrate dehydrogenase 1 that suppresses the TGF-beta signaling pathway, while highlighting the roles of Smad3 and EP300 in promoting expression of mesenchymal markers in the mesenchymal subtype of GBM. Smad3 and hypoxia-inducible factor 1-alpha may be crucial molecular targets for treating glioma due to their coordination in cancer stem cell biology.
Article
Cell Biology
Jun Zhou, Yasamin Dabiri, Rodrigo A. Gama-Brambila, Shahrouz Ghafoory, Mukaddes Altinbay, Arianeb Mehrabi, Mohammad Golriz, Biljana Blagojevic, Stefanie Reuter, Kang Han, Anna Seidel, Ivan Dikic, Stefan Wolfl, Xinlai Cheng
Summary: The study identifies pVHL as an E3 ligase for SMAD3 ubiquitination, which interacts with SMAD3 triggering its degradation, negatively regulating the TGF-beta/SMAD3 signaling pathway. Loss of pVHL in Drosophila leads to up-regulation of TGF-beta targets and a downward wing blade phenotype, rescued by inhibition of SMAD activity. The ectopic veinlets and reduced wing growth observed in Drosophila upon pVHL expression mirrors the effects seen with loss of TGF-beta/SMAD signaling.
JOURNAL OF CELL BIOLOGY
(2021)
Review
Biochemistry & Molecular Biology
Niaz Mahmood, Shafaat A. Rabbani
Summary: Fibrinolysis plays a crucial role in maintaining hemostatic balance and is directly linked to tumor growth, invasiveness, and metastasis. Despite promising preclinical evidence on targeting key components of the fibrinolytic system for cancer therapy, limited clinical trials have prevented successful translation from bench to bedside.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Review
Anatomy & Morphology
Slavko Mojsilovic, Sonja S. Mojsilovic, Suncica Bjelica, Juan F. Santibanez
Summary: TGF-beta 1 and MDSCs play crucial roles in tumor progression, with simultaneous inhibition potentially improving the efficacy of cancer immunotherapy.
DEVELOPMENTAL DYNAMICS
(2022)
Article
Multidisciplinary Sciences
Jelena Krstic, Isabel Reinisch, Katharina Schindlmaier, Markus Galhuber, Zina Riahi, Natascha Berger, Nadja Kupper, Elisabeth Moyschewitz, Martina Auer, Helene Michenthaler, Christoph Noessing, Maria R. Depaoli, Jeta Ramadani-Muja, Sinem Usluer, Sarah Stryeck, Martin Pichler, Beate Rinner, Alexander J. A. Deutsch, Andreas Reinisch, Tobias Madl, Riccardo Zenezini Chiozzi, Albert J. R. Heck, Meritxell Huch, Roland Malli, Andreas Prokesch
Summary: Fasting improves the efficacy of sorafenib and sensitizes sorafenib-resistant HCC by preventing the Warburg shift through reduction in glucose and AKT/mTOR signaling. p53 is necessary for the sorafenib-sensitizing effect of fasting.
Article
Pharmacology & Pharmacy
Dusan Ruzic, Nemanja Djokovic, Tatjana Srdic-Rajic, Cesar Echeverria, Katarina Nikolic, Juan F. Santibanez
Summary: The dysregulation of gene expression plays a critical role in tumorigenesis, and abnormal activation of histone deacetylases (HDAC) has been reported to cause aberrant histone and non-histone acetylation modifications in hematologic and solid types of cancer. Cancer-associated epigenetic alterations, such as HDAC inhibitors (HDACi), have shown promising potential for anticancer therapy and chemoprevention. This review focuses on the biological roles of the Zinc-dependent HDAC family in malignant diseases, and discusses the use of small molecules and natural products as HDACi for cancer therapy. Structural considerations and clinical trials combining HDACi with current therapies are also discussed, highlighting the potential for future clinical applications of HDACi in precision cancer therapies.
