Journal
EUROPEAN JOURNAL OF CANCER
Volume 47, Issue 15, Pages 2299-2305Publisher
ELSEVIER SCI LTD
DOI: 10.1016/j.ejca.2011.05.032
Keywords
Hepatocellular carcinoma; Matrix metalloproteinase-12; Metastasis; Recurrence; Hepatectomy; Survival
Categories
Funding
- Research Grant Council Hong Kong [HKU5/CRF/08]
Ask authors/readers for more resources
Tumour recurrence and metastasis are pressing issues of hepatocellular carcinoma (HCC) patients who receive surgical treatments. Matrix metalloproteinase-12 (MMP-12), previously identified from our animal model, is involved in tumour invasiveness of rat hepatoma. We aimed to investigate the significance and prognostic value of MMP-12 expression in human HCC. MMP-12 mRNA level of 139 pairs of tumour and non-tumour liver tissues of HCC patients after hepatectomy were investigated by quantitative real-time RT-PCR. MMP-12 mRNA was significantly elevated in tumour liver tissues of HCC patients compared to non-tumour and normal liver tissues. By comparing paired tumour and non-tumour liver tissues, MMP-12 mRNA was overexpressed in 58% of tumour tissue of HCC patients. Overexpression of MMP-12 mRNA was significantly correlated with presence of venous infiltration (p = 0.004), high serum AFP level (p = 0.012), early tumour recurrence (p = 0.018) and poor overall survival (p = 0.02) of HCC patients. Moreover, MMP-12 mRNA was an independent factor in predicting the 1- and 3-year overall survival of HCC patients after hepatectomy. Our data demonstrated that MMP-12 mRNA may be a valuable prognostic marker for both overall survival and tumour recurrence of HCC patients after liver resection. (C) 2011 Elsevier Ltd. All rights reserved.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available