Article
Biochemistry & Molecular Biology
Markus Galhuber, Helene Michenthaler, Christoph Heininger, Isabel Reinisch, Christoph Noessing, Jelena Krstic, Nadja Kupper, Elisabeth Moyschewitz, Martina Auer, Ellen Heitzer, Peter Ulz, Ruth Birner-Gruenberger, Laura Liesinger, Georgia Ngawai Lenihan-Geels, Moritz Oster, Emil Spreitzer, Riccardo Zenezini Chiozzi, Tim J. Schulz, Michael Schupp, Tobias Madl, Albert J. R. Heck, Andreas Prokesch
Summary: This study reveals the mechanisms of p53 signaling during starvation using multiple methods. By utilizing BioID and immunoprecipitation techniques, the interaction network of p53 with metabolic enzymes and kinases was identified. Additionally, transcriptomics analysis identified a starvation-specific transcriptome response. These findings shed new light on our understanding of p53 as a nutrient stress sensor.
CELLULAR AND MOLECULAR LIFE SCIENCES
(2022)
Review
Biochemistry & Molecular Biology
Jelena Krstic, Alexander Deutsch, Julia Fuchs, Martin Gauster, Tina Gorsek Sparovec, Ursula Hiden, Julian Christopher Krappinger, Gerit Moser, Katrin Pansy, Marta Szmyra, Daniela Gold, Julia Feichtinger, Berthold Huppertz
Summary: Placenta-specific trophoblast and tumor cells share common characteristics, such as invasion ability and immune evasion. They are both supported by an abetting microenvironment, although trophoblast cells are regulated more tightly.
Article
Genetics & Heredity
Isabel Reinisch, Ingeborg Klymiuk, Helene Michenthaler, Elisabeth Moyschewitz, Markus Galhuber, Jelena Krstic, Magnus Domingo, Fangrong Zhang, Michael Karbiener, Nemanja Vujic, Dagmar Kratky, Renate Schreiber, Michael Schupp, Georgia Lenihan-Geels, Tim J. Schulz, Roland Malli, Tobias Madl, Andreas Prokesch
Summary: This study reveals a fasting-induced pathway involving p53 that activates the transcription of miR-92a-1-5p, which in turn decreases Slc2a5 expression in thermogenic adipocytes. It suggests fructose as an energy substrate in thermogenic adipocytes.
FRONTIERS IN GENETICS
(2022)
Article
Biochemistry & Molecular Biology
Moritz Oster, Markus Galhuber, Jelena Krstic, Julia S. Steinhoff, Georgia Lenihan-Geels, Sascha Wulff, Marie F. Kiefer, Konstantin M. Petricek, Sylvia J. Wowro, Roberto E. Flores, Na Yang, Chen Li, Yueming Meng, Isabel Reinisch, Manuela Sommerfeld, Stefan Weger, Hansjoerg Habisch, Tobias Madl, Tim J. Schulz, Andreas Prokesch, Michael Schupp
Summary: The tumor suppressor p53 plays a crucial role in controlling liver glycogen storage and is linked to insulin signaling through the transcription factor FOXO1. Acute deletion of p53 prevents glycogen accumulation upon refeeding, while chronic loss of p53 leads to compensational activation of glycogen synthesis pathway. Additionally, high-fat diet-induced insulin resistance with persistent FOXO1 activation affects the regulation of p53 and its target genes during fasting, showing overlapping effects of both FOXO1 and p53 on gene expression in a context-dependent manner.
JOURNAL OF BIOLOGICAL CHEMISTRY
(2022)
Editorial Material
Cell Biology
Ivana Gadjanski, Slavko Mojsilovic, Marietta Herrmann, Jelena Krstic
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2022)
Editorial Material
Pharmacology & Pharmacy
Juan F. Santibanez, Victor H. Villar, Cesar Echeverria
Article
Biochemistry & Molecular Biology
Yolanda Prado, Cesar Echeverria, Carmen G. G. Feijoo, Claudia A. A. Riedel, Claudio Cabello-Verrugio, Juan F. F. Santibanez, Felipe Simon
Summary: Sepsis syndrome is characterized by enhanced secretion of pro-inflammatory cytokines and reactive oxygen species, leading to vascular hyperpermeability, hypotension, multiple organ dysfunction syndrome (MODS), and increased mortality. Endotoxemia-derived sepsis plays an important role in sepsis syndrome, where endotoxin interacts with endothelial cells and induces detrimental effects. Nutrient consumption, including omega-3 fatty acids, ascorbic acid, and polyphenolic antioxidant flavonoids, modulates the progression of sepsis. This study aimed to investigate the impact of dietary supplementation with these nutrients on the modulation of fibrotic endothelial gene-expression patterns during sepsis and their effects on sepsis outcomes. The findings suggest that the consumption of omega-3 fatty acids and polyphenolic antioxidant flavonoids improves endotoxemia outcomes, highlighting the potential role of specific nutrient consumption in sepsis treatment.
Article
Chemistry, Applied
Vishnunarayanan Namboothiri Vadakkedathu Palakkeezhillam, Jebiti Haribabu, Vaishnu Suresh Kumar, Vipin Manakkadan, Puthiyavalappil Rasin, Nattamai Bhuvanesh, Cesar Echeverria, Juan F. Santibanez, Anandaram Sreekanth
Summary: A series of thiosemicarbazones were synthesized and evaluated for their anticancer activity. One compound (CFM) showed potent inhibitory effects against breast adenocarcinoma and urinary bladder cancer cells, while exhibiting negligible cytotoxicity against normal cells. Molecular docking studies suggested effective binding of these compounds with cancer proteins and serum proteins. These findings provide insights into the bioactivities of thiosemicarbazones.
APPLIED ORGANOMETALLIC CHEMISTRY
(2023)
Article
Immunology
Olivera Mitrovic-Ajtic, Dragoslava Dikic, Tijana Suboticki, Sandra Bizic-Radulovic, Bojana Beleslin-Cokic, Teodora Dragojevic, Emilija Zivkovic, Sanja Miljatovic, Milica Vukotic, Dejana Stanisavljevic, Juan Santibanez, Vladan P. Cokic
Summary: The severity and mortality of COVID-19 are higher in males than in females, although the infection rate is the same. This study found that male patients with COVID-19 had lower levels of testosterone and free testosterone, while female patients had increased levels of tumor necrosis factor-alpha. Sex hormones may play a protective role during SARS-CoV-2 infection, but impaired testosterone synthesis in men weakens this protective effect.
Article
Chemistry, Multidisciplinary
Rodrigo Ramirez-Tagle, Leonor Alvarado-Soto, Juan F. Santibanez, Cesar Echeverria
Summary: The relationship between the structural characteristic of curcumin and dimethoxycurcumin and their antitumor activity was investigated. Treatment of HepG2 cells with curcumin and dimethoxycurcumin for 24 hours induced apoptosis and inhibited cell proliferation in a dose-dependent manner. Docking and DFT calculations suggested a structure-activity relationship between the activities of dimethoxycurcumin and the structural characteristics of curcumin in inducing apoptosis in HepG2 cells.
Review
Cell Biology
Juan F. Santibanez, Cesar Echeverria, Carola Millan, Felipe Simon
Summary: This review provides an overview of the current knowledge on the mechanisms of the TGF-beta superfamily in MSCs bone differentiation and further insight into the mutual regulation of microRNAs and TGF-beta in osteogenesis.
Article
Biochemistry & Molecular Biology
Milica Vukotic, Suncica Kapor, Teodora Dragojevic, Dragoslava Dikic, Olivera Mitrovic Ajtic, Milos Diklic, Tijana Suboticki, Emilija Zivkovic, Bojana Beleslin Cokic, Aleksandar Vojvodic, Juan F. Santibanez, Mirjana Gotic, Vladan P. Cokic
Summary: Combining treatment options that target inflammatory pathways can improve fibrosis in patients with rare bone marrow disorders. Research has shown that an increase in inflammatory signaling pathways in patients with myeloproliferative neoplasms (MPN) leads to the differentiation of stem cells in the bone marrow into cells with dysregulated extracellular matrices, causing fibrosis. By combining two drugs that target these pathways, the development of fibrosis in MPN cell cultures can be inhibited.
EXPERIMENTAL AND MOLECULAR MEDICINE
(2022)
Article
Oncology
Diego de Miguel-Perez, Edward M. Pickering, Umberto Malapelle, William Grier, Francesco Pepe, Pasquale Pisapia, Gianluca Russo, Joseph A. Pinto, Alessandro Russo, Giancarlo Troncone, Melissa J. Culligan, Katherine A. Scilla, Ranee Mehra, Pranshu Mohindra, Oscar Arrieta, Andres F. Cardona, Marzia Del Re, Ashutosh Sachdeva, Fred R. Hirsch, Andrea Wolf, Joseph S. Friedberg, Christian Rolfo
Summary: In this study, genetic alterations in resectable pleural mesothelioma tissues and blood samples were analyzed, and it was found that high tissue tumor mutational burden, tissue median minor allele frequency, blood tumor mutational burden, and specific mutations were correlated with outcomes in patients with resected PM. These findings suggest that molecular profiling could help identify longer survivors in patients with resected PM.
EUROPEAN JOURNAL OF CANCER
(2024)
Article
Oncology
Davide Melisi, Camilla Zecchetto, Valeria Merz, Giuseppe Malleo, Luca Landoni, Alberto Quinzii, Simona Casalino, Federica Fazzini, Marina Gaule, Camilla Pesoni, Luca Casetti, Alessandro Esposito, Giovanni Marchegiani, Cristiana Piazzola, Mirko D'Onofrio, Riccardo de Robertis, Armando Gabbrielli, Laura Bernardoni, Stefano F. Crino, Silvia Pietrobono, Claudio Luchini, Camillo Aliberti, Guido Martignoni, Stefano Milleri, Giovanni Butturini, Aldo Scarpa, Roberto Salvia, Claudio Bassi
Summary: This study evaluated the safety and activity of liposomal irinotecan in the perioperative treatment of resectable pancreatic ductal adenocarcinoma (rPDAC) patients. The results showed that NALIRIFOX has manageable and active outcomes, and should be further investigated in randomized trials comparing it to standard upfront surgery followed by adjuvant therapy.
EUROPEAN JOURNAL OF CANCER
(2024)
Article
Oncology
Eric Jonasch, Todd M. Bauer, Kyriakos P. Papadopoulos, Elizabeth R. Plimack, Jaime R. Merchan, David F. Mcdermott, M. Dror Michaelson, Leonard J. Appleman, Ananya Roy, Rodolfo F. Perini, Yanfang Liu, Toni K. Choueiri
Summary: After a median follow-up of 41.2 months, belzutifan monotherapy demonstrated durable antitumor activity in patients with advanced ccRCC and acceptable safety.
EUROPEAN JOURNAL OF CANCER
(2024)
Article
Oncology
Patricia A. H. Hamers, Geraldine R. Vink, Marloes A. G. Elferink, Leon M. G. Moons, Cornelis J. A. Punt, Anne M. May, Miriam Koopman
Summary: Screen-detection of the primary tumor is associated with longer overall survival after metachronous metastasis.
EUROPEAN JOURNAL OF CANCER
(2024)
Article
Oncology
Camilla Nero, Nicolo Bizzarri, Stefano Di Berardino, Francesca Sillano, Giuseppe Vizzielli, Francesco Cosentino, Virginia Vargiu, Pierandrea De Iaco, Anna Myriam Perrone, Enrico Vizza, Benito Chiofalo, Stefano Uccella, Fabio Ghezzi, Luigi Carlo Turco, Giacomo Corrado, Diana Giannarelli, Tina Pasciuto, Gian Franco Zannoni, Anna Fagotti, Giovanni Scambia
Summary: This study evaluates the sensitivity and specificity of sentinel-lymph-node mapping compared to systematic lymphadenectomy in detecting lymph node metastasis in early stage ovarian cancer. The results show that sentinel-lymph-node mapping did not reach the expected sensitivity, but ultra-staging protocol improved the accuracy of diagnosis for patients.
EUROPEAN JOURNAL OF CANCER
(2024)
Article
Oncology
Adriana Hepner, Judith M. Versluis, Roslyn Wallace, Clara Allayous, Lauren Julia Brown, Claudia Trojanielloh, Camille Lea Gerardi, Yanina J. L. Jansenj, Prachi Bhave, Bart Neyns, Andrew Haydon, Olivier Michielin, Joanna Manganan Oliver Klein, Alexander N. Shoushtari, Allison Betof Warner, Paolo Antonio Ascierto, Jennifer Leigh McQuade, Matteo S. Carlino, Lisa Zimmer, Celeste Lebbe, Douglas B. Johnson, Shahneen Sandhu, Victoria Atkinson, Christian U. Blank, Serigne N. Lo, Georgina V. Long, Alexander M. Menzies
Summary: Acquired resistance to PD-1 therapy in melanoma is mainly oligometastatic, and patients may have a favorable survival outcome following salvage treatment.
EUROPEAN JOURNAL OF CANCER
(2024)
Article
Oncology
Savannah Roy, Stephanie Lakritz, Anna R. Schreiber, Elizabeth Molina Kuna, Cathy J. Bradley, Lavanya Kondapalli, Jennifer R. Diamond
Summary: This study evaluates major adverse cardiovascular events (MACE) in older women with TNBC treated with anthracycline and taxane-based chemotherapy (ATAX) compared to taxane-based chemotherapy (TAX). The results show that ATAX does not increase the risk of MACE and there is no difference in survival between patients who received TAX and ATAX.
EUROPEAN JOURNAL OF CANCER
(2024)
Letter
Oncology
Pei-Chun Weng, Yau-Li Huang, Chun-Yu Cheng
EUROPEAN JOURNAL OF CANCER
(2024)
Article
Oncology
Philipp Jansen, Jean Le 'Clerc Arrastia, Daniel Otero Baguer, Maximilian Schmidt, Jennifer Landsberg, Joerg Wenzel, Michael Emberger, Dirk Schadendorf, Eva Hadaschik, Peter Maass, Klaus Georg Griewank
Summary: This study highlights the enormous potential of artificial intelligence in pathology, showing that it can aid in the identification of rare cutaneous adnexal tumors and potentially become a standard tool in routine diagnostics.
EUROPEAN JOURNAL OF CANCER
(2024)
Article
Oncology
Casper W. F. van Eijck, Gaby Strijk, Eveline E. Vietscha, Fleur van der Sijde, Maaike Verheij, Dana A. M. Mustafa, Madelief Vinkc, Joachim G. J. V. Aerts, Casper H. J. van Eijck, Marcella Willemsen
Summary: The study reveals that FOLFIRINOX has immunomodulatory effects, suggesting its potential in immune-based combination therapies for pancreatic cancer. Additionally, certain plasma proteins hold promise as circulating predictive biomarkers for early prediction of FOLFIRINOX response in patients with pancreatic cancer.
EUROPEAN JOURNAL OF CANCER
(2024)
Article
Oncology
Marwan Fakih, Chongkai Wang, Jaideep Sandhu, Jian Ye, Colt Egelston, Xiaochen Li
Summary: This study explores the impact of metastatic sites on treatment outcomes for chemotherapy-refractory colorectal cancer patients. It found that patients with liver or peritoneal metastases had poor treatment outcomes, while those with lung-only metastases showed significant response. The presence of concurrent lymph node or other extrahepatic metastatic disease diminished treatment response in patients with lung metastases. Future checkpoint inhibitor trials should stratify patients based on metastatic locations.
EUROPEAN JOURNAL OF CANCER
(2024)
Article
Oncology
Georgios Christos Tsiatsianis, Candace S. Y. Chan, Ioannis Mouratidis, Nikol Chantzi, Anna Maria Tsiatsiani, Nelson S. Yee, Apostolos Zaravinos, Verena Kantere, Ilias Georgakopoulos-Soares
Summary: The study reveals that nullpeptides can serve as biomarkers for cancer detection and treatment, particularly in highly recurrent cancer patients. These nullpeptides primarily occur in highly expressed genes, particularly in specific loci of oncogenes and tumor suppressors. Recurrent nullpeptides are more likely to be found in neoantigens, which play a significant role in immunotherapy.
EUROPEAN JOURNAL OF CANCER
(2024)
